WO2002032306A2 - Procedes et appareil d'execution de neuro-imagerie - Google Patents

Procedes et appareil d'execution de neuro-imagerie Download PDF

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Publication number
WO2002032306A2
WO2002032306A2 PCT/US2001/032586 US0132586W WO0232306A2 WO 2002032306 A2 WO2002032306 A2 WO 2002032306A2 US 0132586 W US0132586 W US 0132586W WO 0232306 A2 WO0232306 A2 WO 0232306A2
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WO
WIPO (PCT)
Prior art keywords
coil
head
ofthe
restrainer
animal
Prior art date
Application number
PCT/US2001/032586
Other languages
English (en)
Other versions
WO2002032306A3 (fr
Inventor
Graig F. Ferris
Jean A. King
Arthur C. Allard
Reinhold Ludwig
Gene Bogdanov
Original Assignee
Insight Neuroimaging Systems, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/694,087 external-priority patent/US6711430B1/en
Application filed by Insight Neuroimaging Systems, Llc filed Critical Insight Neuroimaging Systems, Llc
Priority to EP01981776A priority Critical patent/EP1326532A2/fr
Priority to CA2426324A priority patent/CA2426324C/fr
Priority to AU2002213396A priority patent/AU2002213396A1/en
Publication of WO2002032306A2 publication Critical patent/WO2002032306A2/fr
Publication of WO2002032306A3 publication Critical patent/WO2002032306A3/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/32—Excitation or detection systems, e.g. using radio frequency signals
    • G01R33/34—Constructional details, e.g. resonators, specially adapted to MR
    • G01R33/341—Constructional details, e.g. resonators, specially adapted to MR comprising surface coils
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4076—Diagnosing or monitoring particular conditions of the nervous system
    • A61B5/4094—Diagnosing or monitoring seizure diseases, e.g. epilepsy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/70—Means for positioning the patient in relation to the detecting, measuring or recording means
    • A61B5/702—Posture restraints
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/32—Excitation or detection systems, e.g. using radio frequency signals
    • G01R33/34—Constructional details, e.g. resonators, specially adapted to MR
    • G01R33/34046—Volume type coils, e.g. bird-cage coils; Quadrature bird-cage coils; Circularly polarised coils
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
    • A61B5/004—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
    • A61B5/0042—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part for the brain
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/32—Excitation or detection systems, e.g. using radio frequency signals
    • G01R33/34—Constructional details, e.g. resonators, specially adapted to MR
    • G01R33/34007—Manufacture of RF coils, e.g. using printed circuit board technology; additional hardware for providing mechanical support to the RF coil assembly or to part thereof, e.g. a support for moving the coil assembly relative to the remainder of the MR system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/32—Excitation or detection systems, e.g. using radio frequency signals
    • G01R33/34—Constructional details, e.g. resonators, specially adapted to MR
    • G01R33/345—Constructional details, e.g. resonators, specially adapted to MR of waveguide type
    • G01R33/3453—Transverse electromagnetic [TEM] coils

Definitions

  • the present invention relates to magnetic resonance imaging, and more
  • hemodynamics such as cerebral blood flow, cerebral blood
  • RF spatial image resolution is the generation of radiofrequency (RF) magnetic fields.
  • DC direct current
  • RF probes capable of sending and receiving RF signals
  • coils capable of sending and receiving RF signals
  • resonators capable of sending and receiving RF signals.
  • a RF coil used for magnetic field transmission creates a large homogenous area of proton activation at a very narrow
  • An RF coil used for receiving covers the largest region of interest
  • RF coils are either
  • volume coils or surface coils are volume coils or surface coils.
  • a volume coil has the advantage of both sending and
  • a surface coil has the advantage of improved SNR due to its close
  • the reception efficiency of the acquired NMR signal is furthermore limited
  • the second criterion to be met for a volume coil is the uniformity or
  • Main magnetic field strength is, however, only one of several
  • the restraining assembly incorporates a coil
  • PET emission tomography
  • the present invention employs a coil
  • the apparatus allows for collection of a consistent voxel by voxel
  • MR magnetic resonance
  • mice includes a head restrainer that restrains the head of the conscious animal, a
  • the frame carries both the head restrainer and the body
  • the multi-cylindrical non-magnetic dual- coil animal restrainer to immobilize the head and body of a conscious animal has a cylindrical body restrainer, and a cylindrical head restrainer that are concentrically
  • the frame can also include an adapter to slide into the bore of the MR
  • the frame unit includes a first front-end mounting plate having an access hole
  • support rods also act as rails for sliding and positioning the cylindrical volume coil
  • the body restrainer holds the body ofthe conscious animal.
