WO2002102243A1 - Sampling device and method for obtaining samples of internal body substances and method for producing a sampling device - Google Patents

Sampling device and method for obtaining samples of internal body substances and method for producing a sampling device Download PDF

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Publication number
WO2002102243A1
WO2002102243A1 PCT/SE2002/000951 SE0200951W WO02102243A1 WO 2002102243 A1 WO2002102243 A1 WO 2002102243A1 SE 0200951 W SE0200951 W SE 0200951W WO 02102243 A1 WO02102243 A1 WO 02102243A1
Authority
WO
WIPO (PCT)
Prior art keywords
capsule
inlet opening
sampling device
blocking member
body substance
Prior art date
Application number
PCT/SE2002/000951
Other languages
English (en)
French (fr)
Inventor
Klas Stoltz
Original Assignee
FäRGKLäMMAN AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0101738A external-priority patent/SE522058C2/sv
Application filed by FäRGKLäMMAN AB filed Critical FäRGKLäMMAN AB
Priority to JP2003504833A priority Critical patent/JP4149376B2/ja
Priority to EP02733708A priority patent/EP1387634B1/de
Priority to DE60211142T priority patent/DE60211142T2/de
Priority to US10/697,943 priority patent/US7449001B2/en
Publication of WO2002102243A1 publication Critical patent/WO2002102243A1/en
Priority to US11/723,479 priority patent/US7717862B2/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A61B2010/0061—Alimentary tract secretions, e.g. biliary, gastric, intestinal, pancreatic secretions

