WO2000003687A3 - Potassium channel polypeptide and polynucleotide compositions - Google Patents

Potassium channel polypeptide and polynucleotide compositions Download PDF

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Publication number
WO2000003687A3
WO2000003687A3 PCT/US1999/016471 US9916471W WO0003687A3 WO 2000003687 A3 WO2000003687 A3 WO 2000003687A3 US 9916471 W US9916471 W US 9916471W WO 0003687 A3 WO0003687 A3 WO 0003687A3
Authority
WO
WIPO (PCT)
Prior art keywords
provides
potassium channel
potassium channels
channel polypeptide
screening assays
Prior art date
Application number
PCT/US1999/016471
Other languages
French (fr)
Other versions
WO2000003687A2 (en
Inventor
John R Forsayeth
Byron B Zhao
Raymond A Chavez
Original Assignee
Elan Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm Inc filed Critical Elan Pharm Inc
Priority to EP99944996A priority Critical patent/EP1097166A4/en
Priority to JP2000559822A priority patent/JP2002520039A/en
Priority to AU57702/99A priority patent/AU5770299A/en
Priority to CA002337835A priority patent/CA2337835A1/en
Publication of WO2000003687A2 publication Critical patent/WO2000003687A2/en
Publication of WO2000003687A3 publication Critical patent/WO2000003687A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention provides novel, isolated potassium channel subunits and polynucleotides which identify and encode such subunits. The invention also provides expression vectors and host cells comprising nucleic acid sequences encoding such potassium channels. The invention also provides antibodies directed to the potassium channels and methods of diagnosing and treating diseases associated with activity of such potassium channels. In addition, the invention provides screening assays employing the polypeptide, nucleotide, and antibody compositions, and agonist and antagonist compounds selected by such screening assays.
PCT/US1999/016471 1998-07-20 1999-07-20 Potassium channel polypeptide and polynucleotide compositions WO2000003687A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP99944996A EP1097166A4 (en) 1998-07-20 1999-07-20 Potassium channel polypeptide and polynucleotide compositions
JP2000559822A JP2002520039A (en) 1998-07-20 1999-07-20 Compositions of potassium channel polypeptides and polynucleotides
AU57702/99A AU5770299A (en) 1998-07-20 1999-07-20 Potassium channel polypeptide and polynucleotide compositions
CA002337835A CA2337835A1 (en) 1998-07-20 1999-07-20 Potassium channel polypeptide and polynucleotide compositions

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US9348698P 1998-07-20 1998-07-20
US9665598P 1998-08-13 1998-08-13
US60/096,655 1998-08-13
US60/093,486 1998-08-13

Publications (2)

Publication Number Publication Date
WO2000003687A2 WO2000003687A2 (en) 2000-01-27
WO2000003687A3 true WO2000003687A3 (en) 2000-04-20

Family

ID=26787595

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/016471 WO2000003687A2 (en) 1998-07-20 1999-07-20 Potassium channel polypeptide and polynucleotide compositions

Country Status (5)

Country Link
EP (1) EP1097166A4 (en)
JP (1) JP2002520039A (en)
AU (1) AU5770299A (en)
CA (1) CA2337835A1 (en)
WO (1) WO2000003687A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000001819A1 (en) 1998-07-01 2000-01-13 Icagen, Incorporated Human elk, a voltage-gated potassium channel subunit
EP1297014A2 (en) * 2000-06-29 2003-04-02 Incyte Genomics, Inc. Transporters and ion channels
WO2005052576A1 (en) * 2003-11-27 2005-06-09 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with potassium channel, subfamily k, member 6 (kcnk6)
US9427441B2 (en) 2014-02-19 2016-08-30 Indiana University Research And Technology Corporation Targeting primary cilia to treat glaucoma
EP4367217A1 (en) * 2021-07-08 2024-05-15 Baylor College of Medicine Recombinant microorganism-based methods and compositions for treatment of disease

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5599673A (en) * 1995-03-09 1997-02-04 University Of Utah Research Foundation Long QT syndrome genes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0930364A1 (en) * 1998-01-16 1999-07-21 Synthelabo TWIK-1 related two domains potassium channel
US6670149B1 (en) * 1999-03-01 2003-12-30 Millennium Pharmaceuticals, Inc. TWIK-5 potassium channel nucleic acids and uses therefor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5599673A (en) * 1995-03-09 1997-02-04 University Of Utah Research Foundation Long QT syndrome genes

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GELLENS M.E. ET AL: "Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel", PROC. NATL. ACAD. SCI., vol. 89, January 1992 (1992-01-01), pages 554 - 558, XP002925329 *
See also references of EP1097166A4 *

Also Published As

Publication number Publication date
CA2337835A1 (en) 2000-01-27
AU5770299A (en) 2000-02-07
EP1097166A4 (en) 2003-01-02
EP1097166A2 (en) 2001-05-09
WO2000003687A2 (en) 2000-01-27
JP2002520039A (en) 2002-07-09

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