WO2002043864A3 - Dispositifs et procedes de multiplexage de puces a adn - Google Patents

Dispositifs et procedes de multiplexage de puces a adn Download PDF

Info

Publication number
WO2002043864A3
WO2002043864A3 PCT/US2001/044364 US0144364W WO0243864A3 WO 2002043864 A3 WO2002043864 A3 WO 2002043864A3 US 0144364 W US0144364 W US 0144364W WO 0243864 A3 WO0243864 A3 WO 0243864A3
Authority
WO
WIPO (PCT)
Prior art keywords
devices
biochip
methods
nucleic acid
allow
Prior art date
Application number
PCT/US2001/044364
Other languages
English (en)
Other versions
WO2002043864A2 (fr
Inventor
Robert Terbrueggen
Original Assignee
Clinical Micro Sensors Inc
Robert Terbrueggen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/760,384 external-priority patent/US7312087B2/en
Priority claimed from PCT/US2001/001150 external-priority patent/WO2001054813A2/fr
Priority claimed from US09/904,175 external-priority patent/US20020177135A1/en
Application filed by Clinical Micro Sensors Inc, Robert Terbrueggen filed Critical Clinical Micro Sensors Inc
Priority to AU2002239354A priority Critical patent/AU2002239354A1/en
Priority to EP01987105A priority patent/EP1331999A2/fr
Priority to CA002427669A priority patent/CA2427669A1/fr
Priority to JP2002545830A priority patent/JP2004515231A/ja
Publication of WO2002043864A2 publication Critical patent/WO2002043864A2/fr
Publication of WO2002043864A3 publication Critical patent/WO2002043864A3/fr
Priority to US10/412,660 priority patent/US20040053290A1/en
Priority to AU2005244524A priority patent/AU2005244524A1/en
Priority to US11/532,872 priority patent/US20070098600A1/en
Priority to US11/982,403 priority patent/US20090057147A1/en
Priority to US11/982,368 priority patent/US20110180425A1/en
Priority to US11/982,334 priority patent/US20100285981A1/en
Priority to US11/982,408 priority patent/US20080242553A1/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00871—Communications between instruments or with remote terminals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/021—Identification, e.g. bar codes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0819—Microarrays; Biochips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0605—Valves, specific forms thereof check valves
    • B01L2400/0611—Valves, specific forms thereof check valves duck bill valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0638—Valves, specific forms thereof with moving parts membrane valves, flap valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0661—Valves, specific forms thereof with moving parts shape memory polymer valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B01L7/525—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N2001/021—Correlating sampling sites with geographical information, e.g. GPS
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00158—Elements containing microarrays, i.e. "biochip"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00326—Analysers with modular structure
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Clinical Laboratory Science (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Nanotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Materials Engineering (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La présente invention concerne des dispositifs qui permettent l'analyse simultanée de plusieurs puces à ADN. Notamment, on a conçu les dispositifs pour qu'ils portent des cartouches renfermant des puces à ADN qui contiennent des jeux ordonnés d'échantillons, tels que ceux d'acides nucléiques, et grâce à ces dispositifs, on obtient des analyses d'échantillons à rendement élevé.
PCT/US2001/044364 1999-04-21 2001-11-05 Dispositifs et procedes de multiplexage de puces a adn WO2002043864A2 (fr)

Priority Applications (11)

Application Number Priority Date Filing Date Title
AU2002239354A AU2002239354A1 (en) 2000-11-03 2001-11-05 Devices and methods for biochip multiplexing
EP01987105A EP1331999A2 (fr) 2000-11-03 2001-11-05 Dispositifs et procedes de multiplexage de puces a adn
CA002427669A CA2427669A1 (fr) 2000-11-03 2001-11-05 Dispositifs et procedes de multiplexage de puces a adn
JP2002545830A JP2004515231A (ja) 2000-11-03 2001-11-05 バイオチップを多重化するための装置および方法
US10/412,660 US20040053290A1 (en) 2000-01-11 2003-04-11 Devices and methods for biochip multiplexing
AU2005244524A AU2005244524A1 (en) 2000-11-03 2005-12-14 Devices and methods for biochip multiplexing
US11/532,872 US20070098600A1 (en) 1999-04-21 2006-09-18 Devices and methods for biochip multiplexing
US11/982,408 US20080242553A1 (en) 1999-04-21 2007-10-31 Devices and methods for biochip multiplexing
US11/982,403 US20090057147A1 (en) 1999-04-21 2007-10-31 Devices and methods for biochip multiplexing
US11/982,368 US20110180425A1 (en) 1999-04-21 2007-10-31 Devices and methods for biochip multiplexing
US11/982,334 US20100285981A1 (en) 1999-04-21 2007-10-31 Devices and methods for biochip multiplexing