Definitions

  • the present invention relates to a sampling device for obtaining samples of internal body substances in the digestive system of humans or animals.
  • the sampling device has the shape of a swallowable capsule which allows a sample of the body substance to enter the capsule through an inlet opening which is opened in a predetermined position of the digestive tract following contact with the body substance to be collected.
  • the invention also relates to a sampling method for obtaining samples of internal body substances and a method for producing the sampling device.
  • Examination of internal body substances, gases or solid particles in the digestive system or the gastrointestinal tract in the human or animal body provides essential medical information for diagnosing and treatment.
  • Examination of a sample of the gastric fluid of a patient pro- vides important information of pH, acid contents, abdominal enzyme activity as well as information for diagnosing gastric ulcer and gastritis, cancer and tumour diseases, etc.
  • a gastroscopic examination gives the physician who is treating a patient important information and plays a great role for a diagnosis. These intubation examinations are thus used extensively.
  • a gastroscopic examination in which a tube, having a diameter of a little finger, is inserted into the patient's mouth or nose, through the oesophagus and to the gastrointestinal system, is difficult to perform and demands the assistance of a physician.
  • the intubation of the digestive tract using these methods is a very un- pleasant intervention, both physically and psychologically, especially during the insertion of the tube and also when it is pulled out.
  • the intubation demands that the patient is given a local anaesthetic and in some instances even tranquilliser or a general anaesthetic to overcome the stress to which the patient is subjected.
  • the intubation examination methods described above are disadvantageous since they are very time- consuming for a qualified physician and thus expensive and a very un- pleasant intervention for the patient.
  • the application of a swallowable capsule for automatically obtaining samples of internal gastric fluids has been proposed as an alternative examination method and is described in US-A-4,481,952.
  • the capsule is equipped with mechanisms, which control the opening and closing of the capsule.
  • the mechanisms are blocked by blocking mechanisms, including a mass which is dissolved after a short time following contact with the gastric fluid.
  • the opening of the capsule, the collection of the sample and the reclosing of the capsule takes place automatically in the patient's stomach.
  • the described sampling device is advanta- geous in many ways. However, it has proved to function unsatisfactorily and has therefore not been widely used.
  • the described capsule is expensive, is mechanically complicated and comprises mutually movable parts, mostly metal parts. As a consequence, the parts tend to jam, fluids tend to leak between the parts, friction forces between the parts must be overcome, e.g. by spring forces, and metal parts, such as springs, may loosen in the gastrointestinal tract causing injuries to the patients.
  • the object of the present invention is to solve the above-mentioned problems of the prior art by providing a sampling device which operates automatically in the system of a patient and which is simple, inexpensive to produce, reliable and easy to use.
  • a sampling device for automatically obtaining samples of internal body substances is shaped as a capsule such that it may be swallowed by the patient without any stress or pain.
  • the capsule In a predetermined position in the digestive system, the capsule is opened and a sample of the body substance is aspirated through an inlet opening into the capsule by the force of a vacuum or substantial underpressure in the capsule.
  • a predetermined volume of the sampling substance has been collected in the capsule, i.e.
  • the capsule is filled, the inlet opening is automatically closed, sealing it from the in- side of the capsule, such that the sample remains in the capsule.
  • the capsule with the collected sample is fed through the gastrointestinal tract of the digestive system and, still with no stress or pain for the patient, out of the human body together with the fecies in a normal manner.
  • the capsule with the collected sample subsequently is sent or handed over to a medical institution or laboratory, where the sample is evacuated from the capsule to be analysed.
  • the sampling device according to the invention is simple and is made of a few essential parts. Just one of these part, the elastic blocking member, is resiliently movable between a flow permitting con- figuration and a flow preventing configuration and is affected by forces ensuing from the pressure difference between the outside and the inside of the capsule.
  • the elastic blocking member is resiliently movable between a flow permitting con- figuration and a flow preventing configuration and is affected by forces ensuing from the pressure difference between the outside and the inside of the capsule.
  • a reliable, simple and inexpensive sampling device is achieved with no metal or mutually movable parts that may jam, leak or come loose in the system and cause injuries to the patient.
  • a vacuum or substantial underpressure is created in the capsule and this vacuum or substantial underpressure exerts sufficient forces for opening the closing member and for aspiration of a sample of a body substance into the capsule.
  • Figure 1 is a sectional view of a sampling device according to a first embodiment of the invention, in a first closed and sealed state,
  • Figure 2 shows the sampling device of Figure 1 in a second, open state, and in a flow permitting configuration with the body substance flowing into the device
  • Figure 3 shows the sampling device of Figure 1 in a third, reclosed state, and in a flow preventing configuration in which the body substance has filled up the sampling device
