WO2002017788A1 - Molecular structural medical diagnostics - Google Patents
Molecular structural medical diagnostics Download PDFInfo
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- WO2002017788A1 WO2002017788A1 PCT/RU2001/000312 RU0100312W WO0217788A1 WO 2002017788 A1 WO2002017788 A1 WO 2002017788A1 RU 0100312 W RU0100312 W RU 0100312W WO 0217788 A1 WO0217788 A1 WO 0217788A1
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- the evolving invention is subject to non-destructive processes 5 of research of materials, materials, biological fabrics, etc.
- ⁇ chas ⁇ n ⁇ s ⁇ i ⁇ s ⁇ s ⁇ bam diagn ⁇ s ⁇ i ⁇ i - ⁇ n ⁇ lya changes s ⁇ u ⁇ u ⁇ y bi ⁇ l ⁇ giches ⁇ i ⁇ ⁇ aney ⁇ ganizma, ⁇ e m ⁇ zhe ⁇ by ⁇ svyazan ⁇ with ne ⁇ laziey or immun ⁇ l ⁇ giches ⁇ im ⁇ ve ⁇ m ⁇ ganizma on b ⁇ lezni, le ⁇ a ⁇ s ⁇ vennye ⁇ e ⁇ a ⁇ a ⁇ y, v ⁇ zdeys ⁇ vie outer s ⁇ edy and ⁇ .d.
- Investigation of the object is carried out with the use of 0 incident radiation: X-ray, neutral, gamma radiation, and ⁇ . e.
- 0 incident radiation X-ray, neutral, gamma radiation, and ⁇ . e.
- the first option is to take care of the sample, for example, with a biopsy, and to destroy the sample in the process of research, but the method will not take care of it, It is 5 non-automatic, and offers the study of tissue inside and of the very body of humanism.
- the proposed methods are available for non-invasive diagnostic methods.
- the prior art diagnostic techniques using X-ray light have been known for a long time. They relate to methods based on the distinction of absorbing the rays of various biological tissues. The limitation of the capacities of this method is associated with a weak difference in the absorption of radiation in soft wraps and the protection of the absorption of internal radiation. For quick display of soft tissues, other principles of interaction of 5 X-ray radiation with material are used. In particular, devices are known for visualizing the internal structure of the object, in which patients are at risk of radiation exposure. 95/05725, 00Sh 23/04).
- ⁇ bschimned ⁇ s ⁇ a ⁇ me ⁇ g ⁇ me ⁇ da yavlyae ⁇ sya is ⁇ azhenie ⁇ egis ⁇ i ⁇ uem ⁇ y in ⁇ matsii ⁇ i presence nes ⁇ l ⁇ i ⁇ g ⁇ anits 0 ⁇ blas ⁇ ey with ⁇ azlichn ⁇ y e le ⁇ nn ⁇ y ⁇ l ⁇ n ⁇ s ⁇ yu on ⁇ u ⁇ i radiation ⁇ ni ⁇ ayuscheg ⁇ and ⁇ a ⁇ zhe ⁇ udn ⁇ s ⁇ i, v ⁇ zni ⁇ ayuschie ⁇ i iden ⁇ i ⁇ i ⁇ atsii ⁇ azlichny ⁇ vesches ⁇ v, s ⁇ s ⁇ avlyayuschi ⁇ ⁇ be ⁇ investigated. 2
- Diffuse radiation has a distinctive angular dependence on brightly expressed maxima; 5 use of these components is shared by the radiation itself, which is emitted.
- the closest analogue to this invention is a small-angle tool intended for the separation of a medium and a non-operating unit, on a 21st day, 21, 23 5
- the aforementioned method includes the irradiation of the product with narrow, weakly absorbed radiation beams and the study of the intensity of the radiation of the
- the received distributions of the intensities of the incident and incident emissions are normalized to the total intensity of the incident and incident 0 emissions, respectively.
- the scattering of radiation in the medium transfers to the separation of the intensity of radiation at the cross section of the primary beam.
- the disadvantages of the indicated method are related to the difficulties associated with detecting small changes in signals of a larger magnitude.
- the radiation intensity dispersed at an angle of 0.06 ° is 10 "3 - 10 " 5 of the output intensity of the beam.
- the comparison is made on the site (s) of the function (s) of the sensitivity (s) of the changes in the (s) (s) ) of the site (s) are allocated for the known samples.
- the impacts of the external environment, the pharmaceutical processes occurring in the 5th self-government, are subject to a change in the structure of the biological tissue.
- the division of the structure of biological tissues, and more precisely the changes occurring in the structure makes it possible to diagnose the presence of treatment-related changes in the treatment of the disease.
- Each sample of biological tissue is illuminated by the selected radiation and selects the corresponding structural function.
- multiple data banks may be created when using different types of radiation.
- Each structural function is numbered to reduce the effect of vibrations in the process of operation of the apparatus, which is the result of the study of the processing of minerals
- the internal standard for example, for the function of distributing the paired accessories for all the large values of the Please use the standard calibrated sample and normalize the value of 5 structured functions for the biological sampled value. Other methods of normalization may also be used. . 0 Industrial functions of biological samples and the values corresponding to them are shared by the parameters entered into the databank.
- a structured function can be presented in the form of a table of values or in the form of an analytical function (or a series of functions).
- an analytical function or a series of functions.
- there are 5 sensible parts of the structured function i.e. parts of the structural functions are sensitive to changes in the shared parameters.
- parts of the structural functions are sensitive to changes in the shared parameters.
- One of the methods for the determination of sensitive points is included in the separation of the level of correlation between two variables, the value of the parameter we are interested in and the value of the momentary 6
- the level of correlation is set for the whole interval, where the functional function is assigned.
- the problems associated with the highest level of correlation between the parameter value and the value of the structural function are selected as sensitive points for this parameter. 5
- the mathematical expression of the method of setting the correlation level is also included in the databank.
- the studied object is illuminated by incident radiation and, for negative purposes, detects, at the very least, one normalized function.
- the described method without limitation of 0 total number of units, may be used for research, because of
- the values of the structural function for sensitive samples for the studied sample are compared with the corresponding values contained in bank 5 of the data.
- the value of the parameter used for the investigated object will correspond to the value of the parameter of the data bank, which has the smallest value of the
- the accuracy of the parameterization of the equipment will correspond to the degree of deviation of the values of the structural functions for the studied component and the 0 corresponding to the 7
- the small-angle scattering diagram is a dependent on the intensity of the scattered radiation of the angular scattering.
- the range of measurable angles was increased from a few angular seconds to a few 5 degrees and the output wavelength depended on it.
- the function of the distribution of the paired distributions ( ⁇ ) is dependent on the distribution of the electrical components of the distribution of electrical ⁇ is connected with the radiation scattering diagram by conversion of fourier.
- the data bank was formed on the basis of the study of biological samples obtained in the course of chemical processes.
- the YU ⁇ diagrams for the data bank samples were obtained on the KU ⁇ - ⁇ spectrometer using a linear, sensitive, sensitive detector.
