WO2002003978A3 - A COMBINATION OF FBPase INHIBITORS AND ANTIDIABETIC AGENTS USEFUL FOR THE TREATMENT OF DIABETES - Google Patents

A COMBINATION OF FBPase INHIBITORS AND ANTIDIABETIC AGENTS USEFUL FOR THE TREATMENT OF DIABETES Download PDF

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Publication number
WO2002003978A3
WO2002003978A3 PCT/US2001/021557 US0121557W WO0203978A3 WO 2002003978 A3 WO2002003978 A3 WO 2002003978A3 US 0121557 W US0121557 W US 0121557W WO 0203978 A3 WO0203978 A3 WO 0203978A3
Authority
WO
WIPO (PCT)
Prior art keywords
diabetes
combination
treatment
agents useful
antidiabetic agents
Prior art date
Application number
PCT/US2001/021557
Other languages
French (fr)
Other versions
WO2002003978A2 (en
Inventor
Poelje Paul D Van
Mark D Erion
Toshihiko Fujiwara
Original Assignee
Metabasis Therapeutics Inc
Sankyo Co
Poelje Paul D Van
Mark D Erion
Toshihiko Fujiwara
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU7327101A priority Critical patent/AU7327101A/en
Priority to AU2001273271A priority patent/AU2001273271B2/en
Application filed by Metabasis Therapeutics Inc, Sankyo Co, Poelje Paul D Van, Mark D Erion, Toshihiko Fujiwara filed Critical Metabasis Therapeutics Inc
Priority to HU0301830A priority patent/HUP0301830A3/en
Priority to MXPA02012713A priority patent/MXPA02012713A/en
Priority to CA002412142A priority patent/CA2412142A1/en
Priority to IL15351301A priority patent/IL153513A0/en
Priority to JP2002508433A priority patent/JP2004508297A/en
Priority to EP01952530A priority patent/EP1372660A2/en
Priority to KR1020037000126A priority patent/KR100854851B1/en
Priority to BR0112212-6A priority patent/BR0112212A/en
Priority to NZ523227A priority patent/NZ523227A/en
Priority to SK6-2003A priority patent/SK62003A3/en
Publication of WO2002003978A2 publication Critical patent/WO2002003978A2/en
Priority to IL153513A priority patent/IL153513A/en
Priority to NO20030034A priority patent/NO20030034L/en
Publication of WO2002003978A3 publication Critical patent/WO2002003978A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Abstract

A combination therapy of at least one FBPase inhibitor and at least one other antidiabetic agent is disclosed.
PCT/US2001/021557 2000-07-06 2001-07-05 A COMBINATION OF FBPase INHIBITORS AND ANTIDIABETIC AGENTS USEFUL FOR THE TREATMENT OF DIABETES WO2002003978A2 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
KR1020037000126A KR100854851B1 (en) 2000-07-06 2001-07-05 A Combination of FBPase Inhibitors and Antidiabetic Agents Useful for the Treatment of Diabetes
EP01952530A EP1372660A2 (en) 2000-07-06 2001-07-05 A combination of fbpase inhibitors and antidiabetic agents useful for the treatment of diabetes
HU0301830A HUP0301830A3 (en) 2000-07-06 2001-07-05 Pharmaceutical composition containing a combination of fbpase inhibitors and antidiabetic agents useful for the treatment of diabetes
AU2001273271A AU2001273271B2 (en) 2000-07-06 2001-07-05 A combination of fbpase inhibitors and antidiabetic agents useful for the treatment of diabetes
CA002412142A CA2412142A1 (en) 2000-07-06 2001-07-05 A combination of fbpase inhibitors and antidiabetic agents useful for the treatment of diabetes
IL15351301A IL153513A0 (en) 2000-07-06 2001-07-05 A COMBINATION OF FBPase INHIBITORS AND ANTIDIABETIC AGENTS USEFUL FOR THE TREATMENT OF DIABETES
BR0112212-6A BR0112212A (en) 2000-07-06 2001-07-05 A combination of fbpase inhibitors and antidiabetic agents useful for treating diabetes.
AU7327101A AU7327101A (en) 2000-07-06 2001-07-05 A combination of fbpase inhibitors and antidiabetic agents useful for the treatment of diabetes
MXPA02012713A MXPA02012713A (en) 2000-07-06 2001-07-05 A COMBINATION OF FBPase INHIBITORS AND ANTIDIABETIC AGENTS USEFUL FOR THE TREATMENT OF DIABETES.
JP2002508433A JP2004508297A (en) 2000-07-06 2001-07-05 Combination agent of FBPase inhibitor and antidiabetic drug useful for treatment of diabetes
NZ523227A NZ523227A (en) 2000-07-06 2001-07-05 A combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes
SK6-2003A SK62003A3 (en) 2000-07-06 2001-07-05 A combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes
IL153513A IL153513A (en) 2000-07-06 2002-12-18 Pharmaceutical composition comprising a combination of a sulfonylurea antidiabetic agent and fbpase inhibitor and use thereof in the manufacture of medicaments for the treatment of diabetes
NO20030034A NO20030034L (en) 2000-07-06 2003-01-03 A combination of FBPase inhibitors and antidiabetic agents useful in the treatment of diabetes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21653100P 2000-07-06 2000-07-06
US60/216,531 2000-07-06