  • Figure 4 shows the sampling device of Figure 1 in a fourth, evacuating state, in which the sample of body substance is evacuated from the capsule to be analysed
  • FIG. 5 is a sectional view of a sampling device according to a second embodiment of the invention, in a first closed and sealed state, Figure 6 shows the sampling device of Figure 5 from above,
  • Figure 7 shows an enlarged scale perspective view of an embodiment of the blocking member
  • Figure 8 shows a schematic elevation view of the vacuum chamber.
  • Figure 1 is a sectional view of a sampling device according to the invention, said device being designed to obtain samples of internal body substances, such as body fluids, in the digestive tract of a patient.
  • the sampling device is shown in a first closed and sealed state, in which it is handed over to be swallowed by a patient, from whom a sample of an internal body fluid, such as the gastric fluid in the stomach, for example, shall be collected.
  • the sampling device has the shape of a capsule 2, such as a conventional pharmaceutical capsule, and is thus suitable for ingestion.
  • the capsule 2 is preferably elongated and has rounded end portions and preferably a circular or oval-shaped cross-section.
  • the capsule 2 comprises an inner chamber 5 defined by a capsule wall 3.
  • the capsule 2 preferably made of a thermoplastic material or any other suitable material, is made of at least two capsule members, a cap member 4 and a body member 6, said cap 4 and body 6 members being permanently joined to each other, as will be described more in detail below.
  • the inner chamber 5 of the capsule 2 may comprise a filter 10, preferably clamped in the capsule 2 between the cap member 4 and the body member 6, to filtrate the body fluid sample, when required.
  • a blocking member 12 in the capsule is shown in an enlarged view in Figure 7.
  • the inner blocking member 12 such as a membrane valve, made of a flexible, elastic and resilient rubbery material, has a circular fixation edge 19 which is clamped in the capsule 2 between the cap member 4 and the body member 6.
  • the blocking member 12 has the form of a bulb and has at least one, preferably several, apertures 16 arranged in the slanted side of the bulb.
  • the blocking member 12 bears on a preferably circular contact surface 22 on the inside of the capsule wall 3.
  • the contact or sealing area 17 on the blocking member 12 is shown between the dashed lines in Figure 7.
  • the blocking member 12 bears on the contact surface 22 with a bearing pressure.
  • the circular contact surface 22, formed as a bulge-formed lining, is arranged on the inside of the capsule wall 3 and extends around an inlet opening 18 in said wall.
  • the inlet opening 18 is sealed by a plug 20.
  • the plug 20 in the capsule 2 is made of a material which is chosen depending on the application of the capsule, i.e. the specific body fluid to be collected.
  • the plug 20 is dissolved after a short period of time in the body fluid in question, in the embodiment as described, the digestive fluid.
  • the material of the plug 20 is adapted to the specific fluid or substance in the external environment of the capsule in the position in the body system where the sample is collected.
  • the material of the plug 20 is, for example, gelatine, molten sugar, salt, glue, organic edible materials or any other suitable material.
  • the plug 20 can be made of two or more layers of different materials, which dissolve gradually upon contact with different substances in the external environment of the capsule 2 during its passage through the digestive system. The innermost layer dissolves upon contact with body fluid to be collected by the capsule 2.
  • the notch 24 is used when the body fluid sample in the inner chamber 5 shall be evacuated from the capsule, as will be described more in detail with reference to Figure 4.
  • the patient swallows the capsule 2, e.g. the capsule as shown in Figure 1, without any stress or pain.
  • the size of the capsule 2 may vary depending on the volume of body fluid required for the examination and analysis.
  • a suitable size of a capsule which is easy to swallow has, for example, a length of about 25 mm and a width of about 10 mm.
  • the inlet opening 18 of the capsule 2 has been opened.
  • the capsule When the capsule is in the state as shown in Figure 2, the capsule has previously been swallowed by the patient, has passed the oesophagus and has entered into the stomach.
  • the patient feels no more discomfort than he feels when he swallows an ordinary pharmaceutical capsule, i.e. a discomfort which is principally non-existing.
  • the inlet opening 18 is open.
  • a suction effect is generated by the pressure difference between the external environment of the capsule 2 and the inner chamber 5 in which a vacuum or substantial underpressure prevails.
  • This suction effect forces the resilient blocking member 12 into a flow permitting configuration, as shown in Figure 2.
  • the body fluid 26 in the external environment of the capsule flows into the inlet opening 18 and exerts a pressure on the resilient and elastic, self-sealing blocking member 12, such that a fluid passage into the chamber 5 is opened between the contact surface 22 and the blocking member 12.
  • the body fluid 26 flows further through the apertures 16 in the blocking member 12, through the filter 10, if any, and into the inner chamber 5, as shown in Figure 2.
  • the blocking member 12 is opened and is kept open by the pressure difference between the external environment of the capsule and the inner chamber of the capsule 2. As soon as the external and internal pressure of the capsule have been equalised and the body fluid 26 has filled up the inner chamber 5 of the capsule, the blocking member 12 reverts to a flow preventing configuration, such that the inlet opening 18 is closed and thus the flow of body fluid from the inner chamber 5 of the capsule is prevented.
  • This reclosed state of the capsule is shown in Figure 3. Since the body fluid sample fills up the inner chamber 5 of the capsule and the fluid is prevented by the blocking member 12 to leave the chamber, the exact volume of the collected body fluid in a sampling capsule can be predetermined.
