WO2002101086A3 - Sequences completes du genome mitochondrial servant d'outil diagnostique dans les sciences de la sante - Google Patents

Sequences completes du genome mitochondrial servant d'outil diagnostique dans les sciences de la sante Download PDF

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Publication number
WO2002101086A3
WO2002101086A3 PCT/CA2002/000848 CA0200848W WO02101086A3 WO 2002101086 A3 WO2002101086 A3 WO 2002101086A3 CA 0200848 W CA0200848 W CA 0200848W WO 02101086 A3 WO02101086 A3 WO 02101086A3
Authority
WO
WIPO (PCT)
Prior art keywords
mitochondrial genome
mutations
diagnostic tool
genome sequences
health sciences
Prior art date
Application number
PCT/CA2002/000848
Other languages
English (en)
Other versions
WO2002101086A2 (fr
Inventor
Mark Birch-Machin
Gabriel D Dakubo
Ryan Parr
Robert Thayer
Alioune Ngom
Ng John Th
Original Assignee
1304854 Ontario Ltd
Mark Birch-Machin
Gabriel D Dakubo
Ryan Parr
Robert Thayer
Alioune Ngom
Ng John Th
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 1304854 Ontario Ltd, Mark Birch-Machin, Gabriel D Dakubo, Ryan Parr, Robert Thayer, Alioune Ngom, Ng John Th filed Critical 1304854 Ontario Ltd
Priority to EP02737683A priority Critical patent/EP1397508A2/fr
Priority to JP2003503836A priority patent/JP2005506057A/ja
Priority to CA002450403A priority patent/CA2450403A1/fr
Publication of WO2002101086A2 publication Critical patent/WO2002101086A2/fr
Priority to US10/732,374 priority patent/US20050026167A1/en
Publication of WO2002101086A3 publication Critical patent/WO2002101086A3/fr
Priority to PCT/CA2004/002124 priority patent/WO2005056573A1/fr
Priority to US11/339,751 priority patent/US20070190534A1/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

L'examen de mutations dans l'ensemble du génome mitochondrial sert de système diagnostique pour des maladies telles que le cancer de la prostate et le cancer de la peau sans mélanomes. Des mutations et des réarrangements caractéristiques tels que des mutations ponctuelles (transitions, transversions), délétions, inversions, duplications, recombinaisons, insertions ou des combinaisons de celles-ci dans le génome mitochondrial servent d'indicateurs précoces du cancer de la prostate et du cancer de la peau sans mélanomes. Par ailleurs, 4977bp ou « délétion commune » ainsi que d'autres mutations et/ou délétions associées servent de mesure du vieillissement.
PCT/CA2002/000848 2001-06-11 2002-06-10 Sequences completes du genome mitochondrial servant d'outil diagnostique dans les sciences de la sante WO2002101086A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP02737683A EP1397508A2 (fr) 2001-06-11 2002-06-10 Sequences completes du genome mitochondrial servant d'outil diagnostique dans les sciences de la sante
JP2003503836A JP2005506057A (ja) 2001-06-11 2002-06-10 健康科学のための診断ツールとしての全ミトコンドリアゲノム配列
CA002450403A CA2450403A1 (fr) 2001-06-11 2002-06-10 Sequences completes du genome mitochondrial servant d'outil diagnostique dans les sciences de la sante
US10/732,374 US20050026167A1 (en) 2001-06-11 2003-12-11 Complete mitochondrial genome sequences as a diagnostic tool for the health sciences
PCT/CA2004/002124 WO2005056573A1 (fr) 2002-06-10 2004-12-13 Sequences completes du genome mitochondrial utilisees comme outil de diagnostic pour des sciences de la sante
US11/339,751 US20070190534A1 (en) 2001-06-11 2006-01-26 Mitochondrial sites and genes associated with prostate cancer

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29734001P 2001-06-11 2001-06-11
US60/297,340 2001-06-11
CA002450004A CA2450004A1 (fr) 2001-06-11 2003-12-18 Sequences completes du genome mitochondrial comme outil diagnostic pour les sciences de la sante

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/732,374 Continuation-In-Part US20050026167A1 (en) 2001-06-11 2003-12-11 Complete mitochondrial genome sequences as a diagnostic tool for the health sciences

Publications (2)

Publication Number Publication Date
WO2002101086A2 WO2002101086A2 (fr) 2002-12-19
WO2002101086A3 true WO2002101086A3 (fr) 2003-12-11

Family

ID=34808883

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2002/000848 WO2002101086A2 (fr) 2001-06-11 2002-06-10 Sequences completes du genome mitochondrial servant d'outil diagnostique dans les sciences de la sante

Country Status (4)

