WO2003013602A1 - Inhibitors of her3 activity - Google Patents

Inhibitors of her3 activity Download PDF

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Publication number
WO2003013602A1
WO2003013602A1 PCT/EP2002/008938 EP0208938W WO03013602A1 WO 2003013602 A1 WO2003013602 A1 WO 2003013602A1 EP 0208938 W EP0208938 W EP 0208938W WO 03013602 A1 WO03013602 A1 WO 03013602A1
Authority
WO
WIPO (PCT)
Prior art keywords
her3
antibody
composition
inhibitor
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2002/008938
Other languages
English (en)
French (fr)
Inventor
Axel Ullrich
Edward Htun-Van Der Horst
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Max Planck Gesellschaft zur Foerderung der Wissenschaften
Original Assignee
Max Planck Gesellschaft zur Foerderung der Wissenschaften
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8178284&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2003013602(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to JP2003518606A priority Critical patent/JP5226926B2/ja
Priority to DK02794590T priority patent/DK1414494T3/da
Priority to US10/486,113 priority patent/US9011851B2/en
Priority to DE60231407T priority patent/DE60231407D1/de
Priority to EP02794590A priority patent/EP1414494B1/en
Application filed by Max Planck Gesellschaft zur Foerderung der Wissenschaften filed Critical Max Planck Gesellschaft zur Foerderung der Wissenschaften
Priority to CN028156153A priority patent/CN1541109B/zh
Priority to CA2456723A priority patent/CA2456723C/en
Priority to AU2002333384A priority patent/AU2002333384B2/en
Publication of WO2003013602A1 publication Critical patent/WO2003013602A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals

