WO2002026957A3 - Regulation de la serine protease humaine - Google Patents

Regulation de la serine protease humaine Download PDF

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Publication number
WO2002026957A3
WO2002026957A3 PCT/EP2001/011125 EP0111125W WO0226957A3 WO 2002026957 A3 WO2002026957 A3 WO 2002026957A3 EP 0111125 W EP0111125 W EP 0111125W WO 0226957 A3 WO0226957 A3 WO 0226957A3
Authority
WO
WIPO (PCT)
Prior art keywords
serine protease
human serine
regulation
reagents
regulate
Prior art date
Application number
PCT/EP2001/011125
Other languages
English (en)
Other versions
WO2002026957A2 (fr
Inventor
Alex Smolyar
Original Assignee
Bayer Ag
Alex Smolyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Alex Smolyar filed Critical Bayer Ag
Priority to AU2001293846A priority Critical patent/AU2001293846A1/en
Publication of WO2002026957A2 publication Critical patent/WO2002026957A2/fr
Publication of WO2002026957A3 publication Critical patent/WO2002026957A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Pour réguler la dégradation de la matrice extracellulaire, Il est possible d'utiliser des réactifs qui régulent l'activité de la sérine protéase humaine et des réactifs qui se lient à des produits géniques de la sérine protéase humaine. Une telle régulation convient tout particulièrement bien pour le traitement du cancer (y compris en cas de métastatuisation de cellules malignes et d'angiogenèse tumorale), des troubles inflammatoires, de l'athérosclérose et autres maladies cardiovasculaires, des maladies neurodégénératives, de la bronchopneumopathie chronique obstructive, de l'asthme et des infections pathogènes.
PCT/EP2001/011125 2000-09-28 2001-09-26 Regulation de la serine protease humaine WO2002026957A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001293846A AU2001293846A1 (en) 2000-09-28 2001-09-26 Regulation of a human serine protease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23592100P 2000-09-28 2000-09-28
US60/235,921 2000-09-28

Publications (2)

Publication Number Publication Date
WO2002026957A2 WO2002026957A2 (fr) 2002-04-04
WO2002026957A3 true WO2002026957A3 (fr) 2002-12-12

Family

ID=22887404

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/011125 WO2002026957A2 (fr) 2000-09-28 2001-09-26 Regulation de la serine protease humaine

Country Status (2)

Country Link
AU (1) AU2001293846A1 (fr)
WO (1) WO2002026957A2 (fr)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999058675A2 (fr) * 1998-05-14 1999-11-18 Chiron Corporation Genes humains et produits d'expression genique v
EP1074617A2 (fr) * 1999-07-29 2001-02-07 Helix Research Institute Amorces pour la synthèse de cADN de pleine longueur et leur utilisation
WO2001034800A1 (fr) * 1999-11-12 2001-05-17 Human Genome Sciences, Inc. Nouvelles proteines 19 secretees par l'homme
WO2001053312A1 (fr) * 1999-12-23 2001-07-26 Hyseq, Inc. Nouveaux acides nucleiques et polypeptides
WO2001066748A2 (fr) * 2000-03-03 2001-09-13 Zymogenetics, Inc. Polynucleotides exprimes entiers et polypeptides codes par ces derniers
WO2001098454A2 (fr) * 2000-04-25 2001-12-27 German Human Genome Project Sequences d'adn humain

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999058675A2 (fr) * 1998-05-14 1999-11-18 Chiron Corporation Genes humains et produits d'expression genique v
EP1074617A2 (fr) * 1999-07-29 2001-02-07 Helix Research Institute Amorces pour la synthèse de cADN de pleine longueur et leur utilisation
WO2001034800A1 (fr) * 1999-11-12 2001-05-17 Human Genome Sciences, Inc. Nouvelles proteines 19 secretees par l'homme
WO2001053312A1 (fr) * 1999-12-23 2001-07-26 Hyseq, Inc. Nouveaux acides nucleiques et polypeptides
WO2001066748A2 (fr) * 2000-03-03 2001-09-13 Zymogenetics, Inc. Polynucleotides exprimes entiers et polypeptides codes par ces derniers
WO2001098454A2 (fr) * 2000-04-25 2001-12-27 German Human Genome Project Sequences d'adn humain

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 22 February 2000 (2000-02-22), ISOGAI T. ET AL.: "Homo sapiens cDNA FLJ11342 fis, clone PLACE1010800", XP002209371, Database accession no. AK002204 *
DATABASE GSN [online] 10 August 2001 (2001-08-10), RUBEN S.M. ET AL.: "Human gene 6 encode secreted protein HT5EK75, SEQ ID NO:16", XP002209377, Database accession no. AAD07710 *
DATABASE GSN [online] 19 May 2000 (2000-05-19), WILLIAMS L.T. ET AL.: "Human colon cancer line polynucleotide sequence SEQ ID NO:1910", XP002209373, Database accession no. AAA01919 *
DATABASE GSN [online] 22 October 2001 (2001-10-22), TANG YT: "Human polynucleotide SEQ ID NO:940", XP002209379, Database accession no. AAI58737 *
DATABASE GSN [online] 26 June 2001 (2001-06-26), OTA T. ET AL.: "Human protein sequence SEQ ID NO:13271", XP002209375, Database accession no. AAH15184 *
DATABASE GSN [online] 30 April 2002 (2002-04-30), WIEMANN S.: "Human melanoma derived cDNA clone mel2_7k19", XP002209380, Database accession no. ABA93740 *
DATABASE GSP [online] 10 August 2001 (2001-08-10), RUBEN S.M. ET AL.: "Human gene 6 encode secreted protein HT5EK75, SEQ ID NO:71", XP002209376, Database accession no. AAE03297 *
DATABASE GSP [online] 22 October 2001 (2001-10-22), TANG Y.T. ET AL.: "Human polypeptide SEQ ID NO:6298", XP002209378, Database accession no. AAM41367 *
DATABASE GSP [online] 26 June 2001 (2001-06-26), OTA P. ET AL.: "Human protein sequence SEQ ID NO:13272", XP002209374, Database accession no. AAB93698 *
DATABASE GSP [online] 30 April 2002 (2002-04-30), WIEMANN S.: "Human melanoma derived protein clone mel2_7k19", XP002209381, Database accession no. ABB05702 *
DATABASE TREMBL [online] 1 October 2000 (2000-10-01), ISOGAI T. ET AL.: "Hypothetical protein FLJ11342", XP002209372, Database accession no. Q9NUJ1 *

Also Published As

Publication number Publication date
AU2001293846A1 (en) 2002-04-08
WO2002026957A2 (fr) 2002-04-04

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