WO2002007702A3 - Formulación liposómica de propionato de clobetasol - Google Patents

Formulación liposómica de propionato de clobetasol Download PDF

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Publication number
WO2002007702A3
WO2002007702A3 PCT/CU2001/000005 CU0100005W WO0207702A3 WO 2002007702 A3 WO2002007702 A3 WO 2002007702A3 CU 0100005 W CU0100005 W CU 0100005W WO 0207702 A3 WO0207702 A3 WO 0207702A3
Authority
WO
WIPO (PCT)
Prior art keywords
clobetasol propionate
formulation
active substance
liposomes
liposomic
Prior art date
Application number
PCT/CU2001/000005
Other languages
English (en)
French (fr)
Other versions
WO2002007702A2 (es
Inventor
Gutierrez Xiomara Perez
Leon Ladyth De La Carid Garcia
La Paz Martin-Viana Nilia De
Gonzalez Aymee Roche
Gonzalez Ignacio Hernandez
Diduk Natalia Albertovna
Cortada Dinorah Granda
Original Assignee
Ct De Investigacion Y Desarrol
Gutierrez Xiomara Perez
Leon Ladyth De La Carid Garcia
La Paz Martin-Viana Nilia De
Gonzalez Aymee Roche
Gonzalez Ignacio Hernandez
Diduk Natalia Albertovna
Cortada Dinorah Granda
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ct De Investigacion Y Desarrol, Gutierrez Xiomara Perez, Leon Ladyth De La Carid Garcia, La Paz Martin-Viana Nilia De, Gonzalez Aymee Roche, Gonzalez Ignacio Hernandez, Diduk Natalia Albertovna, Cortada Dinorah Granda filed Critical Ct De Investigacion Y Desarrol
Priority to AU2001276254A priority Critical patent/AU2001276254B2/en
Priority to EP01953764A priority patent/EP1360958B1/en
Priority to MXPA03000207A priority patent/MXPA03000207A/es
Priority to AU7625401A priority patent/AU7625401A/xx
Priority to DK01953764T priority patent/DK1360958T3/da
Priority to DE60123132T priority patent/DE60123132T2/de
Priority to BR0112553-2A priority patent/BR0112553A/pt
Priority to CA002416731A priority patent/CA2416731C/en
Publication of WO2002007702A2 publication Critical patent/WO2002007702A2/es
Publication of WO2002007702A3 publication Critical patent/WO2002007702A3/es
Priority to HK05103910A priority patent/HK1071070A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/14—Liposomes; Vesicles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

En la presente invención se relaciona con una formulación liposómica de propionato de clobetasol para uso tópico para el tratamiento de enfermedades de la piel como dermatitits atópica y psoriasis con excelente aspecto organoléptico, muy buen efecto terapéutico y favorable distribución en el estrato córneo. Los liposomas incluyen el propionato de clobetasol como principio activo en bajas dosis. Estos liposomas son preferiblemente vesículas estables y multilamelares con un tamaño medio entre 2000-5000 nm. La cantidad de principio activo es preferiblemente entre 0.02 y 0.025 %. La forma farmacéutica del producto es preferiblemente jalea.
PCT/CU2001/000005 2000-07-17 2001-07-17 Formulación liposómica de propionato de clobetasol WO2002007702A2 (es)

Priority Applications (9)

Application Number Priority Date Filing Date Title
AU2001276254A AU2001276254B2 (en) 2000-07-17 2001-07-17 Liposomic formulation of clobetasol propionate
EP01953764A EP1360958B1 (en) 2000-07-17 2001-07-17 Liposomic formulation of clobetasol propionate
MXPA03000207A MXPA03000207A (es) 2000-07-17 2001-07-17 Formulacion liposomica de propionato de clobetasol.
AU7625401A AU7625401A (en) 2000-07-17 2001-07-17 Liposomic formulation of clobetasol propionate
DK01953764T DK1360958T3 (da) 2000-07-17 2001-07-17 Liposomformulering af clobetasolpropionat
DE60123132T DE60123132T2 (de) 2000-07-17 2001-07-17 Liposomenformulierung mit clobetasol propionate
BR0112553-2A BR0112553A (pt) 2000-07-17 2001-07-17 Formulação lipossÈmica de propionato de clobetasol para aplicação tópica
CA002416731A CA2416731C (en) 2000-07-17 2001-07-17 Liposomal formulation of clobetasol propionate
HK05103910A HK1071070A1 (en) 2000-07-17 2005-05-10 Liposomic formulation of clobetasol propionate

