WO2002009524A1 - Nouvelle composition antibacterienne contenant de l'huile vegetale saponifiee comme ingredient actif - Google Patents

Nouvelle composition antibacterienne contenant de l'huile vegetale saponifiee comme ingredient actif Download PDF

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Publication number
WO2002009524A1
WO2002009524A1 PCT/SE2001/001676 SE0101676W WO0209524A1 WO 2002009524 A1 WO2002009524 A1 WO 2002009524A1 SE 0101676 W SE0101676 W SE 0101676W WO 0209524 A1 WO0209524 A1 WO 0209524A1
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WIPO (PCT)
Prior art keywords
composition according
pests
weight
composition
saponificated
Prior art date
Application number
PCT/SE2001/001676
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English (en)
Inventor
Lennart HÅKANSSON
Original Assignee
Puritas Ab
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Filing date
Publication date
Priority claimed from SE0002779A external-priority patent/SE0002779D0/xx
Priority claimed from SE0100299A external-priority patent/SE0100299D0/xx
Application filed by Puritas Ab filed Critical Puritas Ab
Priority to AU2001280349A priority Critical patent/AU2001280349A1/en
Priority to US10/333,997 priority patent/US20040037904A1/en
Priority to EP01958728A priority patent/EP1307104A1/fr
Publication of WO2002009524A1 publication Critical patent/WO2002009524A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/02—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/06—Unsaturated carboxylic acids or thio analogues thereof; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08—Magnoliopsida [dicotyledons]
    • A01N65/12—Asteraceae or Compositae [Aster or Sunflower family], e.g. daisy, pyrethrum, artichoke, lettuce, sunflower, wormwood or tarragon
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08—Magnoliopsida [dicotyledons]
    • A01N65/20—Fabaceae or Leguminosae [Pea or Legume family], e.g. pea, lentil, soybean, clover, acacia, honey locust, derris or millettia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Definitions