  • restrainer can include an elongated cylindrical body tube carried by the frame and a
  • front of the body tube fits into a ring on the backside of the front-end mounting
  • mounting plate is cushioned by a bber gasket to decouple vibration between the
  • the head restrainer immobilizes the head of the conscious animal.
  • the head restrainer includes a cylindrical head holder having a bore to receive and restrain the head of an animal, and a docking post at the front of the head restrainer for securing
  • the head holder restrains the head of the animal to prohibit vertical and
  • the head holder has a bite bar
  • the animal's head is further restrained by a pair of lateral ear clamping
  • a nose clamp that extends vertically through the head holder.
  • protective ear piece is placed over the animal's ears and receives the tips o the
  • a further adaptation of an embodiment includes a restraining jacket to restraining an animal and prohibit limb movement. An animal is placed into the
  • Holders for the arms and legs may be used to further restrict the
  • FIG. 1 is a side perspective of a multi-cylindrical non-magnetic dual coil restraint system.
  • FIG. 2 is a side perspective view ofthe chassis unit.
  • FIG. 3 is a front view ofthe front-end mounting plate.
  • FIG. 4 is a rear perspective view of the chassis unit looking from the rear-end mounting plate.
  • FIG. 5 is a top view of a body tube o the body restraining unit.
  • FIG. 6 is a side perspective view ofthe body tube and a shoulder bracket of the body restraining unit.
  • FIG. 7A is a front perspective view of the cylindrical head holder.
  • FIG. 7B is a side view o the head holder.
  • FIG. 7C is a perspective view ofthe assembled dual coil and restrainer system.
  • FIG. 8 is a schematic of the overall MRI system.
  • FIG. 9 is a schematic o the interface between the RF-coils and MRI transmit/receive system.
  • FIG. 10A is a exploded perspective view of a volume coil.
  • JO- FIG. 10B illustrates the slotted volume coil.
  • FIG. 1 1 A is a view of the inner surface of a printed circuit board.
  • FIG. 1 IB is a view ofthe inner surface of a printed circuit board.
  • FIG. 12 is a schematic of circuitry associated with the volume coil.
  • FIG. 13 is a schematic of circuitry system on the volume coil.
  • FIG. 14 is a schematic representation of circuitry associated of the volume
  • FIG. 15A is a schematic ofthe conductor circuitry ofthe volume coil.
  • FIG. 15B is a schematic of interrelation of several of the strip of shielding.
  • FIG. 16A is a view of a single loop surface coil.
  • FIG. 16B is a is a schematic circuit of a single loop surface coil.
  • FIG. 17A is a view of a dome shape surface coil.
  • FIG. 17B is a schematic of circuitry of a dome surface coil.
  • FIG. 18 is a front perspective view of a rat with the semi-circular ear piece.
  • FIG. 19 is a side view of a rat with the semi-circular ear piece.
  • FIG. 20 is a side view of a rat in the cylindrical head holder.
  • FIG. 21 is a front view of a rat in the cylindrical head holder.
  • FIG. 22 is a view ofthe restraining jacket.
  • FIG. 23 is a side view of a rat in the assembled fMRI restraint.
  • FIGS. 24A-24D illustrate head restrainer, support frame and surface coil
  • FIG. 25 shows nine contiguous anatomical sections take prior to and sixty minutes following hemorrhagic stroke.
  • FIG. 26 shows images collected at thirty second intervals over an eight
  • FIG. 27 shows images collected at thirty second intervals over an eight
  • FIG. 28 shows a sequence of graphical illustration of BOLD signal as a
  • FIGS. 29A and 29 B are front and side perspective views of an adjustable
  • FIG. 30 is a perspective view o the adjustable mounting assembly.
  • FIG. 1 shows
  • multi-cylindrical, dual-coil animal restrainer 30 including a volume coil 32 and a
  • fMRI magnetic resonance imaging
  • the multi-cylindrical, dual-coil animal restrainer 30 has
  • volume coil 32 which will be described further below in greater detail, and a
  • the restraining assembly 36 includes a support frame or Ghassis 38, a head retainer 40, and a body retainer 42.