Definitions

  • the present invention relates to a pharmaceutical composition
  • a pharmaceutical composition comprising as an active agent an inhibitor of HER3 activity, particularly an anti-HER3- antibody. Further, the use of this composition for the diagnosis, prevention or treatment of hyperproliferative diseases, particularly tumor diseases is disclosed.
  • Protein tyrosine kinases are known to be enzymes, which mediate signal transduction processes that regulate cell growth and differentiation. Receptor protein tyrosine kinases act via ligand-stimulated tyrosine phosphorylation of substrates.
  • HER3 also called ErbB3 is a member of the epidermal growth factor receptor (EGFR) subfamily of receptor protein tyrosine kinases (Plowman et al., Proc. Natl. Acad. Sci. U.S.A. 87 (1 990), 4905-4909; Kraus et al., Proc. Natl. Acad. Sci. U.S.A. 86 (1 989), 91 93- 91 97 and Kraus et al., Proc. Natl. Acad. Sci. U.S.A. 90 (1 993), 2900- 2904) .
  • EGFR epidermal growth factor receptor
  • HER3 has been found to be overexpressed in several types of cancer such as breast, gastrointestinal and pancreatic cancers.
  • HER3 is co- expressed with HER2, another member of the EGFR subfamily of receptor protein tyrosine kinases, an active heterodimeric signalling complex is formed.
  • Vadlamudi et al. (Oncogenes 1 8 (1 999), 305-314) describe the regulation of the cyclooxygenase (COX-2) pathway by the HER2 receptor. It was found that a specific inhibitor of COX-2 can suppress the mitogenic and invasive action of colorectal cancer cells. Further, it was found that incubation with a monoclonal anti-HER3 antibody leads to a reduction in the levels HER2/HER3 heterodimers, but results in an only partial reduction of COX-2 expression.
  • WO 00/31 048 discloses a quinazoline derivative which acts as an inhibitor of receptor tyrosine kinases such as EGFR, HER2 and HER4. An inhibition of HER3 is however not disclosed.
  • WO 00/78347 discloses methods for arresting or inhibiting cell growth, comprising preventing or reducing ErbB-2/ErbB-3 heterodimer formation.
  • the agent may be a combination of an anti-HER2 extracellular domaine antibody and an anti-HER3 antibody, e.g. the HER3 antibody H3.105.5 purchased from Neomarkers. It is however not clear which type of anti-HER3 antibody is required to obtain desirable therapeutic effects.
  • US-patent 5,804,396 describes a method for identifying an agent for treatment of a proliferative disorder, comprising the steps of assaying a potential agent for activity in inhibition of signal transdcution by a HER2/HER3 or HER2/HER4 or HER3/HER4 heterodimer. Specific HER3 inhibitors are not dislcosed.
  • Herceptin an agonistic monoclonal antibody against HER2 with anti-HER3-antibodies, namely (i) a- HER3-ECD, a murine monoclonal antibody lgG 1 , Upstate Biotechnology, Cat. No. # 05-471 , directed against the Heregulin binding site of HER3, (ii) antibody 1 B4C3 from our laboratory and (iii) antibody 2D102 also from our laboratory, in invasive breast cancer cell lines MCR-7 (DKFZ Heidelberg), MDA-MB-468 (ATCC HTB-1 32) and MDA-MB231 (ATCC HTB-26) expressing different HER2:HER3 ratios.
  • MCR-7 DKFZ Heidelberg
  • MDA-MB-468 ATCC HTB-1 32
  • MDA-MB231 ATCC HTB-26
  • anti-HER3- antibody was also capable of downregulating extracellular signal-regulated kinase 2 (ERK2) after ⁇ / ⁇ -HRG stimulation. Furthermore, we demonstrate a significant reduction of the migratory and proliferative property of the breast cancer cell lines after pretreatment with anti-HER3-antibody. Our data clearly show that ⁇ n anti-HER3-antibody is more potent in diminishing signal transduction processes after HRG stimulation than Herceptin. Furthermore, in specific cancer types, e.g. melanoma, anti-HER3 antibodies are effective in reducing migratory and proliferative properties while anti- HER2 antibodies do not show any significant effect at all. These data demonstrate the great potential of anti-HER3 antibodies or other HER3 inhibitors for the therapy of breast cancer and other malignancies characterized by hypersignalling through HER3 and its heterodimerization partners.
  • ERK2 extracellular signal-regulated kinase 2
  • the present invention relates to a pharmaceutical composition
  • a pharmaceutical composition comprising as an active agent a specific type of inhibitor of HER3 activity and pharmaceutically acceptable carriers, diluents and/or adjuvants.
  • the HER3 inhibitor of the invention is characterized in that binding of the inhibitor to HER3 reduces HER3 mediated signal transduction.
  • a reduction of HER3 mediated signal transduction may be caused by a downregulation of HER3 resulting in an at least partial disappearance of HER3 molecules from the cell surface.
  • the reduction of HER3 mediated signal transduction may be caused by a stabilization of HER3 on the cell surface in a substantially inactive form, i.e. a form which exhibits a lower signal transduction compared to the non-stabilized form.
  • the inhibitor of the invention may influence the binding of Heregulin to HER3, particularly by decreasing the binding of Heregulin to HER3. In other embodiments, however, the inhibitor may not compete with the binding of Heregulin to HER3.
  • the inhibitor is an anti-HER3-antibody.
  • the antibody is directed against the extracellular domain of HER3.
  • HER3 inhibitors particularly low molecular weight inhibitors, e.g. peptides or organic compounds may be used.
  • antibody covers monoclonal antibodies, polyclonal antibodies, multispecific antibodies (e.g. bispecific antibodies) formed from at least two antibodies and antibody fragments as long as they exhibit the desired activity.
  • the antibody may be a monoclonal antibody which may be obtained by the hybridoma method as described by K ⁇ hler et al. (Nature 256 (1 975), 495) or by recombinant DNA methods (cf. e.g. U.S. Patent 4,81 6,567). Monoclonal antibodies may also be isolated from phage antibody libraries using techniques described in Clackson et al. (Nature 352 (1 991 ), 624- 628) and Marks et al. (J.Mol. Biol.222 ( 1 991 ), 581 -597). The antibody may be an IgM, IgG, e.g. lgG 1 , lgG2, lgG3 or lgG4.
  • the antibody is selected from antibodies 1 B4C3 (lgG2a) and 2D1 D1 2 (lgG1 ) produced by the hybridoma cell lines DSM ACC 2527 or DSM ACC 251 7, fragments thereof or recombinant derivatives thereof.
  • 1 B4C3 is an antibody which leads to internalization of HER3
  • 2D1 D1 2 is an antibody which leads to stabilization of HER3.
  • the inhibitor may be selected from non- antibody derived binding proteins such as fibronectin type III domains or anticalins (Skerra, "Engineered protein scaffolds for molecular recognition", J. Mol. Recog. 1 3 (2000), 1 67-1 87 and references cited therein) .
  • Herceptin Particularly, in melanoma cells, the anti-HER3-antibody was effective, while Herceptin did not show a significant effect, even though HER2 was expressed by the melanoma cells.
  • HER3 and/or the association of GRB2 with SHC inhibiting receptor tyrosin phosphorylation, inhibiting AKT phosphorylation, decreasing tumor invasiveness, particularly in breast cancer and melanoma, inhibiting PYK2 tyrosine phosphorylation and inhibiting ERK2 phosphorylation.
  • the adaptor protein SHC mediates MAPK signalling pathways downstream of growth-factor receptors, activating ERK2 and JNK, resepectively.
  • MAPK kinase assays under the same experimental conditions in MCF-7 and MB- 468 ( Figure 3) .
  • HC had no effect on ERK2 activity (data not shown).
  • Monoclonal antibodies 1 B4C3 and 2D1 D12 inhibit proliferation and migration of breast cancer cell lines MDA-MB-435S and melanoma cell line Mel-Juso

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PCT/EP2002/008938 2001-08-09 2002-08-09 Inhibitors of her3 activity Ceased WO2003013602A1 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
AU2002333384A AU2002333384B2 (en) 2001-08-09 2002-08-09 Inhibitors of HER3 activity
DK02794590T DK1414494T3 (da) 2001-08-09 2002-08-09 Hæmmende antistoffer af HER3-aktivitet
US10/486,113 US9011851B2 (en) 2001-08-09 2002-08-09 Inhibitors of her3 activity
DE60231407T DE60231407D1 (de) 2001-08-09 2002-08-09 Hemmende antikörper der her3-aktivität
EP02794590A EP1414494B1 (en) 2001-08-09 2002-08-09 Inhibitory antibodies of her3 activity
JP2003518606A JP5226926B2 (ja) 2001-08-09 2002-08-09 Ｈｅｒ３活性の阻害剤
CN028156153A CN1541109B (zh) 2001-08-09 2002-08-09 Her3活性抑制剂
CA2456723A CA2456723C (en) 2001-08-09 2002-08-09 Inhibitors of her3 activity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01119260.6 2001-08-09
EP01119260A EP1283053A1 (en) 2001-08-09 2001-08-09 Inhibitors of HER3 activity

Publications (1)

Publication Number Publication Date
WO2003013602A1 true WO2003013602A1 (en) 2003-02-20

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ID=8178284

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/008938 Ceased WO2003013602A1 (en) 2001-08-09 2002-08-09 Inhibitors of her3 activity

Country Status (13)