Publications (2)

Publication Number Publication Date
WO2002003978A2 WO2002003978A2 (en) 2002-01-17
WO2002003978A3 true WO2002003978A3 (en) 2003-10-16

Family

ID=22807416

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/021557 WO2002003978A2 (en) 2000-07-06 2001-07-05 A COMBINATION OF FBPase INHIBITORS AND ANTIDIABETIC AGENTS USEFUL FOR THE TREATMENT OF DIABETES

Country Status (18)

Country Link
EP (1) EP1372660A2 (en)
JP (1) JP2004508297A (en)
KR (1) KR100854851B1 (en)
CN (2) CN100396283C (en)
AU (2) AU2001273271B2 (en)
BR (1) BR0112212A (en)
CA (1) CA2412142A1 (en)
CZ (1) CZ20035A3 (en)
HU (1) HUP0301830A3 (en)
IL (2) IL153513A0 (en)
MX (1) MXPA02012713A (en)
NO (1) NO20030034L (en)
NZ (1) NZ523227A (en)
PL (1) PL365779A1 (en)
RU (1) RU2328308C2 (en)
SK (1) SK62003A3 (en)
WO (1) WO2002003978A2 (en)
ZA (1) ZA200300044B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6284748B1 (en) 1997-03-07 2001-09-04 Metabasis Therapeutics, Inc. Purine inhibitors of fructose 1,6-bisphosphatase
WO2000014095A1 (en) 1998-09-09 2000-03-16 Metabasis Therapeutics, Inc. Novel heteroaromatic inhibitors of fructose 1,6-bisphosphatase
EP1607401A1 (en) 2000-03-08 2005-12-21 Metabasis Therapeutics, Inc. Novel aryl fructose-1,6-Bisphosphatase inhibitors
WO2003026591A2 (en) 2001-09-24 2003-04-03 Imperial College Innovations Ltd. Modification of feeding behavior
JP4733922B2 (en) 2002-01-10 2011-07-27 インペリアル・イノベ−ションズ・リミテッド Correction of eating behavior
GB0300571D0 (en) 2003-01-10 2003-02-12 Imp College Innovations Ltd Modification of feeding behaviour
PL3002283T3 (en) 2003-12-26 2017-10-31 Kyowa Hakko Kirin Co Ltd Thiazole derivatives
CN101005847A (en) * 2004-08-18 2007-07-25 症变治疗公司 Novel thiazole inhibitors of fructose 1,6-bisphosphatase
EP1857118A1 (en) * 2004-12-13 2007-11-21 Daiichi Sankyo Company, Limited Medicinal composition for treating diabetes
TW200738245A (en) * 2005-08-22 2007-10-16 Sankyo Co Pharmaceutical composition containing FBPase inhibitor
WO2007129522A1 (en) * 2006-04-10 2007-11-15 Daiichi Sankyo Company, Limited Preparation produced by dry process
EP2089023A2 (en) 2006-11-02 2009-08-19 Aestus Therapeutics, Inc. Methods of treating neuropathic pain with agonists of ppar-gamma
TWI428346B (en) 2006-12-13 2014-03-01 Imp Innovations Ltd Novel compounds and their effects on feeding behaviour
CN103665043B (en) 2012-08-30 2017-11-10 江苏豪森药业集团有限公司 A kind of tenofovir prodrug and its application in medicine
UY35065A (en) * 2012-10-08 2014-05-30 Lg Life Sciences Ltd COMBINED DRUG THAT INCLUDES GEMIGLIPTINE AND METFORMIN AND METHOD FOR PREPARATION
CN104788350A (en) * 2014-01-22 2015-07-22 天津大学 Method for acquiring medicinally-advantageous crystal form of tolbutamide through rapid cooling and crystallization
CN106831437B (en) * 2016-02-03 2019-06-21 华中师范大学 Ester type compound and its preparation method and application containing nitroethenyl group
CN114907285B (en) * 2021-02-10 2023-09-22 华中师范大学 Acylated saccharin compound, preparation method and application thereof, and hypoglycemic drug

