WO2003006670A3 - Derives de l'acide 2-[5-(5-carbamimidoyl-1h-heteroaryl)-6-hydroxybiphenyl-3-yl]-succinique en tant qu'inhibiteurs du facteur viia - Google Patents
Derives de l'acide 2-[5-(5-carbamimidoyl-1h-heteroaryl)-6-hydroxybiphenyl-3-yl]-succinique en tant qu'inhibiteurs du facteur viia Download PDFInfo
- Publication number
- WO2003006670A3 WO2003006670A3 PCT/US2002/021340 US0221340W WO03006670A3 WO 2003006670 A3 WO2003006670 A3 WO 2003006670A3 US 0221340 W US0221340 W US 0221340W WO 03006670 A3 WO03006670 A3 WO 03006670A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- carbamimidoyl
- hydroxybiphenyl
- heteroaryl
- factor viia
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2002313655A AU2002313655A1 (en) | 2001-07-09 | 2002-07-03 | 2-(5-(5-carbamimidoyl-1h-heteroaryl)-6-hydroxybiphenyl-3-yl)-succinic acid derivatives as factor viia inhibitors |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30395301P | 2001-07-09 | 2001-07-09 | |
US60/303,953 | 2001-07-09 | ||
US35105402P | 2002-01-22 | 2002-01-22 | |
US60/351,054 | 2002-01-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003006670A2 WO2003006670A2 (fr) | 2003-01-23 |
WO2003006670A3 true WO2003006670A3 (fr) | 2003-05-22 |
Family
ID=26973737
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/021334 WO2003006011A1 (fr) | 2001-07-09 | 2002-07-03 | Derives de 2-[5-(5-carbamimidoyl-1h-heteroaryl)-6-hydroxybiphenyl-3-yl]-acide succinique utilises comme inhibiteurs du facteur viia |
PCT/US2002/021340 WO2003006670A2 (fr) | 2001-07-09 | 2002-07-03 | Derives de l'acide 2-[5-(5-carbamimidoyl-1h-heteroaryl)-6-hydroxybiphenyl-3-yl]-succinique en tant qu'inhibiteurs du facteur viia |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/021334 WO2003006011A1 (fr) | 2001-07-09 | 2002-07-03 | Derives de 2-[5-(5-carbamimidoyl-1h-heteroaryl)-6-hydroxybiphenyl-3-yl]-acide succinique utilises comme inhibiteurs du facteur viia |
Country Status (5)
Country | Link |
---|---|
US (2) | US20030114457A1 (fr) |
EP (1) | EP1408963A1 (fr) |
AU (1) | AU2002313655A1 (fr) |
CA (1) | CA2452391A1 (fr) |
WO (2) | WO2003006011A1 (fr) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1474400A1 (fr) * | 2002-02-13 | 2004-11-10 | Axys Pharmaceuticals, Inc. | Derives 2- 5-(5-carbamimidoyl-1h-heteroaryl)]-6-hydroxybiphenyl-3-yl comme inhibiteurs du facteur viia |
WO2004050637A2 (fr) | 2002-12-03 | 2004-06-17 | Axys Pharmaceuticals, Inc. | Derives de 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine utilises en tant qu'inhibiteurs du facteur viia |
AU2003300106A1 (en) * | 2003-01-08 | 2004-08-10 | Axys Pharmaceuticals, Inc. | 2-'5-(5-carbamimidoyl-1h-heteroaryl)-6-hydroxybiphenyl-3-yl!- carboxylic acid derivatives as factor viia inhibitors |
GB0319069D0 (en) * | 2003-08-14 | 2003-09-17 | Glaxo Group Ltd | Therapeutically useful compounds |
CA2543079A1 (fr) * | 2003-10-24 | 2005-05-06 | University Of North Carolina At Chapel Hill | Analogues triaryl dicationiques utilises en tant qu'agents antiprotozoaires |
EP1694671A2 (fr) | 2003-12-04 | 2006-08-30 | Vertex Pharmaceuticals Incorporated | Quinoxalines utiles comme inhibiteurs des proteines kinases |
US8729117B2 (en) | 2004-06-02 | 2014-05-20 | Pharmacyclics, Inc. | Factor VIIa inhibitor |
EP1761504A2 (fr) * | 2004-06-02 | 2007-03-14 | Pharmacyclics, Inc. | Inhibiteur de facteur viia |