  • the frame 38 is shown in perspective in FIG. 2.
  • the frame 38 has a first or
  • the front-end mounting plate 46 has a hole 52 which is collinear with a longitudinal axis 54 of the frame 38.
  • mounting plate 48 also has a cylindrical opening 56 which is collinear with the
  • both the mounting plates 46 and 48 have threaded openings 58
  • the bore 212 is used in MR spectrometers used for
  • mounting plates can be made to fit any internal bore diameter in this range.
  • the multi-cylindrical dual coil animal restrainer can be used in both full body human
  • the support rods 50 position the front-end and rear-end mounting plates 46
  • the support rods 50 are connected to the mounting plates
  • the front-end mounting plate receives a docking post 64 whi ⁇ h is part of the
  • mounting unit is fo ⁇ ned of a non-metallic transparent material such as Plexiglass
  • FIG. 3 the front view of the front-end frame plate 46 is shown.
  • the support rods 50 are extending through the mounting plate 46.
  • the support rods 50 are extending through the mounting plate 46.
  • the mounting plate 46 is transparent, the positioning tube 64 can be seen.
  • FIG. 4 a rear perspective view ofthe mounting unit 38 is seen.
  • the rear-end mounting plate 48 has the cylindrical opening 56 which is surrounded
  • the support rods 50 that extend parallel to and spaced from the longitudinal axis 54 ofthe frame.
  • the support rods extend to the front-end mounting plate 46.
  • front-end mounting plate 46 has the hole 52 surrounded by a positioning tube 64.
  • annular groove 66 receives a resilient gasket 70 to improve dampening of motion as explained in further detail below.
  • the body retainer 42 has a body tube 74 which in a
  • the tube 74 has a cylindrical thin wall section
  • the thin wall section 76 has a cut-out portion 80, as seen in FIG. 6, which allows access to the
  • the body retainer 42 also has a shoulder holder 86.
  • the shoulder holder 86 is retained on the thin wall section 76 by a plurality of
  • fasteners 88 received in slots 90 on the thin wall section 76.
  • the shoulder holder 86 limits movement of the shoulder of the animal
  • the shoulder of an animal can be a
  • the head retainer 40 has a head holder 94 and the
  • the head holder 94 has a bore 96 which receives the head ofthe animal. The head is received from the other end of the head holder
  • An aperture 98 extends from the bore 96 to
  • a pair of flanges 102 extend outward on the head holder 94 to encircle the
  • Each of the flanges 102 have a slot 104 to accept a fastener 106, as
  • the head holder 94 has a bite bar 108 extending horizontally along a chord
  • a nose clamping screw 1 10 Mounted through the top of the cylindrical head holder is a nose clamping screw 1 10 with a nose bar to secure the nose of a restrained animal to the bite bar 108.
  • the lateral ear clamping screw 114 has a washer shown in hidden line.
  • lateral ear clamping screws 114 are used to position the animal lateral in the head
  • the head holder 94 has a pair of lower jaw screws 116 for
  • the head holder 94 also has a hole 118 for receiving a post 198 carried on
  • the surface coil 34 which is received in the bore 96 ofthe head holder 94 of
  • the head restrained unit 40 works in conjunction with the volume coil 32 and a
  • tunnel bore 212 in generally a range of 15 to 24 centimeters in
  • a main magnet 214 and a gradient coil set 216 encircle the tunnel bore
  • the multi-cylindrical, dual-coil animal restrainer 30 including the restraining
  • the volume coil 32 is capable moving along the support rods 50 ofthe
  • volume coil 32 are connected via wiring which extends out ofthe tunnel bore 212 to a transceiver unit 220 of the system operating controller 200 as explained in further
  • the volume coil 32 transmits and
  • the surface coil 34 is used for receiving. In other embodiments the surface coil both transmits and receives or the volume coil transmits and receives.
  • the image processing can be performed off-line on a 100 MHZ HP Apollo
  • FIG. 9 a schematic of the interface between the RF coils 32 and
  • the surface coil 34 is connected to a transceiver unit 220.
  • the transceiver unit 220 has a
  • RF transmitter 2344 a RF receiver 226 and a system controller 228.
  • system controller 228 The system
  • controller 228 controls a pair of switching circuits 230 to transmit and receive the
  • system controller 228 also can
  • the TEM volume coil 32 also referred to as the body coil, is active, transmitting
  • the surface coil 34 is detuned in order to avoid interference.
