WO2003020710A1 - Benzothiazepine derivatives - Google Patents

Benzothiazepine derivatives Download PDF

Info

Publication number
WO2003020710A1
WO2003020710A1 PCT/GB2002/003983 GB0203983W WO03020710A1 WO 2003020710 A1 WO2003020710 A1 WO 2003020710A1 GB 0203983 W GB0203983 W GB 0203983W WO 03020710 A1 WO03020710 A1 WO 03020710A1
Authority
WO
WIPO (PCT)
Prior art keywords
solvate
alkyl
carbamoyl
formula
hydrogen
Prior art date
Application number
PCT/GB2002/003983
Other languages
English (en)
French (fr)
Inventor
Ingemar Starke
Mikael Ulf Johan Dahlstrom
David Blomberg
Suzanne Alenfalk
Peter Nordberg
Andreas Christer Wallberg
Stig Jonas Bostrom
Original Assignee
Astrazeneca Ab
Astrazeneca Uk Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2003524981A priority Critical patent/JP4441261B2/ja
Application filed by Astrazeneca Ab, Astrazeneca Uk Limited filed Critical Astrazeneca Ab
Priority to DE60233239T priority patent/DE60233239D1/de
Priority to CA002459346A priority patent/CA2459346A1/en
Priority to IL16050302A priority patent/IL160503A0/xx
Priority to BR0212277-4A priority patent/BR0212277A/pt
Priority to KR10-2004-7003185A priority patent/KR20040029147A/ko
Priority to US10/488,540 priority patent/US7192946B2/en
Priority to NZ531512A priority patent/NZ531512A/en
Priority to EP02755285A priority patent/EP1430040B1/en
Priority to AT02755285T priority patent/ATE438634T1/de
Priority to MXPA04002032A priority patent/MXPA04002032A/es
Publication of WO2003020710A1 publication Critical patent/WO2003020710A1/en
Priority to NO20040924A priority patent/NO20040924L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
PCT/GB2002/003983 2001-09-04 2002-08-30 Benzothiazepine derivatives WO2003020710A1 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
KR10-2004-7003185A KR20040029147A (ko) 2001-09-04 2002-08-30 벤조티아제핀 유도체
DE60233239T DE60233239D1 (de) 2001-09-04 2002-08-30 Benzothiazepinderivate
CA002459346A CA2459346A1 (en) 2001-09-04 2002-08-30 Benzothiazepine derivatives
IL16050302A IL160503A0 (en) 2001-09-04 2002-08-30 Benzothiazepine derivatives
BR0212277-4A BR0212277A (pt) 2001-09-04 2002-08-30 Composto, processo para preparar um composto, uso de um composto, método para produzir um efeito inibidor do ibat, e, composição farmacêutica
JP2003524981A JP4441261B2 (ja) 2001-09-04 2002-08-30 ベンゾチアゼピン誘導体
US10/488,540 US7192946B2 (en) 2001-09-04 2002-08-30 Benzothiazepine derivatives
AT02755285T ATE438634T1 (de) 2001-09-04 2002-08-30 Benzothiazepinderivate
EP02755285A EP1430040B1 (en) 2001-09-04 2002-08-30 Benzothiazepine derivatives
NZ531512A NZ531512A (en) 2001-09-04 2002-08-30 Benzothiazepine derivatives
MXPA04002032A MXPA04002032A (es) 2001-09-04 2002-08-30 Derivados de benzotiacepina.
NO20040924A NO20040924L (no) 2001-09-04 2004-03-03 Benzotiazepinderivater.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0121337.0 2001-09-04
GBGB0121337.0A GB0121337D0 (en) 2001-09-04 2001-09-04 Chemical compounds

Publications (1)

Publication Number Publication Date
WO2003020710A1 true WO2003020710A1 (en) 2003-03-13

Family

ID=9921450

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2002/003983 WO2003020710A1 (en) 2001-09-04 2002-08-30 Benzothiazepine derivatives

Country Status (18)

Country Link
US (1) US7192946B2 (und)
EP (1) EP1430040B1 (und)
JP (1) JP4441261B2 (und)
KR (1) KR20040029147A (und)
CN (1) CN1599731A (und)
AT (1) ATE438634T1 (und)
BR (1) BR0212277A (und)
CA (1) CA2459346A1 (und)
DE (1) DE60233239D1 (und)
ES (1) ES2329226T3 (und)
GB (1) GB0121337D0 (und)
IL (1) IL160503A0 (und)
MX (1) MXPA04002032A (und)
NO (1) NO20040924L (und)
NZ (1) NZ531512A (und)
UY (1) UY27431A1 (und)
WO (1) WO2003020710A1 (und)
ZA (1) ZA200401551B (und)