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CU171/2000 2000-07-17
CU20000171A CU23175A1 (es) 2000-07-17 2000-07-17 Formulacion liposomica de propionato de clobetasol

Publications (2)

Publication Number Publication Date
WO2002007702A2 WO2002007702A2 (es) 2002-01-31
WO2002007702A3 true WO2002007702A3 (es) 2003-07-31

Family

ID=40134847

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CU2001/000005 WO2002007702A2 (es) 2000-07-17 2001-07-17 Formulación liposómica de propionato de clobetasol

Country Status (13)

Country Link
EP (1) EP1360958B1 (es)
CN (1) CN100346773C (es)
AT (1) ATE339188T1 (es)
AU (2) AU2001276254B2 (es)
BR (1) BR0112553A (es)
CA (1) CA2416731C (es)
CU (1) CU23175A1 (es)
DE (1) DE60123132T2 (es)
DK (1) DK1360958T3 (es)
ES (1) ES2272508T3 (es)
HK (1) HK1071070A1 (es)
MX (1) MXPA03000207A (es)
WO (1) WO2002007702A2 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7291626B1 (en) 1998-04-09 2007-11-06 John Hopkins University School Of Medicine Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
CA2386190C (en) 1999-10-13 2009-04-14 Johns Hopkins University School Of Medicine Regulators of the hedgehog pathway, compositions and uses related thereto
EP1561464A3 (en) * 2001-07-02 2007-04-25 Sinan Tas Use of cyclopamine in the treatment of basal cell carcinoma and other tumors
EP1411938B1 (en) * 2001-07-02 2005-07-06 Tas, Sinan Use of cyclopamine for the manufacture of a medicament for the treatemnt of psoriasis
US20180235882A1 (en) 2015-09-02 2018-08-23 Cadila Healthcare Limited Topical compositions comprising corticosteroids

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4427649A (en) * 1976-03-19 1984-01-24 Imperial Chemical Industries Limited Pharmaceutical compositions
US5192528A (en) * 1985-05-22 1993-03-09 Liposome Technology, Inc. Corticosteroid inhalation treatment method

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU661754B2 (en) * 1992-02-12 1995-08-03 Janssen - Cilag - S.p.a. Liposomal itraconazole formulations

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4427649A (en) * 1976-03-19 1984-01-24 Imperial Chemical Industries Limited Pharmaceutical compositions
US5192528A (en) * 1985-05-22 1993-03-09 Liposome Technology, Inc. Corticosteroid inhalation treatment method

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JACOBS A ET AL: "Effects of Phosphatidylcholine on the Topical Bioavailability of Corticosteroids Assessed by the Human Skin Blanching Assay", J PHARM PHARMACOL, vol. 40, 24 June 1988 (1988-06-24), pages 829 - 833, XP002902000 *

Also Published As

Publication number Publication date
DE60123132T2 (de) 2007-04-12
AU2001276254B2 (en) 2006-07-13
CU23175A1 (es) 2006-09-22
BR0112553A (pt) 2003-06-24
CN1547465A (zh) 2004-11-17
WO2002007702A2 (es) 2002-01-31
CA2416731A1 (en) 2003-01-16
DE60123132D1 (de) 2006-10-26
CA2416731C (en) 2009-12-15
ATE339188T1 (de) 2006-10-15
HK1071070A1 (en) 2005-07-08
DK1360958T3 (da) 2007-01-29
ES2272508T3 (es) 2007-05-01
EP1360958B1 (en) 2006-09-13
MXPA03000207A (es) 2004-09-13
CN100346773C (zh) 2007-11-07
AU7625401A (en) 2002-02-05
EP1360958A2 (en) 2003-11-12

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