WO2002079248A3 - Mammalian alpha-helical protein-53 - Google Patents

Mammalian alpha-helical protein-53 Download PDF

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Publication number
WO2002079248A3
WO2002079248A3 PCT/US2001/043884 US0143884W WO02079248A3 WO 2002079248 A3 WO2002079248 A3 WO 2002079248A3 US 0143884 W US0143884 W US 0143884W WO 02079248 A3 WO02079248 A3 WO 02079248A3
Authority
WO
WIPO (PCT)
Prior art keywords
zalpha53
mammalian alpha
helical protein
polypeptides
present
Prior art date
Application number
PCT/US2001/043884
Other languages
French (fr)
Other versions
WO2002079248A2 (en
Inventor
Zeren Gao
Kimberly E Shoemaker
Original Assignee
Zymogenetics Inc
Zeren Gao
Kimberly E Shoemaker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc, Zeren Gao, Kimberly E Shoemaker filed Critical Zymogenetics Inc
Priority to EP01273806A priority Critical patent/EP1355937A2/en
Priority to US10/416,860 priority patent/US20040058354A1/en
Priority to JP2002577872A priority patent/JP2004526446A/en
Priority to CA002429265A priority patent/CA2429265A1/en
Priority to AU2001297949A priority patent/AU2001297949A1/en
Publication of WO2002079248A2 publication Critical patent/WO2002079248A2/en
Publication of WO2002079248A3 publication Critical patent/WO2002079248A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention relates to polynucleotide and polypeptide molecules for mammalian alpha helix-53 (Zalpha53). The polypeptides, and polynucleotides encoding them, are hormonal and may be used to regulate the functioning of the immune system. The present invention also includes antibodies to the Zalpha53 polypeptides. Antagonists to Zalpha53 can be used to treat inflammation and inflammation-related disease.
PCT/US2001/043884 2000-11-17 2001-11-14 Mammalian alpha-helical protein-53 WO2002079248A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP01273806A EP1355937A2 (en) 2000-11-17 2001-11-14 Mammalian alpha-helical protein-53
US10/416,860 US20040058354A1 (en) 2001-11-14 2001-11-14 Mammalian alpha-helical protein-53
JP2002577872A JP2004526446A (en) 2000-11-17 2001-11-14 Mammalian α-helix protein-53
CA002429265A CA2429265A1 (en) 2000-11-17 2001-11-14 Mammalian alpha-helical protein-53
AU2001297949A AU2001297949A1 (en) 2000-11-17 2001-11-14 Mammalian alpha-helical protein-53

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24968600P 2000-11-17 2000-11-17
US60/249,686 2000-11-17

Publications (2)

Publication Number Publication Date
WO2002079248A2 WO2002079248A2 (en) 2002-10-10
WO2002079248A3 true WO2002079248A3 (en) 2003-09-04

Family

ID=22944557

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/043884 WO2002079248A2 (en) 2000-11-17 2001-11-14 Mammalian alpha-helical protein-53

Country Status (5)

Country Link
EP (1) EP1355937A2 (en)
JP (1) JP2004526446A (en)
AU (1) AU2001297949A1 (en)
CA (1) CA2429265A1 (en)
WO (1) WO2002079248A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001057276A2 (en) * 2000-02-04 2001-08-09 Aeomica, Inc. Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human bone marrow
WO2001070986A2 (en) * 2000-03-17 2001-09-27 Zymogenetics, Inc. Helical protein zalpha51

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001057276A2 (en) * 2000-02-04 2001-08-09 Aeomica, Inc. Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human bone marrow
WO2001070986A2 (en) * 2000-03-17 2001-09-27 Zymogenetics, Inc. Helical protein zalpha51

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL/GENBANK/DDJB [online] 19 May 1999 (1999-05-19), STRAUSBERG, R.: "wb12b03.x1 NCI_CGAP_GC6 homo sapiens cDNA clone IMAGE:2305421", XP002237048, retrieved from EBI Database accession no. AI670939 *

Also Published As

Publication number Publication date
AU2001297949A1 (en) 2002-10-15
EP1355937A2 (en) 2003-10-29
JP2004526446A (en) 2004-09-02
CA2429265A1 (en) 2002-10-10
WO2002079248A2 (en) 2002-10-10

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