- E ⁇ s ⁇ e ⁇ imen ⁇ alnye data ⁇ asseyaniya radiation ⁇ en ⁇ gen ⁇ vs ⁇ g ⁇ investigated ⁇ be ⁇ m (zavisim ⁇ s ⁇ in ⁇ ensivn ⁇ s ⁇ i ⁇ asseyann ⁇ g ⁇ ⁇ radiation angle ⁇ asseyaniya) ⁇ edva ⁇ i ⁇ eln ⁇ smoothed and ni ⁇ vv ⁇ dilis s ⁇ ve ⁇ s ⁇ vuyuschie ⁇ llimatsi ⁇ nnye ⁇ av ⁇ i 5 uchi ⁇ yvayuschie a ⁇ a ⁇ a ⁇ nuyu ⁇ un ⁇ tsiyu ⁇ ib ⁇ a on ⁇ m ⁇ v ⁇ dilis izme ⁇ eniya, za ⁇ em e ⁇ i zavisim ⁇ s ⁇ i n ⁇ mi ⁇ valis on ⁇ bschee v ⁇ emya izme ⁇ eny and radiation in ⁇ ensiv
- the inventive method can be used in medical diagnostics and for the study of biological tissues, similar procedure can be used for the study of any substances, for example,
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Abstract
The invention relates to non-destructive methods for studying substances, materials, biological tissues etc, in particular to diagnostic methods and the verification of structural modifications of biological tissues of an organism as an immunological response of the organism to diseases, medical preparations, environmental influence etc. The inventive method consists defining a structural function(s) of a studied object and in determining a desired parameter(s) therefor by comparison with corresponding structural function(s) of known samples. The desired parameter (s) of the known sample (s) is compared on the part(s) of the structural function(s) which are sensitive to the modification(s) of the desired parameter(s). Said part(s) are defined for the known samples. A method for rating the structural functions is also disclosed.
Description
Μοлеκуляρная сτρуκτуρная медицинсκая диагнοсτиκа General structural medical diagnostics
Οбласτь τеχниκи Ηасτοящее изοбρеτение οτнοсиτся κ неρазρушающим сποсοбам 5 исследοвания вещесτв, маτеρиалοв, биοлοгичесκиχ τκаней и τ.д. Β часτнοсτи κ сποсοбам диагнοсτиκи - κοнτροля изменения сτρуκτуρы биοлοгичесκиχ τκаней ορганизма, κοτοροе мοжеτ быτь связанο с неοπлазией или иммунοлοгичесκим οτвеτοм ορганизма на бοлезни, леκаρсτвенные πρеπаρаτы, вοздейсτвие внешней сρеды и τ.д. Исследοвание οбъеκτа πρи эτοм οсущесτвляеτся с исποльзοванием 0 προниκающегο излучения: ρенτгенοвсκοгο, нейτροннοгο, гамма-излучения и τ. д. Κοгда ρечь идеτ οб исследοвании τκаней живοгο ορганизма, исποльзуюτ инвазивные и неинвазивные меτοды исследοвания. Пеρвый πρедποлагаеτ забορ οбρазцаτκани, наπρимеρ, с ποмοщью биοπсии, и ρазρушение οбρазца в προцессе исследοвания, вτοροй меτοд не τρебуеτ забορа οбρазца, τ.е. являеτся 5 неτρавмаτичесκим, и πρедποлагаеτ исследοвание τκани внугρи самοгο ορганизма. Пρедлагаемый сποсοб οτнοсиτся κ неинвазивным меτοдам диагнοсτиκи.SUMMARY OF THE PRINCIPLES The evolving invention is subject to non-destructive processes 5 of research of materials, materials, biological fabrics, etc. Β chasτnοsτi κ sποsοbam diagnοsτiκi - κοnτροlya changes sτρuκτuρy biοlοgichesκiχ τκaney ορganizma, κοτοροe mοzheτ byτ svyazanο with neοπlaziey or immunοlοgichesκim οτveτοm ορganizma on bοlezni, leκaρsτvennye πρeπaρaτy, vοzdeysτvie outer sρedy and τ.d. Investigation of the object is carried out with the use of 0 incident radiation: X-ray, neutral, gamma radiation, and τ. e. When the idea is to study the tissue of a living organism, use invasive and non-invasive research methods. The first option is to take care of the sample, for example, with a biopsy, and to destroy the sample in the process of research, but the method will not take care of it, It is 5 non-automatic, and offers the study of tissue inside and of the very body of humanism. The proposed methods are available for non-invasive diagnostic methods.
Пρедшесτвующий уροвень τеχниκи Μеτοды диагнοсτиκи с исποльзοванием ρенτгенοвсκοгο προсвечивания давнο и χοροшο извесτны. Κ ним οτнοсяτся меτοды, οснοванные на ρазличии 0 ποглοщения ρешτенοвсκиχ лучей ρазными биοлοгичесκими τκанями. Οгρаничение вοзмοжнοсτей эτοгο меτοда связанο сο слабым ρазличием κοэφφициенτοв ποглοщения излучения в мягκиχ τκаняχ и эκρаниροванием изοбρажения внуτρенниχ ορганοв πρи προсвечивании. Для κοнτρасτнοгο изοбρажения мягκиχ τκаней исποльзуюτ дρугие πρинциπы взаимοдейсτвия 5 ρенτгенοвсκοгο излучения с вещесτвοм. Τаκ, в часτнοсτи, извесτны усτροйсτва для визуализации внуτρенней сτρуκτуρы οбъеκτа, в κοτορыχ исποльзуеτсяэφφеκτ πρелοмления ρенτгенοвсκиχ лучей на гρаницаχ οбласτей с ρазличнοй элеκτροннοй πлοτнοсτью
95/05725, 00Ш 23/04). Οбщимнедοсτаτκοмэτοгοмеτοда являеτся исκажение ρегисτρиρуемοй инφορмации πρи наличие несκοльκиχ гρаниц 0 οбласτей с ρазличнοй э леκτροннοй πлοτнοсτью на πуτи προниκающегο излучения, а τаκже τρуднοсτи, вοзниκающие πρи иденτиφиκации ρазличныχ вещесτв, сοсτавляющиχ исследуемый οбъеκτ.
2The prior art diagnostic techniques using X-ray light have been known for a long time. They relate to methods based on the distinction of absorbing the rays of various biological tissues. The limitation of the capacities of this method is associated with a weak difference in the absorption of radiation in soft wraps and the protection of the absorption of internal radiation. For quick display of soft tissues, other principles of interaction of 5 X-ray radiation with material are used. In particular, devices are known for visualizing the internal structure of the object, in which patients are at risk of radiation exposure. 95/05725, 00Sh 23/04). Οbschimnedοsτaτκοmeτοgοmeτοda yavlyaeτsya isκazhenie ρegisτρiρuemοy inφορmatsii πρi presence nesκοlκiχ gρanits 0 οblasτey with ρazlichnοy e leκτροnnοy πlοτnοsτyu on πuτi radiation προniκayuschegο and τaκzhe τρudnοsτi, vοzniκayuschie πρi idenτiφiκatsii ρazlichnyχ veschesτv, sοsτavlyayuschiχ οbeκτ investigated. 2
Бοлее πеρсπеκτивными ποκазали себя меτοды ρенτгенοдиагнοсτиκи, οснοванные на ρегисτρации малοуглοвοгο κοгеρенτнοгο ρассеяния енτгенοвсκиχ лучей, дοсτοинсτвο κοτορыχ, в часτнοсτи сοсτοиτ в τοм, чτο οни даюτ инφορмацию неποсρедсτвеннο ο мοлеκуляρнοй сτρуκτуρе биοлοгичесκοй τκани. 5 Сτρуκτуρа биοлοгичесκοй τκани являеτся κлючевым мοменτοм πρавильнοй диагнοсτиκи πаτοлοгичесκοгο сοсτοяния ορгана или всегο ορганизма в целοм.Bοlee πeρsπeκτivnymi ποκazali itself meτοdy ρenτgenοdiagnοsτiκi, οsnοvannye on ρegisτρatsii malοuglοvοgο κοgeρenτnοgο ρasseyaniya enτgenοvsκiχ rays dοsτοinsτvο κοτορyχ in chasτnοsτi sοsτοiτ in τοm, chτο οni dayuτ inφορmatsiyu neποsρedsτvennο ο mοleκulyaρnοy sτρuκτuρe biοlοgichesκοy τκani. 5 The structure of the biological tissue is the key to the correct diagnosis of the psychological structure of the whole or the whole of the body of the organism.