Country Link
US (1) US9011851B2 (enExample)
EP (3) EP1283053A1 (enExample)
JP (1) JP5226926B2 (enExample)
CN (2) CN102078613A (enExample)
AT (1) ATE424219T1 (enExample)
AU (1) AU2002333384B2 (enExample)
CA (1) CA2456723C (enExample)
CY (1) CY1110322T1 (enExample)
DE (1) DE60231407D1 (enExample)
DK (1) DK1414494T3 (enExample)
ES (1) ES2323772T3 (enExample)
PT (1) PT1414494E (enExample)
WO (1) WO2003013602A1 (enExample)

Cited By (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007077028A2 (en) 2005-12-30 2007-07-12 U3 Pharma Ag Antibodies directed to her-3 and uses thereof
US7846440B2 (en) 2007-02-16 2010-12-07 Merrimack Pharmaceuticals, Inc. Antibodies against ErbB3 and uses thereof
US7919098B2 (en) 2002-03-26 2011-04-05 Zensun ( Shanghai ) Sci & Tech Co., Ltd. ErbB-3 based methods and compositions for treating neoplasms
WO2011060206A2 (en) 2009-11-13 2011-05-19 U3 Pharma Gmbh Material and methods for treating or preventing her-3 associated diseases
WO2011076683A1 (en) 2009-12-22 2011-06-30 Roche Glycart Ag Anti-her3 antibodies and uses thereof
EP2518508A1 (en) 2006-11-28 2012-10-31 U3 Pharma GmbH Activated HER3 as a marker for predicting therapeutic efficacy
WO2012156309A1 (en) 2011-05-13 2012-11-22 Millegen Antibodies against her3
WO2013124419A1 (en) 2012-02-23 2013-08-29 U3 Pharma Gmbh Her3 inhibitor for modulating radiosensitivity
US8597652B2 (en) 2009-03-20 2013-12-03 Genentech, Inc. Multispecific anti-HER antibodies
US8623592B2 (en) 2008-08-15 2014-01-07 Merrimack Pharmaceuticals, Inc. Methods and systems for predicting response of cells to a therapeutic agent
WO2014072306A1 (en) 2012-11-08 2014-05-15 F. Hoffmann-La Roche Ag Her3 antigen binding proteins binding to the beta-hairpin of her3
WO2014108484A2 (en) 2013-01-11 2014-07-17 F. Hoffmann-La Roche Ag Combination therapy of anti-her3 antibodies
US8791244B2 (en) 2011-09-30 2014-07-29 Regeneron Pharmaceuticals, Inc. Anti-ErbB3 antibodies and uses thereof
US8895001B2 (en) 2010-03-11 2014-11-25 Merrimack Pharmaceuticals, Inc. Use of ErbB3 inhibitors in the treatment of triple negative and basal-like breast cancers
US9011851B2 (en) 2001-08-09 2015-04-21 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. Inhibitors of her3 activity
US9085622B2 (en) 2010-09-03 2015-07-21 Glaxosmithkline Intellectual Property Development Limited Antigen binding proteins
WO2015155998A1 (en) 2014-04-10 2015-10-15 Daiichi Sankyo Company, Limited Anti-her3 antibody-drug conjugate
US9217039B2 (en) 2010-11-01 2015-12-22 Symphogen A/S Anti-HER3 antibodies and compositions
US9273143B2 (en) 2011-09-30 2016-03-01 Regeneron Pharmaceuticals, Inc. Methods and compositions comprising a combination of an anti-ErbB3 antibody and an anti-EGFR antibody
US9533042B2 (en) 2007-06-04 2017-01-03 Genentech, Inc. Anti-notch NRR antibodies and methods using same
US9637543B2 (en) 2011-11-09 2017-05-02 The Uab Research Foundation HER3 antibodies and uses thereof
US9688761B2 (en) 2013-12-27 2017-06-27 Merrimack Pharmaceuticals, Inc. Biomarker profiles for predicting outcomes of cancer therapy with ERBB3 inhibitors and/or chemotherapies
US9725511B2 (en) 2012-11-08 2017-08-08 Hoffmann-La Roche Inc. Anti-HER3/HER4 antibodies binding to the beta-hairpin of HER3 and the beta-hairpin of HER4
US9766242B2 (en) 2009-01-15 2017-09-19 Laboratory Corporation Of America Holdings Methods of determining patient response by measurement of HER-3 and P95
US9783611B2 (en) 2014-05-14 2017-10-10 Hoffman-La Roche Inc. Anti-HER3 antibodies binding to the beta-hairpin of HER3
US9783456B1 (en) 1999-06-18 2017-10-10 Zensun (Shanghai) Science & Technology, Co., Ltd. Method for inhibiting cell growth using anti-ErbB-3 and anti-ErbB-2 antibodies
US10184006B2 (en) 2015-06-04 2019-01-22 Merrimack Pharmaceuticals, Inc. Biomarkers for predicting outcomes of cancer therapy with ErbB3 inhibitors
US10273308B2 (en) 2008-12-01 2019-04-30 Laboratory Corporation Of America Holdings Methods of producing antibodies specific for p95
US10358501B2 (en) 2013-03-14 2019-07-23 The Board Of Regents Of The University Of Texas System HER3 specific monoclonal antibodies for diagnostic and therapeutic use
US10906974B2 (en) 2017-01-17 2021-02-02 Daiichi Sankyo Company, Limited Anti-GPR20 antibody and anti-GPR20 antibody-drug conjugate
US11077202B2 (en) 2017-05-15 2021-08-03 Daiichi Sankyo Company, Limited Anti-CDH6 antibody and anti-CDH6 antibody-drug conjugate
US11173213B2 (en) 2015-06-29 2021-11-16 Daiichi Sankyo Company, Limited Method for selectively manufacturing antibody-drug conjugate
US11273155B2 (en) 2016-12-12 2022-03-15 Daiichi Sankyo Company, Limited Combination of antibody-drug conjugate and immune checkpoint inhibitor
US11318212B2 (en) 2017-08-31 2022-05-03 Daiichi Sankyo Company, Limited Method for producing antibody-drug conjugate
US11872289B2 (en) 2018-05-18 2024-01-16 Daiichi Sankyo Co., Ltd. Anti-MUC1 antibody-drug conjugate
US11945882B2 (en) 2017-08-31 2024-04-02 Daiichi Sankyo Company, Limited Method for producing antibody-drug conjugate
US12220604B2 (en) 2018-07-31 2025-02-11 Daiichi Sankyo Company, Limited Treatment of metastatic brain tumor by administration of an antibody-drug conjugate
US12358999B2 (en) 2018-07-27 2025-07-15 Daiichi Sankyo Company, Limited Protein recognizing drug moiety of antibody-drug conjugate
US12503489B2 (en) 2017-08-31 2025-12-23 Daiichi Sankyo Company, Limited Method for producing antibody-drug conjugate

