WO2002098442A2 - Phytasehaltige zusammensetzung - Google Patents
Phytasehaltige zusammensetzung Download PDFInfo
- Publication number
- WO2002098442A2 WO2002098442A2 PCT/EP2002/005781 EP0205781W WO02098442A2 WO 2002098442 A2 WO2002098442 A2 WO 2002098442A2 EP 0205781 W EP0205781 W EP 0205781W WO 02098442 A2 WO02098442 A2 WO 02098442A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- phytase
- composition according
- calcium
- zinc
- magnesium
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/06—Enzymes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
- C12Y301/03026—4-Phytase (3.1.3.26), i.e. 6-phytase
Definitions
- the present invention relates to a phytase-containing composition.
- the present invention relates to a composition containing at least one phytic acid-cleaving reagent and its use, in particular for increasing the bioavailability of essential bioelements such as calcium, magnesium, zinc and / or iron and phosphorus.
- dietary supplements may not be the optimal one
- the problem underlying the present invention now consists in the provision of a composition which has a positive influence on the bioavailability of essential bioelements, such as in particular of minerals (calcium, magnesium, zinc, iron etc.) or phosphorus.
- composition which contains at least one phytic acid-cleaving reagent, preferably enzyme, can positively influence or increase the bioavailability of the aforementioned essential nutritional components.
- the present invention thus relates to a composition, in particular in the form of a pharmaceutical composition, a medicament or a food supplement, which contains at least one reagent which cleaves phytic acid, preferably enzyme, optionally together with at least one pharmaceutical auxiliary and / or carrier.
- the reagent which cleaves phytic acid is a phytase.
- the phytase can be selected from the group of 3-phytase, 6-phytase and mixtures thereof.
- Phytases are enzymes that break down phytic acid (myo-inositol hexaphosphate, phytic acid).
- the phytases are phosphatases that split the phytic acid into myo-inositol and orthophosphate.
- 3-phytase cleaves the phytic acid according to the following reaction equation: myo-inositol-l, 2,3,4,5,6-hexaphosphate + H 2 0 -> m o-inositol-l, 2,4,5,6 -pentaphosphate + orthophosphate.
- 6-phytase catalyzes the following reaction:
- the phytases themselves are commercially available products. For example, they can be obtained from FLUKA Chemie, a division of SIGMA-ALDRICH Corp.
- the phytases used according to the invention can be microbially obtained, e.g. B. from Aspergillus ficuum or Aspergillus niger derivative phytases or plant phytases, e.g. B. phytases obtained from cereals, such as wheat.
- the phytase is usually present in the composition according to the invention in lyophilized form.
- composition according to the invention can optionally contain pharmaceutical auxiliaries and / or carriers.
- pharmaceutical auxiliaries and / or carriers are generally selected from commonly used, inert, non-toxic, pharmaceutically suitable auxiliaries and / or carriers.
- auxiliaries and / or excipients suitable according to the invention are e.g. B. all kinds of sugar, preferably lactose, maltose or sucrose, and water.
- composition according to the invention can be in any application form, in particular in liquid or solid application form. Tablets, capsules, pills, lozenges, coated tablets, solutions are preferred.
- Emulsions or suspensions The composition according to the invention is preferably applied enterally or orally.
- a phytic acid-cleaving reagent preferably phytase (s)
- a phytase preferably phytase (s)
- the absorption of essential bio-elements e.g. Calcium, magnesium, zinc and / or iron in the intestinal tract is a very complicated process that depends on many influencing factors, in particular on the amount of essential bioelements consumed, on the respective needs of the organism, the physical activity and the presence of other nutrients. Furthermore, it also depends, for example, on the pH value, on the relationship between the bioelement and the phosphorus content in the food, and on the fatty acid and vitamin content in the same. For example, it is known that the vitamin D content regulates the process of calcium absorption.
