WO2002017788A1 - Diagnostic medical structurel moleculaire - Google Patents

Diagnostic medical structurel moleculaire Download PDF

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Publication number
WO2002017788A1
WO2002017788A1 PCT/RU2001/000312 RU0100312W WO0217788A1 WO 2002017788 A1 WO2002017788 A1 WO 2002017788A1 RU 0100312 W RU0100312 W RU 0100312W WO 0217788 A1 WO0217788 A1 WO 0217788A1
Authority
WO
WIPO (PCT)
Prior art keywords
radiation
function
φunκtsii
sτρuκτuρnοy
structural
Prior art date
Application number
PCT/RU2001/000312
Other languages
English (en)
Russian (ru)
Inventor
Pavel Ivanovich Lazarev
Mikhail Vitoldovitch Paukshto
Original Assignee
Quanta Vision, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quanta Vision, Inc. filed Critical Quanta Vision, Inc.
Priority to AU2001277830A priority Critical patent/AU2001277830A1/en
Publication of WO2002017788A1 publication Critical patent/WO2002017788A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons

Definitions

  • the evolving invention is subject to non-destructive processes 5 of research of materials, materials, biological fabrics, etc.
  • ⁇ chas ⁇ n ⁇ s ⁇ i ⁇ s ⁇ s ⁇ bam diagn ⁇ s ⁇ i ⁇ i - ⁇ n ⁇ lya changes s ⁇ u ⁇ u ⁇ y bi ⁇ l ⁇ giches ⁇ i ⁇ ⁇ aney ⁇ ganizma, ⁇ e m ⁇ zhe ⁇ by ⁇ svyazan ⁇ with ne ⁇ laziey or immun ⁇ l ⁇ giches ⁇ im ⁇ ve ⁇ m ⁇ ganizma on b ⁇ lezni, le ⁇ a ⁇ s ⁇ vennye ⁇ e ⁇ a ⁇ a ⁇ y, v ⁇ zdeys ⁇ vie outer s ⁇ edy and ⁇ .d.
  • Investigation of the object is carried out with the use of 0 incident radiation: X-ray, neutral, gamma radiation, and ⁇ . e.
  • 0 incident radiation X-ray, neutral, gamma radiation, and ⁇ . e.
  • the first option is to take care of the sample, for example, with a biopsy, and to destroy the sample in the process of research, but the method will not take care of it, It is 5 non-automatic, and offers the study of tissue inside and of the very body of humanism.
  • the proposed methods are available for non-invasive diagnostic methods.
  • the prior art diagnostic techniques using X-ray light have been known for a long time. They relate to methods based on the distinction of absorbing the rays of various biological tissues. The limitation of the capacities of this method is associated with a weak difference in the absorption of radiation in soft wraps and the protection of the absorption of internal radiation. For quick display of soft tissues, other principles of interaction of 5 X-ray radiation with material are used. In particular, devices are known for visualizing the internal structure of the object, in which patients are at risk of radiation exposure. 95/05725, 00Sh 23/04).
  • ⁇ bschimned ⁇ s ⁇ a ⁇ me ⁇ g ⁇ me ⁇ da yavlyae ⁇ sya is ⁇ azhenie ⁇ egis ⁇ i ⁇ uem ⁇ y in ⁇ matsii ⁇ i presence nes ⁇ l ⁇ i ⁇ g ⁇ anits 0 ⁇ blas ⁇ ey with ⁇ azlichn ⁇ y e le ⁇ nn ⁇ y ⁇ l ⁇ n ⁇ s ⁇ yu on ⁇ u ⁇ i radiation ⁇ ni ⁇ ayuscheg ⁇ and ⁇ a ⁇ zhe ⁇ udn ⁇ s ⁇ i, v ⁇ zni ⁇ ayuschie ⁇ i iden ⁇ i ⁇ i ⁇ atsii ⁇ azlichny ⁇ vesches ⁇ v, s ⁇ s ⁇ avlyayuschi ⁇ ⁇ be ⁇ investigated. 2
  • Diffuse radiation has a distinctive angular dependence on brightly expressed maxima; 5 use of these components is shared by the radiation itself, which is emitted.
  • the closest analogue to this invention is a small-angle tool intended for the separation of a medium and a non-operating unit, on a 21st day, 21, 23 5
  • the aforementioned method includes the irradiation of the product with narrow, weakly absorbed radiation beams and the study of the intensity of the radiation of the
  • the received distributions of the intensities of the incident and incident emissions are normalized to the total intensity of the incident and incident 0 emissions, respectively.
  • the scattering of radiation in the medium transfers to the separation of the intensity of radiation at the cross section of the primary beam.
  • the disadvantages of the indicated method are related to the difficulties associated with detecting small changes in signals of a larger magnitude.
  • the radiation intensity dispersed at an angle of 0.06 ° is 10 "3 - 10 " 5 of the output intensity of the beam.
  • the comparison is made on the site (s) of the function (s) of the sensitivity (s) of the changes in the (s) (s) ) of the site (s) are allocated for the known samples.
  • the impacts of the external environment, the pharmaceutical processes occurring in the 5th self-government, are subject to a change in the structure of the biological tissue.