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI229650B (en) * 2002-11-19 2005-03-21 Sharp Kk Substrate accommodating tray
EP2851091B1 (en) 2007-04-13 2017-12-27 Dana-Farber Cancer Institute, Inc. Methods for treating cancer resistant to ERBB therapeutics
BRPI0813583A2 (pt) * 2007-07-13 2014-12-30 Prometheus Lab Inc Métodos para selecionar um medicamento anticâncer, para identificar a resposta de um tumor pulmonar, e para prognosticar a resposta de um paciente, e, arranjo
EP2138511A1 (en) * 2008-06-27 2009-12-30 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. HER3 as a determinant for the prognosis of melanoma
WO2010085845A1 (en) * 2009-01-28 2010-08-05 The University Of Queensland Cancer therapy and/or diagnosis
US8362215B2 (en) * 2009-04-29 2013-01-29 Trellis Bioscience, Llc Antibodies immunoreactive with heregulin-coupled HER3
WO2011136911A2 (en) 2010-04-09 2011-11-03 Aveo Pharmaceuticals, Inc. Anti-erbb3 antibodies
UY33498A (es) 2010-07-09 2013-01-03 Sanofi Aventis Combinaciones de inhibidores de quinasas para el tratamiento de cancer
PL2606070T3 (pl) 2010-08-20 2017-06-30 Novartis Ag Przeciwciała dla receptora epidermalnego czynnika wzrostu 3 (her3)
JP2014508782A (ja) 2011-03-11 2014-04-10 メリマック ファーマシューティカルズ インコーポレーティッド ホルモン不応性乳癌の治療におけるｅｇｆｒファミリー受容体の阻害剤の使用
CN103429262A (zh) 2011-03-15 2013-12-04 梅里麦克制药股份有限公司 克服对erbb途径抑制剂的抗性
HRP20170713T1 (hr) 2011-04-19 2017-07-14 Merrimack Pharmaceuticals, Inc. Bispecifično anti-igf-1r i anti-erbb3 antitijelo
JP2014516960A (ja) * 2011-05-19 2014-07-17 インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル） 抗ヒトｈｅｒ３抗体及びその使用
WO2012176779A1 (ja) * 2011-06-20 2012-12-27 協和発酵キリン株式会社 抗ｅｒｂＢ３抗体
US9828635B2 (en) 2011-10-06 2017-11-28 Aveo Pharmaceuticals, Inc. Predicting tumor response to anti-ERBB3 antibodies
MX350957B (es) * 2011-11-23 2017-09-27 Medimmune Llc Moleculas de union especificas para her3 y usos de las mismas.
AU2012349735B2 (en) 2011-12-05 2016-05-19 Novartis Ag Antibodies for epidermal growth factor receptor 3 (HER3)
US20170275367A1 (en) 2012-11-21 2017-09-28 Janssen Biotech, Inc. Bispecific EGFR/C-Met Antibodies
US9695228B2 (en) 2012-11-21 2017-07-04 Janssen Biotech, Inc. EGFR and c-Met fibronectin type III domain binding molecules
PL2922872T3 (pl) 2012-11-21 2019-03-29 Janssen Biotech, Inc. Bispecyficzne przeciwciała przeciwko egfr/c-met
EP2981828A1 (en) * 2013-04-05 2016-02-10 Laboratory Corporation of America Holdings Systems and methods for facilitating diagnosis, prognosis and treatment of cancer based on detection of her3 activation
EP2821071A1 (en) 2013-07-04 2015-01-07 Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) Compounds for breast cancer treatment
WO2015048008A2 (en) 2013-09-24 2015-04-02 Medimmune, Llc Binding molecules specific for her3 and uses thereof
IL244623B (en) 2013-10-14 2022-08-01 Janssen Biotech Inc Cysteine engineered fibronectin type iii domain binding molecules
WO2015066543A1 (en) * 2013-11-01 2015-05-07 Board Of Regents, The University Of Texas System Targeting her2 and her3 with bispecific antibodies in cancerous cells
WO2015157634A1 (en) 2014-04-11 2015-10-15 Kolltan Pharmaceuticals, Inc. Anti-erbb antibodies and methods of use thereof
HUE066300T2 (hu) 2015-06-24 2024-07-28 Janssen Biotech Inc Immunmoduláció és szolid tumorok kezelése CD38-hoz specifikusan kötõdõ antitestekkel
MX2018003905A (es) 2015-09-30 2018-09-06 Janssen Biotech Inc Anticuerpos agonistas que se unen específicamente a cd40 humana y métodos de uso.
SG11201811062XA (en) 2016-06-21 2019-01-30 Janssen Biotech Inc Cysteine engineered fibronectin type iii domain binding molecules
EP3554561B1 (en) 2016-12-14 2023-06-28 Janssen Biotech, Inc. Cd137 binding fibronectin type iii domains
WO2018111976A1 (en) 2016-12-14 2018-06-21 Janssen Biotech, Inc. Pd-l1 binding fibronectin type iii domains
JP7104703B2 (ja) 2016-12-14 2022-07-21 ヤンセン バイオテツク，インコーポレーテツド Ｃｄ８ａ結合フィブロネクチンｉｉｉ型ドメイン
WO2018160917A1 (en) 2017-03-03 2018-09-07 Janssen Biotech, Inc. Co-therapy comprising a small molecule csf-1r inhibitor and an agonistic antibody that specifically binds cd40 for the treatment of cancer
GB201913079D0 (en) * 2019-09-11 2019-10-23 Hummingbird Bioscience Holdings Pte Ltd Treatment and prevention of cancer using her3 antigen-binding molecules
EP4045061A4 (en) 2019-10-14 2024-04-17 ARO Biotherapeutics Company FIBRONECTIN TYPE III DOMAINS BINDING TO CD137
WO2021076543A1 (en) 2019-10-14 2021-04-22 Aro Biotherapeutics Company Epcam binding fibronectin type iii domains
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JP2024517610A (ja) 2021-04-14 2024-04-23 アロ・バイオセラピューティクス・カンパニー Ｃｄ７１に結合するフィブロネクチンｉｉｉ型ドメイン
BR112023021318A2 (pt) 2021-04-14 2023-12-19 Aro Biotherapeutics Company Conjugados de domínio fn3-sirna e usos dos mesmos
WO2022262772A1 (en) * 2021-06-15 2022-12-22 Beijing Sinotau Bio-Pharmaceuticals Technology Co., Ltd. Anti-her3 antibody, antibody drug conjugate containing the same, and use thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5480968A (en) * 1989-12-01 1996-01-02 The United States Of America As Represented By The Department Of Health And Human Services Isolated polypeptide erbB-3, related to the epidermal growth factor receptor and antibody thereto
WO1997035885A1 (en) * 1996-03-27 1997-10-02 Genentech, Inc. ErbB3 ANTIBODIES
US5804396A (en) * 1994-10-12 1998-09-08 Sugen, Inc. Assay for agents active in proliferative disorders
WO2000031048A1 (en) * 1998-11-19 2000-06-02 Warner-Lambert Company N-[4-(3-chloro-4-fluoro-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylamide, an irreversible inhibitor of tyrosine kinases
WO2000078347A1 (en) * 1999-06-18 2000-12-28 The Victor Chang Cardiac Research Institute Limited Cell growth inhibition
US6277640B1 (en) * 2000-07-31 2001-08-21 Isis Pharmaceuticals, Inc. Antisense modulation of Her-3 expression

