WO2002031160A3 - Regulation de l'enzyme de type a2 phospholipase humaine - Google Patents

Regulation de l'enzyme de type a2 phospholipase humaine Download PDF

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Publication number
WO2002031160A3
WO2002031160A3 PCT/EP2001/011640 EP0111640W WO0231160A3 WO 2002031160 A3 WO2002031160 A3 WO 2002031160A3 EP 0111640 W EP0111640 W EP 0111640W WO 0231160 A3 WO0231160 A3 WO 0231160A3
Authority
WO
WIPO (PCT)
Prior art keywords
enzyme
human phospholipase
regulation
reagents
phospholipase
Prior art date
Application number
PCT/EP2001/011640
Other languages
English (en)
Other versions
WO2002031160A2 (fr
Inventor
Zhimin Zhu
Original Assignee
Bayer Ag
Zhimin Zhu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Zhimin Zhu filed Critical Bayer Ag
Priority to AU2001295602A priority Critical patent/AU2001295602A1/en
Publication of WO2002031160A2 publication Critical patent/WO2002031160A2/fr
Publication of WO2002031160A3 publication Critical patent/WO2002031160A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

L'invention concerne des réactifs qui régulent l'enzyme de type A2 phospholipase humaine et des réactifs qui se lient aux produits génétiques de l'enzyme de type A2 phospholipase humaine peuvent jouer un rôle en empêchant, améliorant ou corrigeant des dysfonctionnements ou des maladies incluant de manière non exhaustive, l'asthme, les cancers, les inflammations, les troubles du SNC, les troubles cardiovasculaires, la bronchopneumopathie chronique obstructive, le diabète et l'obésité.
PCT/EP2001/011640 2000-10-10 2001-10-09 Regulation de l'enzyme de type a2 phospholipase humaine WO2002031160A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001295602A AU2001295602A1 (en) 2000-10-10 2001-10-09 Regulation of human phospholipase a2-like enzyme

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US23843200P 2000-10-10 2000-10-10
US60/238,432 2000-10-10
US25805300P 2000-12-27 2000-12-27
US60/258,053 2000-12-27
US31796401P 2001-09-10 2001-09-10
US60/317,964 2001-09-10

Publications (2)

Publication Number Publication Date
WO2002031160A2 WO2002031160A2 (fr) 2002-04-18
WO2002031160A3 true WO2002031160A3 (fr) 2003-10-09

Family

ID=27399096

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/011640 WO2002031160A2 (fr) 2000-10-10 2001-10-09 Regulation de l'enzyme de type a2 phospholipase humaine

Country Status (2)

Country Link
AU (1) AU2001295602A1 (fr)
WO (1) WO2002031160A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002031125A2 (fr) * 2000-10-10 2002-04-18 Bayer Aktiengesellschaft Regulation de l'enzyme semblable a phospholipase a2 humaine
EP1358329A2 (fr) * 2001-02-06 2003-11-05 Incyte Genomics, Inc. Molecules associees au lipid
FR2847267B1 (fr) * 2002-11-19 2006-07-28 Coletica Procede de test de l'activite d'une substance potentiellement active pour inhiber l'activite enzymatique de la phospholipase a2

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 1 May 1999 (1999-05-01), XP002225010, retrieved from EBI Database accession no. O95712 *
DATABASE EMBL [online] Database accession no. Q9UKV7 *
SONG CHUANZHENG ET AL: "Molecular characterization of cytosolic phospholipase A2-beta.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 24, Q9ukv7, 11 June 1999 (1999-06-11), pages 17063 - 17067, XP002212884, ISSN: 0021-9258, Retrieved from the Internet <URL:EBI> *
TODD PICKARD R ET AL: "Molecular cloning of two new human paralogs of 85-KDa cytosolic phospholipase A2", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 274, no. 13, O95712, 26 March 1999 (1999-03-26), pages 8823 - 8831, XP002143988, ISSN: 0021-9258, Retrieved from the Internet <URL:EBI> *

Also Published As

Publication number Publication date
WO2002031160A2 (fr) 2002-04-18
AU2001295602A1 (en) 2002-04-22

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