WO2002043650A3 - Systems and methods for delivering interferon to a subject - Google Patents

Systems and methods for delivering interferon to a subject Download PDF

Info

Publication number
WO2002043650A3
WO2002043650A3 PCT/IL2001/001099 IL0101099W WO0243650A3 WO 2002043650 A3 WO2002043650 A3 WO 2002043650A3 IL 0101099 W IL0101099 W IL 0101099W WO 0243650 A3 WO0243650 A3 WO 0243650A3
Authority
WO
WIPO (PCT)
Prior art keywords
plant
subject
interferon
systems
methods
Prior art date
Application number
PCT/IL2001/001099
Other languages
French (fr)
Other versions
WO2002043650A2 (en
Inventor
Amit Gal-On
Yoel Moshe Shiboleth
Tsachi Arazi
Yaron Ilan
Original Assignee
Virogene Ltd
Amit Gal-On
Yoel Moshe Shiboleth
Tsachi Arazi
Yaron Ilan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virogene Ltd, Amit Gal-On, Yoel Moshe Shiboleth, Tsachi Arazi, Yaron Ilan filed Critical Virogene Ltd
Priority to EP01998303A priority Critical patent/EP1425395A4/en
Priority to AU2002221011A priority patent/AU2002221011A1/en
Priority to US10/432,777 priority patent/US20040117875A1/en
Publication of WO2002043650A2 publication Critical patent/WO2002043650A2/en
Publication of WO2002043650A3 publication Critical patent/WO2002043650A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
    • C12N15/8202—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation by biological means, e.g. cell mediated or natural vector
    • C12N15/8203—Virus mediated transformation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins

Abstract

Systems and methods for providing supplemental interferon to a subject. One disclosed system includes a viral vector capable of infecting a plant and expressing interferon therein and the plant, which is edible. Another disclosed system includes a DNA capable of expressing an interferon gene in a plant and the plant, which is edible and susceptible to transformation by the DNA sequence. Further disclosed is a method including causing a plant to express at least a portion of an interferon gene and feeding at least a portion of the plant to the subject.
PCT/IL2001/001099 2000-11-28 2001-11-28 Systems and methods for delivering interferon to a subject WO2002043650A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP01998303A EP1425395A4 (en) 2000-11-28 2001-11-28 Systems and methods for delivering interferon to a subject
AU2002221011A AU2002221011A1 (en) 2000-11-28 2001-11-28 Systems and methods for delivering interferon to a subject
US10/432,777 US20040117875A1 (en) 2001-11-28 2001-11-28 Systems and methods for delivering interferon to a subject

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25313600P 2000-11-28 2000-11-28
US60/253,136 2000-11-28

Publications (2)

Publication Number Publication Date
WO2002043650A2 WO2002043650A2 (en) 2002-06-06
WO2002043650A3 true WO2002043650A3 (en) 2004-02-26

Family

ID=22959018

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2001/001099 WO2002043650A2 (en) 2000-11-28 2001-11-28 Systems and methods for delivering interferon to a subject

Country Status (4)

Country Link
EP (1) EP1425395A4 (en)
CN (1) CN1575336A (en)
AU (1) AU2002221011A1 (en)
WO (1) WO2002043650A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8022270B2 (en) * 2000-07-31 2011-09-20 Biolex Therapeutics, Inc. Expression of biologically active polypeptides in duckweed
US7959910B2 (en) 2000-07-31 2011-06-14 Biolex Therapeutics, Inc. C-terminally truncated interferon alpha variants
US20060024272A1 (en) 2004-07-29 2006-02-02 Large Scale Biology Corporation C-terminally truncated interferon

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5866787A (en) * 1993-03-08 1999-02-02 Cleveland Clinic Foundation Transgenic plants co-expressing a functional human 2-5A system
US6096547A (en) * 1985-07-29 2000-08-01 Calgene, Llc Method and transgenic plant for producing mammalian peptides

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999051749A2 (en) * 1998-04-07 1999-10-14 State Of Israel/Ministry Of Agriculture Recombinant potyvirus construct and use thereof
EP1364035A4 (en) * 2001-01-24 2005-05-04 Virogene Ltd Vectors capable of imparting herbicide resistance and viral cross protection and methods

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6096547A (en) * 1985-07-29 2000-08-01 Calgene, Llc Method and transgenic plant for producing mammalian peptides
US5866787A (en) * 1993-03-08 1999-02-02 Cleveland Clinic Foundation Transgenic plants co-expressing a functional human 2-5A system

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1425395A4 *

Also Published As

Publication number Publication date
EP1425395A2 (en) 2004-06-09
WO2002043650A2 (en) 2002-06-06
EP1425395A4 (en) 2006-03-01
AU2002221011A1 (en) 2002-06-11
CN1575336A (en) 2005-02-02

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