WO2002081741A3 - Utilisation des produits des genes de la famille 2'-5' oligoadenylate synthetase (oas) pour le criblage d'antiviraux et la detection de la sensibilite a l'infection par les flaviviridae - Google Patents

Utilisation des produits des genes de la famille 2'-5' oligoadenylate synthetase (oas) pour le criblage d'antiviraux et la detection de la sensibilite a l'infection par les flaviviridae Download PDF

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Publication number
WO2002081741A3
WO2002081741A3 PCT/FR2002/001169 FR0201169W WO02081741A3 WO 2002081741 A3 WO2002081741 A3 WO 2002081741A3 FR 0201169 W FR0201169 W FR 0201169W WO 02081741 A3 WO02081741 A3 WO 02081741A3
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WIPO (PCT)
Prior art keywords
oas
genes
products
antiviral agents
oligoadenylate synthetase
Prior art date
Application number
PCT/FR2002/001169
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English (en)
Other versions
WO2002081741A2 (fr
Inventor
Jean-Louis Guenet
Tomoji Mashimo
Dominique Simon-Chazottes
Xavier Montagutelli
Marie-Pascale Frenkiel
Philippe Despres
Vincent Deubel
Francois Bonhomme
Marianne Lucas
Original Assignee
Pasteur Institut
Centre Nat Rech Scient
Jean-Louis Guenet
Tomoji Mashimo
Dominique Simon-Chazottes
Xavier Montagutelli
Marie-Pascale Frenkiel
Philippe Despres
Vincent Deubel
Bonhomme F R
Marianne Lucas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pasteur Institut, Centre Nat Rech Scient, Jean-Louis Guenet, Tomoji Mashimo, Dominique Simon-Chazottes, Xavier Montagutelli, Marie-Pascale Frenkiel, Philippe Despres, Vincent Deubel, Bonhomme F R, Marianne Lucas filed Critical Pasteur Institut
Priority to AU2002302677A priority Critical patent/AU2002302677A1/en
Publication of WO2002081741A2 publication Critical patent/WO2002081741A2/fr
Publication of WO2002081741A3 publication Critical patent/WO2002081741A3/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0337—Animal models for infectious diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Environmental Sciences (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Animal Husbandry (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)

Abstract

Utilisation des produits des gènes de la famille 2'-5' oligoadénylate synthétase (OAS) pour le criblage d'antiviraux et la détection de la sensibilité à l'infection par les Flaviviridae.
PCT/FR2002/001169 2001-04-04 2002-04-04 Utilisation des produits des genes de la famille 2'-5' oligoadenylate synthetase (oas) pour le criblage d'antiviraux et la detection de la sensibilite a l'infection par les flaviviridae WO2002081741A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002302677A AU2002302677A1 (en) 2001-04-04 2002-04-04 Use of products of genes of the 2'-5' oligoadenylate synthetase family (oas) for screening antiviral agents and for detecting responsiveness to flaviviridae infection

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0104598A FR2823224B1 (fr) 2001-04-04 2001-04-04 Utilisation de genes oas impliques dans la sensibilite/resistance a l'infection par les flaviviridae pour le criblage de molecules antivirales
FR01/04598 2001-04-04

Publications (2)

Publication Number Publication Date
WO2002081741A2 WO2002081741A2 (fr) 2002-10-17
WO2002081741A3 true WO2002081741A3 (fr) 2003-11-06

Family

ID=8861949

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2002/001169 WO2002081741A2 (fr) 2001-04-04 2002-04-04 Utilisation des produits des genes de la famille 2'-5' oligoadenylate synthetase (oas) pour le criblage d'antiviraux et la detection de la sensibilite a l'infection par les flaviviridae

Country Status (3)

Country Link
AU (1) AU2002302677A1 (fr)
FR (1) FR2823224B1 (fr)
WO (1) WO2002081741A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1910293B (zh) * 2003-10-23 2011-04-13 伊洛默格生物科学公司 检测与抗病毒感染性有关的基因oas1中的突变的方法