- the applicant has now found that the preferably enteral or oral application of phytase (s), in particular in the form of the composition according to the invention, leads to better bioavailability of the aforementioned essential bioelements, in particular if the phytases (s) or the invention Composition to be administered before, during and / or after food.
- the amount of phytic acid-cleaving reagent or phytase (s) to be administered before, during and / or after ingestion of the food can vary within wide limits and is particularly dependent on the type and amount of the ingested foods, on the body weight of the person being treated, and on the individual Behavior towards the active substance, the type and severity of the disease, if any, the type of preparation and application, and the time or interval at which the administration takes place.
- the phytic acid-splitting reagent preferably phytase (s)
- s phytase
- the phytic acid-splitting reagent is used in each application, in particular before, during and / or after * food intake, in amounts of 0.1 ⁇ g to 250 mg, in particular 1 ⁇ g to 250 mg, preferably 10 ⁇ g up to 150 mg.
- At least one mineral is administered together with the phytic acid-cleaving reagent or phytase (s), in particular an essential bioelement such as calcium, magnesium, zinc and / or iron, preferably each in the form of their ions.
- the composition is a combination preparation consisting of a reagent which cleaves phytic acid or phytase (s) plus essential bioelements (eg calcium, magnesium, zinc and / or iron). It can also be advantageous if the composition according to the invention contains one or more vitamins.
- the composition according to the invention contains calcium in addition to phytase (s) - to also add vitamin D to the composition because this vitamin has a positive effect on the calcium absorption capacity.
- the present invention also relates to the use of the composition according to the invention for increasing the bioavailability of essential bioelements, in particular calcium, magnesium, zinc and / or iron, preferably each in the form of their ions, and / or for increasing the bioavailability of phosphorus, preferably in the form of phosphates.
- composition according to the invention can be used, for example, for the prophylactic and / or curative treatment of deficiency in essential bioelements, in particular calcium, magnesium, zinc and / or iron deficiency, as well as related diseases such as osteoporosis (osteoporosis), iron deficiency diseases such as anemia and the like , are used.
- essential bioelements in particular calcium, magnesium, zinc and / or iron deficiency
- related diseases such as osteoporosis (osteorosis), iron deficiency diseases such as anemia and the like
- the present invention thus also relates to the use of phytase (s), in particular 3-phytase, 6-phytase and mixtures thereof, for
- the applicant has surprisingly found that the preferably oral administration of phytase (s), preferably in the form of the composition according to the invention, in particular before, during and / or after eating, leads to a significant increase in the serum level of calcium, magnesium, zinc and iron , d. H. the absorption capacity of the aforementioned elements is significantly increased. This improves the utilization of the food consumed, especially in the case of plant food.
- phytase preferably in the form of the composition according to the invention, in particular before, during and / or after eating, leads to a significant increase in the serum level of calcium, magnesium, zinc and iron , d. H. the absorption capacity of the aforementioned elements is significantly increased. This improves the utilization of the food consumed, especially in the case of plant food.