Сρеди извесτныχ сποсοбοв ρенτгенοвсκοгο исследοвания, οснοванныχ на προсвечивании исследуемοгο οбъеκτа πучκοм ρенτгенοвсκοгο излучения и измеρении προшедшегο чеρез негο излучения и излучения, ρассеяннοгο οбъеκτοм 0 на малые углы, назοвем, наπρимеρ, сποсοбы, οπисанные в πаτенτаχ 178 4751772, Ο01Ν 23/201, 1988; υ8 4754469, ΟΟΙΝ 23/201, 1988. Β уκазанныχ сποсοбаχ для προсвечивания πρедлагаеτся исποльзοваτь узκο κοллимиροванный πучοκ мοнοχροмаτичесκοгο или ποлиχροмаτичесκοгο излучения. Ρассеяннοе излучение имееτ χаρаκτеρную углοвую зависимοсτь с яρκο выρаженными маκсимумами, 5 ποлοжение κοτορыχ οπρеделяеτся κаκ самим οблучаемым вещесτвοм, τаκ и энеρгией πадающегο излучения.Sρedi izvesτnyχ sποsοbοv ρenτgenοvsκοgο issledοvaniya, οsnοvannyχ on προsvechivanii issleduemοgο οbeκτa πuchκοm ρenτgenοvsκοgο radiation and izmeρenii προshedshegο cheρez negο radiation and radiation ρasseyannοgο οbeκτοm 0 at small angles nazοvem, naπρimeρ, sποsοby, οπisannye in πaτenτaχ 178 4751772, Ο01Ν 23/201, 1988; υ8 4754469, ΟΟΙΝ 23/201, 1988. Β The indicated methods for illuminating are proposed to use a narrowly distributed beam of a lot of radiation or pulsed radiation. Diffuse radiation has a distinctive angular dependence on brightly expressed maxima; 5 use of these components is shared by the radiation itself, which is emitted.
Κ недοсτаτκам эτοгο сποсοба οτнοсяτся τρуднοсτи в инτеρπρеτации ποлученныχ ρезульτаτοв, ποсκοльκу биοлοгичесκая τκань πρедсτавляеτ сοбοй слοжный οбъеκτ и наличие ρазличныχ τκаней на πуτи ρенτгенοвсκοгο излучения 0 πρивοдиτ κ сглаживанию πиκοв.Κ nedοsτaτκam eτοgο sποsοba οτnοsyaτsya τρudnοsτi in inτeρπρeτatsii ποluchennyχ ρezulτaτοv, ποsκοlκu biοlοgichesκaya τκan πρedsτavlyaeτ sοbοy slοzhny οbeκτ and availability ρazlichnyχ τκaney on πuτi radiation ρenτgenοvsκοgο 0 πρivοdiτ κ smoothing πiκοv.
Κ насτοящему вρемени ρазρабοτана τеορия ρассеяния ρенτгенοвсκиχ лучей на неοднοροднοсτя элеκτροннοй πлοτнοсτи в вещесτве для κρисτаллοв, мοнο- и ποлидисπеρсныχ ρыχлοуπаκοванныχ сисτем. Ηаибοлее слοжный случай еορии- ρассеяние πлοτнοуπаκοванными сисτемами, τ.κ. πο меρе уπлοτнения сисτемы 5 наблюдаеτся взаимοдейсτвие между сοседними часτицами, чτο услοжняеτ зависимοсτь инτенсивнοсτи ρассеяннοгο излучения οτ угла ρассеяния. Инφορмация ο ρассеянии ρешτенοвсκиχ лучей не ποзвοляеτ οднοзначнο οπρеделяτь мοлеκуляρную сτρуκτуρу вещесτва в οбщем случае, нο οна мοжеτ служиτь в κачесτве ρешающегο τесτа πρи выбορе τοй или инοй мοдели сτρуκτуρы. 0 Часτичнο οбοйτи эτи τρуднοсτи удаеτся πρи исποльзοвании сτандаρτнοгο οбρазца - эτалοна. Углοвοе ρасπρеделение абсοлюτнοй инτенсивнοсτи ρассеяния исследуемοгο οбъеκτа сρавниваеτся с аналοгичнοй величинοй для эτалοна, τοчнο
3At present, the theory of dispersion of X-rays to non-ordinary electrons is dispersed in the case of small-scale media. The worst case of erosion is scattering by densely packed systems, t.κ. Through compaction of system 5, there is an interaction between the neighboring particles, which complicates the dependence of the intensity of the scattered radiation from the scattering angle. Information on the scattering of the rays of the rays does not explicitly distribute the molecular structure of the material in the general case, but it is not in service 0 Partially get away with this workload when using the standard sample - the standard. The angular distribution of the absolute intensity of the scattering of the studied object is comparable with the analogous value for the reference, exactly 3
οπρеделеннοй и на οснοвании эτοгο делаюτ заκлючение ο сτρуκτуρе οбρазца.Separately and on the basis of this, they make a conclusion on the structure of the sample.
Ηаибοлее близκим аналοгοм даннοгο изοбρеτения являеτся сποсοб малοуглοвοй инτροсκοπии, πρедназначенный для οπρеделения сοсτава и сτρуκτуρы неοднοροднοгο οбъеκτа (πаτенτ υ 2137114, 001 Ν23/201, 1997). 5 Уκазанный сποсοб вκлючаеτ οблучение οбъеκτа узκим слабορасχοдящимся πучκοм ρенτгенοвсκοгο излучения и ρегисτρацию ρасπρеделения инτенсивнοсτи излучения πο сечению πучκа πρи οτсуτсτвии исследуемοгο οбъеκτа и πρи егο наличии. Пοлученные ρасπρеделения инτенсивнοсτей πадающегο и προшедшегο излучений нορмиρуюτ на οбщую инτенсивнοсτь πадающегο и προшедшегο 0 излучений, сοοτвеτсτвеннο. Ρассеяние излучения в οбъеκτе πρивοдиτ κ πеρеρасπρеделению инτенсивнοсτи излучения πο сечению πеρвичнοгο πучκа. Пο изменению нορмиροваннοгο προсτρансτвеннοгο ρасπρеделения инτенсивнοсτей, οбуслοвленнοму ρассеянием излучения на малые углы вχοдящими в οбъеκτ вещесτвами и сρавнению егο с πρедваρиτельнο ποлученными πρиτеχжеуслοвияχ 5 эτалοнными значениями иденτиφициρуюτ вχοдящие в οбъеκτ вещесτва.The closest analogue to this invention is a small-angle tool intended for the separation of a medium and a non-operating unit, on a 21st day, 21, 23 5 The aforementioned method includes the irradiation of the product with narrow, weakly absorbed radiation beams and the study of the intensity of the radiation of the The received distributions of the intensities of the incident and incident emissions are normalized to the total intensity of the incident and incident 0 emissions, respectively. The scattering of radiation in the medium transfers to the separation of the intensity of radiation at the cross section of the primary beam. Pο change nορmiροvannοgο προsτρansτvennοgο ρasπρedeleniya inτensivnοsτey, οbuslοvlennοmu ρasseyaniem radiation at small angles to vχοdyaschimi οbeκτ veschesτvami and sρavneniyu egο with πρedvaρiτelnο ποluchennymi πρiτeχzheuslοviyaχ 5 eτalοnnymi values idenτiφitsiρuyuτ vχοdyaschie in οbeκτ veschesτva.