CN1976903A (zh) * | 2004-06-02 | 2007-06-06 | 法莫西克立克斯公司 | 因子VⅡa抑制剂 |
EP2190810B1 (fr) * | 2007-09-17 | 2014-02-26 | Simpson Biotech Co., Ltd. | Composés isolés à partir d'antrodia cinnamomea et leur utilisation |
CN101861335B (zh) | 2007-10-16 | 2013-09-04 | 环状药物公司 | 凝血因子viia调节剂的制造、组合物和用途 |
CA2713139C (fr) | 2008-02-01 | 2013-04-23 | Amira Pharmaceuticals, Inc. | Antagonistes aminoalkylbiphenyle disubstitues par n,n des recepteurs de la prostaglandine d2 |
EP2245022A4 (fr) | 2008-02-25 | 2012-02-22 | Panmira Pharmaceuticals Llc | Antagonistes des récepteurs d2 de la prostaglandine |
GB2463788B (en) | 2008-09-29 | 2010-12-15 | Amira Pharmaceuticals Inc | Heteroaryl antagonists of prostaglandin D2 receptors |
WO2010039977A2 (fr) | 2008-10-01 | 2010-04-08 | Amira Pharmaceuticals, Inc. | Antagonistes d’hétéroaryle des récepteurs de la prostaglandine d2 |
WO2010042652A2 (fr) * | 2008-10-08 | 2010-04-15 | Amira Pharmaceuticals, Inc. | Antagonistes hétéroalkyl biphényle des récepteurs de la prostaglandine d2 |
CN102596902A (zh) | 2009-08-05 | 2012-07-18 | 潘米拉制药公司 | Dp2拮抗剂及其用途 |
JP2013516475A (ja) | 2010-01-06 | 2013-05-13 | アミラ ファーマシューティカルズ,インク. | Dp2アンタゴニストおよびその使用 |
AU2011342039B2 (en) | 2010-12-17 | 2015-06-11 | Mitsubishi Tanabe Pharma Corporation | Continuous arycyclic compound |
US9546155B2 (en) | 2012-06-15 | 2017-01-17 | Mitsubishi Tanabe Pharma Corporation | Aromatic heterocyclic compound |
CN104717973A (zh) * | 2012-10-10 | 2015-06-17 | 诺和诺德保健Ag(股份有限公司) | 因子vii多肽的液体药物组合物 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000035886A2 (fr) * | 1998-12-18 | 2000-06-22 | Axys Pharmaceuticals, Inc. | Inhibiteurs de proteases |
WO2002014307A1 (fr) * | 2000-08-11 | 2002-02-21 | Axys Pharmaceuticals, Inc. | Inhibiteurs du facteur viia |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA928276B (en) * | 1991-10-31 | 1993-05-06 | Daiichi Seiyaku Co | Aromatic amidine derivates and salts thereof. |
US5849764A (en) * | 1995-12-14 | 1998-12-15 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
US5942532A (en) * | 1997-09-05 | 1999-08-24 | Ortho Pharmaceutical Corporation | 2-substituted phenyl-benzimidazole antibacterial agents |
WO2003060475A2 (fr) * | 2002-01-10 | 2003-07-24 | Neurogen Corporation | Ligands recepteurs de l'hormone de concentration de la melanine: 2-(4-benzyl-piperazine-1-ylmethyl)- substitue et analogues de 2-(4-benzyl-diazepan-1-ylmethyl)-1h-benzoimidazole |
-
2002
- 2002-07-03 CA CA002452391A patent/CA2452391A1/fr not_active Abandoned
- 2002-07-03 AU AU2002313655A patent/AU2002313655A1/en not_active Abandoned
- 2002-07-03 WO PCT/US2002/021334 patent/WO2003006011A1/fr not_active Application Discontinuation
- 2002-07-03 US US10/190,147 patent/US20030114457A1/en not_active Abandoned
- 2002-07-03 WO PCT/US2002/021340 patent/WO2003006670A2/fr not_active Application Discontinuation
- 2002-07-03 EP EP02746886A patent/EP1408963A1/fr not_active Withdrawn
-
2004
- 2004-09-13 US US10/940,001 patent/US20050176797A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000035886A2 (fr) * | 1998-12-18 | 2000-06-22 | Axys Pharmaceuticals, Inc. | Inhibiteurs de proteases |
WO2002014307A1 (fr) * | 2000-08-11 | 2002-02-21 | Axys Pharmaceuticals, Inc. | Inhibiteurs du facteur viia |
Non-Patent Citations (1)
Title |
---|