  • FIG. 4 shows the recovered capsule 2 in a state in which the body fluid sample is evacuated from the inner chamber 5 of the capsule.
  • Figures 5 and 6 show a second preferred embodiment of the invention, which differs from the embodiment of Figures 1 - 4 only in that the inlet of the capsule 2 is designed differently.
  • protrusions 30 are disposed externally on the capsule 2 at the inlet opening 18. Between the protrusions 30 laterally directed inlet grooves 32 are formed.
  • the protrusions 30 protect the inlet opening 18 in such a way that they prevent the capsule 2 from being adhered to the walls of the digestive system by the suction forces generated by the internal underpressure. A free flow of body fluid through the inlet grooves 32 into the capsule 2 is thus always secured.
  • the capsule 2 consists of two members 4, 6 which are permanently joined together.
  • the members 4, 6 are preferably made of injection-moulded thermoplastic, such as Macrolon® D for example, which is a strong, acid resistant and transparent material and thus suitable for this purpose.
  • the blocking member 12 is preferably made of an elastic rubbery material and may be injection-moulded.
  • the shape (see for example Figures 3 - 5) and the material properties of the blocking member 12 generate the self-closing function and force the blocking member to bear on and seal off the inlet opening 18 from the inside of the capsule 2.
  • the sampling device is made of a few parts, i.e. the cap member 4 with the plug 20, the body member 6, the blocking member 12 and, when required, also the filter 10. As shown in Figure 7, these parts are fully or partly assembled in a vacuum chamber 40, in which a vacuum or substantial underpressure is maintained by means of a vacuum pump (not shown) connected to the vacuum chamber through the vacuum hose 42.
  • a vacuum pump not shown
  • at least the assembly-step that finally seals off the inner chamber 5 of the capsule from the external environment shall be carried out in the vacuum chamber 40 in order to achieve a vacuum or substantial underpressure in the inner chamber 5, such that sufficient suction forces are generated to force the blocking member 12 to a flow permitting configuration and the body fluid sample to enter and fill the capsule.
  • the blocking member 12 and possibly the filter 10 are initially mounted in the cap member 4 or the body member 6 and subsequently the two members of the capsule are permanently joined together, preferably by ultrasonic welding.
  • the plug 20 may previously have been inserted in the inlet opening 18 of the capsule.
  • the joining of the two members 4, 6 together constitutes the assembly- step that seals off the inner chamber 5 of the capsule.
  • at least this assembly-step must be carried out in the vacuum chamber 40.
  • the blocking member 12 and the filter 10 have been mounted in either of the two members 4, 6 of the capsule 2, these two members 4, 6 are permanently joined together, and then the final sealing of the inner chamber 5 of the capsule is made by introducing the plug 20 into the inlet opening 18.
  • the plug 20 for example made of an organic glue, is quickly set when it is cooled.
  • the plug 20 is applied by means of a nozzle 44 and the glue is fed into the nozzle from the container 46.
  • the nozzle 44 initially is inserted into and through the inlet opening 18 of the capsule in the vacuum chamber, such that the elastic and self-closing blocking member 12 is forced by the nozzle 44 to open the communication to the inner chamber 5 of the capsule and the vacuum in the vacuum chamber is transmitted to the inner chamber 5.
  • the nozzle 44 is then withdrawn to the position of the inlet opening 18, where the plug 20 is applied by the nozzle 44 and sets, such that the capsule with its internal vacuum or substantial underpressure is finally sealed.
  • the nozzle 44 is first used to open the blocking member 12 and subsequently to apply the plug 20 of glue in the inlet opening 18.
  • the capsule 2 may further be provided with an additional outer, covering film of gelatine or any other suitable material, which is dissolved in the digestive system.
  • the film may be applied in order to minimise the resistance when the capsule is swallowed by the patient.
  • the plug may be formed to be fully dissolved after a predetermined time in the digestive system, such that a time delay of the opening of the inlet opening is obtained.
  • the elastic blocking member may have other forms and shapes and be placed differently in the capsule. Instead of one single inlet opening, as de- scribed in the embodiments above, several adjoining inlet openings may be provided in the capsule. In the description above, only samples of body fluids have been discussed. It should, however, be noted that the sampling device according to the invention also may be used to collect samples comprising gases and/ or solid particles in the digestive system.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
PCT/SE2002/000951 2001-05-17 2002-05-17 Sampling device and method for obtaining samples of internal body substances and method for producing a sampling device WO2002102243A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2003504833A JP4149376B2 (ja) 2001-05-17 2002-05-17 体内物質のサンプルを得るためのサンプリング装置および方法ならびにサンプリング装置を作製するための方法
EP02733708A EP1387634B1 (de) 2001-05-17 2002-05-17 Probenentnahmevorrichtung und verfahren zur entnahme von proben von körpersubstanzen sowie verfahren zur herstellung einer probenentnahmevorrichtung
DE60211142T DE60211142T2 (de) 2001-05-17 2002-05-17 Probenentnahmevorrichtung und verfahren zur entnahme von proben von körpersubstanzen sowie verfahren zur herstellung einer probenentnahmevorrichtung
US10/697,943 US7449001B2 (en) 2001-05-17 2002-05-17 Sampling device and method for obtaining samples of internal body substances and method for producing a sampling device
US11/723,479 US7717862B2 (en) 2001-05-17 2007-03-20 Sampling device and method for obtaining samples of internal body substances and method for producing a sampling device