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US6906058B2 (en) 2000-03-08 2005-06-14 Astrazeneca Ab 1,5-Benzothiazepines and their use as hypolipidaemics
WO2005092845A1 (en) * 2004-03-10 2005-10-06 Pfizer Products Inc. Substituted heteroaryl- and phenylsulfamoyl compounds
US7125864B2 (en) 2001-09-07 2006-10-24 Astrazeneca Ab Benzothiazepine derivatives for the treatment of hyperlipidemia
US7132416B2 (en) 2001-09-08 2006-11-07 Astrazeneca Ab Benzothiazepine and benzothiazepine derivatives with ileal bile acid transport (IBAT) inhibotory activity for the treatment hyperlipidaemia
US7192945B2 (en) 2000-12-21 2007-03-20 Astrazeneca Ab Benzothiazepine derivatives
US7192947B2 (en) 2002-06-14 2007-03-20 Astrazeneca Ab Peptides derivatives comprising thiazepine group for the treatment of hyperlipidemic conditions
US7226943B2 (en) 2001-09-07 2007-06-05 Astrazeneca Ab Benzothiepine ileal bile acid transport inhibitors
US7238684B2 (en) 2002-04-25 2007-07-03 Astrazeneca Ab Benzothiadiazepine derivatives, processes for their preparation and pharmaceutical compositions containing them
US7276539B2 (en) 2001-12-19 2007-10-02 Astrazeneca Ab 3-Phenyl-2-arylalkylthiopropionic acid derivatives as selective agonists of ppar-alpha
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US7355069B2 (en) 2002-06-20 2008-04-08 Astrazeneca Ab Ortho-substituted benzoic acid derivatives for the treatment of insulin resistance
US8067584B2 (en) 2003-02-25 2011-11-29 Albireo Ab Benzothiazepine derivatives
WO2012064267A1 (en) 2010-11-08 2012-05-18 Albireo Ab A pharmaceutical combination comprising an ibat inhibitor and a bile acid binder
WO2013063526A1 (en) 2011-10-28 2013-05-02 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease
WO2014144485A1 (en) 2013-03-15 2014-09-18 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of barrett's esophagus and gastroesophageal reflux disease
WO2014144650A2 (en) 2013-03-15 2014-09-18 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease
EP2995317A1 (en) 2010-05-26 2016-03-16 Satiogen Pharmaceuticals, Inc. Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions
US9409875B2 (en) 2013-04-26 2016-08-09 Elobix Ab Crystal modifications of elobixibat
US9688720B2 (en) 2010-11-08 2017-06-27 Albireo Ab IBAT inhibitors for the treatment of liver diseases
WO2017138878A1 (en) 2016-02-09 2017-08-17 Albireo Ab Oral cholestyramine formulation and use thereof
WO2017138877A1 (en) 2016-02-09 2017-08-17 Albireo Ab Oral cholestyramine formulation and use thereof
EP3266457A1 (en) 2011-10-28 2018-01-10 Lumena Pharmaceuticals LLC Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases
US10183920B2 (en) 2014-10-24 2019-01-22 Elobix Ab Crystal modifications of elobixibat
WO2019032027A1 (en) 2017-08-09 2019-02-14 Albireo Ab CHOLESTYRAMINE TABLETS, ORAL FORMULATIONS OF CHOLESTYRAMINE AND THEIR USE
WO2019032026A1 (en) 2017-08-09 2019-02-14 Albireo Ab CHOLESTYRAMINE GRANULES, ORAL FORMULATIONS OF CHOLESTYRAMINE AND THEIR USE
US10428109B1 (en) 2018-03-09 2019-10-01 Elobix Ab Process for the preparation of 1,5-benzothiazepine compounds
US10441605B2 (en) 2016-02-09 2019-10-15 Albireo Ab Oral cholestyramine formulation and use thereof
US10441604B2 (en) 2016-02-09 2019-10-15 Albireo Ab Cholestyramine pellets and methods for preparation thereof
WO2019234077A1 (en) 2018-06-05 2019-12-12 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
US10709755B2 (en) 2014-06-25 2020-07-14 Elobix Ab Solid formulation and method for preventing or reducing coloration thereof
US10722457B2 (en) 2018-08-09 2020-07-28 Albireo Ab Oral cholestyramine formulation and use thereof
WO2020161217A1 (en) 2019-02-06 2020-08-13 Albireo Ab Benzothiadiazepine compounds and their use as bile acid modulators
WO2020161216A1 (en) 2019-02-06 2020-08-13 Albireo Ab Benzothiazepine compounds and their use as bile acid modulators
US10786529B2 (en) 2016-02-09 2020-09-29 Albireo Ab Oral cholestyramine formulation and use thereof
US10793534B2 (en) 2018-06-05 2020-10-06 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
US10941127B2 (en) 2019-02-06 2021-03-09 Albireo Ab Benzothiadiazepine compounds and their use as bile acid modulators
US10975045B2 (en) 2019-02-06 2021-04-13 Aibireo AB Benzothiazepine compounds and their use as bile acid modulators
US10975046B2 (en) 2018-06-20 2021-04-13 Albireo Ab Crystal modifications of odevixibat
US11007142B2 (en) 2018-08-09 2021-05-18 Albireo Ab Oral cholestyramine formulation and use thereof
US11014898B1 (en) 2020-12-04 2021-05-25 Albireo Ab Benzothiazepine compounds and their use as bile acid modulators
WO2021110886A1 (en) 2019-12-04 2021-06-10 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
WO2021110884A1 (en) 2019-12-04 2021-06-10 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
WO2021110883A1 (en) 2019-12-04 2021-06-10 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
WO2021110885A1 (en) 2019-12-04 2021-06-10 Albireo Ab Benzothiadiazepine compounds and their use as bile acid modulators
WO2021110887A1 (en) 2019-12-04 2021-06-10 Albireo Ab Benzothiazepine compounds and their use as bile acid modulators
US11111224B2 (en) 2019-12-04 2021-09-07 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
US11180465B2 (en) 2019-12-04 2021-11-23 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
US11225466B2 (en) 2019-12-04 2022-01-18 Albireo Ab Benzothiadiazepine compounds and their use as bile acid modulators
WO2022029101A1 (en) 2020-08-03 2022-02-10 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
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WO2022117778A1 (en) 2020-12-04 2022-06-09 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
US11377429B2 (en) 2020-08-03 2022-07-05 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
WO2022253997A1 (en) 2021-06-03 2022-12-08 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
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ATE438634T1 (de) 2009-08-15
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US20040254160A1 (en) 2004-12-16
US7192946B2 (en) 2007-03-20
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UY27431A1 (es) 2003-03-31
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EP1430040B1 (en) 2009-08-05
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