YOUNG, W. B. ET AL: "Optimization of a screening lead for factor VIIa/TF", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2001), 11(17), 2253-2256, 3 September 2001 (2001-09-03), XP002212336 * |
Also Published As
Publication number | Publication date |
---|---|
CA2452391A1 (fr) | 2003-01-23 |
US20050176797A1 (en) | 2005-08-11 |
AU2002313655A1 (en) | 2003-01-29 |
WO2003006011A1 (fr) | 2003-01-23 |
WO2003006670A2 (fr) | 2003-01-23 |
EP1408963A1 (fr) | 2004-04-21 |
US20030114457A1 (en) | 2003-06-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2003006670A3 (fr) | Derives de l'acide 2-[5-(5-carbamimidoyl-1h-heteroaryl)-6-hydroxybiphenyl-3-yl]-succinique en tant qu'inhibiteurs du facteur viia | |
WO2004050637A3 (fr) | Derives de 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine utilises en tant qu'inhibiteurs du facteur viia | |
WO2002096361A3 (fr) | Derives de 5-aralkylsulfonyl-3-(pyrrol-2-ylmethylidene)-2-indolinone utilises comme inhibiteurs de kinase | |
WO2006017836A3 (fr) | Nouveaux derives de 2-amino-quinazoline utiles en tant qu'inhibiteurs de la $g(b)-secretase (bace) | |
WO2004062613A3 (fr) | Inhibiteurs d'integrase hiv | |
WO2002015662A3 (fr) | Fractions heteroaryle substituees par quinuclidine destinees au traitement de maladies | |
WO2007120647A3 (fr) | Compositions utiles en tant qu'inhibiteurs de canaux sodiques sensibles a la tension | |
WO2002017358A3 (fr) | Fractions heteroaryle substituees par quinuclidine destinees au traitement de maladies | |
WO2003045912A8 (fr) | Inhibiteurs du facteur xa et autres serine proteases intervenant dans la cascade de la coagulation | |
WO2006005609A3 (fr) | Derives d'oxindole substitues, et medicaments les renfermant | |
WO2002016357A3 (fr) | Composes aryle substitues par quinuclidine destines au traitement de maladies | |
WO2002096905A8 (fr) | Composes de thiazole inhibiteurs des proteines kinases | |
WO2002016358A3 (fr) | Composes aryliques substitues par quinuclidine destines au traitement de maladies | |
WO2004074244A3 (fr) | Composes de pyrimidine | |
NO20056010L (no) | Biaryloksymetylaren-karboksylsyrer | |
BRPI0307351B8 (pt) | composto, composição farmacêutica, uso de um composto, e, processo para preparar um composto | |
WO2006062982A3 (fr) | Inhibiteurs urée de map kinases | |
WO2004014322A3 (fr) | Compositions immunomodulatrices, leurs methodes de preparation et utilisation | |
WO2002008190A3 (fr) | Nouveaux derives d'heteroaryle et leur utilisation en tant que medicaments | |
WO2004009549A3 (fr) | Piperidines utiles pour traiter des maladies du systeme nerveux central | |
WO2003087088A3 (fr) | Nouveaux composes | |
NO20045042L (no) | 7-aryl -3,9-diazabicyklo (3.1.1)non-6-en-derivater og deres anvendelse som renin. inhibitorer ved behandling av hypertensjon, kardiovaskulaere og nyresykdommer | |
WO2002008194A8 (fr) | Derives acridine et utilisation en tant qu'agents pharmaceutiques | |
WO2003091259A8 (fr) | Inhibiteurs de la triaryl-oxy-aryl-spiro-pyrimidine-2, 4, 6-trione metalloproteinase | |
WO2006042103A3 (fr) | Inhibiteurs reversibles de la cathepsine b |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
122 | Ep: pct application non-entry in european phase | ||
NENP | Non-entry into the national phase |
Ref country code: JP |
|
WWW | Wipo information: withdrawn in national office |
Country of ref document: JP |