WO2002012523A3 - Vecteurs d'apport de gene a specificite de type cellulaire pour chondrocytes humains primaires - Google Patents

Vecteurs d'apport de gene a specificite de type cellulaire pour chondrocytes humains primaires Download PDF

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Publication number
WO2002012523A3
WO2002012523A3 PCT/NL2001/000595 NL0100595W WO0212523A3 WO 2002012523 A3 WO2002012523 A3 WO 2002012523A3 NL 0100595 W NL0100595 W NL 0100595W WO 0212523 A3 WO0212523 A3 WO 0212523A3
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WO
WIPO (PCT)
Prior art keywords
chondrocytes
transduction
adenoviral vectors
nucleic acid
delivery vehicle
Prior art date
Application number
PCT/NL2001/000595
Other languages
English (en)
Other versions
WO2002012523A2 (fr
Inventor
Menzo Jans Emco Havenga
Ronald Vogels
Abraham Bout
Original Assignee
Crucell Holland Bv
Menzo Jans Emco Havenga
Ronald Vogels
Abraham Bout
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Crucell Holland Bv, Menzo Jans Emco Havenga, Ronald Vogels, Abraham Bout filed Critical Crucell Holland Bv
Priority to EP01974977A priority Critical patent/EP1307573B1/fr
Priority to CA2418977A priority patent/CA2418977C/fr
Priority to AU9434801A priority patent/AU9434801A/xx
Priority to DE60116513T priority patent/DE60116513T2/de
Publication of WO2002012523A2 publication Critical patent/WO2002012523A2/fr
Publication of WO2002012523A3 publication Critical patent/WO2002012523A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10345—Special targeting system for viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
    • C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
    • C12N2810/6009—Vectors comprising as targeting moiety peptide derived from defined protein from viruses dsDNA viruses
    • C12N2810/6018—Adenoviridae

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PCT/NL2001/000595 2000-08-10 2001-08-09 Vecteurs d'apport de gene a specificite de type cellulaire pour chondrocytes humains primaires WO2002012523A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP01974977A EP1307573B1 (fr) 2000-08-10 2001-08-09 Vecteurs adenoviraux pour la transduction de chondrocytes
CA2418977A CA2418977C (fr) 2000-08-10 2001-08-09 Vecteurs de transfert de genes presentant une specificite vis-a-vis des chondrocytes humains primaires
AU9434801A AU9434801A (en) 2000-08-10 2001-08-09 Gene delivery vectors with cell type specificity for primary human chondrocytes
DE60116513T DE60116513T2 (de) 2000-08-10 2001-08-09 Adenovirenvektoren zur transduktion der chondrozyten

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP00202835.5 2000-08-10
EP00202835 2000-08-10
US22491100P 2000-08-11 2000-08-11
US60/224,911 2000-08-11

Publications (2)

Publication Number Publication Date
WO2002012523A2 WO2002012523A2 (fr) 2002-02-14
WO2002012523A3 true WO2002012523A3 (fr) 2002-04-25

Family

ID=26072592

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/NL2001/000595 WO2002012523A2 (fr) 2000-08-10 2001-08-09 Vecteurs d'apport de gene a specificite de type cellulaire pour chondrocytes humains primaires

Country Status (8)

Country Link
US (2) US6803234B2 (fr)
EP (1) EP1307573B1 (fr)
AT (1) ATE315095T1 (fr)
AU (1) AU9434801A (fr)
CA (1) CA2418977C (fr)
DE (1) DE60116513T2 (fr)
ES (1) ES2256302T3 (fr)
WO (1) WO2002012523A2 (fr)