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
CA2037440A1 (en) 1990-03-02 1991-09-03 Gregory D. Plowman Her3: a novel egf receptor homolog
WO1994002602A1 (en) 1992-07-24 1994-02-03 Cell Genesys, Inc. Generation of xenogeneic antibodies
US5968511A (en) 1996-03-27 1999-10-19 Genentech, Inc. ErbB3 antibodies
DE69740038D1 (enExample) 1996-07-12 2010-12-16 Genentech Inc
EP2111870A1 (en) 1999-08-27 2009-10-28 Genentech, Inc. Dosages for treatment of anti-erbB2 antibodies
EP1228766A1 (en) 2001-01-31 2002-08-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. PYK2 phosphorylation by HER3 induces tumor invasion
EP1283053A1 (en) 2001-08-09 2003-02-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Inhibitors of HER3 activity

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5480968A (en) * 1989-12-01 1996-01-02 The United States Of America As Represented By The Department Of Health And Human Services Isolated polypeptide erbB-3, related to the epidermal growth factor receptor and antibody thereto
US5804396A (en) * 1994-10-12 1998-09-08 Sugen, Inc. Assay for agents active in proliferative disorders
WO1997035885A1 (en) * 1996-03-27 1997-10-02 Genentech, Inc. ErbB3 ANTIBODIES
WO2000031048A1 (en) * 1998-11-19 2000-06-02 Warner-Lambert Company N-[4-(3-chloro-4-fluoro-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylamide, an irreversible inhibitor of tyrosine kinases
WO2000078347A1 (en) * 1999-06-18 2000-12-28 The Victor Chang Cardiac Research Institute Limited Cell growth inhibition
US6277640B1 (en) * 2000-07-31 2001-08-21 Isis Pharmaceuticals, Inc. Antisense modulation of Her-3 expression