  • a new antibacterial composition comprising as an active ingredient saponificated vegetable oil
  • the present invention relates to an antibacterial composition, comprising as an active ingredient saponificated vegetable oil, preferably a soybean oil, or one or more components thereof; and at least one carrier. Also a ready-to-use composition comprising a with water diluted above composition and a process for the production of an above composition is disclosed. Use of a saponificated vegetable oil, preferably soybean oil, or one or more components thereof is disclosed. Additionally the present invention relates to a method for controlling bacteria on pests comprising the application of an anti-bacterially effective amount of an above composition onto said pests.
  • compositions previously known for controlling pests on animals e.g. through EP 794701 where the control of pests using pyretroid compositions is disclosed.
  • saponificated soybean oil, or saponificated vegetable oil for anti-bacterial treatment of bacteria on pests.
  • a drawback with this is the complex nature of the composition requiring an emulsifier.
  • Soy hydrolysate has been disclosed for use in insect control of trees in O99/63840.
  • Phosphatides from soybean oil have been disclosed for use in controlling grain insects (US 4721706).
  • neither of these documents is disclosing the use of saponificated soybean oil, or saponificated vegetable oil, for anti-bacterial treatment of bacteria on pests.
  • a disadvantage with the compositions in WO99/63840 is the necessity of using an enzyme for hydrolysing soy.
  • the soybean phosphatides used in US 4721706 is separated with several process step, thus a complex refining process is necessary, which obviously is a drawback.
  • an arthropod control composition for plant protection is disclosed through EP 583774.
  • the composition may comprise soybean oil; but this is complex through the use of several components.
  • saponificated soybean oil, or saponificated vegetable oil for anti-bacterial treatment of bacteria on pests.
  • acaricide compositions are disclosed in JP56008308 where soybean oil with a saponification equivalent of 176-286 and iodine value of 11-214 may be used together with an emulsifier for killing insects on fruits.
  • soybean oil with a saponification equivalent of 176-286 and iodine value of 11-214 may be used together with an emulsifier for killing insects on fruits.
  • saponificated soybean oil, or saponificated vegetable oil for anti-bacterial treatment of bacteria on pests.
  • a drawback is here the necessity of an emulsifier.
  • the present invention solves the above problems by providing an antibacterial composition, comprising as an active ingredient saponificated vegetable oil, preferably soybean oil, or one or more components thereof; and at least one carrier. Also a ready-to-use composition comprising a with water diluted composition and a process for the production of an above composition comprising saponification of a vegetable oil, preferably soybean oil, by adding an alkali hydroxide thereto, preferably potassium hydroxide; and adding a carrier is disclosed. Use of a saponificated vegetable oil, preferably soybean oil, or one or more components thereof in medicine and use of a saponificated vegetable oil, preferably soybean oil, or one or more components thereof in the manufacture of an agent for treating bacteria is also disclosed. Additionally a method for controlling bacteria on pests comprising the application of an anti-bacterially-effective amount of an above composition onto said pests.
  • soybean oil is meant in the present description an oil selected from the group consisting of soybean oil, rape seed oil and sunflower oil or a mixture thereof. These three vegetable oils have similar fatty acid patterns (see “Matfettslexikon-fran fro till bytta” ed. H. Korp, N Lindskoug, Bokhuset och Margarinfo, 1984, pp. 80, 88 and 89; hereby incorporated by reference thereto).
  • soybean oil is used in the composition according to the present invention.
  • the vegetable oil preferably soy bean oil
  • the alkali hydroxide may be sodium hydroxide or potassium hydroxide, preferably potassium hydroxide, thus rendering into potassium oleate.
  • Preferably 98% of the fatty acid(s) in the composition is (are) saponificated.
  • carrier in the present description an organic or inorganic carrier which may be natural or synthetic, and which is associated with the active ingredient and which preferably facilitates its application to the pests to be treated.
  • This carrier is thus generally inert and may preferably be a veterinarily or pharmaceutically acceptable carrier.
  • the carrier may be water, alcohols, ketones, polar solvents, aromatic solvents, oil solvents, saturated or unsaturated hydrocarbons, chlorinated hydrocarbons, liquefied petroleum gas or mixtures thereof; preferably water is the carrier.
  • Pharmaceutically acceptable carriers are well known in the art.
  • liquid pharmaceutically acceptable carriers are sterile aqueous solutions that contain no materials in addition to the active ingredients and water, or contain a buffer such as sodium phosphate at physiological pH value, physiological saline or both, such as phosphate-buffered saline.
  • the composition comprises a potassium oleate
  • the composition may preferably have an altered fatty acid pattern rendering into an enhanced anti-microbial effect.
  • This altered pattern may preferably be formed by an increased amount of at least one fatty acid with a short carbon chain, which may preferably be at least one fatty acid with a carbon chain from C 12 (lauric acid) to C 18 (stearic acid), most preferred C l4 (myristic acid), thus rendering into an enhanced anti- microbial effect
  • the composition has an amount of at least one fatty acid with a short carbon chain from approximately 0.01 to 50 % (weight), preferably from 0.1 to 5 % (weight), most preferred from 2 to 4 % (weight). All percentage amounts, regarding the composition according to the present invention, appearing in the present description are percentages by weight (if not other is stated).
  • the composition has an amount of approximately 2 % (weight) C 8 (caprylic acid), 2 % (weight) C 10 (capric acid), 2 % (weight) C 12 (lauric acid) and/or 2 % (weight) C 14 (myristic acid).
  • the composition has an amount of approximately 6 % (weight) with fatty acids ranging (when regarding the number of carbons) from C 6 (caproic acid) to C 1 (myristic acid).