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US20030017138A1 (en) * 1998-07-08 2003-01-23 Menzo Havenga Chimeric adenoviruses
US20060238702A1 (en) 1999-04-30 2006-10-26 Advanced Medical Optics, Inc. Ophthalmic lens combinations
US6492169B1 (en) 1999-05-18 2002-12-10 Crucell Holland, B.V. Complementing cell lines
EP1157999A1 (fr) * 2000-05-24 2001-11-28 Introgene B.V. Méthodes et moyens pour améliorer la transplantation de la peau en utilisant des vecteurs d'apport de genes munis d'un tropisme pour des fibroblastes primaires ainsi que d'autres utilisations de celles-ci
ATE315095T1 (de) * 2000-08-10 2006-02-15 Crucell Holland Bv Adenovirenvektoren zur transduktion der chondrozyten
US7763069B2 (en) 2002-01-14 2010-07-27 Abbott Medical Optics Inc. Accommodating intraocular lens with outer support structure
US7662180B2 (en) 2002-12-05 2010-02-16 Abbott Medical Optics Inc. Accommodating intraocular lens and method of manufacture thereof
US7927599B2 (en) 2003-09-08 2011-04-19 Ethicon, Inc. Chondrocyte therapeutic delivery system
US8257963B2 (en) 2007-06-01 2012-09-04 Depuy Mitek, Inc. Chondrocyte container and method of use
US7897384B2 (en) * 2003-09-08 2011-03-01 Ethicon, Inc. Chondrocyte therapeutic delivery system
US20050131535A1 (en) 2003-12-15 2005-06-16 Randall Woods Intraocular lens implant having posterior bendable optic
CN100361710C (zh) * 2004-06-07 2008-01-16 成都康弘生物科技有限公司 肿瘤细胞专一表达免疫调节因子gm-csf的溶瘤性腺病毒重组体的构建及其应用
WO2006061824A2 (fr) * 2004-12-06 2006-06-15 Prochon Biotech Limited Implant a base de chondrocytes pour l'administration d'agents therapeutiques
US8921109B2 (en) 2005-09-19 2014-12-30 Histogenics Corporation Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof
US9636213B2 (en) 2005-09-30 2017-05-02 Abbott Medical Optics Inc. Deformable intraocular lenses and lens systems
US20080161914A1 (en) 2006-12-29 2008-07-03 Advanced Medical Optics, Inc. Pre-stressed haptic for accommodating intraocular lens
US20090054984A1 (en) 2007-08-20 2009-02-26 Histogenics Corporation Method For Use Of A Double-Structured Tissue Implant For Treatment Of Tissue Defects
US8685107B2 (en) 2007-07-03 2014-04-01 Histogenics Corporation Double-structured tissue implant and a method for preparation and use thereof
US8034108B2 (en) 2008-03-28 2011-10-11 Abbott Medical Optics Inc. Intraocular lens having a haptic that includes a cap
AU2010266020B2 (en) 2009-06-26 2015-03-26 Johnson & Johnson Surgical Vision, Inc. Accommodating intraocular lenses
US8343217B2 (en) 2009-08-03 2013-01-01 Abbott Medical Optics Inc. Intraocular lens and methods for providing accommodative vision
CA2857087C (fr) 2011-11-28 2021-05-25 Crucell Holland B.V. Vaccins contre le virus de la grippe et leurs utilisations
US9084674B2 (en) 2012-05-02 2015-07-21 Abbott Medical Optics Inc. Intraocular lens with shape changing capability to provide enhanced accomodation and visual acuity
EP2971008B1 (fr) 2013-03-14 2018-07-25 Salk Institute for Biological Studies Compositions d'adénovirus oncolytiques
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
EP3390428B1 (fr) 2016-02-23 2019-09-25 Salk Institute for Biological Studies Dosage à haut débit pour mesurer la cinétique de réplication d'un adénovirus
KR102471633B1 (ko) 2016-02-23 2022-11-25 솔크 인스티튜트 포 바이올로지칼 스터디즈 바이러스 동역학에 미치는 영향 최소화를 위한 치료용 아데노바이러스의 외인성 유전자 발현
AU2017375633C1 (en) 2016-12-12 2023-04-27 Salk Institute For Biological Studies Tumor-targeting synthetic adenoviruses and uses thereof
AU2018330604A1 (en) 2017-09-11 2020-04-02 Amo Groningen B.V. Methods and apparatuses to increase intraocular lenses positional stability

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000003029A2 (fr) * 1998-07-08 2000-01-20 Introgene B.V. Adenovirus chimeres
WO2000052186A1 (fr) * 1999-03-04 2000-09-08 Introgene B.V. Transduction de cellules ressemblant a des fibroblastes ou a des macrophages et moyens a cet effet

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US5846782A (en) * 1995-11-28 1998-12-08 Genvec, Inc. Targeting adenovirus with use of constrained peptide motifs
CA2342396A1 (fr) * 1998-09-11 2000-03-23 Genvec, Inc. Adenovirus a ciblage altnernatif
US6869936B1 (en) * 1999-03-04 2005-03-22 Crucell Holland B.V. Means and methods for fibroblast-like or macrophage-like cell transduction
US6315992B1 (en) * 1999-06-30 2001-11-13 Tissuegene Co. Generating cartilage in a mammal using fibroblasts transfected with a vector encoding TGF-β-1
US6445314B1 (en) * 2000-03-01 2002-09-03 Cisco Technology Inc. System and method for the decoding of variable length codes
US6939540B1 (en) * 2000-07-31 2005-09-06 Cornell Research Foundation, Inc. Method of enhancing bone density
ATE315095T1 (de) * 2000-08-10 2006-02-15 Crucell Holland Bv Adenovirenvektoren zur transduktion der chondrozyten

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
WO2000003029A2 (fr) * 1998-07-08 2000-01-20 Introgene B.V. Adenovirus chimeres
WO2000052186A1 (fr) * 1999-03-04 2000-09-08 Introgene B.V. Transduction de cellules ressemblant a des fibroblastes ou a des macrophages et moyens a cet effet

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Also Published As

Publication number Publication date
DE60116513D1 (de) 2006-03-30
ES2256302T3 (es) 2006-07-16
ATE315095T1 (de) 2006-02-15
US20020115218A1 (en) 2002-08-22
WO2002012523A2 (fr) 2002-02-14
US6803234B2 (en) 2004-10-12
AU9434801A (en) 2002-02-18
CA2418977C (fr) 2011-01-18
CA2418977A1 (fr) 2002-02-14
EP1307573A2 (fr) 2003-05-07
EP1307573B1 (fr) 2006-01-04
DE60116513T2 (de) 2006-09-21
US20040142472A1 (en) 2004-07-22

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