WO2004031375A3 - Regulation de la pde1c humaine - Google Patents

Regulation de la pde1c humaine Download PDF

Info

Publication number
WO2004031375A3
WO2004031375A3 PCT/EP2003/010833 EP0310833W WO2004031375A3 WO 2004031375 A3 WO2004031375 A3 WO 2004031375A3 EP 0310833 W EP0310833 W EP 0310833W WO 2004031375 A3 WO2004031375 A3 WO 2004031375A3
Authority
WO
WIPO (PCT)
Prior art keywords
pde1c
human
regulation
cyclic nucleotide
nucleotide phosphodiesterase
Prior art date
Application number
PCT/EP2003/010833
Other languages
English (en)
Other versions
WO2004031375A2 (fr
Inventor
Jiing-Ren Liou
Original Assignee
Bayer Ag
Jiing-Ren Liou
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Jiing-Ren Liou filed Critical Bayer Ag
Priority to AU2003276009A priority Critical patent/AU2003276009A1/en
Publication of WO2004031375A2 publication Critical patent/WO2004031375A2/fr
Publication of WO2004031375A3 publication Critical patent/WO2004031375A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des réactifs qui régulent la PDE1C humaine et des réactifs qui fixent des produits géniques de la PDE1C, pouvant jouer un rôle dans la prévention, le traitement ou la correction de dysfonctions ou de maladies, telles que, sans en exclure d'autres, le cancer, le diabète, les troubles neurologiques, l'asthme, l'obésité et les troubles cardiovasculaires.
PCT/EP2003/010833 2002-10-01 2003-09-30 Regulation de la pde1c humaine WO2004031375A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003276009A AU2003276009A1 (en) 2002-10-01 2003-09-30 Regulation of human 3', 5' cyclic nucleotide phosphodiesterase pde1c

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US41463402P 2002-10-01 2002-10-01
US60/414,634 2002-10-01
US43444402P 2002-12-19 2002-12-19
US60/434,444 2002-12-19

Publications (2)

Publication Number Publication Date
WO2004031375A2 WO2004031375A2 (fr) 2004-04-15
WO2004031375A3 true WO2004031375A3 (fr) 2004-07-15

Family

ID=32073336

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/010833 WO2004031375A2 (fr) 2002-10-01 2003-09-30 Regulation de la pde1c humaine

Country Status (2)

Country Link
AU (1) AU2003276009A1 (fr)
WO (1) WO2004031375A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004080374A2 (fr) * 2003-03-13 2004-09-23 Bayer Healthcare Ag Diagnostics et therapies pour maladies associees a la phosphodi-esterase 1c (pde1c)
US20090030065A1 (en) * 2005-06-17 2009-01-29 Nycomed Gmbh Use of Pde1c and Inhibitors Thereof
EP2370080A1 (fr) * 2008-12-02 2011-10-05 University of Utah Research Foundation Pde1 en tant que cible thérapeutique dans les maladies cardiaques
JP2016518343A (ja) 2013-03-15 2016-06-23 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 新規使用
EP3436083A4 (fr) 2016-03-28 2019-11-27 Intra-Cellular Therapies, Inc. Nouvelles compositions et méthodes
EP3970719A1 (fr) 2016-09-12 2022-03-23 Intra-Cellular Therapies, Inc. Inhibiteur de pde1 pour utilisation dans une methode de traitement ou de prophylaxie de l'inflammation et/ou d'une maladie ou d'un trouble inflammatoire

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5800987A (en) * 1991-04-19 1998-09-01 The Board Of Regents Of The University Of Washington Assay methods using DNA encoding mammalian phosphodiesterases
EP1308459A2 (fr) * 2001-11-05 2003-05-07 Helix Research Institute Séquences d'ADN complementaires pleine longueur