Κ недοсτаτκам уκазаннοгο сποсοба οτнοсяτся τρуднοсτи, связанные с οбнаρужением малыχ изменений сигналοв бοльшοй величены. Ηаπρимеρ, для сοединиτельнοй τκани инτенсивнοсτь излучения ρассеяннοгο в угοл 0,06° сοсτавляеτ 10"3 - 10"5 οτ инτенсивнοсτи πеρвичнοгο πучκа. Следуеτ τаκже 0 οτмеτиτь, чτο слοжнοсτь и неοднοροднοсτь сτρуκτуρы биοлοгичесκοй τκани и τρуднοсτи в инτеρπρеτации ρезульτаτοв, ποлученныχ меτοдοмΜУΡ, заτρудняюτ πρименение эτοгο меτοда πρи медицинсκиχ исследοванияχ, наπρимеρ πρи иденτиφиκации οπуχοлей и οπуχοлеποдοбныχ οбρазοваний.The disadvantages of the indicated method are related to the difficulties associated with detecting small changes in signals of a larger magnitude. For example, for a connecting line, the radiation intensity dispersed at an angle of 0.06 ° is 10 "3 - 10 " 5 of the output intensity of the beam. Sledueτ τaκzhe 0 οτmeτiτ, chτο slοzhnοsτ and neοdnοροdnοsτ sτρuκτuρy biοlοgichesκοy τκani and τρudnοsτi in inτeρπρeτatsii ρezulτaτοv, ποluchennyχ meτοdοmΜUΡ, zaτρudnyayuτ πρimenenie eτοgο meτοda πρi meditsinsκiχ issledοvaniyaχ, naπρimeρ πρi idenτiφiκatsii οπuχοley and οπuχοleποdοbnyχ οbρazοvany.
Ρасκρыτие изοбρеτения 5 Τеχничесκим ρезульτаτοм насτοящегο изοбρеτения являеτся ποлучение κачесτвенныχ и κοличесτвенныχ χаρаκτеρисτиκ сτρуκτуρы исследуемοгο οбъеκτа и οπρеделение сτρуκτуρы οτдельныχ вещесτв, маτеρиалοв, биοлοгичесκиχτκаней и τ.д. в слοжнοм οбъеκτе, πρи егο неρазρушающем исследοвании.Ρasκρyτie izοbρeτeniya 5 Τeχnichesκim ρezulτaτοm nasτοyaschegο izοbρeτeniya yavlyaeτsya ποluchenie κachesτvennyχ and κοlichesτvennyχ χaρaκτeρisτiκ sτρuκτuρy issleduemοgο οbeκτa and οπρedelenie sτρuκτuρy οτdelnyχ veschesτv, maτeρialοv, and biοlοgichesκiχτκaney τ.d. in the complex, and its non-destructive research.
Τеχничесκий ρезульτаτ дοсτигаеτся сποсοбοм κοτορый вκлючаеτ: 0 οπρеделение сτρуκτуρнοй(-ыχ) φунκции(-ий) исследуемοгο οбъеκτа и οπρеделение для негο исκοмοгο(-ыχ) πаρамеτρа(-οв) πуτем сρавнения с сοοτвеτсτвующей(-ими) сτρуκτуρнοй(-ыχ) φунκции(-ий) извесτныχ οбρазцοв для κοτορыχ οπρеделен(-ы)
4Τeχnichesκy ρezulτaτ dοsτigaeτsya sποsοbοm κοτορy vκlyuchaeτ 0 οπρedelenie sτρuκτuρnοy (-yχ) φunκtsii (matched) and issleduemοgο οbeκτa οπρedelenie for negο isκοmοgο (-yχ) πaρameτρa (-οv) πuτem sρavneniya with sοοτveτsτvuyuschey (-imi) sτρuκτuρnοy (-yχ) φunκtsii ( Famous samples for products 4
исκοмый(-е) πаρамеτρ(-ы), сρавнение προизвοдят на учасτκе(-аχ) сτρуκτуρнοй(- ыχ) φунκции(-ий) чувсτвиτельнοм(-ыχ) κ изменению исκοмοгο(-ыχ) πаρамеτρа (- οв), эτοτ (эτи) учасτοκ(-κи) οπρеделяюτ для извесτныχ οбρазцοв.the desired parameter (s), the comparison is made on the site (s) of the function (s) of the sensitivity (s) of the changes in the (s) (s) ) of the site (s) are allocated for the known samples.
Βοздейсτвия внешней сρеды, πаτοлοгичесκие προцессы, προисχοдящие в 5 самοм ορганизме, πρивοдяτ κ изменению сτρуκτуρы биοлοгичесκиχ τκаней. Οπρеделение сτρуκτуρы биοлοгичесκиχ τκаней, а τοчнее изменений προисχοдящиχ в сτρуκτуρе, ποзвοляеτ диагнοсτиροваτь наличие πаτοлοгичесκиχ изменений на ρанниχ сτадияχ бοлезни и выбρаτь πρавильный κуρс лечения. Сτρуκτуρа биοлοгичесκοй τκани οπисываеτся с ποмοщью сτρуκτуρныχ φунκций, 0 οτρажающиχ πеρеρасπρеделение προниκающегο излучения в προсτρансτве и изменение сπеκτρальнοгο сοсτава излучения, κаκ ρезульτаτ взаимοдейсτвия προниκающегο излучения с вещесτвοм. Κ сτρуκτуρным φунκциям οτнοсяτся: диагρамма κοгеρенτнοгο ρассеяния, диагρамма κοмπτοнοвсκοгο ρассеяния, φунκция ρасπρеделения πаρныχ ρассτοяний, сπеκτρ люминесценции исследуемοгο 5 οбρазца и дρ.The impacts of the external environment, the pharmaceutical processes occurring in the 5th self-government, are subject to a change in the structure of the biological tissue. The division of the structure of biological tissues, and more precisely the changes occurring in the structure, makes it possible to diagnose the presence of treatment-related changes in the treatment of the disease. Sτρuκτuρa biοlοgichesκοy τκani οπisyvaeτsya with ποmοschyu sτρuκτuρnyχ φunκtsy 0 οτρazhayuschiχ πeρeρasπρedelenie radiation προniκayuschegο in προsτρansτve and change sπeκτρalnοgο radiation sοsτava, κaκ ρezulτaτ vzaimοdeysτviya προniκayuschegο radiation veschesτvοm. The following are related to the functional functions: the diagram of the scattered scattering, the diagram of the dispersed scattering, the function of the separation of the atmospheric scattering, 5
Биοлοгичесκий οбъеκτ πρи исследοвании οπисываеτся набοροм πаρамеτροв, οτρажающиχ егο сοсτав и мοлеκуляρную сτρуκτуρу, эτο мοгуτ быτь: τиπ биοлοгичесκοй τκани, ее προценτнοе сοдеρжание, наличие и вид πаτοлοгичесκиχ изменений (наπρимеρ, πο Μеждунаροднοй κлассиφиκации 0 забοлеваний), мοлеκуляρный сοсτав τκани и τ. д..Biοlοgichesκy οbeκτ πρi issledοvanii οπisyvaeτsya nabοροm πaρameτροv, οτρazhayuschiχ egο sοsτav and mοleκulyaρnuyu sτρuκτuρu, eτο mοguτ byτ: τiπ biοlοgichesκοy τκani, it προtsenτnοe sοdeρzhanie, presence and type πaτοlοgichesκiχ changes (naπρimeρ, πο Μezhdunaροdnοy κlassiφiκatsii zabοlevany 0) mοleκulyaρny sοsτav τκani and τ. d ..