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
D. BAECKSTRÖM ET AL.: "Morphogenetic and proliferative responses to heregulin of mammary epithelial cells in vitro are dependent on HER2 and HER3 and differ from the responses to HER2 homodimerisation or hepatocyte growth factor.", INTERNATIONAL JOURNAL OF ONCOLOGY, vol. 16, no. 6, June 2000 (2000-06-01), Greece, pages 1081 - 1090, XP001030626 *
D. TODD ET AL.: "Ionizing radiation stimulates existing signal transduction pathways involving the activation of epidermal growth factor receptor ans erbB-3, and changes of intracellular calcium in A431 human squamous carcinoma cells.", JOURNAL OF RECEPTOR AND SIGNAL TRANSDUCTION RESEARCH, vol. 19, no. 6, November 1999 (1999-11-01), USA, pages 885 - 908, XP001030590 *
R. VADLAMUDI ET AL.: "Regulation of cyclooxygenase-2 pathway by HER2 receptor.", ONCOGENE, vol. 18, no. 2, 14 January 1999 (1999-01-14), Basingstoke, GB, pages 305 - 314, XP001030629 *
T. RAJKUMAR ET AL.: "A monoclonal antibody to the human c-erbB3 protein stimulates the anchorage-independent growth of breast cancer cell lines.", BRITISH JOURNAL OF CANCER, vol. 70, 1994, GB, pages 459 - 465, XP000676619 *