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US24584000P 2000-11-03 2000-11-03
US60/145,840 2000-11-03
PCT/US2001/001150 WO2001054813A2 (fr) 2000-01-11 2001-01-11 Dispositifs et procedes pour mettre en oeuvre des reactions multiples sur biopuces
US09/760,384 US7312087B2 (en) 2000-01-11 2001-01-11 Devices and methods for biochip multiplexing
USPCT/US01/01150 2001-01-11
US09/760,384 2001-01-11
US09/904,175 2001-07-11
US09/904,175 US20020177135A1 (en) 1999-07-27 2001-07-11 Devices and methods for biochip multiplexing

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US09/904,175 Continuation-In-Part US20020177135A1 (en) 1999-04-21 2001-07-11 Devices and methods for biochip multiplexing

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US19371202A Continuation-In-Part 1999-04-21 2002-07-11
US10/412,660 Continuation-In-Part US20040053290A1 (en) 1999-04-21 2003-04-11 Devices and methods for biochip multiplexing

Publications (2)

Publication Number Publication Date
WO2002043864A2 WO2002043864A2 (fr) 2002-06-06
WO2002043864A3 true WO2002043864A3 (fr) 2002-08-01

Family

ID=56290216

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/044364 WO2002043864A2 (fr) 1999-04-21 2001-11-05 Dispositifs et procedes de multiplexage de puces a adn

Country Status (5)