- Blood was drawn from the rats at various times before and after food intake, and the blood drawn after analysis was analyzed with a liquid scintillation counter to determine the dynamics of appearance of 45 Ca in the blood, which was used for the research of the intestinal 45 Ca. - Absorption is important.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Inorganic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2002316927A AU2002316927A1 (en) | 2001-06-01 | 2002-05-27 | Composition containing phytase |
EP02745320A EP1392353A2 (de) | 2001-06-01 | 2002-05-27 | Phytasehaltige zusammensetzung |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10126970A DE10126970A1 (de) | 2001-06-01 | 2001-06-01 | Phytasehaltige Zusammensetzung |
DE10126970.6 | 2001-06-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002098442A2 true WO2002098442A2 (de) | 2002-12-12 |
WO2002098442A3 WO2002098442A3 (de) | 2003-12-04 |
Family
ID=7687052
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2002/005781 WO2002098442A2 (de) | 2001-06-01 | 2002-05-27 | Phytasehaltige zusammensetzung |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1392353A2 (de) |
AU (1) | AU2002316927A1 (de) |
DE (1) | DE10126970A1 (de) |
RU (1) | RU2003109268A (de) |
WO (1) | WO2002098442A2 (de) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2888249A1 (fr) * | 2005-07-08 | 2007-01-12 | Adisseo France Sas Soc Par Act | Effet synergique de l'association de phytases sur l'hydrolyse de l'acide phytique |
WO2009012953A1 (en) | 2007-07-25 | 2009-01-29 | Dsm Ip Assets B.V. | Iron fortification nutritional blend |
ITMI20091566A1 (it) * | 2009-09-14 | 2011-03-14 | Nyelis S R L | Composizioni farmaceutiche,medicali,nutraceutiche e dietetiche aventi lo scopo di massimizzare la bioaccessibilita' e la biodisponibilita' del magnesio |
WO2014159886A1 (en) | 2013-03-14 | 2014-10-02 | Amip, Llc | Phosphorus-sparing nutritional composition |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060110492A1 (en) * | 2003-02-11 | 2006-05-25 | Hugo Streekstra | Preparation and food product comprising an active phytase |
GB0422052D0 (en) | 2004-10-04 | 2004-11-03 | Dansico As | Enzymes |
GB0423139D0 (en) | 2004-10-18 | 2004-11-17 | Danisco | Enzymes |
US8143046B2 (en) | 2007-02-07 | 2012-03-27 | Danisco Us Inc., Genencor Division | Variant Buttiauxella sp. phytases having altered properties |
WO2011134885A1 (en) * | 2010-04-28 | 2011-11-03 | Dsm Ip Assets B.V. | Lipid based ready-to-use food comprising phytase |
Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0772978A1 (de) * | 1995-11-10 | 1997-05-14 | Loevens Kemiske Fabrik (Leo Pharmaceutical Products) | Trinkwasser- und Futtermittelzusatz und Additionsverfahren und -gerät |
WO1997035016A1 (en) * | 1996-03-18 | 1997-09-25 | Novo Nordisk Biotech Inc | Polypeptides having phytase activity and nucleic acids encoding same |
WO1998028408A1 (en) * | 1996-12-20 | 1998-07-02 | Novo Nordisk A/S | Peniophora phytase |
WO1998030681A1 (en) * | 1997-01-09 | 1998-07-16 | Novo Nordisk A/S | Phytase combinations |
EP0897985A2 (de) * | 1997-07-24 | 1999-02-24 | F.Hoffmann-La Roche Ag | Konsensus-Phytasen |
WO1999012431A1 (en) * | 1997-09-05 | 1999-03-18 | Wisconsin Alumni Research Foundation | Animal feed containing carboxylic acids |
WO1999049740A1 (en) * | 1998-04-01 | 1999-10-07 | Dsm N.V. | Application of phytase in feed having low content of phytate |
WO2000043503A1 (en) * | 1999-01-22 | 2000-07-27 | Novozymes A/S | Improved phytases |
EP1043028A1 (de) * | 1997-12-19 | 2000-10-11 | Kyowa Hakko Kogyo Co., Ltd. | Verfahren zur vorbeugung/behandlung von mastitis |