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI415944B (zh) * 2004-02-06 2013-11-21 Kineta Two Llc 偵測與病毒感染抗性有關基因（ｏａｓｉ）中之突變之方法
UA95446C2 (ru) 2005-05-04 2011-08-10 Іллюміджен Байосайєнсіз, Інк. Мутаци в генах oas1
EP2123748A1 (fr) 2008-05-20 2009-11-25 Institut Pasteur 2'-5'-oligoadénylate synthétase 3 pour prévenir et traiter une infection par virus à ARN à brin unique de sens positif
JP6057460B2 (ja) 2009-08-31 2017-01-11 ジェン−プローブ・インコーポレーテッド デングウイルスアッセイ
US20110104138A1 (en) 2009-11-03 2011-05-05 Institut Pasteur Use of the innate immunity gene oasl for preventing or treating infection with negative strand rna viruses

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BONNEVIE-NIELSEN V ET AL: "Lymphocytic 2',5'-Oligoadenylate Synthetase Activity Increases prior to the Appearance of Neutralizing Antibodies and Immunoglobulin M and Immunoglobulin G antibodies after Primary and Secondary Immunization with Yellow Fever Vaccine.", CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, vol. 2, no. 3, 1995, pages 302 - 306, XP001052856 *
CASTELLI J ET AL: "The 2-5A system in viral infection and apoptosis.", BIOMEDICINE & PHARMACOTHERAPY, vol. 52, no. 9, October 1998 (1998-10-01), pages 386 - 390, XP001042331 *
MASHIMO T ET AL: "A nonsense mutation in the gene encoding 2'-5'-oligoadenylate synthetase/L1 isoform is associated with West Nile virus susceptibility in laboratory mice.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 99, no. 17, 20 August 2002 (2002-08-20), pages 11311 - 11316, XP002228287, ISSN: 0027-8424 *
PAWLOTSKY J-M ET AL: "Activity of the interferon-induced 2',5'-oligoadenylate synthetase in patients with chronic hepatitis C.", JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, vol. 15, no. 10, 1995, pages 857 - 862, XP001052852 *
PERELYGIN A A ET AL: "Positional cloning of the murine Flavivirus resistance gene.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 99, no. 14, 9 July 2002 (2002-07-09), pages 9322 - 9327, XP002228288, ISSN: 0027-8424 *
SAMUEL C E: "Host genetic variability and West Nile virus susceptibility.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 99, no. 18, 3 September 2002 (2002-09-03), pages 11555 - 11557, XP002228286, ISSN: 0027-8424 *
SHELLAM G R ET AL: "Genetic control of host resistance to flavivirus infection in animals.", REVUE SCIENTIFIQUE ET TECHNIQUE, OFFICE INTERNATIONAL DES EPIZOOTIES, vol. 17, no. 1, April 1998 (1998-04-01), pages 231 - 248, XP001042370 *
TAKAHASHI A ET AL: "Quantitative analysis of p40/p46 and p69/p71 forms of 2',5'-oligoadenylate synthetase mRNA by competitive PCR and its clinical application.", CLINICAL CHEMISTRY, vol. 48, no. 9, September 2002 (2002-09-01), September, 2002, pages 1551 - 1559, XP008012723, ISSN: 0009-9147 *
TRUVE E ET AL: "Transgenic potato plants expressing mammalian 2'-5' oligoadenylate synthetase are protected from potato virus X infection under field conditions", BIO/TECHNOLOGY, 1 September 1993 (1993-09-01), pages 1048 - 1052, XP000612063 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1910293B (zh) * 2003-10-23 2011-04-13 伊洛默格生物科学公司 检测与抗病毒感染性有关的基因oas1中的突变的方法

Also Published As

Publication number Publication date
WO2002081741A2 (fr) 2002-10-17
FR2823224A1 (fr) 2002-10-11
AU2002302677A1 (en) 2002-10-21
FR2823224B1 (fr) 2003-10-31

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