WO2001036645A3 - Serine/threonine kinase and serine protease polypeptides and nucleic acids encoding same - Google Patents

Serine/threonine kinase and serine protease polypeptides and nucleic acids encoding same Download PDF

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Publication number
WO2001036645A3
WO2001036645A3 PCT/US2000/031744 US0031744W WO0136645A3 WO 2001036645 A3 WO2001036645 A3 WO 2001036645A3 US 0031744 W US0031744 W US 0031744W WO 0136645 A3 WO0136645 A3 WO 0136645A3
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WO
WIPO (PCT)
Prior art keywords
serine
serx
nucleic acids
acids encoding
threonine kinase
Prior art date
Application number
PCT/US2000/031744
Other languages
French (fr)
Other versions
WO2001036645A2 (en
Inventor
Kerry E Quinn
Kimberley Ann Spytek
Kumud Majumder
Corine Vernet
Catherine Burgess
Elma Fernandes
Raymond Taupier Jr
Luca Rastelli
John L Herrmann
Original Assignee
Curagen Corp
Kerry E Quinn
Kimberley Ann Spytek
Kumud Majumder
Corine Vernet
Catherine Burgess
Elma Fernandes
Raymond Taupier Jr
Luca Rastelli
John L Herrmann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curagen Corp, Kerry E Quinn, Kimberley Ann Spytek, Kumud Majumder, Corine Vernet, Catherine Burgess, Elma Fernandes, Raymond Taupier Jr, Luca Rastelli, John L Herrmann filed Critical Curagen Corp
Priority to EP00980526A priority Critical patent/EP1244793A2/en
Priority to JP2001538523A priority patent/JP2003533174A/en
Priority to AU17779/01A priority patent/AU1777901A/en
Priority to CA002391908A priority patent/CA2391908A1/en
Publication of WO2001036645A2 publication Critical patent/WO2001036645A2/en
Publication of WO2001036645A3 publication Critical patent/WO2001036645A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Reproductive Health (AREA)
  • Peptides Or Proteins (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention provides novel isolated SERX polynucleotides and polypeptides encoded by the SERX polynucleotides. Also provided are the antibodies that immunospecifically bind to a SERX polypeptide or any derivative, variant, mutant or fragment of the SERX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the SERX polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.
PCT/US2000/031744 1999-11-17 2000-11-17 Serine/threonine kinase and serine protease polypeptides and nucleic acids encoding same WO2001036645A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP00980526A EP1244793A2 (en) 1999-11-17 2000-11-17 Serine/threonine kinase and serine protease polypeptides and nucleic acids encoding same
JP2001538523A JP2003533174A (en) 1999-11-17 2000-11-17 Novel polypeptide and nucleic acid encoding this polypeptide
AU17779/01A AU1777901A (en) 1999-11-17 2000-11-17 Novel polypeptides and nucleic acids encoding same
CA002391908A CA2391908A1 (en) 1999-11-17 2000-11-17 Novel polypeptides and nucleic acids encoding same

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US16598699P 1999-11-17 1999-11-17
US60/165,986 1999-11-17
US18134700P 2000-02-09 2000-02-09
US60/181,347 2000-02-09
US19419500P 2000-04-03 2000-04-03
US60/194,195 2000-04-03
US19483900P 2000-04-05 2000-04-05
US60/194,839 2000-04-05
US19563700P 2000-04-07 2000-04-07
US60/195,637 2000-04-07
US19708000P 2000-04-13 2000-04-13
US60/197,080 2000-04-13
US23267700P 2000-09-15 2000-09-15
US60/232,677 2000-09-15
US71542700A 2000-11-16 2000-11-16
US09/715,427 2000-11-16

Publications (2)

Publication Number Publication Date
WO2001036645A2 WO2001036645A2 (en) 2001-05-25
WO2001036645A3 true WO2001036645A3 (en) 2002-06-06

Family

ID=27575039

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/031744 WO2001036645A2 (en) 1999-11-17 2000-11-17 Serine/threonine kinase and serine protease polypeptides and nucleic acids encoding same

Country Status (4)

Country Link
EP (1) EP1244793A2 (en)
JP (1) JP2003533174A (en)
CA (1) CA2391908A1 (en)
WO (1) WO2001036645A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7105333B2 (en) 2001-03-27 2006-09-12 Deadreon Corporation Nucleic acid molecules encoding a transmembrane serine protease 9, the encoded polypeptides and methods based thereon

