WO2001072973A3 - Regulation d'une enzyme humaine de type heparanase - Google Patents

Regulation d'une enzyme humaine de type heparanase Download PDF

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Publication number
WO2001072973A3
WO2001072973A3 PCT/EP2001/001997 EP0101997W WO0172973A3 WO 2001072973 A3 WO2001072973 A3 WO 2001072973A3 EP 0101997 W EP0101997 W EP 0101997W WO 0172973 A3 WO0172973 A3 WO 0172973A3
Authority
WO
WIPO (PCT)
Prior art keywords
regulation
human heparanase
enzyme
reagents
regulate
Prior art date
Application number
PCT/EP2001/001997
Other languages
English (en)
Other versions
WO2001072973A2 (fr
Inventor
Shyam Ramakrishnan
Original Assignee
Bayer Ag
Shyam Ramakrishnan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Shyam Ramakrishnan filed Critical Bayer Ag
Priority to AU50331/01A priority Critical patent/AU5033101A/en
Publication of WO2001072973A2 publication Critical patent/WO2001072973A2/fr
Publication of WO2001072973A3 publication Critical patent/WO2001072973A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01166—Heparanase (3.2.1.166)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Pour réguler une dégradation de la matrice extracellulaire, on peut utiliser des réactifs qui régulent l'activité de l'enzyme humaine de type héparanase et des réactifs qui se lient à des produits géniques d'une enzyme humaine de type héparanase. Une telle régulation s'avère particulièrement utile pour traiter la métastase de cellules malignes, l'angiogénère tumorigène, l'inflammation, l'athérosclerose, les maladies neurodégénératives et les infections pathogènes.
PCT/EP2001/001997 2000-02-24 2001-02-22 Regulation d'une enzyme humaine de type heparanase WO2001072973A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU50331/01A AU5033101A (en) 2000-02-24 2001-02-22 Regulation of human heparanase-like enzyme

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US18466000P 2000-02-24 2000-02-24
US60/184,660 2000-02-24
US25291300P 2000-11-27 2000-11-27
US60/252,913 2000-11-27

Publications (2)

Publication Number Publication Date
WO2001072973A2 WO2001072973A2 (fr) 2001-10-04
WO2001072973A3 true WO2001072973A3 (fr) 2002-06-06

Family

ID=26880358

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/001997 WO2001072973A2 (fr) 2000-02-24 2001-02-22 Regulation d'une enzyme humaine de type heparanase

Country Status (2)

Country Link
AU (1) AU5033101A (fr)
WO (1) WO2001072973A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL162276A0 (en) * 2004-06-01 2005-11-20 Hadasit Med Res Service Nucleic acid molecules as heparanase potent inhibitors, compositions and methods of use thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001021814A1 (fr) * 1999-09-23 2001-03-29 Merck Patent Gmbh L'heparanase-2, membre de la famille des proteines heparanases
WO2001046392A2 (fr) * 1999-12-22 2001-06-28 Oxford Glycosciences (Uk) Ltd. Substances
WO2001048161A2 (fr) * 1999-12-23 2001-07-05 Schering Aktiengesellschaft Acide nucleique et polypeptide apparentes a l'heparanase humaine

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001021814A1 (fr) * 1999-09-23 2001-03-29 Merck Patent Gmbh L'heparanase-2, membre de la famille des proteines heparanases
WO2001046392A2 (fr) * 1999-12-22 2001-06-28 Oxford Glycosciences (Uk) Ltd. Substances
WO2001048161A2 (fr) * 1999-12-23 2001-07-05 Schering Aktiengesellschaft Acide nucleique et polypeptide apparentes a l'heparanase humaine

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL 18 October 1999 (1999-10-18), HATTORI M ET AL: "Homo sapiens genomic DNA, chromosome 21q", XP002193530 *
DATABASE EMBL 18 October 1999 (1999-10-18), HATTORI M ET AL: "Homo sapiens genomic DNA, chromosome 21q", XP002193531 *
DATABASE EMBL 28 October 1998 (1998-10-28), STRAUSBERG R: "national Cancer Institute, Cancer Genome Anatomy Project", XP002193532 *
MCKENZIE EDWARD ET AL: "Cloning and expression profiling of Hpa2, a novel mammalian heparanase family member.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 276, no. 3, 5 October 2000 (2000-10-05), pages 1170 - 1177, XP002193529, ISSN: 0006-291X *

Also Published As

Publication number Publication date
AU5033101A (en) 2001-10-08
WO2001072973A2 (fr) 2001-10-04

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