WO2002008248A1 - Method for producing peptide derivative - Google Patents

Method for producing peptide derivative Download PDF

Info

Publication number
WO2002008248A1
WO2002008248A1 PCT/JP2001/006295 JP0106295W WO0208248A1 WO 2002008248 A1 WO2002008248 A1 WO 2002008248A1 JP 0106295 W JP0106295 W JP 0106295W WO 0208248 A1 WO0208248 A1 WO 0208248A1
Authority
WO
WIPO (PCT)
Prior art keywords
peptide derivative
hydrogen atom
producing
producing peptide
methyl group
Prior art date
Application number
PCT/JP2001/006295
Other languages
French (fr)
Japanese (ja)
Inventor
Tsutomu Sato
Hirohito Shimizu
Original Assignee
Chugai Seiyaku Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Seiyaku Kabushiki Kaisha filed Critical Chugai Seiyaku Kabushiki Kaisha
Priority to AU2001272769A priority Critical patent/AU2001272769A1/en
Publication of WO2002008248A1 publication Critical patent/WO2002008248A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

A method for producing a compound represented by the general formula (VI): (VI) wherein R1 represents a hydrogen atom or a linear or branched aliphatic alkyl group having 1 to 4 carbon atoms, R2 represents a hydrogen atom or methyl group, R3 represents a hydrogen atom or methyl group, and R4 represents a halogen atom. The method can be advantageously used for producing a novel peptide derivative in a commercial process.
PCT/JP2001/006295 2000-07-21 2001-07-19 Method for producing peptide derivative WO2002008248A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001272769A AU2001272769A1 (en) 2000-07-21 2001-07-19 Method for producing peptide derivative

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000219977A JP2005097119A (en) 2000-07-21 2000-07-21 Method for producing peptide derivative
JP2000-219977 2000-07-21

Publications (1)

Publication Number Publication Date
WO2002008248A1 true WO2002008248A1 (en) 2002-01-31

Family

ID=18714662

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2001/006295 WO2002008248A1 (en) 2000-07-21 2001-07-19 Method for producing peptide derivative

Country Status (3)

Country Link
JP (1) JP2005097119A (en)
AU (1) AU2001272769A1 (en)
WO (1) WO2002008248A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1312612A1 (en) * 2000-08-24 2003-05-21 Chugai Seiyaku Kabushiki Kaisha Cyclic peptide derivative

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5555917B2 (en) * 2010-02-22 2014-07-23 公益財団法人名古屋産業科学研究所 Process for monomethylation of aliphatic primary amines

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6357562A (en) * 1986-08-27 1988-03-12 Kao Corp Novel acylated ethylenediamine derivative, production and use thereof
WO1990006914A1 (en) * 1988-12-22 1990-06-28 The Upjohn Company N-alkylation of n-alpha-boc-protected amino acids
WO1994008676A1 (en) * 1992-10-22 1994-04-28 Kabushiki Kaisha Ace Denken Screen display type slot machine

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6357562A (en) * 1986-08-27 1988-03-12 Kao Corp Novel acylated ethylenediamine derivative, production and use thereof
WO1990006914A1 (en) * 1988-12-22 1990-06-28 The Upjohn Company N-alkylation of n-alpha-boc-protected amino acids
WO1994008676A1 (en) * 1992-10-22 1994-04-28 Kabushiki Kaisha Ace Denken Screen display type slot machine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NIPPON SEIKAGAKUKAI ED.: "Shin eikagaku jikken kouza 1, tanpakushitsu VI; Gousei oyobi hatsugen", 15 June 1992, TOKYO KAGAKU DOUJIN *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1312612A1 (en) * 2000-08-24 2003-05-21 Chugai Seiyaku Kabushiki Kaisha Cyclic peptide derivative
EP1312612A4 (en) * 2000-08-24 2004-09-22 Chugai Pharmaceutical Co Ltd Cyclic peptide derivative
US7018981B2 (en) 2000-08-24 2006-03-28 Chugai Seiyaku Kabushiki Kaisha Cyclic motilin receptor antagonists

Also Published As

Publication number Publication date
AU2001272769A1 (en) 2002-02-05
JP2005097119A (en) 2005-04-14

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