  • the TEM volume coil 32 is detuned.
  • the volume coil 32 has a cylindrical
  • the core module 120 has a cylindrical bore 122 that extends through the core module 120 along a longitudinal axis 124.
  • bore 122 defines an inner surface 126.
  • the core module 120 has a plurality of bores 128 extending through the annular core module 120 parallel to and
  • the apertures 128 accept the support rods 50
  • volume coil 32 has a plurality of conductive strip lines 130 extending parallel to the
  • the volume coil 32 has a pair of printed circuit boards (PCB) 134 mounted
  • volume coil 32 has
  • shielding 136 is formed in strips to reduce the occurrence of eddy currents induced
  • the shielding 136 in strips forms a plurality of coaxial slots 137 along the coil's length which serve to interrupt switched gradient induced eddy propagation.
  • Reactively bridged azimuthal slots can extend around the TEM coil's outer wall, end
  • walls, and inner “wall” further limit eddies, and extend the coil's frequency band
  • the inner elements can be flat, copper foil
  • FIGS. 10A and 10B shows copper foil strip line elements for strip lines
  • This segmented TEM coil combines the internal line element 130 with the external cavity segment, the shielding 136, forming a resonance circuit.
  • Each functional element can be sub-divided capacitively into one through four or more
  • Trimmer capacitors 139 on the outside wall of the FIG. 10B coil depict one such division. As in a simple surface coil, the number of capacitive divisions in
  • each resonant unit can be chosen to be few when a more inductive, lower frequency
  • each unit can be divided four or
  • the printed circuit board 134 shown in FIG. 1 1 A is an exposed surface 138,
  • FIG. 1 IB shows the inner surface, the surface which faces the core module
  • FIG. 1 A schematic of circuitry associated with the volume coil 32 is shown in FIG.
  • the volume coil 32 has a plurality of resonating elements 146 which include the
  • TEM volume coil 32 can have more or less elements 146, such as 8 or 16.
  • resonating elements 146 are connected to a detuning/tuning circuits 156 in order to
  • the volume coil 32 in addition has a matching circuit 172 for adjusting the
  • the TEM volume coil 32 is shown in FIG. 12 with the transceiver unit 220 and a detuning source 142
  • the RF source 140, the transceiver unit 220 and the detuning source, 142 are not part of and are located remote from the
  • volume coil 32 and are connected through coaxial cables which extend out of the
  • the coil 32 has an RF decoupling circuit 190.
  • the RF decoupling circuit 128 ensures
  • FIG. 13 shows a more detail view of circuitry associated with the volume coil
  • the matching circuit 172 includes a variable
  • the detuning source 142 is connected to the detuning circuit
  • the filter circuit 164 is configured to filter the RF decoupling circuit 178.
  • the filter 164 is for separating the
  • the RF radio frequency
  • decoupling circuit 178 has three radio-frequency chokes (RFC) 184 which represent
  • FIG. 14 shows additional elements ofthe circuitry of volume coil 32.
  • the volume coil 32 has several inputs including the RF source 140
  • the strip lines 130 are each part of a resonating element 146.
  • lines 130 are represented in the circuit as distributed inductor 148 in the resonating
  • the strip lines 130 as represented by the inductors 148, are connected
  • variable, tuneable capacitor 152 in series to a pair of capacitors 150 and 152.
  • One of the capacitors is the variable, tuneable capacitor 152.
  • the variable, tuneable capacitor 152 In the embodiment shown in FIG. 14, the variable, tuneable
  • capacitors 152 of one of the resonating element 146 is located on the front PCB 134 and the variable, tuneable capacitors 152 ofthe adjacent resonating elements 146 are
  • variable, tuneable capacitors 152 are equally located on the front PCB and
  • variable, tuneable capacitor 152 is located on the other PCB 134 than that of the variable, tuneable capacitor 152.
  • resonating elements 146 are located on the front PCB 134.
  • capacitor 150 is located on the rear PCB 134.
  • the front PCB 134 is represented by boxes 190 in FIG. 14 and the rear PCB
  • the stripes of shielding 136 are represented by a
  • variable, tuneable capacitors 152 can be tuned manually or
  • the capacitors 150 and 152 are each carried on the printed circuit
  • Each of the detuning circuits 156 has a pair of diodes 158 and 160. In one
  • the diodes 158 and 160 are pin diodes.
  • the decoupling circuits 178 are each interposed between one of the resonating
  • the filter 164 is connected to the DC source 142 through a resistor 170.
  • DC source 142 is used in operating the circuit in conjunction with surface coil 34 as explained below. Still referring to FIG. 14, the RF source 140 and the matching circuit 172 are
  • the matching circuit 172 includes
  • variable tuneable capacitor 174 which is tuned manually.
  • FIG. 15A twelve elements are located on the volume coil 32.
  • the strip lines 130 are represented by distributed inductors. Connected to
  • the strip line 130 is a pair of capacitors in the series 150 and 152 wherein one ofthe
  • capacitors 152 is a variable tuneable capacitor. In the embodiment shown in FIG.
  • variable, tunable capacitors 152 is shown alternating from being on the
  • each element shows the shielding 136
  • the volume coil 32 has shielding 136 located on the outer
  • the strips of shielding 136 are connected to each
  • capacitors 186 are located on the outer surface of the resonating element as part of
  • Additional capacitors may be located at the other end of the
  • strips of shielding 136 may be shorted in an effort to reduce the
  • the first element shown connected to a detuning circuit.
  • FIG. 15B The strips of shielding 136 are
  • capacitors located on the outer surface ofthe resonating element as part ofthe shielding such as seen in FIG. 10B.
  • the capacitors are located
  • volume coil 32 Working with the volume coil 32 is the surface coil 34 that can be used in
  • the surface coil 32 can take various shapes.
  • the surface coil 32 can have a
  • FIGS. 17A and 17B are arranged in a dome shaped surface coil 196 as seen in FIGS. 17A and 17B.
  • a surface coil 32 with a single loop is
  • FIG. 16A The circuitry of the surface coil of FIG. 16A is shown.
  • FIG. 16B The circuitry of the surface coil of FIG. 16A is shown.
  • resonating element 192 of the single loop has a pair of metallic strips with interposed
  • the single loop surface coil has a detuning circuit 193 and a decoupling circuit 194.
  • the single loop surface coil 34 has a connection to the transceiver and the
  • the single loop surface coil 34 has a post 198 for attaching to the
  • FIG. 17B is a schematic o the multiple loop surface coil 196 of the dome shaped device 252.
  • the surface coil 196 has a post 198 as seen in FIG. 17A for attaching to the
  • the surface coil 196 a pair of connectors 204 and 206 which are connected to the RF source 140 and the DC source 142. Similar to the volume coil 32, the surface coil 196 has a detuning circuit
  • coil 196 has the inputs of the RS source 140, the DC source 142 and the ground 144.
  • the surface coil 196 has a plurality of resonating elements 226 each with a
  • a capacitor is used to match the circuit.
  • the animal 260 is lightly anesthetized prior to insertion into the restraining
  • head 264 ofthe animal 260 whereupon the animal's head 264 is placed into head holder 94.
  • nose clamping screw 110 is tightened against the snout of the animal to secure it to
  • the bite bar 108 and thereby eliminate vertical movement maintaining a stereotaxic position of the animal's head.
  • FIG. 22 shows a restraining jacket 268 used to restrain the animal 260.
  • jacket 268 is made of a looped lined, such as marketed under the name Velcro,
  • the restraining jacket 268 has a pair of arm holders 272 and a pair of leg
  • the jacket 268 has holes for
  • the head holder 94 is fixedly mounted to the position tube 64 by a pair of
  • the pair of flanges or lips 102 extend outward on the head holder 94
  • Each ofthe flanges 102 have a slot 104 to accept
  • the fastener 106 The position tube 64 is received with a gasket 70 interposed.
  • the surface coil 34 is installed into the head restraint 40 prior to the
  • volume coil 32 is slid along the support rods 50 to the proper position encircling the animal 260.
  • the multi-cylindrical, dual-coil animal restrainer 30 is installed into the
  • FIG. 24A shows a nose clamp 240 and different size ear caps for rodents.
  • FIG. 24B shows the head restrainer 250 mounted within the support from described
  • FIGS. 24C and 24D show a head restrainer 250 that can be used with a
  • FIG. 17A figures also show the dome coil 252 of FIG. 17A mounted with the head restrainer.
