WO2001079466A3 - Regulation de la serine protease semblable a l'epithine humaine - Google Patents

Regulation de la serine protease semblable a l'epithine humaine Download PDF

Info

Publication number
WO2001079466A3
WO2001079466A3 PCT/EP2001/004134 EP0104134W WO0179466A3 WO 2001079466 A3 WO2001079466 A3 WO 2001079466A3 EP 0104134 W EP0104134 W EP 0104134W WO 0179466 A3 WO0179466 A3 WO 0179466A3
Authority
WO
WIPO (PCT)
Prior art keywords
serine protease
regulation
epithin
human epithin
human
Prior art date
Application number
PCT/EP2001/004134
Other languages
English (en)
Other versions
WO2001079466A2 (fr
Inventor
Yonghong Xiao
Original Assignee
Bayer Ag
Yonghong Xiao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Yonghong Xiao filed Critical Bayer Ag
Priority to EP01947220A priority Critical patent/EP1287124A2/fr
Priority to AU2001268967A priority patent/AU2001268967A1/en
Publication of WO2001079466A2 publication Critical patent/WO2001079466A2/fr
Publication of WO2001079466A3 publication Critical patent/WO2001079466A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Des réactifs qui régulent l'activité de sérine protéase semblable à l'épithine humaine et des réactifs qui se fixent aux produits géniques de sérine protéase semblable à l'épithine humaine peuvent être utilisés pour réguler la dégradation matricielle extracellulaire. Cette régulation est utilisée, en particulier, dans le traitement des métastases des cellules malignes, de l'angiogenèse tumorale, de l'inflammation, de l'athérosclérose, des maladies neurodégénératives, et des infections pathogènes.
PCT/EP2001/004134 2000-04-18 2001-04-11 Regulation de la serine protease semblable a l'epithine humaine WO2001079466A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP01947220A EP1287124A2 (fr) 2000-04-18 2001-04-11 Regulation de la serine protease semblable a l'epithine humaine
AU2001268967A AU2001268967A1 (en) 2000-04-18 2001-04-11 Regulation of human epithin-like serine protease

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US19786500P 2000-04-18 2000-04-18
US60/197,865 2000-04-18
US25520100P 2000-12-13 2000-12-13
US60/255,201 2000-12-13
US26175501P 2001-01-17 2001-01-17
US60/261,755 2001-01-17

Publications (2)

Publication Number Publication Date
WO2001079466A2 WO2001079466A2 (fr) 2001-10-25
WO2001079466A3 true WO2001079466A3 (fr) 2002-06-06

Family

ID=27393792

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/004134 WO2001079466A2 (fr) 2000-04-18 2001-04-11 Regulation de la serine protease semblable a l'epithine humaine

Country Status (3)

Country Link
EP (1) EP1287124A2 (fr)
AU (1) AU2001268967A1 (fr)
WO (1) WO2001079466A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002008392A2 (fr) * 2000-07-25 2002-01-31 Bayer Aktiengesellschaft Regulation de la serine protease humaine semblable a matriptase
WO2003064641A1 (fr) * 2002-01-30 2003-08-07 Geneprot, Inc. Genes codant la protease a serine

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999042120A1 (fr) * 1998-02-20 1999-08-26 The Board Of Trustees Of The University Of Arkansas Serine protease extracellulaire surexprimee dans les cancers du sein ou les cancers ovariens
WO1999046281A2 (fr) * 1998-03-10 1999-09-16 Genentech, Inc. Nouveaux polypeptides et acides nucleiques les codant
WO2000055350A1 (fr) * 1999-03-12 2000-09-21 Human Genome Sciences, Inc. Sequences et polypeptides geniques associes au cancer chez l'homme
WO2001057190A2 (fr) * 2000-02-03 2001-08-09 Hyseq, Inc. Acides nucleiques et polypeptides
WO2002000860A2 (fr) * 2000-06-26 2002-01-03 Sugen, Inc. Nouvelles proteases