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5800987A (en) * 1991-04-19 1998-09-01 The Board Of Regents Of The University Of Washington Assay methods using DNA encoding mammalian phosphodiesterases
EP1308459A2 (fr) * 2001-11-05 2003-05-07 Helix Research Institute Séquences d'ADN complementaires pleine longueur

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BEAVO J A: "CYCLIC NUCLEOTIDE PHOSPHODIESTERASES: FUNCTIONAL IMPLICATIONS OF MULTIPLE ISOFORMS", PHYSIOLOGICAL REVIEWS, AMERICAN PHYSIOLOGICAL SOCIETY, US, vol. 75, no. 4, 1 October 1995 (1995-10-01), pages 725 - 748, XP002034532, ISSN: 0031-9333 *
CHEN YAN ET AL: "Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 92, no. 21, 10 October 1995 (1995-10-10), pages 9677 - 9681, XP002139647, ISSN: 0027-8424 *
DATABASE EMBL SEQUENCE LIBRARY [online] 16 July 2002 (2002-07-16), ISOGAI T., YAMAMOTO J.: "Homo sapiens cDNA FLJ34415 fis, clone HEART2004764, highly similar to CALCIUM/CALMODULIN-DEPENDENT 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1C (EC 3.1.4.17)", XP002280868, retrieved from HTTP://SRS.EBI.AC.UK Database accession no. AK091734 *
LOUGHNEY KATE ET AL: "Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 2, 1996, pages 796 - 806, XP002280866, ISSN: 0021-9258 *
YAN CHEN ET AL: "The calmodulin-dependent phosphodiesterase gene PDE1C encodes several functional different splice variants in a tissue-specific manner", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 41, 1996, pages 25699 - 25706, XP002280867, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
WO2004031375A2 (fr) 2004-04-15
AU2003276009A8 (en) 2004-04-23
AU2003276009A1 (en) 2004-04-23

Similar Documents

Publication Publication Date Title
WO2004031375A3 (fr) Regulation de la pde1c humaine
WO2002061092A3 (fr) Regulation de la lysyl oxydase humaine
WO2002070675A3 (fr) Regulation de l'histone acetyltransferase humaine
WO2001077149A3 (fr) Regulation d'une proteine gpcr type cyslt2 humaine
WO2003052088A3 (fr) Regulation de la sialyltransferase humaine
WO2002032938A3 (fr) Regulation de la proteine humaine de type pgc-1
WO2002055712A3 (fr) Regulation de l'alanine aminotransferase humaine
WO2002036613A3 (fr) Regulation de la proteine humaine de type 'patched'
WO2002055710A3 (fr) Regulation de l'acide phosphatase pourpre humain
WO2002055681A3 (fr) Regulation de la tau-tubuline kinase humaine
WO2002099106A3 (fr) Regulation de gpcr de type secretine humaine
WO2002033056A3 (fr) Regulation de serine-threonine kinase humaine
WO2002042435A3 (fr) Regulation de la tyrosine phosphatase humaine
WO2002062975A3 (fr) Regulation de la proteine humaine du type elongase hselo1
WO2003072767A3 (fr) Regulation de la lipase humaine
WO2003018815A3 (fr) Regulation de la grk humaine
WO2003000903A3 (fr) Regulation de serine/threonine proteine kinase humaine de type nek
WO2003025174A3 (fr) Regulation de la proteine humaine de type mrp1
WO2002053749A3 (fr) Regulation de la proteine kinase serine/threonine humaine
WO2002046403A3 (fr) Regulation de la proteine humaine du type 'patched'
WO2004033495A3 (fr) Regulation de la pde6b humaine
WO2003000873A3 (fr) Régulation de la sérine/thréonine protéine kinase humaine nek1
WO2003033709A3 (fr) Regulation de la proteine kinase serine/threonine humaine
WO2002053756A3 (fr) Regulation de glucosamine-6-phosphate desaminase humaine
WO2002031161A3 (fr) Regulation de l'enzyme humaine de type phospholipase

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP