WO2002030959A3 - Peptides derives de smac (diablo) et procedes d'utilisation de ceux-ci - Google Patents

Peptides derives de smac (diablo) et procedes d'utilisation de ceux-ci Download PDF

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Publication number
WO2002030959A3
WO2002030959A3 PCT/US2001/032121 US0132121W WO0230959A3 WO 2002030959 A3 WO2002030959 A3 WO 2002030959A3 US 0132121 W US0132121 W US 0132121W WO 0230959 A3 WO0230959 A3 WO 0230959A3
Authority
WO
WIPO (PCT)
Prior art keywords
diablo
smac
peptides derived
methods
use therefor
Prior art date
Application number
PCT/US2001/032121
Other languages
English (en)
Other versions
WO2002030959A2 (fr
Inventor
Stephen W Fesik
Robert P Meadows
Stephen P Betz
Zhihong Liu
Edward T Olejniczak
Chaohong Sun
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of WO2002030959A2 publication Critical patent/WO2002030959A2/fr
Publication of WO2002030959A3 publication Critical patent/WO2002030959A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8139—Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne des peptides dérivés de la protéine humaine smac (DIABLO) de type sauvage qui se lie avec un membre de la famille des IAP (inhibitor of apoptosis proteins : protéines inhibant l'apoptose). Ces peptides peuvent être utilisés dans un procédé permettant l'identification de substances candidates induisant ou favorisant l'apoptose dans les cellules..
PCT/US2001/032121 2000-10-13 2001-10-12 Peptides derives de smac (diablo) et procedes d'utilisation de ceux-ci WO2002030959A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68754900A 2000-10-13 2000-10-13
US09/687,549 2000-10-13

Publications (2)

Publication Number Publication Date
WO2002030959A2 WO2002030959A2 (fr) 2002-04-18
WO2002030959A3 true WO2002030959A3 (fr) 2002-09-26

Family

ID=24760847

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/032121 WO2002030959A2 (fr) 2000-10-13 2001-10-12 Peptides derives de smac (diablo) et procedes d'utilisation de ceux-ci

Country Status (1)

Country Link
WO (1) WO2002030959A2 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001293189A1 (en) * 2000-09-29 2002-04-08 Trustees Of Princeton University Compositions and methods for regulating apoptosis
EP1519918A1 (fr) * 2002-07-02 2005-04-06 Novartis AG Inhibiteurs peptidiques de la liaison de la proteine smac avec les proteines inhibitrices de l'apoptose (iap)
AU2005218555B2 (en) 2004-03-01 2008-01-03 Board Of Regents, The University Of Texas System Dimeric small molecule potentiators of apoptosis
AU2005228950B2 (en) 2004-03-23 2012-02-02 Genentech, Inc. Azabicyclo-octane inhibitors of IAP
CA2570321C (fr) 2004-07-02 2013-10-08 Genentech, Inc. Inhibiteurs de pai
US7749520B2 (en) 2004-07-07 2010-07-06 Statens Serum Institut Compositions and methods for stabilizing lipid based adjuvant formulations using glycolipids
CA2574040C (fr) 2004-07-15 2014-05-06 Tetralogic Pharmaceuticals Corporation Composes de liaison aux proteines iap
EA019420B1 (ru) 2004-12-20 2014-03-31 Дженентех, Инк. Пирролидиновые ингибиторы иап (ингибиторов апоптоза)
CN103083644B (zh) 2005-02-25 2014-05-28 泰特拉洛吉克药业公司 Iap二聚体抑制剂
JP4954983B2 (ja) 2005-05-18 2012-06-20 ファーマサイエンス・インコーポレイテッド Ｂｉｒドメイン結合化合物
KR20080067357A (ko) 2005-10-25 2008-07-18 에게라 쎄라퓨틱스 인코포레이티드 Ｉａｐ ｂｉｒ 도메인 결합 화합물
US8247557B2 (en) 2005-12-19 2012-08-21 Genentech, Inc. IAP inhibitors
TWI504597B (zh) 2006-03-16 2015-10-21 Pharmascience Inc 結合於細胞凋亡抑制蛋白（ｉａｐ）之桿狀病毒ｉａｐ重複序列（ｂｉｒ）區域之化合物
BRPI0711591A2 (pt) 2006-05-16 2011-11-16 Aegera Therapeutics Inc composto de ligação de domìnio bir da iap
JP5452223B2 (ja) 2006-07-24 2014-03-26 テトラロジック ファーマシューティカルズ コーポレーション Ｉａｐ阻害剤
US7985735B2 (en) 2006-07-24 2011-07-26 Tetralogic Pharmaceuticals Corporation Dimeric IAP inhibitors
CA2671607A1 (fr) 2006-12-19 2008-07-03 Genentech, Inc. Inhibiteurs imidazopyridine de iap
JP5368428B2 (ja) 2007-04-30 2013-12-18 ジェネンテック， インコーポレイテッド Ｉａｐのインヒビター
JP2011529962A (ja) 2008-08-02 2011-12-15 ジェネンテック， インコーポレイテッド Ｉａｐのインヒビター
US8283372B2 (en) 2009-07-02 2012-10-09 Tetralogic Pharmaceuticals Corp. 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic
NZ602368A (en) 2010-02-12 2014-10-31 Pharmascience Inc Iap bir domain binding compounds
CN110713546B (zh) * 2019-10-31 2021-04-20 中国医科大学附属第一医院 靶向survivin-XIAP复合物的抗肿瘤多肽Sur-X与用途

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999021015A2 (fr) * 1997-10-21 1999-04-29 Cranfield University Ligands d'affinite, leur production, et leur utilisation
WO2002016418A2 (fr) * 2000-08-24 2002-02-28 Thomas Jefferson University Peptide ou polypeptide capable de liaison avec l'inhibiteur de la proteine de l'apoptose
WO2002016402A2 (fr) * 2000-08-23 2002-02-28 Board Of Regents, The University Of Texas System Composes apoptotiques
WO2002026775A2 (fr) * 2000-09-29 2002-04-04 Trustees Of Princeton University Compositions et methodes de regulation de l'apoptose

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999021015A2 (fr) * 1997-10-21 1999-04-29 Cranfield University Ligands d'affinite, leur production, et leur utilisation
WO2002016402A2 (fr) * 2000-08-23 2002-02-28 Board Of Regents, The University Of Texas System Composes apoptotiques
WO2002016418A2 (fr) * 2000-08-24 2002-02-28 Thomas Jefferson University Peptide ou polypeptide capable de liaison avec l'inhibiteur de la proteine de l'apoptose
WO2002026775A2 (fr) * 2000-09-29 2002-04-04 Trustees Of Princeton University Compositions et methodes de regulation de l'apoptose

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHAI JIJIE ET AL: "STRUCTURAL AND BIOCHEMICAL BASIS OF APOPTOTIC ACTIVATION BY SMAC/DIABLO.", NATURE (LONDON), vol. 406, no. 6798, 2000, pages 855 - 862, XP002200489, ISSN: 0028-0836 *
DU CHUNYING ET AL: "Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 102, no. 1, 7 July 2000 (2000-07-07), pages 33 - 42, XP002175396, ISSN: 0092-8674 *
VERHAGEN ANNE M ET AL: "IDENTIFICATION OF DIABLO, A MAMMALIAN PROTEIN THAT PROMOTES APOPTOSIS BY BINDING TO AND ANTAGONIZING IAP PROTEINS", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 102, 7 July 2000 (2000-07-07), pages 43 - 53, XP002175397, ISSN: 0092-8674 *

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Publication number Publication date
WO2002030959A2 (fr) 2002-04-18

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