WO2002070674A3 - A human member of the phospholipase d superfamily and methods for regulating its activity - Google Patents

A human member of the phospholipase d superfamily and methods for regulating its activity Download PDF

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Publication number
WO2002070674A3
WO2002070674A3 PCT/EP2002/001102 EP0201102W WO02070674A3 WO 2002070674 A3 WO2002070674 A3 WO 2002070674A3 EP 0201102 W EP0201102 W EP 0201102W WO 02070674 A3 WO02070674 A3 WO 02070674A3
Authority
WO
WIPO (PCT)
Prior art keywords
phospholipase
superfamily
regulating
activity
methods
Prior art date
Application number
PCT/EP2002/001102
Other languages
French (fr)
Other versions
WO2002070674A2 (en
Inventor
Rainer H Koehler
Original Assignee
Bayer Ag
Rainer H Koehler
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Rainer H Koehler filed Critical Bayer Ag
Priority to AU2002247679A priority Critical patent/AU2002247679A1/en
Publication of WO2002070674A2 publication Critical patent/WO2002070674A2/en
Publication of WO2002070674A3 publication Critical patent/WO2002070674A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Reagents that regulate human lipase-like enzyme and reagents which bind to human lipase-like enzyme gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, cancer, COPD, and CNS disorders.
PCT/EP2002/001102 2001-02-05 2002-02-04 A human member of the phospholipase d superfamily and methods for regulating its activity WO2002070674A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002247679A AU2002247679A1 (en) 2001-02-05 2002-02-04 A human member of the phospholipase d superfamily and methods for regulating its activity

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US26589201P 2001-02-05 2001-02-05
US60/265,892 2001-02-05
US27649401P 2001-03-19 2001-03-19
US60/276,494 2001-03-19

Publications (2)

Publication Number Publication Date
WO2002070674A2 WO2002070674A2 (en) 2002-09-12
WO2002070674A3 true WO2002070674A3 (en) 2002-10-24

Family

ID=26951482

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/001102 WO2002070674A2 (en) 2001-02-05 2002-02-04 A human member of the phospholipase d superfamily and methods for regulating its activity

Country Status (2)

Country Link
AU (1) AU2002247679A1 (en)
WO (1) WO2002070674A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998024905A2 (en) * 1996-12-06 1998-06-11 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998024905A2 (en) * 1996-12-06 1998-06-11 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CAO JINGXIN ET AL: "A human homolog of the vaccinia virus HindIII K4L gene is a member of the phospholipase D superfamily.", VIRUS RESEARCH, vol. 48, no. 1, U60644, 1997, pages 11 - 18, XP002209546, ISSN: 0168-1702, Retrieved from the Internet <URL:EMBL> *
DATABASE EMBL [online] 9 March 2001 (2001-03-09), STRAUBERG R: "Homo sapiens, similar to vaccinia virus HindIII K4L ORF, clone MGC:870", XP002209296, retrieved from EMBL Database accession no. BC000553 *
DATABASE EMBL 13 November 1998 (1998-11-13), PEDERSEN K M: "Mus musculus schwannoma-associated protein (SAM9) mRNA, complete cds", XP002209548, retrieved from EMBL Database accession no. AF026124 *
DATABASE EMBL 4 October 1996 (1996-10-04), UPTON C ET AL: "Human HU-K4, complete cds", XP002209547, retrieved from EMBL Database accession no. U60644 *
PEDERSEN K M ET AL: "EXPRESSION OF A NOVEL MURINE PHOSPHOLIPASE D HOMOLOG COINCIDES WITHLATE NEURONAL DEVELOPMENT IN THE FOREBRAIN-", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 273, no. 47, AF026124, 20 November 1998 (1998-11-20), pages 31494 - 31504, XP002926191, ISSN: 0021-9258, Retrieved from the Internet <URL:EMBL> *
PONTING C P ET AL: "A novel family of phospholipase D homologues that includes phospholipid synthases and putative endonucleases: Identification of duplicated repeats and potential active site residues.", PROTEIN SCIENCE, vol. 5, no. 5, 1996, pages 914 - 922, XP001098616, ISSN: 0961-8368 *

Also Published As

Publication number Publication date
WO2002070674A2 (en) 2002-09-12
AU2002247679A1 (en) 2002-09-19

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