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999042120A1 (fr) * 1998-02-20 1999-08-26 The Board Of Trustees Of The University Of Arkansas Serine protease extracellulaire surexprimee dans les cancers du sein ou les cancers ovariens
WO1999046281A2 (fr) * 1998-03-10 1999-09-16 Genentech, Inc. Nouveaux polypeptides et acides nucleiques les codant
WO2000055350A1 (fr) * 1999-03-12 2000-09-21 Human Genome Sciences, Inc. Sequences et polypeptides geniques associes au cancer chez l'homme
WO2001057190A2 (fr) * 2000-02-03 2001-08-09 Hyseq, Inc. Acides nucleiques et polypeptides
WO2002000860A2 (fr) * 2000-06-26 2002-01-03 Sugen, Inc. Nouvelles proteases

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE EBI 23 June 2000 (2000-06-23), XP002192906 *
DATABASE EBI 29 September 1996 (1996-09-29), XP002192905 *
DATABASE EBI 8 October 1999 (1999-10-08), XP002192904 *
DATABASE EBI EMBL; 6 July 1999 (1999-07-06), XP002192903 *
LIN C-Y ET AL: "Molecular cloning of cDNA for Matriptase, a matrix-degrading serine protease with trypsin-like activity", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 274, no. 26, 25 June 1999 (1999-06-25), pages 8231 - 18236, XP002139963, ISSN: 0021-9258 *
UNDERWOOD L J ET AL: "CLONING OF TUMOR-ASSOCIATED DIFFERENTIALLY EXPRESSED GENE-14, A NOVEL SERINE PROTEASE OVEREXPRESSED BY OVARIAN CARCINOMA", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 59, no. 17, 1 September 1999 (1999-09-01), pages 4435 - 4439, XP000982596, ISSN: 0008-5472 *

Also Published As

Publication number Publication date
AU2001268967A1 (en) 2001-10-30
WO2001079466A2 (fr) 2001-10-25
EP1287124A2 (fr) 2003-03-05

Similar Documents

Publication Publication Date Title
WO2001096538A3 (fr) Regulation de la serine protease transmembranaire humaine
TR200101307T2 (tr) Antranilik asit amidler ve ilaç olarak kullanılmaları.
Sorsa et al. Identification of proteases from periodontopathogenic bacteria as activators of latent human neutrophil and fibroblast-type interstitial collagenases
AU2003264192A1 (en) Plant extracts for treatment of angiogenesis and metastasis
IS6194A (is) Serínprótínasar úr fiski og notkun þeirra í lyf og snyrtivörur
RS30104A (en) Keratinocytes which may be used as a biologically active substance in the treatment of wounds
Sangeetha et al. Anti-inflammatory activity of a serine protease produced from Bacillus pumilus SG2
WO2001096378A3 (fr) Regulation de la serine protease humaine de type epithin
WO2001079466A3 (fr) Regulation de la serine protease semblable a l'epithine humaine
DE60034879D1 (en) Lantibiotikum
WO2001098340A3 (fr) Regulation d'une enzyme du type protease mastocytaire humaine 6
AU2001278488A1 (en) Regulation of human matriptase-like serine protease
AU2001287555A1 (en) Regulation of human prostasin-like serine protease
WO2002000702A3 (fr) Regulation de la serine protease specifique de l'epiderme humain
WO2001085959A3 (fr) Regulation de la protease de type lysostaphine humaine
WO2001072973A3 (fr) Regulation d'une enzyme humaine de type heparanase
WO2001062941A3 (fr) Regulation de l'enzyme 2 semblable a la gelatinase b humaine
WO2002024886A3 (fr) Regulation de la serine protease humaine
AU2001283872A1 (en) Regulation of human eosinophil serine protease 1-like enzyme
WO2002012461A3 (fr) Regulation de la serine protease membranaire humaine
AU2002251788A1 (en) Novel compounds and uses thereof
WO2002026957A3 (fr) Regulation de la serine protease humaine
ATE252641T1 (de) Erhöhung der proteinproduktion in gram-positiven mikroorganismen
MX9700113A (es) Amido-quinoxalindionas novedosas, su preparacion y uso.
AU2001264245A1 (en) Novel enzyme gene and its expression product

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 2001947220

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 10240730

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 2001947220

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: JP

WWR Wipo information: refused in national office

Ref document number: 2001947220

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 2001947220

Country of ref document: EP