Cited By (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9783456B1 (en) 1999-06-18 2017-10-10 Zensun (Shanghai) Science & Technology, Co., Ltd. Method for inhibiting cell growth using anti-ErbB-3 and anti-ErbB-2 antibodies
US9011851B2 (en) 2001-08-09 2015-04-21 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. Inhibitors of her3 activity
US7919098B2 (en) 2002-03-26 2011-04-05 Zensun ( Shanghai ) Sci & Tech Co., Ltd. ErbB-3 based methods and compositions for treating neoplasms
EP2993187A3 (en) * 2005-12-30 2016-06-01 U3 Pharma GmbH Antibodies directed to her-3 and uses thereof
EP3196213A2 (en) 2005-12-30 2017-07-26 Daiichi Sankyo Europe GmbH Antibodies directed to her-3 and uses thereof
NO346160B1 (no) * 2005-12-30 2022-03-28 Amgen Inc Antistoffer rettet mot her-3 og anvendelse av den
EP3950715A1 (en) 2005-12-30 2022-02-09 Amgen Inc. Antibodies directed to her-3 and uses thereof
EA015782B1 (ru) * 2005-12-30 2011-12-30 У3 Фарма Гмбх Выделенный связывающий белок, который связывается с her-3, и его применение
CN101365723B (zh) * 2005-12-30 2012-05-02 U3制药有限公司 针对her-3的抗体及其用途
CN102633881A (zh) * 2005-12-30 2012-08-15 U3制药有限公司 针对her-3的抗体及其用途
WO2007077028A3 (en) * 2005-12-30 2007-09-07 U3 Pharma Ag Antibodies directed to her-3 and uses thereof
US7705130B2 (en) 2005-12-30 2010-04-27 U3 Pharma Gmbh Antibodies directed to HER-3 and uses thereof
CN102633881B (zh) * 2005-12-30 2014-08-13 U3制药有限公司 针对her-3的抗体及其用途
WO2007077028A2 (en) 2005-12-30 2007-07-12 U3 Pharma Ag Antibodies directed to her-3 and uses thereof
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KR101418606B1 (ko) 2005-12-30 2014-07-17 우드라이 파마 게엠베하 Ｈｅｒ-３ 지향 항체 및 그 용도
EP2993187A2 (en) 2005-12-30 2016-03-09 U3 Pharma GmbH Antibodies directed to her-3 and uses thereof
US9988462B2 (en) 2005-12-30 2018-06-05 Daiichi Sankyo Europe Gmbh Material and methods for treating or preventing HER-3 associated diseases
US8771695B2 (en) 2005-12-30 2014-07-08 U3 Pharma Gmbh Antibodies directed to HER-3 and uses thereof
US10365283B2 (en) 2006-11-28 2019-07-30 Daiichi Sankyo Europe Gmbh Activated HER3 as a marker for predicting therapeutic efficacy
EP2518508A1 (en) 2006-11-28 2012-10-31 U3 Pharma GmbH Activated HER3 as a marker for predicting therapeutic efficacy
US8691225B2 (en) 2007-02-16 2014-04-08 Merrimack Pharmaceuticals, Inc. Antibodies against the ectodomain of ErbB3 and uses thereof
US7846440B2 (en) 2007-02-16 2010-12-07 Merrimack Pharmaceuticals, Inc. Antibodies against ErbB3 and uses thereof
US9487588B2 (en) 2007-02-16 2016-11-08 Merrimack Pharmaceuticals, Inc. Antibodies against the ectodomain of ERBB3 and uses thereof
US8961966B2 (en) 2007-02-16 2015-02-24 Merrimack Pharmaceuticals, Inc. Antibodies against ERBB3 and uses thereof
US10005844B2 (en) 2007-06-04 2018-06-26 Genentech, Inc. Polynucleotides encoding anti-Notch1 NRR antibody polypeptides
US9533042B2 (en) 2007-06-04 2017-01-03 Genentech, Inc. Anti-notch NRR antibodies and methods using same
US8623592B2 (en) 2008-08-15 2014-01-07 Merrimack Pharmaceuticals, Inc. Methods and systems for predicting response of cells to a therapeutic agent
US10273308B2 (en) 2008-12-01 2019-04-30 Laboratory Corporation Of America Holdings Methods of producing antibodies specific for p95
US9766242B2 (en) 2009-01-15 2017-09-19 Laboratory Corporation Of America Holdings Methods of determining patient response by measurement of HER-3 and P95
US8597652B2 (en) 2009-03-20 2013-12-03 Genentech, Inc. Multispecific anti-HER antibodies
US9327035B2 (en) 2009-03-20 2016-05-03 Genentech, Inc. Anti-HER antibodies
US9803025B2 (en) 2009-11-13 2017-10-31 Amgen, Inc. Material and methods for treating or preventing HER-3 associated diseases
EP2896632A2 (en) 2009-11-13 2015-07-22 U3 Pharma GmbH Material and methods for treating or preventing HER-3 associated diseases
EP3351558A2 (en) 2009-11-13 2018-07-25 Daiichi Sankyo Europe GmbH Material and methods for treating or preventing her-3 associated diseases
EP2719708A2 (en) 2009-11-13 2014-04-16 U3 Pharma GmbH Material and methods for treating or preventing HER-3 associated diseases
US12139549B2 (en) 2009-11-13 2024-11-12 Daiichi Sankyo Europe Gmbh Material and methods for treating or preventing HER-3 associated diseases
WO2011060206A2 (en) 2009-11-13 2011-05-19 U3 Pharma Gmbh Material and methods for treating or preventing her-3 associated diseases
US9101760B2 (en) 2009-11-13 2015-08-11 U3 Pharma Gmbh Material and methods for treating or preventing HER-3 associated diseases
EP3670539A1 (en) 2009-11-13 2020-06-24 Daiichi Sankyo Europe GmbH Material and methods for treating or preventing her-3 associated diseases
US9611331B2 (en) 2009-12-22 2017-04-04 Roche Glycart Ag Anti-HER3 antibodies and uses thereof
WO2011076683A1 (en) 2009-12-22 2011-06-30 Roche Glycart Ag Anti-her3 antibodies and uses thereof
US8859737B2 (en) 2009-12-22 2014-10-14 Roche Glycart Ag Anti-HER3 antibodies and uses thereof
US10196456B2 (en) 2009-12-22 2019-02-05 Roche Glycart Ag Anti-HER3 antibodies and uses thereof
US8895001B2 (en) 2010-03-11 2014-11-25 Merrimack Pharmaceuticals, Inc. Use of ErbB3 inhibitors in the treatment of triple negative and basal-like breast cancers
US9518130B2 (en) 2010-03-11 2016-12-13 Merrimack Pharmaceuticals, Inc. Use of ERBB3 inhibitors in the treatment of triple negative and basal-like breast cancers
US9085622B2 (en) 2010-09-03 2015-07-21 Glaxosmithkline Intellectual Property Development Limited Antigen binding proteins
US9217039B2 (en) 2010-11-01 2015-12-22 Symphogen A/S Anti-HER3 antibodies and compositions
WO2012156309A1 (en) 2011-05-13 2012-11-22 Millegen Antibodies against her3
US10632194B2 (en) 2011-09-30 2020-04-28 Regeneron Pharmaceuticals, Inc. Anti-ErbB3 antibodies and uses thereof
US11771762B2 (en) 2011-09-30 2023-10-03 Regeneron Pharmaceuticals, Inc. Anti-ErbB3 antibodies and uses thereof
US8791244B2 (en) 2011-09-30 2014-07-29 Regeneron Pharmaceuticals, Inc. Anti-ErbB3 antibodies and uses thereof
