WO2003008626A3 - Novel human nucleic acids encoding a pantothenate kinase and methods of use - Google Patents

Novel human nucleic acids encoding a pantothenate kinase and methods of use Download PDF

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Publication number
WO2003008626A3
WO2003008626A3 PCT/US2002/022952 US0222952W WO03008626A3 WO 2003008626 A3 WO2003008626 A3 WO 2003008626A3 US 0222952 W US0222952 W US 0222952W WO 03008626 A3 WO03008626 A3 WO 03008626A3
Authority
WO
WIPO (PCT)
Prior art keywords
disclosed
methods
pantothenate kinase
pank
nucleic acids
Prior art date
Application number
PCT/US2002/022952
Other languages
French (fr)
Other versions
WO2003008626A2 (en
Inventor
Susan J Hayflick
Jane Gitschier
Bing Zhou
Shawn Westaway
Barbara Levinson
Monique Johnson
Original Assignee
Univ Oregon Health & Science
Univ California
Susan J Hayflick
Jane Gitschier
Bing Zhou
Shawn Westaway
Barbara Levinson
Monique Johnson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Oregon Health & Science, Univ California, Susan J Hayflick, Jane Gitschier, Bing Zhou, Shawn Westaway, Barbara Levinson, Monique Johnson filed Critical Univ Oregon Health & Science
Priority to AU2002326412A priority Critical patent/AU2002326412A1/en
Publication of WO2003008626A2 publication Critical patent/WO2003008626A2/en
Publication of WO2003008626A3 publication Critical patent/WO2003008626A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01033—Pantothenate kinase (2.7.1.33)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Several substantially purified pantothenate kinase polypeptides are disclosed, as are polyclonal and monoclonal antibodies that specifically bind a pantothenate kinase. Isolated polynucleotides encoding these polypeptides are also disclosed. Vectors including these polynucleotides, and host cells transfected with these polypeptides, are also disclosed herein. Methods are also disclosed herein for treating a neurodegenerative disorder by administering a PANK polynucleotide or a PANK polypeptide to a subject. Pharmaceutical compositions are further disclosed herein that include a PANK polynucleotide or polypeptide. Methods of predicting a predisposition to, or severity of, a neurodegenerative disorder are also disclosed, as are kits useful for this detection. Also disclosed herein are methods of treating a neurodegenerative disorder in a subject.
PCT/US2002/022952 2001-07-20 2002-07-19 Novel human nucleic acids encoding a pantothenate kinase and methods of use WO2003008626A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002326412A AU2002326412A1 (en) 2001-07-20 2002-07-19 Novel human nucleic acids encoding a pantothenate kinase and methods of use

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US30708101P 2001-07-20 2001-07-20
US60/307,081 2001-07-20
US30805501P 2001-07-25 2001-07-25
US60/308,055 2001-07-25

Publications (2)

Publication Number Publication Date
WO2003008626A2 WO2003008626A2 (en) 2003-01-30
WO2003008626A3 true WO2003008626A3 (en) 2003-10-30

Family

ID=26975528

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/022952 WO2003008626A2 (en) 2001-07-20 2002-07-19 Novel human nucleic acids encoding a pantothenate kinase and methods of use

Country Status (2)

Country Link
AU (1) AU2002326412A1 (en)
WO (1) WO2003008626A2 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8691224B2 (en) 2005-11-30 2014-04-08 Abbvie Inc. Anti-Aβ globulomer 5F7 antibodies
US8877190B2 (en) 2006-11-30 2014-11-04 Abbvie Inc. Aβ conformer selective anti-Aβ globulomer monoclonal antibodies
US8895004B2 (en) 2007-02-27 2014-11-25 AbbVie Deutschland GmbH & Co. KG Method for the treatment of amyloidoses
US8987419B2 (en) 2010-04-15 2015-03-24 AbbVie Deutschland GmbH & Co. KG Amyloid-beta binding proteins
US9176150B2 (en) 2003-01-31 2015-11-03 AbbVie Deutschland GmbH & Co. KG Amyloid beta(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102898519B (en) 2005-11-30 2015-10-28 Abbvie公司 Monoclonal antibody of anti-amyloid beta protein and uses thereof
US9062101B2 (en) 2010-08-14 2015-06-23 AbbVie Deutschland GmbH & Co. KG Amyloid-beta binding proteins
EP3112372B1 (en) 2012-04-27 2018-11-07 Retrophin, Inc. Pantothenate derivatives for the treatment of neurologic disorders
WO2015061792A1 (en) 2013-10-25 2015-04-30 Retrophin, Inc. Panothenate derivatives for the treatment of neurological disorders
EP2868662A1 (en) * 2013-11-04 2015-05-06 Acies Bio d.o.o. Stable pantetheine derivatives for the treatment of pantothenate kinase associated neurodegeneration (pkan) and methods for the synthesis of such compounds
CA3007063A1 (en) 2015-12-08 2017-06-15 Retrophin, Inc. Cyclic phosphates and cyclic phosphoramidates for the treatment of neurologic disorders

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KAWAI ET AL.: "Functional annonation of a full-length mouse cDNA collection", NATURE, vol. 409, 8 February 2001 (2001-02-08), pages 685 - 690, XP002952962 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9176150B2 (en) 2003-01-31 2015-11-03 AbbVie Deutschland GmbH & Co. KG Amyloid beta(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof
US8691224B2 (en) 2005-11-30 2014-04-08 Abbvie Inc. Anti-Aβ globulomer 5F7 antibodies
US9540432B2 (en) 2005-11-30 2017-01-10 AbbVie Deutschland GmbH & Co. KG Anti-Aβ globulomer 7C6 antibodies
US8877190B2 (en) 2006-11-30 2014-11-04 Abbvie Inc. Aβ conformer selective anti-Aβ globulomer monoclonal antibodies
US9359430B2 (en) 2006-11-30 2016-06-07 Abbvie Inc. Abeta conformer selective anti-Abeta globulomer monoclonal antibodies
US9394360B2 (en) 2006-11-30 2016-07-19 Abbvie Inc. Aβ conformer selective anti-Aβ globulomer monoclonal antibodies
US8895004B2 (en) 2007-02-27 2014-11-25 AbbVie Deutschland GmbH & Co. KG Method for the treatment of amyloidoses
US8987419B2 (en) 2010-04-15 2015-03-24 AbbVie Deutschland GmbH & Co. KG Amyloid-beta binding proteins

Also Published As

Publication number Publication date
WO2003008626A2 (en) 2003-01-30
AU2002326412A1 (en) 2003-03-03

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