WO2003003007A3 - Methods and compositions useful for the prediction of blood-brain barrier permeation - Google Patents

Methods and compositions useful for the prediction of blood-brain barrier permeation Download PDF

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Publication number
WO2003003007A3
WO2003003007A3 PCT/US2002/019736 US0219736W WO03003007A3 WO 2003003007 A3 WO2003003007 A3 WO 2003003007A3 US 0219736 W US0219736 W US 0219736W WO 03003007 A3 WO03003007 A3 WO 03003007A3
Authority
WO
WIPO (PCT)
Prior art keywords
blood
brain barrier
prediction
methods
compositions useful
Prior art date
Application number
PCT/US2002/019736
Other languages
French (fr)
Other versions
WO2003003007A2 (en
Inventor
Li Di
Edward Harvel Kerns
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Priority to CNA028126556A priority Critical patent/CN1791669A/en
Priority to MXPA03011439A priority patent/MXPA03011439A/en
Priority to BR0210697-3A priority patent/BR0210697A/en
Priority to AU2002315398A priority patent/AU2002315398A1/en
Priority to JP2003509140A priority patent/JP2005501230A/en
Priority to CA002448746A priority patent/CA2448746A1/en
Priority to EP02742248A priority patent/EP1399539A2/en
Publication of WO2003003007A2 publication Critical patent/WO2003003007A2/en
Publication of WO2003003007A3 publication Critical patent/WO2003003007A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)

Abstract

The present invention provides a method for the in vitro determination of the ability of a compound or a mixture of compounds to permeate the blood-brain barrier and a membrane composition useful therefor.
PCT/US2002/019736 2001-06-29 2002-06-20 Methods and compositions useful for the prediction of blood-brain barrier permeation WO2003003007A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CNA028126556A CN1791669A (en) 2002-06-20 2002-06-20 Method and compositions useful for the prediction of blood-brain barrier permeation
MXPA03011439A MXPA03011439A (en) 2001-06-29 2002-06-20 Methods and compositions useful for the prediction of blood-brain barrier permeation.
BR0210697-3A BR0210697A (en) 2001-06-29 2002-06-20 Methods and compositions useful for predicting blood-brain barrier permeation
AU2002315398A AU2002315398A1 (en) 2001-06-29 2002-06-20 Methods and compositions useful for the prediction of blood-brain barrier permeation
JP2003509140A JP2005501230A (en) 2001-06-29 2002-06-20 Methods and compositions useful for predicting blood-brain barrier penetration
CA002448746A CA2448746A1 (en) 2001-06-29 2002-06-20 Methods and compositions useful for the prediction of blood-brain barrier permeation
EP02742248A EP1399539A2 (en) 2001-06-29 2002-06-20 Methods and compositions useful for the prediction of blood-brain barrier permeation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30208501P 2001-06-29 2001-06-29
US60/302,085 2001-06-29

Publications (2)

Publication Number Publication Date
WO2003003007A2 WO2003003007A2 (en) 2003-01-09
WO2003003007A3 true WO2003003007A3 (en) 2003-05-22

Family

ID=23166189

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/019736 WO2003003007A2 (en) 2001-06-29 2002-06-20 Methods and compositions useful for the prediction of blood-brain barrier permeation

Country Status (8)

Country Link
EP (1) EP1399539A2 (en)
JP (1) JP2005501230A (en)
AR (1) AR036121A1 (en)
AU (1) AU2002315398A1 (en)
BR (1) BR0210697A (en)
CA (1) CA2448746A1 (en)
MX (1) MXPA03011439A (en)
WO (1) WO2003003007A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE453119T1 (en) 2002-01-31 2010-01-15 Pion Inc METHOD AND DEVICE FOR MEASURING MEMBRANE PERMEABILITY
US8986781B2 (en) * 2005-10-27 2015-03-24 Corning Incorporated Immobilized multi-layer artificial membrane for permeability measurements (PAMPA)
DE102008007673A1 (en) * 2008-01-25 2009-07-30 Nimbus Biotechnologie Gmbh Determination of the permeability of substances through the blood-brain barrier
US10143187B2 (en) 2017-02-17 2018-12-04 Denali Therapeutics Inc. Transferrin receptor transgenic models
DK3583120T3 (en) 2017-02-17 2022-12-19 Denali Therapeutics Inc MODIFIED TRANSFERRIN RECEPTOR BINDING POLYPEPTIDES
US10457717B2 (en) 2017-02-17 2019-10-29 Denali Therapeutics Inc. Engineered polypeptides

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260210A (en) * 1989-09-27 1993-11-09 Rubin Lee L Blood-brain barrier model

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260210A (en) * 1989-09-27 1993-11-09 Rubin Lee L Blood-brain barrier model

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CESTELLI A ET AL: "Functional feature of a novel model of blood brain barrier: studies on permeation of test compounds", JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 76, no. 1-2, 11 September 2001 (2001-09-11), pages 139 - 147, XP004302045, ISSN: 0168-3659 *
GIROD J ET AL: "TRANSPORT OF CATIONIZED ANTI-TETANUS FAB'2 FRAGMENTS ACROSS AN IN VITRO BLOOD-BRAIN BARRIER MODEL: INVOLVEMENT OF THE TRANSCYTOSIS PATHWAY", JOURNAL OF NEUROCHEMISTRY, NEW YORK, NY, US, vol. 73, November 1999 (1999-11-01), pages 2002 - 2008, XP000984882, ISSN: 0022-3042 *
MARK GUMBLETON, KENETH L. AUDUS: "Progress and Limitations in the Use of In Vitro Cell Cultures to Serve as a Permeability Screen for the Blood Brain Barrier", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 90, no. 11, November 2001 (2001-11-01), pages 1681 - 1698, XP002233364 *
MURUGANANDAM A ET AL: "DEVELOPMENT OF IMMORTALIZED HUMAN CEREBROMICROVASCULAR ENDOTHELIAL CELL LINE AS AN IN VITRO MODEL OF THE HUMAN BLOOD-BRAIN BARRIER", FASEB JOURNAL, FED. OF AMERICAN SOC. FOR EXPERIMENTAL BIOLOGY, BETHESDA, MD, US, vol. 11, no. 13, October 1997 (1997-10-01), pages 1187 - 1197, XP000881413, ISSN: 0892-6638 *
SAWADA G A ET AL: "NOVEL, HIGHLY LIPOPHILIC ANTIOXIDANTS READILY DIFFUSE ACROSS THE BLOOD-BRAIN BARRIER AND ACCESS INTRACELLULAR SITES", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, AMERICAN SOCIETY FOR PHARMACOLOGY AND, US, vol. 288, no. 3, March 1999 (1999-03-01), pages 1327 - 1333, XP001117669, ISSN: 0022-3565 *

Also Published As

Publication number Publication date
CA2448746A1 (en) 2003-01-09
BR0210697A (en) 2004-09-21
JP2005501230A (en) 2005-01-13
MXPA03011439A (en) 2004-04-05
AU2002315398A1 (en) 2003-03-03
EP1399539A2 (en) 2004-03-24
WO2003003007A2 (en) 2003-01-09
AR036121A1 (en) 2004-08-11

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