  • the composition according to the present invention contains an increased amount of at least two fatty acids with a short carbon chain, preferably one fatty acid with a carbon chain of C 12 (lauric acid) and one fatty acid with a carbon chain with' a length from C 1 (myristic acid) to C 18 (stearic acid), wherein the amounts for each fatty acid may be as in the above earlier mentioned preferred embodiment.
  • composition according to the present invention may comprise: a) from 0.1 to 50 % of saponificated vegetable oil, preferably potassium oleate, b) optionally one or more other fatty acid(s) which may be saponificated, and c) water for the rest, totalling 100%; preferably 25% potassium oleate and 75 % water.
  • composition according to the present invention may also be pesticidal and/or anti- ovulating.
  • a ready-to-use composition comprising a with water diluted composition according to the present invention, wherein the composition according to the present invention may be diluted with water giving a relationship composition: water from 1 :20 to 1 :40.
  • a diluted composition according to the present invention is used for application to pests preferably a diluted composition according to the present invention is used.
  • compositions "concentrated” according to the invention may preferably be commercialised, transported or stored.
  • a process for the production of a composition according to the present invention comprising saponification of a vegetable oil, preferably soybean oil, by adding an alkali hydroxide thereto, preferably potassium hydroxide; and adding a carrier.
  • the fatty acids are extracted through a basic hydrolysis of the oils and these fatty acids regulates the length of the carbon chains.
  • the hydrogen in the COOH-group is split and replaced by a potassium-ion.
  • the process has a stable equilibrium that demands a surplus of OH-ions, which means that a soap or a soft soap solution generally is basic.
  • a saponificated vegetable oil preferably soybean oil, or one or more components thereof for medical use.
  • a saponificated vegetable oil preferably soybean oil, or one or more components thereof in the manufacture of an agent (a medicament) for treatment, prevention or management of bacterial, viral or fungal diseases, preferably bacterial.
  • a saponificated vegetable oil preferably soybean oil, or one or more components thereof for inhibiting ovulation of pests or for repelling of pests.
  • a method for controlling bacteria on pests comprising the application of an anti- bacterially effective amount of a composition according to the present invention onto said pests.
  • the pests may be scabies, insects, arachnids, arthropod, nematode, helminth and protozoan pests, thrips, mites, weevils, aphids, pear suckers, ants, termites, flies, ticks, mealy bugs, dandruff, pollen (blossom) beetle (Meligethes aeneus), lice or fleas (or fungi as set out below), preferably scabies, flies (e.g.
  • the pests may be infesting or suspected to infest an animal or a human being, whereby the composition according to the present invention may be termed a dermatology composition.
  • the animal is selected from the " group comprising dogs, cats, horses, camels and other pets with furs or poultry (which may be carriers of mites, which in turn may be carriers of Salmonella bacteria).
  • the pests may also be infesting or suspected to infest a locus preferably a barn or a stable.
  • the pests may be exposed to the composition according to the present invention when in nymph, larvae or fully grown-up phases.
  • a method for controlling bacteria on pests comprising the application of an anti- bacterially effective amount of a composition according to the present invention onto said pests, wherein the pests may be a fungus, e.g. scurf, powdery mildew (Sphaerotheca humuli) or downy mildew (Pseudoperonospora humuli).
  • the fungi may e.g. be carriers of Salmonella bacteria.
  • the fungi may be infesting or suspected to infest animals or loci as set out above or fields for cultivation of e.g. crops.
  • the fungi may further be infesting or suspected to infest crops as such, which may be standing crops or crop.
  • the crops may e.g. be potatoes, rape seed, species belonging to the family Brassica, mustard, Swedish turnip, rutabaga, cabbage (red or white), Brussels sprouts or hops.
  • composition according to the present invention may preferably be applied to the pests through the use of spraying.
  • a diluted composition previously made from more concentrated formulations, is used for the spraying.
  • a fine spray with small droplets is used, which may be obtained by using high pressure and a nozzle with appropriate size.
  • the composition according to the present invention may further be present in a spray bottle.
  • composition according to the present invention may further be used as an admixture of other active substances e.g. a pesticide, which may be an insecticide, acaricide, fungicide or herbicide.
  • a pesticide which may be an insecticide, acaricide, fungicide or herbicide.
  • a further advantage with the composition according to the present invention is the non-necessity for using an additive which normally is the case when adapting a soft soap or soap solution for use as an insecticide in order to get a water/fat balance.
  • Another advantage is that the composition according to the present application is environmentally friendly compared to other pesticides. The composition is easily degradable in the nature, inexpensive, non-toxic and not prone to the effects of genetic resistance.
  • Figure 1 shows the mortality percentage when using RB 86TM (azadiraktin, a herb extract), against Musca domestica (adult).
  • Figure 2 shows the mortality percentage when using BionimTM (azadiraktin) against Musca domestica (adult).
  • Figure 3 shows the mortality percentage when using emulsifier against Musca domestica (adult).
  • Figure 4 shows the mortality percentage when using potassium oleate against Musca domestica (adult).
  • Figure 5 shows the mortality percentage when using BlidolTM (a washing agent), against Musca domestica (adult).
  • Figure 6 shows the control with larvae in water for comparison with figures 7-11.
  • Figure 7 shows the mortality percentage when using RB 86TM, against Musca domestica (larvae).
  • Figure 8 shows the mortality percentage when using emulsifier, against Musca domestica (larvae).
  • Figure 9 shows the mortality percentage when using BionimTM, against Musca domestica (larvae).
  • Figure 10 shows the mortality percentage when using BlidolTM, against Musca domestica (larvae).
  • Figure 11 shows the mortality percentage when using oleate, against Musca domestica (larvae).
  • Figure 12 shows spiracle opening for M. domestica with non-affected bristles.