  • the division of the structure of biological tissues, and more precisely the changes occurring in the structure makes it possible to diagnose the presence of treatment-related changes in the treatment of the disease.
  • Each sample of biological tissue is illuminated by the selected radiation and selects the corresponding structural function.
  • multiple data banks may be created when using different types of radiation.
  • Each structural function is numbered to reduce the effect of vibrations in the process of operation of the apparatus, which is the result of the study of the processing of minerals
  • the internal standard for example, for the function of distributing the paired accessories for all the large values of the Please use the standard calibrated sample and normalize the value of 5 structured functions for the biological sampled value. Other methods of normalization may also be used. . 0 Industrial functions of biological samples and the values corresponding to them are shared by the parameters entered into the databank.
  • a structured function can be presented in the form of a table of values or in the form of an analytical function (or a series of functions).
  • an analytical function or a series of functions.
  • there are 5 sensible parts of the structured function i.e. parts of the structural functions are sensitive to changes in the shared parameters.
  • parts of the structural functions are sensitive to changes in the shared parameters.
  • One of the methods for the determination of sensitive points is included in the separation of the level of correlation between two variables, the value of the parameter we are interested in and the value of the momentary 6
  • the level of correlation is set for the whole interval, where the functional function is assigned.
  • the problems associated with the highest level of correlation between the parameter value and the value of the structural function are selected as sensitive points for this parameter. 5
  • the mathematical expression of the method of setting the correlation level is also included in the databank.
  • the studied object is illuminated by incident radiation and, for negative purposes, detects, at the very least, one normalized function.
  • the described method without limitation of 0 total number of units, may be used for research, because of
  • the values of the structural function for sensitive samples for the studied sample are compared with the corresponding values contained in bank 5 of the data.
  • the value of the parameter used for the investigated object will correspond to the value of the parameter of the data bank, which has the smallest value of the
  • the accuracy of the parameterization of the equipment will correspond to the degree of deviation of the values of the structural functions for the studied component and the 0 corresponding to the 7
  • the small-angle scattering diagram is a dependent on the intensity of the scattered radiation of the angular scattering.
  • the range of measurable angles was increased from a few angular seconds to a few 5 degrees and the output wavelength depended on it.
  • the function of the distribution of the paired distributions ( ⁇ ) is dependent on the distribution of the electrical components of the distribution of electrical ⁇ is connected with the radiation scattering diagram by conversion of fourier.
  • the data bank was formed on the basis of the study of biological samples obtained in the course of chemical processes.
  • the YU ⁇ diagrams for the data bank samples were obtained on the KU ⁇ - ⁇ spectrometer using a linear, sensitive, sensitive detector.
  • E ⁇ s ⁇ e ⁇ imen ⁇ alnye data ⁇ asseyaniya radiation ⁇ en ⁇ gen ⁇ vs ⁇ g ⁇ investigated ⁇ be ⁇ m (zavisim ⁇ s ⁇ in ⁇ ensivn ⁇ s ⁇ i ⁇ asseyann ⁇ g ⁇ ⁇ radiation angle ⁇ asseyaniya) ⁇ edva ⁇ i ⁇ eln ⁇ smoothed and ni ⁇ vv ⁇ dilis s ⁇ ve ⁇ s ⁇ vuyuschie ⁇ llimatsi ⁇ nnye ⁇ av ⁇ i 5 uchi ⁇ yvayuschie a ⁇ a ⁇ a ⁇ nuyu ⁇ un ⁇ tsiyu ⁇ ib ⁇ a on ⁇ m ⁇ v ⁇ dilis izme ⁇ eniya, za ⁇ em e ⁇ i zavisim ⁇ s ⁇ i n ⁇ mi ⁇ valis on ⁇ bschee v ⁇ emya izme ⁇ eny and radiation in ⁇ ensiv
  • the inventive method can be used in medical diagnostics and for the study of biological tissues, similar procedure can be used for the study of any substances, for example,