  • the first example uses magnetic resonance imaging with T2* weighted
  • T2* weighted technique is used to image the onset and progression of a spontaneous
  • MRI data were acquired using a Bruker Biospec DBX 4.7/40 (4.7 Tesla, 40
  • the tail vein was catheterized
  • the sequence was repeated 24 times for a total of 240 images.
  • ventricles is hyperintense. Indeed, one hr after hemorrhagic stroke, the brain shows
  • norepinephrine injection corresponds in time with the peak change in blood pressure
  • caudate/putamen is the putative site of intracranial hemorrhage. There appears to be
  • cortices and basal ganglia showed no ostensible changes in BOLD signal during the
  • hypothalamus particularly the paraventricular and supraoptic nuclei ofthe
  • hypothalamus showed a sustained increase in BOLD signal. There were no
  • the restraining assembly 36 was sized to fit a 4 kg rhesus (young adult) into
  • a operant/restrainer designed for a 24 cm tunnel bore 212 of an MRI device 210.
  • the restraining assembly 36 with RF electronics including the volume coil 32 and
  • dome shaped surface coil 196 discussed above is used with a trained rhesus
  • the rhesus monkeys are habituated for six-eight weeks to the
  • amygdala an area identified in cocaine craving has over twenty different nuclei and subnuclei 18, 67
  • the nuclei that can be divided into the corticomedial and basolateral areas.
  • Any minor head movement can distort the image and may also create a
  • the multi-cylindrical, dual-coil animal restrainer 30 reduces motion artifact while
  • headpiece 262 with blunted ear supports that fit into the ear canals is position over
  • the head 264 is
  • the body tube 74 "floats" down
  • the restraining assembly 36 isolates all of the
  • the body restraining unit 42 including the body tube 74 is designed
  • the volume coil 32 is slide over the head
  • rhesus monkey in a 24 cm bore gradient set are similar to those discussed above.
  • the volume coil 32 has in one embodiment 16 elements in contrast to the 12 elements discussed above.
  • Step 1 A prototype two-part chassis is constructed of nylon to fit into the 24
  • monkey is placed into the body restrainer with its head secured into the head holder
  • This unit is connected with two screw rods
  • the head restrainer is locked into a support post on the front
  • the TEM volume coil slides along rails extending from the front chassis
  • Step 2 Three young adult rhesus monkeys (4.0 to 5.0 kg) are anesthetized
  • Step 3 The head and body restrainers are fitted into supports that can be screwed into the front and back plates.
  • the body supports have rubber gaskets at their contact with the plates to help isolate any body movement.
  • Step 4 Male rhesus monkeys (4-5 kg) are examined under imaging
  • the two samples of saliva are assayed for cortisol to evaluate adaptation to the stress
  • RF volume coils can be used for anatomical and functional
  • the system scaleable to accommodate differences in head size of these monkeys.
  • the designs can be utilized for uniform imaging of the
  • the coil must be as efficient as possible. Transmision efficiency minimizes RF
  • This third example relates to the functional neuroanatomy of seizures.
  • fMRI Functional magnetic resonance imaging
  • BOLD blood oxygenation-level-dependent
  • seizure activity its propagation and generalization is an important step towards a
  • Seizures can be induced by administration of chemical convulsants in normal animals; thus, administration of
  • PTZ pentylenetetrazole
  • pentobarbital 25 mg/kg; i.p.
  • a catheter of 20 gauge polyethylene was inserted into
  • control animals were placed in a small cage outside the magnet within the shielded
  • seizures consisted of brief myoclonus jerks that evolve to forelimb clonus followed by generalized tonic-clonic activity with loss of posture.
  • tonic-clonic seizure occurred about two minutes following PTZ injection, and 2-4
  • corticolimbic areas that favored laterization to the left parietal and temporal cortices.