  • Figure 13 shows spiracle opening for M. domestica treated with BlidolTM. The bristles are deformed.
  • Figure 14 shows spiracle opening for M. domestica treated with BionimTM. The bristles are deformed.
  • Figure 15 shows spiracle opening for M. domestica treated with oleate. The bristles are minimally affected. Examples
  • Example 1 Control of flies in stables
  • the following example had the purpose of studying effects on flies using extracts of herbs and fatty acids.
  • the tested substances were: a) RB 86TM (azadiraktin, a herb extract from seeds of Azadirachta indica), 6 % concentration b) BionimTM (azadiraktin), 0.4 % concentration c) Emulsifier, 6 % concentration d) Potassium oleate, 5 % concentration e) BlidolTM (a washing agent), 0.02 % concentration f) Control (water)
  • Test vessels were Petri dishes made of glass with a diameter of 9 cm. With the help of a spraying bottle the bottoms of the vessels were treated with each of the compositions a) - f). After transferring 10 adult flies to each of the pre-treated dishes, the dishes were covered with plastic film and the registration started. Observations were performed by counting the surviving flies at the start, after 5 minutes and subsequently every 10 th minute up to a total of 60 minutes. Two further observations were made after 1.5 and 2 hours from the start, respectively. No flies within the control group died during the test. The both azadiraktin preparations had an effect whereby all flies were killed within 20 minutes (see Figure 1) and 50 minutes (see Figure 2), respectively.
  • Example 2 Effects on flies studied in scanning electron microscope
  • a scanning electron microscope (SEM) was used to microscope adult flies treated with: i) BionimTM 1 (azadiraktin), 0.4 % concentration ii) potassium oleate, 5 % concentration; and iii) BlidolTM (a washing agent), 0.02 % concentration, whereby morphological changes could be detected. These flies were photographed and compared with normal flies. Morphological changes could be detected on the spiracle opening on the middle part of the body. Bristles (see Figure 12) surround this breathing hole. Flies treated with the test compositions showed different levels of deformation on these bristles.
  • Example 3 Flea control on dogs 15 dogs infested with fleas were treated with oleate. The oleate was sprayed from pump bottles. At the first treatment the dogs were sprayed with oleate in the groins, armpits and head/neck. At the second treatment, twenty-four hours later, the dogs were sprayed only in the armpits and behind the ears. The result was that after the first treatment only one or two fleas were found on some dogs (those badly infested with fleas). Forty-eight hours later, after the second treatment, no living flea was found. When another check was made four days later the result was the same.
  • Example 4 -pollen beetle control on rape seed
  • BionimTM and Puricide a composition according to the present invention
  • Both compositions had an inhibiting effect on pollen beetles regarding their detrimental effect on rape buds and also on their eating capacity.
  • the composition according to the present invention had a stronger detrimental effect on the beetles in terms of their ovulation capacity, the number of eggs and their eating capacity. Thus a clear anti-ovulation (ovulation damaging) effect could be seen.
  • the composition according to the present invention also had a stronger repelling effect.
  • the experiment essentially comprised two different methods: 1) ovulation and eating method 2) repelling method
  • Table 3 shows the number of beetles in rape a half day after spraying (counted 28/6)
  • Table 4 shows the number of beetles in white mustard a half day after spraying (counted 28/6) Table 4
  • Table 5 shows the number of beetles in rape a whole day after spraying (counted 29/6)
  • Table 6 shows the number of beetles in white mustard a whole day after spraying (counted 29/6) Table 6
  • Table 7 shows the number of beetles in rape a half day after spraying (counted 3/7)
  • Table 8 shows the number of beetles in white mustard a half day after spraying (counted 3/7)
  • Table 9 shows the number of beetles in rape a whole day after spraying (counted 4/7)
  • Table 10 shows the number of beetles in white mustard a whole day after spraying (counted 4/7)
  • Example 5 control of hop diseases, powdery mildew (Sphaerotheca humuli) and downy mildew (Pseudoperonospora humuli)
  • a trial site was set up for the 1999 season on a half acre of fertile sandy loam near Newent, Gloucestershire, and was managed by a professional horticulturist. The site was planted with new roots in March, Challenger (for powdery mildew) and First Gold (for downy). The hops were trained up plastic netting supported by a simple wirework trellis six feet high.
  • the new site gave the opportunity to run screening tests with lower disease pressures than previously experienced, but some presence of disease would be required to make the necessary assessments.
  • a total of 11 chemical treatments were selected for each disease, and spray applications were made using a knapsack motorised mist blower at volumes of 30 to 50 gallons per acre.
  • the disease assessments were thorough, requiring detailed examination of at least 20 leaves (typically the 6th, i.e. young leaf, for all except the basal leaves in the downy trial), or 200 hop cones per plot. Each plot was a seven-metre panel of 'hedge', and there were two plots for each treatment.
  • the spray treatments, disease assessments and data handling were performed by Oxford Agricultural Trials Ltd. (registered with MAFF PSD as an official research company). Powdery mildew had to be introduced to the site on pots of young Goldings, and the
  • Example 6 fatty acid content of a composition according to the present invention The fatty acid content of a composition according to the present invention was assessed and is given below in table 4
  • the fatty acids comprised in the composition are normally saponificated; preferably at least 98 % of said fatty acids are normally saponificated.
  • the fatty acids may be comprised in a vegetable oil, preferably a soybean oil.
  • the composition has an amount of approximately 2 % (weight) Cg (caprylic acid), 2 % (weight) C 10 (capric acid) and 2 % (weight) C 14 (myristic acid), wherein the content of Cl 8 is lowered with 6%.
  • the composition has an amount of approximately 6 % (weight) with fatty acids ranging (when regarding the number of carbons) from C 6 (caproic acid) to C 14 (myristic acid), wherein the content of C18 is lowered with 6%.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
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Abstract