US9273143B2 (en) 2011-09-30 2016-03-01 Regeneron Pharmaceuticals, Inc. Methods and compositions comprising a combination of an anti-ErbB3 antibody and an anti-EGFR antibody
US9827310B2 (en) 2011-09-30 2017-11-28 Regeneron Pharmaceuticals, Inc. Anti-ErbB3 antibodies and uses thereof
US9284380B2 (en) 2011-09-30 2016-03-15 Regeneron Pharmaceuticals, Inc. Anti-ErbB3 antibodies and uses thereof
US9637543B2 (en) 2011-11-09 2017-05-02 The Uab Research Foundation HER3 antibodies and uses thereof
US11351259B2 (en) 2012-02-23 2022-06-07 Daiichi Sankyo Europe Gmbh HER3 inhibitor for modulating radiosensitivity
US10357566B2 (en) 2012-02-23 2019-07-23 Daiichi Sankyo Europe Gmbh HER3 inhibitor for modulating radiosensitivity
WO2013124419A1 (en) 2012-02-23 2013-08-29 U3 Pharma Gmbh Her3 inhibitor for modulating radiosensitivity
US10626177B2 (en) 2012-11-08 2020-04-21 Hoffmann-La Roche Inc. HER3 antigen binding proteins binding to the beta-hairpin of HER3
US10364290B2 (en) 2012-11-08 2019-07-30 Hoffmann-La Roche Inc. Anti-HER3/HER4 antibodies binding to the beta-hairpin of HER3 and the beta-hairpin of HER4
WO2014072306A1 (en) 2012-11-08 2014-05-15 F. Hoffmann-La Roche Ag Her3 antigen binding proteins binding to the beta-hairpin of her3
US9725511B2 (en) 2012-11-08 2017-08-08 Hoffmann-La Roche Inc. Anti-HER3/HER4 antibodies binding to the beta-hairpin of HER3 and the beta-hairpin of HER4
US9725512B2 (en) 2012-11-08 2017-08-08 Hoffmann-La Roche Inc. HER3 antibodies binding to the beta-hairpin of HER3
US9180185B2 (en) 2013-01-11 2015-11-10 Hoffman-La Roche Inc. Combination therapy of anti-HER3 antibodies
WO2014108484A2 (en) 2013-01-11 2014-07-17 F. Hoffmann-La Roche Ag Combination therapy of anti-her3 antibodies
US10358501B2 (en) 2013-03-14 2019-07-23 The Board Of Regents Of The University Of Texas System HER3 specific monoclonal antibodies for diagnostic and therapeutic use
US11174320B2 (en) 2013-03-14 2021-11-16 The Board Of Regents Of The University Of Texas System HER3 specific monoclonal antibodies for diagnostic and therapeutic use
US10273304B2 (en) 2013-12-27 2019-04-30 Merrimack Pharmaceuticals, Inc. Biomarker profiles for predicting outcomes of cancer therapy with ERBB3 inhibitors and/or chemotherapies
US9688761B2 (en) 2013-12-27 2017-06-27 Merrimack Pharmaceuticals, Inc. Biomarker profiles for predicting outcomes of cancer therapy with ERBB3 inhibitors and/or chemotherapies
KR20200136052A (ko) 2014-04-10 2020-12-04 다이이찌 산쿄 가부시키가이샤 항her3 항체-약물 콘주게이트
US10383878B2 (en) 2014-04-10 2019-08-20 Daiichi Sankyo Company, Limited Anti-HER3 antibody-drug conjugate
KR20200077620A (ko) 2014-04-10 2020-06-30 다이이찌 산쿄 가부시키가이샤 항her3 항체-약물 콘주게이트
EP3789042A1 (en) 2014-04-10 2021-03-10 Daiichi Sankyo Company, Limited Method for producing anti-her3 antibody-drug conjugate
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WO2015155998A1 (en) 2014-04-10 2015-10-15 Daiichi Sankyo Company, Limited Anti-her3 antibody-drug conjugate
KR20220012402A (ko) 2014-04-10 2022-02-03 다이이찌 산쿄 가부시키가이샤 항her3 항체-약물 콘주게이트
KR20160144396A (ko) 2014-04-10 2016-12-16 다이이찌 산쿄 가부시키가이샤 항her3 항체-약물 콘주게이트
KR20230021173A (ko) 2014-04-10 2023-02-13 다이이찌 산쿄 가부시키가이샤 항her3 항체-약물 콘주게이트
KR20190004837A (ko) 2014-04-10 2019-01-14 다이이찌 산쿄 가부시키가이샤 항her3 항체-약물 콘주게이트
US11298359B2 (en) 2014-04-10 2022-04-12 Daiichi Sankyo Company, Limited Anti-HER3 antibody-drug conjugate
KR20220132025A (ko) 2014-04-10 2022-09-29 다이이찌 산쿄 가부시키가이샤 항her3 항체-약물 콘주게이트
US9783611B2 (en) 2014-05-14 2017-10-10 Hoffman-La Roche Inc. Anti-HER3 antibodies binding to the beta-hairpin of HER3
US10184006B2 (en) 2015-06-04 2019-01-22 Merrimack Pharmaceuticals, Inc. Biomarkers for predicting outcomes of cancer therapy with ErbB3 inhibitors
US11173213B2 (en) 2015-06-29 2021-11-16 Daiichi Sankyo Company, Limited Method for selectively manufacturing antibody-drug conjugate
US11273155B2 (en) 2016-12-12 2022-03-15 Daiichi Sankyo Company, Limited Combination of antibody-drug conjugate and immune checkpoint inhibitor
US12319736B2 (en) 2016-12-12 2025-06-03 Daiichi Sankyo Company, Limited Combination of antibody-drug conjugate and immune checkpoint inhibitor
US10906974B2 (en) 2017-01-17 2021-02-02 Daiichi Sankyo Company, Limited Anti-GPR20 antibody and anti-GPR20 antibody-drug conjugate
US11434289B2 (en) 2017-01-17 2022-09-06 Daiichi Sankyo Company, Limited Anti-GPR20 antibody and anti-GPR20 antibody-drug conjugate
US11446386B2 (en) 2017-05-15 2022-09-20 Daiichi Sankyo Company, Limited Anti-CDH6 antibody and method of producing an anti-CDH6 antibody-drug conjugate
US11077202B2 (en) 2017-05-15 2021-08-03 Daiichi Sankyo Company, Limited Anti-CDH6 antibody and anti-CDH6 antibody-drug conjugate
US12233155B2 (en) 2017-05-15 2025-02-25 Daiichi Sankyo Company, Limited Polynucleotides encoding antibodies which bind the EC3 domain of cadherin-6 (CDH6) and possess internalization ability
US11945882B2 (en) 2017-08-31 2024-04-02 Daiichi Sankyo Company, Limited Method for producing antibody-drug conjugate
US11318212B2 (en) 2017-08-31 2022-05-03 Daiichi Sankyo Company, Limited Method for producing antibody-drug conjugate
US12503489B2 (en) 2017-08-31 2025-12-23 Daiichi Sankyo Company, Limited Method for producing antibody-drug conjugate
US11872289B2 (en) 2018-05-18 2024-01-16 Daiichi Sankyo Co., Ltd. Anti-MUC1 antibody-drug conjugate
US12291577B2 (en) 2018-05-18 2025-05-06 Daiichi Sankyo Co., Ltd. Anti-MUC1 antibody-drug conjugate
US12297289B2 (en) 2018-05-18 2025-05-13 Glycotope Gmbh Anti-MUC1 antibody
US12479926B2 (en) 2018-05-18 2025-11-25 Daiichi Sankyo Co., Ltd. Anti-MUC1 antibody-drug conjugate
US12358999B2 (en) 2018-07-27 2025-07-15 Daiichi Sankyo Company, Limited Protein recognizing drug moiety of antibody-drug conjugate
US12220604B2 (en) 2018-07-31 2025-02-11 Daiichi Sankyo Company, Limited Treatment of metastatic brain tumor by administration of an antibody-drug conjugate

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