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE0101738A SE522058C2 (sv) 2001-05-17 2001-05-17 Anordning för provtagning av inre kroppsvätskor
SE0101738-3 2001-05-17
US30125401P 2001-06-28 2001-06-28
US60/301,254 2001-06-28

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10697943 A-371-Of-International 2002-05-17
US11/723,479 Division US7717862B2 (en) 2001-05-17 2007-03-20 Sampling device and method for obtaining samples of internal body substances and method for producing a sampling device

Publications (1)

Publication Number Publication Date
WO2002102243A1 true WO2002102243A1 (en) 2002-12-27

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PCT/SE2002/000951 WO2002102243A1 (en) 2001-05-17 2002-05-17 Sampling device and method for obtaining samples of internal body substances and method for producing a sampling device

Country Status (7)

Country Link
US (2) US7449001B2 (de)
EP (1) EP1387634B1 (de)
JP (1) JP4149376B2 (de)
AT (1) ATE324830T1 (de)
DE (1) DE60211142T2 (de)
ES (1) ES2263783T3 (de)
WO (1) WO2002102243A1 (de)

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WO2005046485A1 (en) * 2003-11-12 2005-05-26 FäRGKLäMMAN AB Sampling device, method of producing a sampling device and use of a sampling device
US7459305B2 (en) * 2003-04-24 2008-12-02 Levy Mark M Ingestible gastrointestinal device
US7856676B2 (en) 2004-08-23 2010-12-28 Olympus Corporation Capsule-type medical device collector and capsule-type medical device collecting kit
US8249681B2 (en) 2005-01-31 2012-08-21 Given Imaging Ltd. Device, system and method for in vivo analysis
US8402843B2 (en) 2008-01-23 2013-03-26 Savannah River Nuclear Solutions, Llc Dissolution actuated sample container
US9220688B2 (en) 2004-02-10 2015-12-29 Slendine Sa Device and method for reducing calorie intake
US9320715B2 (en) 2011-03-29 2016-04-26 Slendine Sa Devices and methods for weight control and weight loss
CN106999166A (zh) * 2014-09-17 2017-08-01 马斯公司 装置
GB2554444A (en) * 2016-09-28 2018-04-04 Biome Oxford Ltd A device for sampling gastro-intestinal material
US10172598B2 (en) 2012-02-17 2019-01-08 Progenity, Inc. Ingestible medical device
US11007356B2 (en) 2018-11-19 2021-05-18 Progenity, Inc. Ingestible device for delivery of therapeutic agent to the gastrointestinal tract
US11413022B2 (en) 2014-09-17 2022-08-16 Mars, Incorporated Sampling device with ejectable compartment
US11419586B2 (en) 2014-09-17 2022-08-23 Mars, Incorporated Sampling device with ejectable compartment
GB2607276A (en) * 2021-05-10 2022-12-07 Vestlandets Innovasjonsselskap As Intestinal capsule assembly
CN117554556A (zh) * 2024-01-12 2024-02-13 佳木斯大学 一种用于消化系统的胃液酸性检测装置