Country Link
EP (1) EP1397508A2 (fr)
JP (1) JP2005506057A (fr)
CA (2) CA2450403A1 (fr)
WO (1) WO2002101086A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0200817D0 (sv) * 2002-03-15 2002-03-15 Ulf Gyllensten Method and kit for detection of mutations in mitochondrial DNA
CA2550135A1 (fr) * 2003-12-11 2005-06-23 1304854 Ontario Ltd. Sequences completes du genome mitochondrial utilisees comme outil de diagnostic pour des sciences de la sante
US20130022979A1 (en) 2005-04-18 2013-01-24 Genesis Genomics Inc. 3.4kb MITOCHONDRIAL DNA DELETION FOR USE IN THE DETECTION OF CANCER
CN103789405B (zh) 2005-04-18 2018-03-30 Mdna生命科学有限公司 作为检测日光照射、前列腺癌和其它癌症的诊断工具的线粒体突变及重排
NZ584815A (en) * 2007-09-26 2012-07-27 Mitomics Inc 3.4 kb mitochondrial dna deletion for use in the detection of cancer
WO2009059414A1 (fr) * 2007-11-09 2009-05-14 Genesis Genomics Inc. Suppression de mutations d'adn mitochondrial entre les résidus 12317-16254 pour une utilisation dans la détection d'un cancer
CN107011428B (zh) 2008-03-28 2022-02-25 Mdna生命科学有限公司 异常线粒体dna、相关的融合转录物及其杂交探针
JP5734947B2 (ja) * 2009-03-27 2015-06-17 ミトミクス インコーポレイテッドＧｅｎｅｓｉｓ Ｇｅｎｏｍｉｃｓ Ｉｎｃ． 異常型ミトコンドリアｄｎａ、関連融合転写物および翻訳産物、並びにそのハイブリダイゼーションプローブ
WO2014038622A1 (fr) * 2012-09-05 2014-03-13 国立大学法人大阪大学 Biomarqueur pour maladies autoimmunes
EP2953639B1 (fr) * 2013-02-06 2021-06-02 Brandeis University Traitement d'une altération de l'adn et de dysfonctionnement mitochondrial au moyen de jus de fruit de palmier
US12012633B2 (en) 2018-06-11 2024-06-18 The Broad Institute, Inc. Lineage tracing using mitochondrial genome mutations and single cell genomics

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001068923A2 (fr) * 2000-03-15 2001-09-20 The Johns Hopkins University Dosimetre a mitochondries

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001068923A2 (fr) * 2000-03-15 2001-09-20 The Johns Hopkins University Dosimetre a mitochondries

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
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CORTOPASSI G ET AL: "MODELLING THE EFFECTS OF AGE-RELATED MTDNA MUTATION ACCUMULATION;COMPLEX 1 DEFICIENCY, SUPEROXIDE AND CELL DEATH", BIOCHIMICA ET BIOPHYSICA ACTA, AMSTERDAM, NL, vol. 1271, 24 May 1995 (1995-05-24), pages 171 - 176, XP000944048, ISSN: 0006-3002 *
ESHAGHIAN ALEX ET AL: "Alterations of mitochondrial DNA in aging skin and in non-melanoma skin cancers.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL, vol. 43, March 2002 (2002-03-01), 93rd Annual Meeting of the American Association for Cancer Research;San Francisco, California, USA; April 06-10, 2002, March, 2002, pages 304 - 305, XP001153120, ISSN: 0197-016X *
FLISS MAKIKO S ET AL: "Facile detection of mitochondrial DNA mutations in tumors and bodily fluids.", SCIENCE (WASHINGTON D C), vol. 287, no. 5460, 17 March 2000 (2000-03-17), pages 2017 - 2019, XP002244376, ISSN: 0036-8075 *
JERONIMO C ET AL: "Mitochondrial mutations in early stage prostate cancer and bodily fluids.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL, vol. 42, March 2001 (2001-03-01), 92nd Annual Meeting of the American Association for Cancer Research;New Orleans, LA, USA; March 24-28, 2001, March, 2001, pages 63, XP001153112, ISSN: 0197-016X *
JESSIE BENJAMIN C ET AL: "Accumulation of mitochondrial DNA deletions in the aging prostate.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL, vol. 42, March 2001 (2001-03-01), 92nd Annual Meeting of the American Association for Cancer Research;New Orleans, LA, USA; March 24-28, 2001, March, 2001, pages 862 - 863, XP001153110, ISSN: 0197-016X *
JESSIE BENJAMIN C ET AL: "Accumulation of mitochondrial DNA deletions in the malignant prostate of patients of different ages.", EXPERIMENTAL GERONTOLOGY, vol. 37, no. 1, December 2001 (2001-12-01), pages 169 - 174, XP002244377, ISSN: 0531-5565 *
PARRELLA PAOLA ET AL: "Detection of mitochondrial DNA mutations in primary breast cancer and fine-needle aspirates.", CANCER RESEARCH, vol. 61, no. 20, 15 October 2001 (2001-10-15), pages 7623 - 7626, XP002244378, ISSN: 0008-5472 *
PENTA JS ET AL.: "Mitochondrial DNA in human malignancy", REVIEWS IN MUTATION RESEARCH, vol. 488, 2001, pages 119 - 133, XP002244375 *
PETROS JOHN ANTHONY ET AL: "Mitochondrial DNA point mutations are common in prostate cancer and enhance malignant phenotype.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL, vol. 42, March 2001 (2001-03-01), 92nd Annual Meeting of the American Association for Cancer Research;New Orleans, LA, USA; March 24-28, 2001, March, 2001, pages 517, XP001153111, ISSN: 0197-016X *
THAYER ROBERT ET AL: "Mitochondrial DNA mutations and/or deletions in prostate cancers.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL, vol. 42, March 2001 (2001-03-01), 92nd Annual Meeting of the American Association for Cancer Research;New Orleans, LA, USA; March 24-28, 2001, March, 2001, pages 532 - 533, XP001153105, ISSN: 0197-016X *

Also Published As

Publication number Publication date
CA2450403A1 (fr) 2002-12-19
CA2450004A1 (fr) 2005-06-18
EP1397508A2 (fr) 2004-03-17
WO2002101086A2 (fr) 2002-12-19
JP2005506057A (ja) 2005-03-03

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