La présente invention concerne une composition antibactérienne saponifiée contenant, comme ingrédient actif, de l'huile végétale saponifiée, de préférence de l'huile de soja ou au moins un composant de cette dernière. Cette composition contient aussi au moins un excipient. L'invention concerne également une composition prête à l'emploi contenant une composition diluée dans l'eau, et un procédé de production d'une telle composition. L'invention concerne l'utilisation d'une huile végétale saponifiée, de préférence, de l'huile de soja, ou au moins un composant de cette dernière. La présente invention concerne également un procédé de contrôle des bactéries sur les animaux nuisibles, consistant à appliquer cette composition sur les animaux nuisibles en quantité efficace en termes d'action anti-bactérienne.
PCT/SE2001/001676 2000-07-27 2001-07-26 Nouvelle composition antibacterienne contenant de l'huile vegetale saponifiee comme ingredient actif WO2002009524A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2001280349A AU2001280349A1 (en) 2000-07-27 2001-07-26 A new antibacterial composition comprising as an active ingredient saponificatedvegetable oil
US10/333,997 US20040037904A1 (en) 2000-07-27 2001-07-26 Antibacterial composition comprising as an active ingredient saponificated vegetable oil
EP01958728A EP1307104A1 (fr) 2000-07-27 2001-07-26 Nouvelle composition antibacterienne contenant de l'huile vegetale saponifiee comme ingredient actif