  • BOLD signal was greater in the cerebral hemisphere that exhibited an earlier neuronal activation (BOLD signal) following PTZ injection. The increased levels in
  • BOLD signal were mainly observed in cortical sites including perirhinal, insular,
  • cortex frontal, perirhinal, piriform, insular
  • neuronal depression was observed during PTZ seizures, and was primarily localized in the contralateral cerebral hemisphere that did not exhibit increased levels in
  • an alternative front-end mounting plate 294 is shown. Referring to FIGS. 29A and 29B, an alternative front-end mounting plate 294
  • the front-end mounting plate 294 has a plurality of projecting mounting
  • the mounting rods 296 are
  • bias mechanism such as an elastic received on a protrusion 299 of each
  • An adjustment handle 300 shown in FfG. 30 is
  • positioned in the hole has an adjustment mechanism, such a tapered shape that
  • the present invention demonstrates novel images of neuronal activation in

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Abstract

L'invention concerne des systèmes et des procédés d'exécution d'imagerie par résonance magnétique (IRM) sur des animaux éveillés. Afin de positionner un animal éveillé par rapport au système radiofréquence de bobine double fonctionnant dans un système d'imagerie par résonance magnétique de haute résolution afin de produire des images de haute résolution sans artéfacts dus aux mouvements, on utilise des appareils de contention de la tête et du corps de l'animal.
PCT/US2001/032586 2000-10-20 2001-10-18 Procedes et appareil d'execution de neuro-imagerie WO2002032306A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP01981776A EP1326532A2 (fr) 2000-10-20 2001-10-18 Procedes et appareil d'execution de neuro-imagerie
CA2426324A CA2426324C (fr) 2000-10-20 2001-10-18 Ensemble de retenue pour utilisation avec un dispositif d'imagerie par resonance magnetique
AU2002213396A AU2002213396A1 (en) 2000-10-20 2001-10-18 Method and apparatus for performing neuroimaging

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US09/694,087 US6711430B1 (en) 1998-10-09 2000-10-20 Method and apparatus for performing neuroimaging

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EP1551275A2 (fr) * 2002-10-10 2005-07-13 VisualSonics Inc. Systeme d'imagerie a multi-rails integres
US7084630B2 (en) 2004-01-28 2006-08-01 Worcester Polytechnic Institute Multi-modal RF coil for magnetic resonance imaging
WO2008060682A1 (fr) * 2006-05-05 2008-05-22 M2M Imaging Corp. Système à bobine de résonance magnétique cryogénique
WO2009015678A1 (fr) 2007-08-01 2009-02-05 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Dispositif de maintien d'échantillon, en particulier pour maintenir un rongeur ou un fantôme de rm dans un dispositif de trm
US8022705B2 (en) 2006-03-09 2011-09-20 Insight Neuroimaging Systems, Llc Microstrip coil designs for MRI devices
US8078256B2 (en) 2002-10-10 2011-12-13 Visualsonics Inc. Integrated multi-rail imaging system

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US9320453B2 (en) 2011-05-06 2016-04-26 Rapid Biomedical Gmbh Assembly to perform imaging on rodents
CN113100780B (zh) * 2021-03-04 2022-07-26 北京大学 同步脑电-功能磁共振数据的自动化处理方法

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Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1551275A2 (fr) * 2002-10-10 2005-07-13 VisualSonics Inc. Systeme d'imagerie a multi-rails integres
EP1551275A4 (fr) * 2002-10-10 2008-12-31 Visualsonics Inc Systeme d'imagerie a multi-rails integres
US8078256B2 (en) 2002-10-10 2011-12-13 Visualsonics Inc. Integrated multi-rail imaging system
US8945014B2 (en) 2002-10-10 2015-02-03 Fujifilm Sonosite, Inc. Integrated multi-rail imaging system
US10575808B2 (en) 2002-10-10 2020-03-03 Fujifilm Sonosite, Inc. Integrated multi-rail imaging system
US7084630B2 (en) 2004-01-28 2006-08-01 Worcester Polytechnic Institute Multi-modal RF coil for magnetic resonance imaging
US8022705B2 (en) 2006-03-09 2011-09-20 Insight Neuroimaging Systems, Llc Microstrip coil designs for MRI devices
WO2008060682A1 (fr) * 2006-05-05 2008-05-22 M2M Imaging Corp. Système à bobine de résonance magnétique cryogénique
US7777491B2 (en) 2006-05-05 2010-08-17 M2M Imaging Corp. Magnetic resonance coil system
WO2009015678A1 (fr) 2007-08-01 2009-02-05 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Dispositif de maintien d'échantillon, en particulier pour maintenir un rongeur ou un fantôme de rm dans un dispositif de trm
US8334698B2 (en) 2007-08-01 2012-12-18 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Sample holding device, in particular for holding a rodent or an MR phantom in an MRT device

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CA2426324C (fr) 2010-09-21
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EP1326532A2 (fr) 2003-07-16
WO2002032306A3 (fr) 2003-02-06

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