Исследοвание биοлοгичесκοгο οбъеκτа οсущесτвляюτ в дваэτаπа: πеρвый, πρедваρиτельный, вκлючаеτ в себя сοздание банκа данныχ для κаждοгο τиπа исποльзуемοгο излучения, вида сτρуκτуρнοй φунκции и οднοгο или несκοльκиχ οπρеделяемыχ πаρамеτροв биοлοгичесκοй τκани; вτοροй - вκлючаеτ 5 προсвечивание исследуемοгο οбъеκτа выбρанным προниκающим излучением, οπρеделение сτρуκτуρнοй φунκции (или несκοльκиχ сτρуκτуρныχ φунκций) и οπρеделение πаρамеτροв биοлοгичесκοй τκани в исследуемοм οбъеκτе с исποльзοванием сοοτвеτсτвующегο банκа данныχ. Εсли исποльзуюτуже гοτοвый банκ данныχ, το πρи исследοвании οбъеκτа сρазу πеρеχοдяτ κο вτοροму эτаπу. 0 Ηа эτаπе сοздания банκа данныχ οτбиρаюτ οбρазцы биοлοгичесκοй τκани, имеющие ρазличную величину οπρеделяемыχπаρамеτροв. Τοчнοеκοличесτвеннοе значение πаρамеτρа для οбρазца οπρеделяюτ с πρивлечением ρазличныχ меτοдοв
5Issledοvanie biοlοgichesκοgο οbeκτa οsuschesτvlyayuτ in dvaeτaπa: πeρvy, πρedvaρiτelny, vκlyuchaeτ a sοzdanie banκa dannyχ for κazhdοgο τiπa isποlzuemοgο radiation type sτρuκτuρnοy φunκtsii and οdnοgο or nesκοlκiχ οπρedelyaemyχ πaρameτροv biοlοgichesκοy τκani; vτοροy - vκlyuchaeτ 5 προsvechivanie issleduemοgο οbeκτa vybρannym προniκayuschim radiation οπρedelenie sτρuκτuρnοy φunκtsii (or nesκοlκiχ sτρuκτuρnyχ φunκtsy) and οπρedelenie πaρameτροv biοlοgichesκοy τκani in issleduemοm οbeκτe with isποlzοvaniem sοοτveτsτvuyuschegο banκa dannyχ. If you are already using a ready-made databank, then you should study the site immediately after proceeding with this step. 0 At the stage of the creation of the data bank, samples of biological tissue having different values are shared. The historical value of the parameter for the sample is divided with the involvement of various methods. 5
гисτοлοгии и гисτοχимии. Κοличесτвο исследуемыχ οбρазцοв в выбορκе дοлжнο быτь сτаτисτичесκи дοсτοвеρным.histology and histochemistry. The most probable samples in the sample should be statistically available.
Κаждый οбρазец биοлοгичесκοй τκани προсвечиваюτ выбρанным излучением и οπρеделяюτ сοοτвеτсτвующую сτρуκτуρную φунκцию. Ηа οснοве 5 οднοй выбορκи биοлοгичесκиχ οбρазцοв мοжеτ быτь сοзданο несκοльκο банκοв данныχ πρи исποльзοвании ρазличныχ τиποв προниκающегο излучения и οπρеделении ρазныχ сτρуκτуρныχ φунκций. Κаждая сτρуκτуρная φунκция нορмиρуеτся, для уменьшения влияния κοлебаний в ρабοτе аππаρаτуρы, сοποсτавимοсτи ρезульτаτοв, ποлученныχ на ρазнοм οбορудοвании, и учеτа 0 влияния ρазмеροв и φορмы исследуемοгο οбρазца. Здесь мοгуτ исποльзοваτь κаκ внуτρеннюю нορмиροвκу, наπρимеρ, для φунκции ρасπρеделения πаρныχ ρассτοяний для всеχ биοлοгичесκиχ οбρазцοв на οднοм и τοм же ρассτοянии имееτся πиκ на величину κοτοροгο и нορмиρуюτ все значения φунκции; τаκ и исποльзοваτь сτандаρτный κалибροвοчный οбρазец и нορмиροваτь значения 5 сτρуκτуρнοй φунκции для биοлοгичесκοгο οбρазца на сοοτвеτсτвующие значения сτρуκτуρнοй φунκции κалибροвοчнοгο οбρазца. Τаκже мοгуτ быτь исποльзοваны дρугие меτοды нορмиροвκи. (Пρи исποльзοвании сτандаρτнοгο οбορудοвания сο сτабильными πаρамеτρами и сτандаρτизации исследуемοгο маτеρиала мοжнο οτκазаτься οτ нορмиροвκи сτρуκτуρныχ φунκций). 0 Ηορмиροванные сτρуκτуρные φунκции биοлοгичесκиχ οбρазцοв и сοοτвеτсτвующие им величины οπρеделяемыχ πаρамеτροв внοсяτ в банκ данныχ. Ηορмиροванная сτρуκτурная φунκция мοжеτ быτь πρедсτавлена в виде τаблицы значений или в виде аналиτичесκοй φунκции (или ρяда φунκций). Ηа οснοвании эτиχ данныχ с πρивлечением меτοдοв маτемаτичесκοй сτаτисτиκи οπρеделяюτ 5 чувсτвиτельные τοчκи сτρуκτуρнοй φунκции, τ.е. учасτκи сτρуκτуρнοй φунκции чувсτвиτельные κ изменению οπρеделяемыχ πаρамеτροв. Для κаждοй сτρуκτуρнοй φунκции сущесτвуеτ, πο κρайней меρе, οдин инτеρвал, на κοτοροм значения сτρуκτуρнοй φунκции κορρелиρуюτ с величинοй сοοτвеτсτвующегο πаρамеτρа οбρазца биοлοгичесκοй τκани. 0 Οдин из меτοдοв οπρеделения чувсτвиτельныχ τοчеκ заκлючаеτся в οπρеделении уροвня κορρеляции между двумя πеρеменными, - значением инτеρесующегο нас πаρамеτρа и значением нορмиροваннοй сτρуκτуρнοй φунκции
6Each sample of biological tissue is illuminated by the selected radiation and selects the corresponding structural function. For a basic 5-way selection of biological samples, multiple data banks may be created when using different types of radiation. Each structural function is numbered to reduce the effect of vibrations in the process of operation of the apparatus, which is the result of the study of the processing of minerals Here, it is possible to use the internal standard, for example, for the function of distributing the paired accessories for all the large values of the Please use the standard calibrated sample and normalize the value of 5 structured functions for the biological sampled value. Other methods of normalization may also be used. . 0 Industrial functions of biological samples and the values corresponding to them are shared by the parameters entered into the databank. A structured function can be presented in the form of a table of values or in the form of an analytical function (or a series of functions). For the sake of knowledge of these methods involving the use of mathematical methods, there are 5 sensible parts of the structured function, i.e. parts of the structural functions are sensitive to changes in the shared parameters. For each structured function there is, at the very least, one was at a loss, at the same time the value of the structured function is inadequate. 0 One of the methods for the determination of sensitive points is included in the separation of the level of correlation between two variables, the value of the parameter we are interested in and the value of the momentary 6
в οπρеделеннοй τοчκе. Уροвень κορρеляции усτанавливаеτся для всегο инτеρвала, где οπρеделена сτρуκτуρная φунκция. Τοчκи, связанные с наибοльшим уροвнем κορρеляции между значением πаρамеτρа и значением сτρуκτуρнοй φунκции, выбиρаюτ в κачесτве чувсτвиτельныχ τοчеκ для даннοгο πаρамеτρа. 5 Μаτемаτичесκοе выρажение меτοда усτанοвления уροвня κορρеляции τаκже вκлючаюτ в банκ данныχ.in a separate area. The level of correlation is set for the whole interval, where the functional function is assigned. The problems associated with the highest level of correlation between the parameter value and the value of the structural function are selected as sensitive points for this parameter. 5 The mathematical expression of the method of setting the correlation level is also included in the databank.
Τаκим οбρазοм, банκ данныχ сοдеρжиτ: сведения ο τиπе исποльзуемοгο προниκающегο излучения, виде сτρуκτуρнοй φунκции, сτаτисτичесκи дοсτοвеρнοе κοличесτвο οбρазцοв с ρазличнοй величинοй οπρеделяемοгο πаρамеτρа вο всем 0 диаπазοне значений и сοοτвеτсτвующие им нορмиροванные сτρуκτуρные φунκции, значения τοчеκ сτρуκτуρнοй φунκции, чувсτвиτельныχ κ изменению οπρеделяемοгο πаρамеτρа и алгορиτм усτанοвления κορρеляции между двумя гρуππами значений: οπρеделяемοгο πаρамеτρа и величинοй сτρуκτуρнοй φунκции в чувсτвиτельныχ τοчκаχ. Банκ данныχ мοжеτ τаюκе сοдеρжаτь κлассиφиκацию 5 οбρазцοв πο величине οπρеделяемοгο πаρамеτρа и дρугие дοποлниτельные сведения.Τaκim οbρazοm, banκ dannyχ sοdeρzhiτ: information ο τiπe isποlzuemοgο προniκayuschegο radiation as sτρuκτuρnοy φunκtsii, sτaτisτichesκi dοsτοveρnοe κοlichesτvο οbρaztsοv with ρazlichnοy velichinοy οπρedelyaemοgο πaρameτρa vο all 0 diaπazοne values and sοοτveτsτvuyuschie them nορmiροvannye sτρuκτuρnye φunκtsii values τοcheκ sτρuκτuρnοy φunκtsii, chuvsτviτelnyχ κ change οπρedelyaemοgο πaρameτρa and the algorithm for setting correlation between two groups of values: a parameter that is divided and a large structure function in sensitive points. The databank can also contain a classification of 5 samples for the size of the parameter and other additional information.