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US22125400P 2000-07-27 2000-07-27
SE0002779A SE0002779D0 (sv) 2000-07-27 2000-07-27 New composition
SE0002779-7 2000-07-27
US60/221,254 2000-07-27
US26581501P 2001-02-01 2001-02-01
US60/265,815 2001-02-01
SE0100299A SE0100299D0 (sv) 2000-07-27 2001-02-01 New use of a composition
SE0100299-7 2001-02-01

Publications (1)

Publication Number Publication Date
WO2002009524A1 true WO2002009524A1 (fr) 2002-02-07

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PCT/SE2001/001676 WO2002009524A1 (fr) 2000-07-27 2001-07-26 Nouvelle composition antibacterienne contenant de l'huile vegetale saponifiee comme ingredient actif

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EP (1) EP1307104A1 (fr)
AU (1) AU2001280349A1 (fr)
WO (1) WO2002009524A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013069890A1 (fr) * 2011-11-09 2013-05-16 Woongjin Coway Co., Ltd Antimicrobiens naturels et article les comprenant

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US4442125A (en) * 1978-06-26 1984-04-10 Oxford Hill, Ltd. Process for detaching or preventing attachment of microorganisms to a surface
GB2181349A (en) * 1985-10-07 1987-04-23 Rochas Parfums Skin care composition containing polyunsaturated fatty acids
US4874610A (en) * 1987-06-23 1989-10-17 The Mead Corporation Tall oil neutrals to protect plants from insects and the like
FR2634103A1 (fr) * 1988-07-13 1990-01-19 Sogard Services Sarl Procede et produit permettant l'elimination des insectes nuisibles et accelerant le developpement des plantes traitees
WO1990003730A1 (fr) * 1988-10-03 1990-04-19 Safer, Inc. Insecticide sans danger pour l'environnement
EP0635267A1 (fr) * 1993-07-23 1995-01-25 Jean-Claude Doutreleau Compositions à base d'acides gras douées de propriétés anti-inflammatoires
JPH1017414A (ja) * 1996-06-28 1998-01-20 Japan Tobacco Inc 農園芸用種子消毒剤

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US4442125A (en) * 1978-06-26 1984-04-10 Oxford Hill, Ltd. Process for detaching or preventing attachment of microorganisms to a surface
SU965414A1 (ru) * 1981-05-20 1982-10-15 Войсковая Часть 25840 Фунгистатический состав дл защиты техники и сооружений
GB2181349A (en) * 1985-10-07 1987-04-23 Rochas Parfums Skin care composition containing polyunsaturated fatty acids
US4874610A (en) * 1987-06-23 1989-10-17 The Mead Corporation Tall oil neutrals to protect plants from insects and the like
FR2634103A1 (fr) * 1988-07-13 1990-01-19 Sogard Services Sarl Procede et produit permettant l'elimination des insectes nuisibles et accelerant le developpement des plantes traitees
WO1990003730A1 (fr) * 1988-10-03 1990-04-19 Safer, Inc. Insecticide sans danger pour l'environnement
EP0635267A1 (fr) * 1993-07-23 1995-01-25 Jean-Claude Doutreleau Compositions à base d'acides gras douées de propriétés anti-inflammatoires
JPH1017414A (ja) * 1996-06-28 1998-01-20 Japan Tobacco Inc 農園芸用種子消毒剤

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013069890A1 (fr) * 2011-11-09 2013-05-16 Woongjin Coway Co., Ltd Antimicrobiens naturels et article les comprenant
US9968100B2 (en) 2011-11-09 2018-05-15 Coway Co., Ltd Natural antimicrobials and article comprising the same

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AU2001280349A1 (en) 2002-02-13

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