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2387805C (en) 1999-11-18 2012-08-28 Corvas International, Inc. Nucleic acids encoding endotheliases, endotheliases and uses thereof
US20020151005A1 (en) * 2000-06-15 2002-10-17 Meyers Rachel A. 53070, a novel human protein kinase family member and uses thereof
US20030198953A1 (en) * 2000-03-30 2003-10-23 Spytek Kimberly A. Novel proteins and nucleic acids encoding same
WO2001081558A2 (en) * 2000-04-25 2001-11-01 Millennium Pharmaceuticals, Inc. 13295 novel protein kinase molecules and uses therefor
JP2003531617A (en) * 2000-05-05 2003-10-28 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング Novel serine-threonine kinase
US20030096313A1 (en) * 2000-05-12 2003-05-22 Burkhard Scharm Novel serine-threonine kinase-4
US6482935B1 (en) * 2000-05-24 2002-11-19 Applera Corporation Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
WO2001096538A2 (en) * 2000-06-13 2001-12-20 Bayer Aktiengesellschaft Regulation of human transmembrane serine protease
US20030171324A1 (en) * 2000-07-18 2003-09-11 Shyam Ramakrishnan Regulation of human desc1-like serine protease
WO2002006455A2 (en) * 2000-07-19 2002-01-24 Bayer Aktiengesellschaft Regulation of human airway trypsin protease-like enzyme
US6365391B1 (en) * 2000-09-27 2002-04-02 Pe Corporation (Ny) Isolated human serine protease, nucleic acid molecules encoding human serine protease, and uses thereof
AU2002305052A1 (en) 2001-03-13 2002-09-24 Corvas International, Inc. Nucleic acid molecules encoding a transmembrane serine protease 7, the encoded polypeptides and methods based thereon
EP1383884A4 (en) 2001-03-22 2004-12-15 Dendreon Corp Nucleic acid molecules encoding serine protease cvsp14, the encoded polypeptides and methods based thereon
CA2447050A1 (en) 2001-05-14 2002-11-21 Dendreon San Diego Llc Nucleic acid molecules encoding a transmembrane serine protease 10, the encoded polypeptides and methods based thereon
WO2002099096A1 (en) * 2001-06-07 2002-12-12 Bayer Aktiengesellschaft Regulation of human serine/threonine protein kinase-like enzyme
WO2003062429A1 (en) * 2002-01-23 2003-07-31 Yamanouchi Pharmaceutical Co., Ltd. Novel serine protease
WO2005019270A2 (en) * 2003-08-14 2005-03-03 Dyax Corp. Endotheliase-2 ligands
EP2275547B1 (en) 2004-12-13 2014-03-05 Alethia Biotherapeutics Inc. Polynucleotides and polypeptide sequences involved in the process of bone remodeling

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998036054A1 (en) * 1997-02-13 1998-08-20 Amrad Operations Pty. Ltd. Novel molecules
WO2000058473A2 (en) * 1999-03-31 2000-10-05 Curagen Corporation Nucleic acids including open reading frames encoding polypeptides; 'orfx'

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998036054A1 (en) * 1997-02-13 1998-08-20 Amrad Operations Pty. Ltd. Novel molecules
WO2000058473A2 (en) * 1999-03-31 2000-10-05 Curagen Corporation Nucleic acids including open reading frames encoding polypeptides; 'orfx'

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BIELKE W ET AL: "Characterization of a novel murine testis-specific serine/threonine kinase.", GENE (AMSTERDAM), vol. 139, no. 2, 1994, pages 235 - 239, XP002174517, ISSN: 0378-1119 *
DATABASE EMBL [online] 12 July 1999 (1999-07-12), ROBERT STRAUSBERG: "wj59g02.x1 NCI_CGAP_Lu19 Homo sapiens cDNA clone IMAGE:2407154 3' similar to TR:O54863 O54863 TESTIS SPECIFIC SERINE/ THREONINE KINASE 2", XP002174518, retrieved from EBI Database accession no. AI819667 *
DATABASE EMBL [online] 8 October 1999 (1999-10-08), "Homo sapiens chromosome 19 clone CTC-260F20, complete sequence.", XP002174519, retrieved from EBI Database accession no. AC011448 *
DATABASE GENESEQ [online] derwent; 27 March 2001 (2001-03-27), SHIMKETS RA, LEACH M: "Human ORFX ORF1931 polypeptide sequence SEQ ID NO:3862.", XP002174521, retrieved from EBI Database accession no. AAB42167 *
DATABASE SWALL [online] 1 June 1998 (1998-06-01), KUENG P. ET AL.: "TESTIS SPECIFIC SERINE/ THREONINE KINASE 2 (PROTEIN KINASE).", XP002174520, retrieved from EBI Database accession no. O54863 *
DATABASE SWALL [online] 1 November 1996 (1996-11-01), BIELKE W. ET AL.: "TESTIS-SPECIFIC SERINE/THREONINE KINASE.", retrieved from EBI Database accession no. Q61241 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7105333B2 (en) 2001-03-27 2006-09-12 Deadreon Corporation Nucleic acid molecules encoding a transmembrane serine protease 9, the encoded polypeptides and methods based thereon

Also Published As

Publication number Publication date
CA2391908A1 (en) 2001-05-25
EP1244793A2 (en) 2002-10-02
WO2001036645A2 (en) 2001-05-25
JP2003533174A (en) 2003-11-11

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