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiation-Therapy Devices (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)

Abstract

La présente invention concerne des procédés non destructifs d'étude de substances, de matériaux, de tissus biologiques, etc. Elle concerne notamment des procédés diagnostiques, à savoir le contrôle de la modification de la structure des tissus biologiques de l'organisme qui est liée à une réaction immunologique de l'organisme à des maladies ou des médicaments ainsi qu'à l'influence de l'environnement, etc. Le procédé de l'invention consiste en ce qui suit: déterminer une ou plusieurs fonctions structurelles de l'objet étudié et déterminer les paramètres désirés pour cet objet par la comparaison de ces derniers avec une ou plusieurs fonctions structurelles correspondantes des échantillons connus pour lesquels on a déterminé le ou les paramètres désirés; la comparaison est effectuée dans une ou plusieurs parties d'une plusieurs fonctions structurelles qui sont sensibles au changement du paramètre désiré. Ces parties sont déterminées pour les échantillons connus. L'invention concerne aussi un procédé de notation des fonctions structurelles.
PCT/RU2001/000312 2000-09-01 2001-07-26 Diagnostic medical structurel moleculaire WO2002017788A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001277830A AU2001277830A1 (en) 2000-09-01 2001-07-26 Molecular structural medical diagnostics

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2000122731A RU2210986C2 (ru) 2000-09-01 2000-09-01 Молекулярная структурная медицинская диагностика
RU2000122731 2000-09-01

Publications (1)

Publication Number Publication Date
WO2002017788A1 true WO2002017788A1 (fr) 2002-03-07

Family

ID=20239667

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RU2001/000312 WO2002017788A1 (fr) 2000-09-01 2001-07-26 Diagnostic medical structurel moleculaire

Country Status (3)

Country Link
AU (1) AU2001277830A1 (fr)
RU (1) RU2210986C2 (fr)
WO (1) WO2002017788A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2751797C1 (ru) * 2020-12-11 2021-07-19 Общество С Ограниченной Ответственностью "Аптасайенс" Способ определения пространственной структуры биомолекул

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996014014A2 (fr) * 1994-11-04 1996-05-17 Telbus Gesellschaft Für Elektronische Kommunikations-Systeme Mbh Appareil portatif medical de mesure et de diagnostic
RU94042608A (ru) * 1994-11-30 1996-09-20 А.В. Курбатов Способ получения проекции объекта с помощью проникающего излучения и устройство для его осуществления
RU2119660C1 (ru) * 1997-04-08 1998-09-27 Закрытое акционерное общество "Кванта Инвест" Устройство для определения состава и структуры неоднородного объекта (варианты)

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996014014A2 (fr) * 1994-11-04 1996-05-17 Telbus Gesellschaft Für Elektronische Kommunikations-Systeme Mbh Appareil portatif medical de mesure et de diagnostic
RU94042608A (ru) * 1994-11-30 1996-09-20 А.В. Курбатов Способ получения проекции объекта с помощью проникающего излучения и устройство для его осуществления
RU2119660C1 (ru) * 1997-04-08 1998-09-27 Закрытое акционерное общество "Кванта Инвест" Устройство для определения состава и структуры неоднородного объекта (варианты)

Also Published As

Publication number Publication date
RU2210986C2 (ru) 2003-08-27
AU2001277830A1 (en) 2002-03-13

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