Country Link
EP (1) EP1331999A2 (fr)
JP (1) JP2004515231A (fr)
AU (1) AU2002239354A1 (fr)
CA (1) CA2427669A1 (fr)
WO (1) WO2002043864A2 (fr)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8388908B2 (en) 2009-06-02 2013-03-05 Integenx Inc. Fluidic devices with diaphragm valves
US8431390B2 (en) 2004-09-15 2013-04-30 Integenx Inc. Systems of sample processing having a macro-micro interface
US8476063B2 (en) 2004-09-15 2013-07-02 Integenx Inc. Microfluidic devices
US8512538B2 (en) 2010-05-28 2013-08-20 Integenx Inc. Capillary electrophoresis device
US8557518B2 (en) 2007-02-05 2013-10-15 Integenx Inc. Microfluidic and nanofluidic devices, systems, and applications
US8584703B2 (en) 2009-12-01 2013-11-19 Integenx Inc. Device with diaphragm valve
US8672532B2 (en) 2008-12-31 2014-03-18 Integenx Inc. Microfluidic methods
US8748165B2 (en) 2008-01-22 2014-06-10 Integenx Inc. Methods for generating short tandem repeat (STR) profiles
US8763642B2 (en) 2010-08-20 2014-07-01 Integenx Inc. Microfluidic devices with mechanically-sealed diaphragm valves
US8841116B2 (en) 2006-10-25 2014-09-23 The Regents Of The University Of California Inline-injection microdevice and microfabricated integrated DNA analysis system using same
US9121058B2 (en) 2010-08-20 2015-09-01 Integenx Inc. Linear valve arrays
US9151746B2 (en) 1999-04-21 2015-10-06 Osmetech Technology, Inc. Use of microfluidic systems in the electrochemical detection of target analytes
US11845081B2 (en) 2007-07-13 2023-12-19 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6541617B1 (en) 1998-10-27 2003-04-01 Clinical Micro Sensors, Inc. Detection of target analytes using particles and electrodes
US6875619B2 (en) 1999-11-12 2005-04-05 Motorola, Inc. Microfluidic devices comprising biochannels
US7338760B2 (en) 2001-10-26 2008-03-04 Ntu Ventures Private Limited Sample preparation integrated chip
KR100450818B1 (ko) * 2002-03-09 2004-10-01 삼성전자주식회사 다챔버 ｐｃｒ 칩
EP1385006A3 (fr) * 2002-07-24 2004-09-01 F. Hoffmann-La Roche Ag Système et cartouche pour traiter un échantillon biologique
EP1419821A1 (fr) * 2002-11-14 2004-05-19 F. Hoffmann-La Roche Ag Méthode, dispositifs et enceinte de réaction pour le traitment d'échantillons biologiques
JP2006512092A (ja) 2002-12-30 2006-04-13 ザ・リージェンツ・オブ・ジ・ユニバーシティ・オブ・カリフォルニア 病原体の検出および分析のための方法および装置
WO2004072632A1 (fr) * 2003-02-14 2004-08-26 Arkray Inc. Outil d'analyse presentant un element a bouton
DE10318139B4 (de) * 2003-04-18 2005-02-17 PRO DESIGN Gesellschaft für Produktentwicklung mbH Selbstkonfigurerbarer Biochip
JP4038575B2 (ja) * 2003-07-25 2008-01-30 独立行政法人産業技術総合研究所 バイオセンサ、バイオセンサ装置またはバイオセンサの保存方法
US7390622B2 (en) 2003-10-16 2008-06-24 Hai Kang Life Corporation Limited Apparatus and methods for detecting nucleic acid in biological samples
KR101165860B1 (ko) 2003-10-16 2012-07-13 하이 캉 라이프 코포레이션 리미티드 생물학적 샘플에서 핵산을 검출하는 장치 및 방법
JP4750412B2 (ja) * 2003-12-25 2011-08-17 モレックス インコーポレイテド 生体由来分子、ダイオキシン類及び内分泌撹乱物質検出装置及び当該装置を使用した検出方法
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
JP2008509387A (ja) * 2004-08-04 2008-03-27 スピンエックス インコーポレイテッド マイクロ流体デバイスを流体処理デバイスと接続する装置及び方法
JP4583937B2 (ja) * 2005-01-07 2010-11-17 積水化学工業株式会社 砒素イオンの電気化学測定方法
JP4714475B2 (ja) * 2005-02-15 2011-06-29 株式会社島津製作所 反応容器、遺伝子多型検出方法及び装置
JP2006223126A (ja) * 2005-02-15 2006-08-31 Shimadzu Corp 反応容器、遺伝子多型検出方法及び装置、並びに診断方法及び装置
JP2006242925A (ja) 2005-03-07 2006-09-14 Seiko Epson Corp 電極基板、該基板を備える検出装置および該装置を含むキット、並びに該キットを用いた検出方法
JP4660662B2 (ja) * 2005-09-06 2011-03-30 アークレイ株式会社 カートリッジ
US7723120B2 (en) 2005-10-26 2010-05-25 General Electric Company Optical sensor array system and method for parallel processing of chemical and biochemical information
US8133741B2 (en) 2005-10-26 2012-03-13 General Electric Company Methods and systems for delivery of fluidic samples to sensor arrays
AU2007204589B2 (en) * 2006-01-12 2012-11-01 Mycrolab Diagnostics Pty Ltd New instrumentation systems and methods
DK3088083T3 (en) 2006-03-24 2018-11-26 Handylab Inc Method of carrying out PCR down a multi-track cartridge
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US8883490B2 (en) 2006-03-24 2014-11-11 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
EP1878495A1 (fr) * 2006-07-14 2008-01-16 Roche Diagnostics GmbH Dispositif analytique pour traiter thermiquement un fluide et/ou pour en surveiller une propriété
WO2008006618A1 (fr) * 2006-07-14 2008-01-17 Roche Diagnostics Gmbh Dispositif analytique pour traiter thermiquement un fluide et/ou surveiller une propriété de fluide
EP1886727A1 (fr) * 2006-07-14 2008-02-13 Roche Diagnostics GmbH Dispositif pour analyse
JP4751302B2 (ja) * 2006-11-21 2011-08-17 株式会社日立製作所 電位差式センサ及び分析用素子
US8888470B2 (en) * 2007-02-27 2014-11-18 Deka Products Limited Partnership Pumping cassette
US20090107335A1 (en) 2007-02-27 2009-04-30 Deka Products Limited Partnership Air trap for a medical infusion device
US7883898B2 (en) 2007-05-07 2011-02-08 General Electric Company Method and apparatus for measuring pH of low alkalinity solutions
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
EP2028488B1 (fr) * 2007-08-02 2015-02-25 F. Hoffmann-La Roche AG Unité de transfert pour éléments test
JP2009085829A (ja) * 2007-10-01 2009-04-23 Nec Corp 生体材料測定装置
BR112013026451B1 (pt) 2011-04-15 2021-02-09 Becton, Dickinson And Company sistema e método para realizar ensaios de diagnóstico molecular em várias amostras em paralelo e simultaneamente amplificação em tempo real em pluralidade de câmaras de reação de amplificação
EP2773892B1 (fr) 2011-11-04 2020-10-07 Handylab, Inc. Dispositif de préparation d'échantillons de polynucléotides
US20140200167A1 (en) 2012-08-01 2014-07-17 Nanomdx, Inc. Functionally integrated device for multiplex genetic identification
WO2014022700A2 (fr) * 2012-08-01 2014-02-06 Prakash Ranjit A Dispositif fonctionnellement intégré pour identification génétique multiplexe et procédé de séparation et de détection de fragments d'adn
EP2890497B1 (fr) 2012-08-30 2018-07-04 Life Technologies Corporation Dispositif de serrage vertical
DE102014205728B3 (de) * 2014-03-27 2015-03-05 Robert Bosch Gmbh Chiplabor-Kartusche für ein mikrofluidisches System zum Analysieren einer Probe biologischen Materials, mikrofluidisches System zum Analysieren einer Probe biologischen Materials sowie Verfahren und Vorrichtung zum Analysieren einer Probe biologischen Materials
GB201510723D0 (en) * 2015-06-18 2015-08-05 Alere Switzerland Gmbh High throughput isothermal nucleic acid amplification
JP7012301B2 (ja) * 2017-09-12 2022-02-14 株式会社八光電機 薬物検出システム
JP7303623B2 (ja) * 2018-12-07 2023-07-05 積水化学工業株式会社 検査用具
DE102022209418A1 (de) * 2022-09-09 2024-03-14 Robert Bosch Gesellschaft mit beschränkter Haftung Mikrofluidische Vorrichtung und Verfahren zu ihrem Betrieb