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990009163A2 (en) * 1989-01-24 1990-08-23 Gensia Pharmaceuticals, Inc. Method and compounds for aica riboside delivery and for lowering blood glucose
WO1999047549A1 (en) * 1998-03-16 1999-09-23 Ontogen Corporation PIPERAZINES AS INHIBITORS OF FRUCTOSE-1,6-BISPHOSPHATASE (FBPase)
WO2000014095A1 (en) * 1998-09-09 2000-03-16 Metabasis Therapeutics, Inc. Novel heteroaromatic inhibitors of fructose 1,6-bisphosphatase
WO2000038666A2 (en) * 1998-12-24 2000-07-06 Metabasis Therapeutics, Inc. A COMBINATION OF FBPase INHIBITORS AND INSULIN SENSITIZERS FOR THE TREATMENT OF DIABETES
WO2001052825A2 (en) * 2000-01-21 2001-07-26 Novartis Ag Combinations comprising dipeptidylpeptidase-iv inhibitors and antidiabetic agents
WO2002000673A1 (en) * 2000-06-26 2002-01-03 Rodaris Pharmaceuticals Limited Phosphoglycan messengers and their medical uses

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6691798A (en) * 1997-03-07 1998-09-22 Metabasis Therapeutics, Inc. Novel indole and azaindole inhibitors of fructose-1,6-bisphosphatase
US6284748B1 (en) * 1997-03-07 2001-09-04 Metabasis Therapeutics, Inc. Purine inhibitors of fructose 1,6-bisphosphatase
JP2001515482A (en) * 1997-03-07 2001-09-18 メタバシス・セラピューティクス・インコーポレイテッド Novel benzimidazole inhibitors of fructose-1,6-bisphosphatase

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990009163A2 (en) * 1989-01-24 1990-08-23 Gensia Pharmaceuticals, Inc. Method and compounds for aica riboside delivery and for lowering blood glucose
WO1999047549A1 (en) * 1998-03-16 1999-09-23 Ontogen Corporation PIPERAZINES AS INHIBITORS OF FRUCTOSE-1,6-BISPHOSPHATASE (FBPase)
WO2000014095A1 (en) * 1998-09-09 2000-03-16 Metabasis Therapeutics, Inc. Novel heteroaromatic inhibitors of fructose 1,6-bisphosphatase
WO2000038666A2 (en) * 1998-12-24 2000-07-06 Metabasis Therapeutics, Inc. A COMBINATION OF FBPase INHIBITORS AND INSULIN SENSITIZERS FOR THE TREATMENT OF DIABETES
WO2001052825A2 (en) * 2000-01-21 2001-07-26 Novartis Ag Combinations comprising dipeptidylpeptidase-iv inhibitors and antidiabetic agents
WO2002000673A1 (en) * 2000-06-26 2002-01-03 Rodaris Pharmaceuticals Limited Phosphoglycan messengers and their medical uses

Also Published As

Publication number Publication date
ZA200300044B (en) 2004-05-06
MXPA02012713A (en) 2004-09-10
KR20030031952A (en) 2003-04-23
NZ523227A (en) 2005-04-29
BR0112212A (en) 2003-12-30
EP1372660A2 (en) 2004-01-02
HUP0301830A2 (en) 2003-11-28
CA2412142A1 (en) 2002-01-17
WO2002003978A2 (en) 2002-01-17
CZ20035A3 (en) 2003-05-14
CN101301294A (en) 2008-11-12
AU7327101A (en) 2002-01-21
IL153513A0 (en) 2003-07-06
KR100854851B1 (en) 2008-08-27
PL365779A1 (en) 2005-01-10
CN100396283C (en) 2008-06-25
HUP0301830A3 (en) 2007-10-29
SK62003A3 (en) 2003-09-11
AU2001273271B2 (en) 2006-01-05
JP2004508297A (en) 2004-03-18
RU2328308C2 (en) 2008-07-10
IL153513A (en) 2014-07-31
CN1599612A (en) 2005-03-23
NO20030034D0 (en) 2003-01-03
NO20030034L (en) 2003-03-05

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