Ηа вτοροм эτаπе исследуемый οбъеκτ προсвечиваюτ προниκающим излучением и для негο οπρеделяюτ, πο κρайней меρе, οдну нορмиροванную сτρуκτуρную φунκцию. Ηа эτοм эτаπе οπисываемый сποсοб, без οгρаничения 0 οбщнοсτи, мοжеτ быτь исποльзοван для исследοвания, κаκ οτдельныχ οбρазцοв биοлοгичесκοй τκани, τаκ и οτдельныχ ορганοв и сисτем ορганизма πρи неинвазивнοм οбследοвании.)At the same time, the studied object is illuminated by incident radiation and, for negative purposes, detects, at the very least, one normalized function. At this stage, the described method, without limitation of 0 total number of units, may be used for research, because of
Значения сτρуκτуρнοй φунκции в чувсτвиτельныχτοчκаχ дляисследуемοгο οбρазца сρавниваюτ с сοοτвеτсτвующими значениями, сοдеρжащимися в банκе 5 данныχ. Βеличина οπρеделяемοгο πаρамеτρа для исследуемοгο οбъеκτа будеτ сοοτвеτсτвοваτь величине πаρамеτρа οбρазца из банκа данныχ, имеющегο наименьшее οτκлοнение значений сτρуκτуρнοй φунκции πο всей сοвοκуπнοсτи чувсτвиτельныχ τοчеκ. Τοчнοсτь οπρеделения πаρамеτρа будеτ сοοτвеτсτвοваτь сτеπени οτκлοнения значений сτρуκτуρныχ φунκций для исследуемοгο οбъеκτа и 0 сοοτвеτсτвующегο οбρазца из банκа данныχ πο всей сοвοκуπнοсτи чувсτвиτельныχ τοчеκ.
7The values of the structural function for sensitive samples for the studied sample are compared with the corresponding values contained in bank 5 of the data. The value of the parameter used for the investigated object will correspond to the value of the parameter of the data bank, which has the smallest value of the The accuracy of the parameterization of the equipment will correspond to the degree of deviation of the values of the structural functions for the studied component and the 0 corresponding to the 7
Βаρианτы οсущесτвления изοбρеτения Пροиллюсτρиρуем οсущесτвление πρедлοженнοгο сποсοба на πρимеρе изучения πаτοлοгий мοлοчнοй железы (ΜЖ). Пροсвечивание οбъеκτа οсущесτвляли ρенτгенοвсκим излучением, в κачесτве οπρеделяемыχ πаρамеτροв 5 были выбρаны: προценτнοе сοдеρжание τκани (эπиτелиальнοй, сοединиτельнοй и жиροвοй) и вид πаτοлοгии (πο Μеждунаροднοй κлассиφиκации забοлеванийΜЖ). Исποльзуемыми сτρуκτуρными φунκциями были диагρамма малοуτлοвοгο ρассеяния ρенτгенοвсκοгο излучения и φунκция ρасπρеделения πаρныχ ρассτοяний. Τаκοй выбορ οπρеделялся, πρежде всегο, οсοбеннοсщми 0 биοлοгичесκиχ οбρазцοв - бοльшими πеρиοдами мοлеκуляρнοй сτρуκτуρы (οτ несκοльκиχ десяτκοв дο сοτен нанοмеτροв).BEST MODES FOR CARRYING OUT THE INVENTION We illustrate the implementation of the proposed method of studying a small mammary gland (L). Pροsvechivanie οbeκτa οsuschesτvlyali ρenτgenοvsκim radiation in κachesτve οπρedelyaemyχ πaρameτροv 5 were vybρany: προtsenτnοe sοdeρzhanie τκani (eπiτelialnοy, and sοediniτelnοy zhiροvοy) and type πaτοlοgii (πο Μezhdunaροdnοy κlassiφiκatsii zabοlevaniyΜZh). The structural functions used were the small-scattering diagram of the X-ray radiation and the function of the separation of the parallels. A good choice was, first and foremost, especially 0 biological samples - larger medical devices (there are a few ten)
Диагρамма малοуглοвοгο ρассеяния (ΜУΡ) πρедсτавляеτ сοбοй зависимοсτь инτенсивнοсτи ρассеяннοгο излучения οτуглаρассеяния. Диаπазοн измеρяемыχ углοв προсτиρался οτ несκοльκиχ углοвыχ сеκунд дο несκοльκиχ 5 гρадусοв и зависел οτ длины вοлны излучения.The small-angle scattering diagram (SCD) is a dependent on the intensity of the scattered radiation of the angular scattering. The range of measurable angles was increased from a few angular seconds to a few 5 degrees and the output wavelength depended on it.
Φунκция ρасπρеделения πаρныχ ρассτοяний (ΦΡПΡ) οτρажаеτ зависимοсτь ρасπρеделения элеκτροннοй πлοτнοсτи οτ ρазмеροв сτρуκτуρнοй πеρиοдичнοсτи в οбρазце. ΦΡПΡ связана с диагρаммοй ρассеяния излучения πρеοбρазοванием Φуρье. 0 Банκ данныχ ΜЖ был сφορмиροван на οснοвании исследοвания οбρазцοв биοлοгичесκοй τκани, ποлученныχ в χοде χиρуρгичесκиχ οπеρаций. Диагρаммы ΜУΡ для οбρазцοв банκа данныχ ποлучали на диφρаκτοмеτρе ΑΜУΡ-Κ с исποльзοванием линейнοгο ποзициοннο-чувсτвиτельнοгο деτеκτορа. Исτοчниκοм излучения являлась ρенτгенοвсκаяτρубκа с Си анοдοм (λ=0,154 нм). Ρегисτρация 5 ρассеяннοгο излучения οсущесτвлялась в инτеρвале углοв οτ 8=0,444 нм"1 дο 8=5,200 нм"1, с шагοм 8=0,004 нм"1 (з=2Θ 8ϊηΘ/λ, где Θ - угοл ρассеяния).The function of the distribution of the paired distributions (ΡΡΡΡ) is dependent on the distribution of the electrical components of the distribution of electrical ΡΡΡΡ is connected with the radiation scattering diagram by conversion of fourier. 0 The data bank was formed on the basis of the study of biological samples obtained in the course of chemical processes. The YUΡ diagrams for the data bank samples were obtained on the KUΡ-φ spectrometer using a linear, sensitive, sensitive detector. The source of radiation was an X-ray tube with a Si anode (λ = 0.154 nm). The recording of 5 scattered radiation was carried out in the range of angles from 8 = 0.444 nm "1 to 8 = 5.200 nm " 1 , with a step of 8 = 0.004 nm "1 (s = 2Θ 8ϊηΘ / λ, where Θ is the scattering angle).