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5519635A (en) * 1993-09-20 1996-05-21 Hitachi Ltd. Apparatus for chemical analysis with detachable analytical units
WO1997041425A1 (fr) * 1996-04-25 1997-11-06 Pence, Inc. Biocapteur et methode afferente
WO1998005424A1 (fr) * 1996-08-02 1998-02-12 Caliper Technologies Corporation Dispositif analytique et procede correspondant
WO1998057159A1 (fr) * 1997-06-12 1998-12-17 Clinical Micro Sensors, Inc. Procedes electroniques de detection d'analytes
US5866345A (en) * 1992-05-01 1999-02-02 The Trustees Of The University Of Pennsylvania Apparatus for the detection of an analyte utilizing mesoscale flow systems
WO1999033559A1 (fr) * 1997-12-24 1999-07-08 Cepheid Cartouche de manipulation de fluide integree
US6114122A (en) * 1996-03-26 2000-09-05 Affymetrix, Inc. Fluidics station with a mounting system and method of using
WO2000062931A1 (fr) * 1999-04-21 2000-10-26 Clinical Micro Sensors, Inc. Utilisation de systemes microfluidiques pour la detection electrochimique d'analytes cibles

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5866345A (en) * 1992-05-01 1999-02-02 The Trustees Of The University Of Pennsylvania Apparatus for the detection of an analyte utilizing mesoscale flow systems
US5519635A (en) * 1993-09-20 1996-05-21 Hitachi Ltd. Apparatus for chemical analysis with detachable analytical units
US6114122A (en) * 1996-03-26 2000-09-05 Affymetrix, Inc. Fluidics station with a mounting system and method of using
WO1997041425A1 (fr) * 1996-04-25 1997-11-06 Pence, Inc. Biocapteur et methode afferente
WO1998005424A1 (fr) * 1996-08-02 1998-02-12 Caliper Technologies Corporation Dispositif analytique et procede correspondant
WO1998057159A1 (fr) * 1997-06-12 1998-12-17 Clinical Micro Sensors, Inc. Procedes electroniques de detection d'analytes
WO1999033559A1 (fr) * 1997-12-24 1999-07-08 Cepheid Cartouche de manipulation de fluide integree
WO2000062931A1 (fr) * 1999-04-21 2000-10-26 Clinical Micro Sensors, Inc. Utilisation de systemes microfluidiques pour la detection electrochimique d'analytes cibles

