WO2002000675A3 - Haplotypes of the hnf3a gene - Google Patents

Haplotypes of the hnf3a gene Download PDF

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Publication number
WO2002000675A3
WO2002000675A3 PCT/US2001/020213 US0120213W WO0200675A3 WO 2002000675 A3 WO2002000675 A3 WO 2002000675A3 US 0120213 W US0120213 W US 0120213W WO 0200675 A3 WO0200675 A3 WO 0200675A3
Authority
WO
WIPO (PCT)
Prior art keywords
haplotypes
hnf3a
gene
disclosed
hnf3a gene
Prior art date
Application number
PCT/US2001/020213
Other languages
French (fr)
Other versions
WO2002000675A2 (en
Inventor
Elizabeth M Lanz
Katie E Parks
Angela Sanchis
Original Assignee
Genaissance Pharmaceuticals
Elizabeth M Lanz
Katie E Parks
Angela Sanchis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaissance Pharmaceuticals, Elizabeth M Lanz, Katie E Parks, Angela Sanchis filed Critical Genaissance Pharmaceuticals
Priority to AU2001271439A priority Critical patent/AU2001271439A1/en
Publication of WO2002000675A2 publication Critical patent/WO2002000675A2/en
Publication of WO2002000675A3 publication Critical patent/WO2002000675A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

Novel genetic variants of the Hepatocyte Nuclear Factor 3, Alpha (HNF3A) gene are described. Various genotypes, haplotypes, and haplotype pairs that exist in the general United States population are disclosed for the HNF3A gene. Compositions and methods for haplotyping and/or genotyping the HNF3A gene in an individual are also disclosed. Polynucleotides defined by the haplotypes disclosed herein are also described.
PCT/US2001/020213 2000-06-23 2001-06-25 Haplotypes of the hnf3a gene WO2002000675A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001271439A AU2001271439A1 (en) 2000-06-23 2001-06-25 Haplotypes of the hnf3a gene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21363500P 2000-06-23 2000-06-23
US60/213,635 2000-06-23

Publications (2)

Publication Number Publication Date
WO2002000675A2 WO2002000675A2 (en) 2002-01-03
WO2002000675A3 true WO2002000675A3 (en) 2002-05-30

Family

ID=22795865

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/020213 WO2002000675A2 (en) 2000-06-23 2001-06-25 Haplotypes of the hnf3a gene

Country Status (2)

Country Link
AU (1) AU2001271439A1 (en)
WO (1) WO2002000675A2 (en)

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BROOKES A.J.: "The essence of SNPs", GENE, vol. 234, no. 2, 1999, pages 177 - 186, XP004173090 *
BROOKES ET AL.: "HGBASE: a database of SNPs and other variations in and around human genes", vol. 28, no. 1, January 2000 (2000-01-01), pages 356 - 360, XP002949088 *
LAI ET AL.: "HNF-3A, a hepatocyte-enriched transcription factor of novel structure in regulated transcriptionally", GENES & DEVELOPMENT, vol. 4, 1998, pages 1427 - 1436, XP000351711 *
MCCARTHY ET AL.: "The use of single-nucleotide polymorphism maps in pharmacogenetics", vol. 18, no. 5, May 2000 (2000-05-01), pages 505 - 508, XP000941628 *
NAVAS ET AL.: "The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis", HUMAN HEREDITY, vol. 50, no. 6, June 2000 (2000-06-01), pages 370 - 381, XP002905782 *
STEPHENS J.C.: "Single-nucleotide polymorphisms, haplotypes and their relevance to pharmacogenetics", MOLECULAR DIAGNOSTICS, vol. 4, no. 4, 1999, pages 309 - 317, XP002937520 *

Also Published As

Publication number Publication date
WO2002000675A2 (en) 2002-01-03
AU2001271439A1 (en) 2002-01-08

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