WO2002054881A2 (en) * | 2001-01-10 | 2002-07-18 | Dsm Ip Assets B.V. | The use of food and drink as a delevery system for phytase in humans |
-
2001
- 2001-06-01 DE DE10126970A patent/DE10126970A1/de not_active Withdrawn
-
2002
- 2002-05-27 RU RU2003109268/15A patent/RU2003109268A/ru not_active Application Discontinuation
- 2002-05-27 EP EP02745320A patent/EP1392353A2/de not_active Withdrawn
- 2002-05-27 AU AU2002316927A patent/AU2002316927A1/en not_active Abandoned
- 2002-05-27 WO PCT/EP2002/005781 patent/WO2002098442A2/de not_active Application Discontinuation
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0772978A1 (de) * | 1995-11-10 | 1997-05-14 | Loevens Kemiske Fabrik (Leo Pharmaceutical Products) | Trinkwasser- und Futtermittelzusatz und Additionsverfahren und -gerät |
WO1997035016A1 (en) * | 1996-03-18 | 1997-09-25 | Novo Nordisk Biotech Inc | Polypeptides having phytase activity and nucleic acids encoding same |
WO1998028408A1 (en) * | 1996-12-20 | 1998-07-02 | Novo Nordisk A/S | Peniophora phytase |
WO1998030681A1 (en) * | 1997-01-09 | 1998-07-16 | Novo Nordisk A/S | Phytase combinations |
EP0897985A2 (de) * | 1997-07-24 | 1999-02-24 | F.Hoffmann-La Roche Ag | Konsensus-Phytasen |
WO1999012431A1 (en) * | 1997-09-05 | 1999-03-18 | Wisconsin Alumni Research Foundation | Animal feed containing carboxylic acids |
EP1043028A1 (de) * | 1997-12-19 | 2000-10-11 | Kyowa Hakko Kogyo Co., Ltd. | Verfahren zur vorbeugung/behandlung von mastitis |
WO1999049740A1 (en) * | 1998-04-01 | 1999-10-07 | Dsm N.V. | Application of phytase in feed having low content of phytate |
WO2000043503A1 (en) * | 1999-01-22 | 2000-07-27 | Novozymes A/S | Improved phytases |
WO2002054881A2 (en) * | 2001-01-10 | 2002-07-18 | Dsm Ip Assets B.V. | The use of food and drink as a delevery system for phytase in humans |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2888249A1 (fr) * | 2005-07-08 | 2007-01-12 | Adisseo France Sas Soc Par Act | Effet synergique de l'association de phytases sur l'hydrolyse de l'acide phytique |
WO2007006952A1 (fr) * | 2005-07-08 | 2007-01-18 | Adisseo France S.A.S. | Effet synergique de l'association de phytases sur l'hydrolyse de l'acide phytique |
US8541036B2 (en) | 2005-07-08 | 2013-09-24 | Adisseo France S.A.S. | Synergetic effect of the phytase combination on the hydrolysis of phytic acid |
NO339291B1 (no) * | 2005-07-08 | 2016-11-21 | Adisseo France Sas | Preparat, som kombinerer minst to fytaser for hydrolysen av fytinsyre, anvendelse derav for fremstillingen av et ernæringstilskudd for dyr eller et dyrefor, sett eller sammensetning til foring av dyr samt en fremgangsmåte for hydrolyse av fytinsyre. |
WO2009012953A1 (en) | 2007-07-25 | 2009-01-29 | Dsm Ip Assets B.V. | Iron fortification nutritional blend |
CN101765375B (zh) * | 2007-07-25 | 2013-01-09 | 帝斯曼知识产权资产管理有限公司 | 铁强化营养混合物 |
ITMI20091566A1 (it) * | 2009-09-14 | 2011-03-14 | Nyelis S R L | Composizioni farmaceutiche,medicali,nutraceutiche e dietetiche aventi lo scopo di massimizzare la bioaccessibilita' e la biodisponibilita' del magnesio |
WO2014159886A1 (en) | 2013-03-14 | 2014-10-02 | Amip, Llc | Phosphorus-sparing nutritional composition |
US10912796B2 (en) | 2013-03-14 | 2021-02-09 | Albion Laboratories, Inc. | Phosphorus-sparing nutritional composition |
US11534458B2 (en) | 2013-03-14 | 2022-12-27 | Albion Laboratories, Inc. | Phosphorus-sparing nutritional composition |
Also Published As
Publication number | Publication date |
---|---|
EP1392353A2 (de) | 2004-03-03 |
AU2002316927A1 (en) | 2002-12-16 |
WO2002098442A3 (de) | 2003-12-04 |
RU2003109268A (ru) | 2004-09-10 |
DE10126970A1 (de) | 2002-12-05 |
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