MXPA03011439A - Methods and compositions useful for the prediction of blood-brain barrier permeation. - Google Patents

Methods and compositions useful for the prediction of blood-brain barrier permeation.

Info

Publication number
MXPA03011439A
MXPA03011439A MXPA03011439A MXPA03011439A MXPA03011439A MX PA03011439 A MXPA03011439 A MX PA03011439A MX PA03011439 A MXPA03011439 A MX PA03011439A MX PA03011439 A MXPA03011439 A MX PA03011439A MX PA03011439 A MXPA03011439 A MX PA03011439A
Authority
MX
Mexico
Prior art keywords
blood
brain barrier
prediction
methods
compositions useful
Prior art date
Application number
MXPA03011439A
Other languages
Spanish (es)
Inventor
Di Li
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of MXPA03011439A publication Critical patent/MXPA03011439A/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors

Abstract

The present invention provides a method for the in vitro determination of the ability of a compound or a mixture of compounds to permeate the blood-brain barrier and a membrane composition useful therefor.
MXPA03011439A 2001-06-29 2002-06-20 Methods and compositions useful for the prediction of blood-brain barrier permeation. MXPA03011439A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30208501P 2001-06-29 2001-06-29
PCT/US2002/019736 WO2003003007A2 (en) 2001-06-29 2002-06-20 Methods and compositions useful for the prediction of blood-brain barrier permeation

Publications (1)

Publication Number Publication Date
MXPA03011439A true MXPA03011439A (en) 2004-04-05

Family

ID=23166189

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03011439A MXPA03011439A (en) 2001-06-29 2002-06-20 Methods and compositions useful for the prediction of blood-brain barrier permeation.

Country Status (8)

Country Link
EP (1) EP1399539A2 (en)
JP (1) JP2005501230A (en)
AR (1) AR036121A1 (en)
AU (1) AU2002315398A1 (en)
BR (1) BR0210697A (en)
CA (1) CA2448746A1 (en)
MX (1) MXPA03011439A (en)
WO (1) WO2003003007A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE453119T1 (en) 2002-01-31 2010-01-15 Pion Inc METHOD AND DEVICE FOR MEASURING MEMBRANE PERMEABILITY
US8986781B2 (en) * 2005-10-27 2015-03-24 Corning Incorporated Immobilized multi-layer artificial membrane for permeability measurements (PAMPA)
DE102008007673A1 (en) * 2008-01-25 2009-07-30 Nimbus Biotechnologie Gmbh Determination of the permeability of substances through the blood-brain barrier
US10143187B2 (en) 2017-02-17 2018-12-04 Denali Therapeutics Inc. Transferrin receptor transgenic models
US10457717B2 (en) 2017-02-17 2019-10-29 Denali Therapeutics Inc. Engineered polypeptides
AU2018221731C1 (en) 2017-02-17 2021-11-18 Denali Therapeutics Inc. Engineered transferrin receptor binding polypeptides

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260210A (en) * 1989-09-27 1993-11-09 Rubin Lee L Blood-brain barrier model

Also Published As

Publication number Publication date
EP1399539A2 (en) 2004-03-24
JP2005501230A (en) 2005-01-13
CA2448746A1 (en) 2003-01-09
BR0210697A (en) 2004-09-21
WO2003003007A2 (en) 2003-01-09
WO2003003007A3 (en) 2003-05-22
AR036121A1 (en) 2004-08-11
AU2002315398A1 (en) 2003-03-03

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