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9557295B2 (en) 1999-04-21 2017-01-31 Osmetech Technology, Inc. Use of microfluidic systems in the electrochemical detection of target analytes
US9151746B2 (en) 1999-04-21 2015-10-06 Osmetech Technology, Inc. Use of microfluidic systems in the electrochemical detection of target analytes
US8431390B2 (en) 2004-09-15 2013-04-30 Integenx Inc. Systems of sample processing having a macro-micro interface
US8431340B2 (en) 2004-09-15 2013-04-30 Integenx Inc. Methods for processing and analyzing nucleic acid samples
US8476063B2 (en) 2004-09-15 2013-07-02 Integenx Inc. Microfluidic devices
US8551714B2 (en) 2004-09-15 2013-10-08 Integenx Inc. Microfluidic devices
US8841116B2 (en) 2006-10-25 2014-09-23 The Regents Of The University Of California Inline-injection microdevice and microfabricated integrated DNA analysis system using same
US8557518B2 (en) 2007-02-05 2013-10-15 Integenx Inc. Microfluidic and nanofluidic devices, systems, and applications
US11845081B2 (en) 2007-07-13 2023-12-19 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8748165B2 (en) 2008-01-22 2014-06-10 Integenx Inc. Methods for generating short tandem repeat (STR) profiles
US8672532B2 (en) 2008-12-31 2014-03-18 Integenx Inc. Microfluidic methods
US8388908B2 (en) 2009-06-02 2013-03-05 Integenx Inc. Fluidic devices with diaphragm valves
US8584703B2 (en) 2009-12-01 2013-11-19 Integenx Inc. Device with diaphragm valve
US8512538B2 (en) 2010-05-28 2013-08-20 Integenx Inc. Capillary electrophoresis device
US9121058B2 (en) 2010-08-20 2015-09-01 Integenx Inc. Linear valve arrays
US8763642B2 (en) 2010-08-20 2014-07-01 Integenx Inc. Microfluidic devices with mechanically-sealed diaphragm valves

Also Published As

Publication number Publication date
EP1331999A2 (fr) 2003-08-06
AU2002239354A1 (en) 2002-06-11
JP2004515231A (ja) 2004-05-27
CA2427669A1 (fr) 2002-06-06
WO2002043864A2 (fr) 2002-06-06

Similar Documents

Publication Publication Date Title
WO2002043864A3 (fr) Dispositifs et procedes de multiplexage de puces a adn
WO2001054813A8 (fr) Dispositifs et procedes pour mettre en oeuvre des reactions multiples sur biopuces
CA2362939C (fr) Procede de production de polymeres
EP1828381B1 (fr) Synthese mixte et de dedoublement (split-mix), dirigee par matrice, de banques de petites molecules
JP2004501665A5 (fr)
WO2003056030A3 (fr) Procedes et systemes pour le sequençage d'acides nucleiques
WO2005063372A3 (fr) Dispositif et procede de regulation de pression et de debit dans des reacteurs paralleles
IL145459A (en) Individual addressable micro-electromagnetic unit array chips
EP1473084A3 (fr) Cassette pour reaction biochimique
US20080125330A1 (en) Real-Time Pcr Detection of Microorganisms Using an Integrated Microfluidics Platform
EP0683790A4 (fr) Synthese automatisee d'oligonucleotides.
WO2005066343A1 (fr) Puce de purification d'acide nucleique
AU2009203047A1 (en) A disposable multiplex polymerase chain reaction (PCR) chip and device
EP2436778A3 (fr) Nucleotides fluorescents photoclivables destinés à séquencer de l'ADN sur une puce construite par chimie de couplage specifique au site
AU2003226679A1 (en) Microcapsules with controlable permeability encapsulating a nucleic acid amplification reaction mixture and their use as reaction compartments for parallels reactions
WO2005028629A3 (fr) Systeme d'analyse d'expression de genome entier
EP1574586A3 (fr) Procede et dispositif d'amplification d'acide nucleique
EP1127658A3 (fr) Dispositif de mélange de suspension de polissage
US20140274809A1 (en) Multi-well manifold assembly system for oligonucleotide synthesis
EP0822401A3 (fr) Système hydraulique pour un analyseur hématologique
WO2003043712A8 (fr) Colonne de distillation pourvue de plateaux a ecoulement double
WO2004088280A3 (fr) Procede et dispositif servant a ameliorer la detection d'un gaz
WO2003015896A3 (fr) Dispositif et procede de piegeage de produits de gaz d'echappement
US11931738B2 (en) Sequenced droplet ejection to deliver fluids
WO2002092221A8 (fr) Systeme destine a la realisation d'experiences, notamment pour l'experimentation a haut debit

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2002239354

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2427669

Country of ref document: CA

Ref document number: 2002545830

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2001987105

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2001987105

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642