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US8738106B2 (en) 2005-01-31 2014-05-27 Given Imaging, Ltd Device, system and method for in vivo analysis
EP2007433B1 (de) 2006-04-03 2011-10-26 Given Imaging Ltd. Vorrichtung, system und verfahren zur in-vivo-analyse
US20110270127A1 (en) * 2006-09-18 2011-11-03 Shany Vered Biological Fluid Receptacle
US8517728B2 (en) * 2007-01-24 2013-08-27 Colgate-Palmolive Company Oral care implement having fluid delivery system
US20090149839A1 (en) * 2007-12-11 2009-06-11 Hyde Roderick A Treatment techniques using ingestible device
US8202230B2 (en) 2009-08-20 2012-06-19 Colgate-Palmolive Company Oral care implement having a liquid collection system
EP3111800B1 (de) 2009-12-23 2018-11-21 Colgate-Palmolive Company Vorrichtung zur identifizierung von zuständen des oralbereichs
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CA2885057C (en) 2012-10-26 2021-04-06 Colgate-Palmolive Company Oral care implement with storage reservoir
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US8491495B1 (en) * 2012-11-16 2013-07-23 L. Zane Shuck Human intestinal tract research and diagnostic system to evaluate patients and advance medical science and bioengineering and to determine processes in the gut and causes of diseases
US9215997B2 (en) * 2012-11-16 2015-12-22 L. Zane Shuck In vivo technology system for human gut research, diagnostics and treatment
US8926526B2 (en) * 2012-11-30 2015-01-06 L. Zane Shuck Patient in vivo gut diagnostic and treatment tool
GB201304738D0 (en) * 2013-03-15 2013-05-01 Mars Inc Sampling Device
US11064905B2 (en) 2016-03-04 2021-07-20 University Of Miami Ingestible capsule device for collecting fluid aspirates
FR3052046B1 (fr) * 2016-06-07 2021-12-24 Univ Grenoble Alpes Dispositif de prise d'echantillon intestinal
IL297016B2 (en) 2016-09-09 2024-01-01 Biora Therapeutics Inc An edible electromechanical device for dispensing a dispensable substance
WO2018050647A1 (en) * 2016-09-15 2018-03-22 Stoco 10 GmbH Fluid sampling device
US10045760B2 (en) 2017-04-13 2018-08-14 Xibo Wei Sampling device capable of continuously sampling content in a biological conduit and method thereof
US11766249B2 (en) 2017-05-19 2023-09-26 Envivo Bio Inc. Devices and methods for collecting gastrointestinal samples
FR3072556A1 (fr) * 2017-10-25 2019-04-26 Universite Grenoble Alpes Dispositif de prelevement de fluide intestinal
US20210228157A1 (en) * 2017-12-06 2021-07-29 James Phillip Jones Sampling capsule system and methods
US10980482B2 (en) 2017-12-06 2021-04-20 James Phillip Jones Sampling capsule system and methods
CN109222874B (zh) * 2018-11-09 2024-04-09 安翰科技(武汉)股份有限公司 消化道采样胶囊
WO2020185326A1 (en) * 2019-03-12 2020-09-17 Tidhar Shalon Devices and methods for collecting gastrointestinal samples
CN109820540B (zh) * 2019-03-20 2024-02-27 大连医科大学 一种可吞咽的用于提取消化道内容物的胶囊
CN110236599A (zh) * 2019-07-15 2019-09-17 安翰科技(武汉)股份有限公司 采样胶囊及采样胶囊系统
EP3870261B1 (de) 2019-12-13 2024-01-31 Biora Therapeutics, Inc. Einnehmbare vorrichtung zur abgabe eines therapeutischen mittels an den magen-darm-trakt
WO2021212031A1 (en) * 2020-04-17 2021-10-21 Exact Sciences Development Company, Llc Ingestible sampling device
JP7457615B2 (ja) 2020-09-18 2024-03-28 株式会社日立製作所 消化器内内容物採取カプセル
KR102669000B1 (ko) * 2022-01-28 2024-05-27 순천향대학교 산학협력단 마이크로바이옴 채취 장치
CN115414069A (zh) * 2022-05-26 2022-12-02 小护士(天津)科技股份有限公司 一种三级尿液收集器

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US9220688B2 (en) 2004-02-10 2015-12-29 Slendine Sa Device and method for reducing calorie intake
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CN117554556A (zh) * 2024-01-12 2024-02-13 佳木斯大学 一种用于消化系统的胃液酸性检测装置
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JP4149376B2 (ja) 2008-09-10
US20070173738A1 (en) 2007-07-26
ATE324830T1 (de) 2006-06-15
EP1387634A1 (de) 2004-02-11
ES2263783T3 (es) 2006-12-16
DE60211142T2 (de) 2007-01-25
EP1387634B1 (de) 2006-05-03
US7449001B2 (en) 2008-11-11
DE60211142D1 (de) 2006-06-08
US7717862B2 (en) 2010-05-18
US20040097834A1 (en) 2004-05-20
JP2004529733A (ja) 2004-09-30

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