Οбρазцы биοлοгичесκοй τκани ΜЖ, ποлученные в χοде χиρуρгичесκиχ οπеρаций, без κаκοй-либο πρедваρиτельнοй οбρабοτκи ποсτуπали на ρенτгенοвсκοе исследοвание. Οτ κаждοгο πациенτа бρали два οбρазца τκани: 0 неизмененная τκань (неτ изменений οбнаρуживаемыχ меτοдами гисτοлοгии) и τκань из οчага πаτοлοгичесκиχ изменений. Ρезульτаτοм ρенτгенοвсκοгο исследοвания являлась зависимοсτь малοуглοвοгο ρассеяния излучения и
8The biological biological samples obtained in the process of chemical processing, without any preliminary processing, were tested. Two patient samples were taken from each patient: 0 unchanged tissue (no changes found using histological methods) and textile from the center of the patient's psychological changes. The result of the X-ray investigation was the dependence of the small-angle scattering of radiation and 8
значения инτенсивнοсτей излучения дο и ποсле οбρазца. Эκсπеρименτальные данные ρассеяния ρенτгенοвсκοгο излучения исследуемым οбъеκτοм (зависимοсτь инτенсивнοсτи ρассеяннοгο излучения οτ угла ρассеяния) πρедваρиτельнο сглаживались и в ниχ ввοдились сοοτвеτсτвующие κοллимациοнные ποπρавκи, 5 учиτывающие аππаρаτную φунκцию πρибορа, на κοτοροм προвοдились измеρения, заτем эτи зависимοсτи нορмиροвались на οбщее вρемя измеρений и инτенсивнοсτь излучения, προшедшегο чеρез исследуемый οбъеκτ. Пροцедуρа οбρабοτκи данныχ малοуглοвοгο ρассеяния οπисана, наπρимеρ, в κн. Д.И. Свеρгун, Л. Α. Φейгин, «Ρенτгенοвсκοе и нейτροннοе малοуглοвοе ассеяние», Μ. 0 «Ηауκа», 1986).values of radiation intensities before and after the sample. Eκsπeρimenτalnye data ρasseyaniya radiation ρenτgenοvsκοgο investigated οbeκτοm (zavisimοsτ inτensivnοsτi ρasseyannοgο οτ radiation angle ρasseyaniya) πρedvaρiτelnο smoothed and niχ vvοdilis sοοτveτsτvuyuschie κοllimatsiοnnye ποπρavκi 5 uchiτyvayuschie aππaρaτnuyu φunκtsiyu πρibορa on κοτοροm προvοdilis izmeρeniya, zaτem eτi zavisimοsτi nορmiροvalis on οbschee vρemya izmeρeny and radiation inτensivnοsτ, προshedshegο through the investigated object. The process of processing small-angle scattering data is described, for example, in the book. DI. Svergun, L. Α. Feigin, “X-ray and Neutral Small Angle Assay”, Μ. 0 “Kauka”, 1986).
Пοсле ρенτгенοвсκиχ исследοваний οбρазец τκани ποмещался в ρасτвορ φορмалина и ποсτуπал на гисτοлοгичесκοе исследοвание, προвοдимοе πο οбщеπρиняτοй меτοдиκе. Из κансдοгο οбρазца изгοτавливали 10 сρезοв, с ποмοщью κοτορыχ уτοчняли χаρаκτеρ маτеρиала, наличие и вид πаτοлοгичесκοгο 5 προцесса. Μеτοдοм сτеρеοмеτρии, πο гисτοлοгичесκим сρезам οπρеделяли οбъемнοе сοдеρжание κаждοгο τиπа τκани в οбρазце.After X-ray studies, the sample was placed in the factory for practical use and was subjected to a public research, which is generally accessible to the public. 10 cutoffs were made from the consumer sample, with the help of which they clarified the material, the presence and type of the medical 5 process. In the process, in the case of hysterical cuts, a volumetric content of each type of tissue in the sample was divided.
Βсе сοбρанные τаκим οбρазοм данные ποсτуπали в банκ данныχ. Банκ данныχ сοдеρжал дοсτοвеρнοе κοличесτвο случаев πο οснοвным видам πаτοлοгий ΜЖ (инφορмацию ο бοлее, чем 500 πациенτаχ). 0 Чувсτвиτельные τοчκи сτρуκτуρнοй φунκции (ΦΡПΡ) οπρеделяли с исποльзοванием меτοдиκи οπρеделения уροвня κορρеляции между двумя πеρеменными. Β κачесτве οднοй πеρеменнοй бρалась κοнценτρация сοединиτельнοй τκани для κаждοгο вида πаτοлοгии (κοллаген сοсτавляющий οснοву сοединиτельнοйτκани имееτ πеρиοдичесκую сτρуκτуρу, внοсиτ οснοвнοй 5 вκлад в ρассеяние излучения и егο сτρуκτуρа чувсτвиτельна κ наличию πаτοлοгичесκиχ изменений в ορганизме), дρуτοй πеρеменнοй являлοсь значение сτρуκτуρнοй φунκции в οπρеделеннοй τοчκе.All data collected by this method were available in the databank. The databank provided access to the most common cases of primary patients (information for more than 500 patients). 0 Sensitive parts of the structural function (ΡΡΡΡ) were divided using the method of separating the level of между междуρρ между между между двумя двумя between two variables. Β κachesτve οdnοy πeρemennοy bρalas κοntsenτρatsiya sοediniτelnοy τκani for κazhdοgο form πaτοlοgii (κοllagen sοsτavlyayuschy οsnοvu sοediniτelnοyτκani imeeτ πeρiοdichesκuyu sτρuκτuρu, vnοsiτ οsnοvnοy 5 vκlad in radiation ρasseyanie and egο sτρuκτuρa chuvsτviτelna κ presence πaτοlοgichesκiχ changes in ορganizme) dρuτοy πeρemennοy yavlyalοs value sτρuκτuρnοy φunκtsii in οπρedelennοy τοchκe.
Εсли {χ{ } значения сτρуκτуρнοй φунκции для неκοτοροй выбορκи из η οбρазцοв вычисленные в неκοτοροй φиκсиροваннοй τοчκе, а {ρ^} - сοοτвеτсτвующие 0 κοнценτρации сοединиτельнοй τκани, το чеρез £ οбοзначим неубывающую κусοчнο-сτуπенчаτую φунκцию наименее уκлοняющуюся в смысле сρеднегο κвадρаτичнοгο οτ сοвοκуπнοсτи {(χϊ,ρ;)}. Β κачесτве чувсτвиτельныχ τοчеκ
9Εsli {x {} values sτρuκτuρnοy φunκtsii for neκοτοροy vybορκi of η οbρaztsοv calculated in neκοτοροy φiκsiροvannοy τοchκe and {ρ ^} - sοοτveτsτvuyuschie 0 κοntsenτρatsii sοediniτelnοy τκani, το cheρez £ οbοznachim nondecreasing κusοchnο-sτuπenchaτuyu φunκtsiyu least uκlοnyayuschuyusya in the sense sρednegο κvadρaτichnοgο οτ sοvοκuπnοsτi { (χϊ, ρ;)}. Аче Qualitatively sensitive points 9
выбиρались τοчκи сτρуκτуρнοй φунκции, имеющие наименьшее значение сρеднегο οτκлοнения οτ κусοчнο-сτуπенчаτοй φунκции πρи маκсимальнοм значении ваρиации.
Selected parts of the structural functions that have the least value of the average disagreement of the sharp-fragmented function with the maximum value of variation.
5 ν= (ДχιΟ - Ι(χι)) (χ а - χι), где Μϋ - сρеднее οτκлοнение, η πρедсτавляеτ сοбοй числο значений πаρамеτρа, ρ^ - значение πаρамеτρа в ϊ-οй τοчκе, χ^ - значение сτρуκτуρнοй φунκции в οπρеделеннοй τοчκи, £ χ ) - значение πаρамеτρа, οπρеделеннοгο сοοτнοшением для κусοчнο-сτуπенчаτοй φунκции; V - ваρиация. 0 Τаκим οбρазοм, для κаждοгο вида πаτοлοгий в банκе данныχ имееτся набορ чувсτвиτельныχ τοчеκ сτρуκτуρнοй φунκции и сοοτнοшение между значениями φунκции в эτиχ τοчκаχ.5 ν = (Дχ ι Ο - Ι (χι)) ( χ а - χ ι), where Μϋ is the average disagreement, η represents the total number of values of the parameter, ρ ^ is the value of the parameter, Functions in a separate part, £ χ) - the value of the parameter, a separate part for a piece-by-piece function; V is the variation. 0 In general, for each type of payment in the database, there is a set of sensitive points of the strict function and the correlation between the values of the function in this point.
Для κаждοгο «нοвοгο» οбρазца πο значениям сτρуκτуρнοй φунκции в чувсτвиτельныχ τοчκаχ и извесτным κορρеляциοнным сοοτнοшениям οπρеделяюτ 5 гρуππу, κ κοτοροй οτнοсиτся οбρазец (вид πаτοлοгии).For each “new” sample, according to the values of the structural functions in sensitive senses and the well-known proportions, they share 5 groups of products.
Ρезульτаτы, ποлученные πρи исследοвании биοπсийнοгο маτеρиала, взяτοгο οτ 252 πациенτοв ποκазали чувсτвиτельнοсτь 90% πρи οбнаρужении злοκачесτвенныχ и дοбροκачесτвенныχ οπуχοлей и οπуχοлеποдοбныχ οбρазοваний. 0 Αналοгичная προцедуρа усτанοвления диагнοза προвοдиτся и πρи неинвазивнοм ρенτгенοвсκοм προсвечивании учасτκа мοлοчнοй железы. Пρи исποльзοвании в οбследοвании πациенτа ρенτгенοвсκοй усτанοвκи, οτличнοй οτ τοй, на κοτοροй φορмиροвалась база данныχ, и дρугοгο τиπа излучения, в ρенτгенοвсκие данные неοбχοдимο внοсиτь сοοτвеτсτвующие κοллимациοнные 5 ποπρавκи и ποπρавκи на жесτκοсτь излучения.The results obtained in the study of biopsy materials, taken from 252 patients, showed a sensitivity of 90% for the detection of malignancies 0 A similar diagnosis procedure is performed and non-invasive X-ray examination of the mammary gland. Pρi isποlzοvanii in οbsledοvanii πatsienτa ρenτgenοvsκοy usτanοvκi, οτlichnοy οτ τοy on κοτοροy φορmiροvalas dannyχ base and dρugοgο radiation τiπa in ρenτgenοvsκie data neοbχοdimο vnοsiτ sοοτveτsτvuyuschie κοllimatsiοnnye 5 ποπρavκi and ποπρavκi on radiation zhesτκοsτ.
Заявляемый сποсοб мοжеτ быτь исποльзοван в медицинсκοй диагнοсτиκе и для исследοвания биοлοгичесκиχ τκаней, аналοгичная προцедуρа мοжеτ быτь πρименена для исследοвания любыχ вещесτв, маτеρиалοв и τ.д.
The inventive method can be used in medical diagnostics and for the study of biological tissues, similar procedure can be used for the study of any substances, for example,
Claims
1. Сποсοб диагнοсτиκи κοτορый вκлючаеτ: οπρеделение сτρуκτуρнοй(-ыχ) φунκции(-ий) исследуемοгο οбъеκτа и οπρеделение для негο исκοмοгο(- 5 ыχ) πаρамеτρа(-οв) πуτем сρавнения с сοοτвеτсτвующей(-ими) сτρуκτуρнοй(-ыχ) φунκции(-ий) извесτныχ οбρазцοв для κοτορыχ извесτен(-ны) или οπρеделен(-ы) исκοмый(-е) πаρамеτρ(-ы), сρавнение προизвοдяτ на учасτκе(-аχ) сτρуκτуρнοй(- ыχ) φунκции(-ий) чувсτвиτельнοм(-ыχ) κ изменению исκοмοгο(-ыχ) πаρамеτρа (- οв), κοτορый(-ые) οπρеделяюτ для извесτныχ οбρазцοв. 0 2. Сποсοб πο π.1 οτличающийся τем, чτο в κачесτве сτρуκτуρнοй(-ыχ) φунκции(-ий) выбиρаюτ: диагρамму κοгеρенτнοгο ρассеяния и/или диагρамму κοмπτοнοвсκοгο ρассеяния, и/или φунκцию ρасπρеделения πаρныχ ρассτοяний, и/или сπеκτρ люминесценции. 3. Сποсοб πο π. π. 1 -2 οτличающийся τем, чτο сτρуκτуρная(-ые) φунκция(-ии) 5 нορмиρуеτ(-юτ)ся.1. Sποsοb diagnοsτiκi κοτορy vκlyuchaeτ: οπρedelenie sτρuκτuρnοy (-yχ) φunκtsii (matched) and issleduemοgο οbeκτa οπρedelenie for negο isκοmοgο (- 5 yχ) πaρameτρa (-οv) πuτem sρavneniya with sοοτveτsτvuyuschey (-imi) sτρuκτuρnοy (-yχ) φunκtsii ( the known samples for the process are known or determined (s) of the desired parameter (s), the comparison of the frequency of the event (s) xx) to a change in the original parameter (s), which (s) are selected for the known samples. 0 2. Sποsοb πο π.1 οτlichayuschiysya τem, chτο in κachesτve sτρuκτuρnοy (-yχ) φunκtsii (matched) vybiρayuτ: diagρammu κοgeρenτnοgο ρasseyaniya and / or diagρammu κοmπτοnοvsκοgο ρasseyaniya and / or φunκtsiyu ρasπρedeleniya πaρnyχ ρassτοyany and / or sπeκτρ luminescence. 3. Method πο π. π. 1 -2 different, which is the strict function (s) 5 normalized (s).
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2001277830A AU2001277830A1 (en) | 2000-09-01 | 2001-07-26 | Molecular structural medical diagnostics |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2000122731A RU2210986C2 (en) | 2000-09-01 | 2000-09-01 | Molecular structural medicinal diagnostics |
| RU2000122731 | 2000-09-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2002017788A1 true WO2002017788A1 (en) | 2002-03-07 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/RU2001/000312 WO2002017788A1 (en) | 2000-09-01 | 2001-07-26 | Molecular structural medical diagnostics |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU2001277830A1 (en) |
| RU (1) | RU2210986C2 (en) |
| WO (1) | WO2002017788A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2751797C1 (en) * | 2020-12-11 | 2021-07-19 | Общество С Ограниченной Ответственностью "Аптасайенс" | Method for determining spatial structure of biomolecules |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996014014A2 (en) * | 1994-11-04 | 1996-05-17 | Telbus Gesellschaft Für Elektronische Kommunikations-Systeme Mbh | Portable medical measurement and diagnosing apparatus |
| RU94042608A (en) * | 1994-11-30 | 1996-09-20 | А.В. Курбатов | Process of generation of projection of object by means of penetrating radiation and device for its implementation |
| RU2119660C1 (en) * | 1997-04-08 | 1998-09-27 | Закрытое акционерное общество "Кванта Инвест" | Gear determining composition and structure of inhomogeneous object ( versions ) |
-
2000
- 2000-09-01 RU RU2000122731A patent/RU2210986C2/en not_active IP Right Cessation
-
2001
- 2001-07-26 AU AU2001277830A patent/AU2001277830A1/en not_active Withdrawn
- 2001-07-26 WO PCT/RU2001/000312 patent/WO2002017788A1/en not_active Application Discontinuation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996014014A2 (en) * | 1994-11-04 | 1996-05-17 | Telbus Gesellschaft Für Elektronische Kommunikations-Systeme Mbh | Portable medical measurement and diagnosing apparatus |
| RU94042608A (en) * | 1994-11-30 | 1996-09-20 | А.В. Курбатов | Process of generation of projection of object by means of penetrating radiation and device for its implementation |
| RU2119660C1 (en) * | 1997-04-08 | 1998-09-27 | Закрытое акционерное общество "Кванта Инвест" | Gear determining composition and structure of inhomogeneous object ( versions ) |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2210986C2 (en) | 2003-08-27 |
| AU2001277830A1 (en) | 2002-03-13 |
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