WO2002000613A3 - Inhibiteurs d'infections par le virus de l'hepatite b (vhb) - Google Patents

Inhibiteurs d'infections par le virus de l'hepatite b (vhb) Download PDF

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Publication number
WO2002000613A3
WO2002000613A3 PCT/EP2001/007260 EP0107260W WO0200613A3 WO 2002000613 A3 WO2002000613 A3 WO 2002000613A3 EP 0107260 W EP0107260 W EP 0107260W WO 0200613 A3 WO0200613 A3 WO 0200613A3
Authority
WO
WIPO (PCT)
Prior art keywords
hbv
inhibitors
infections
hepatitis
treatment
Prior art date
Application number
PCT/EP2001/007260
Other languages
English (en)
Other versions
WO2002000613A2 (fr
Inventor
Dorian Bevec
Sabine Obert
Original Assignee
Axxima Pharmaceuticals Ag
Dorian Bevec
Sabine Obert
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axxima Pharmaceuticals Ag, Dorian Bevec, Sabine Obert filed Critical Axxima Pharmaceuticals Ag
Priority to AU2001269092A priority Critical patent/AU2001269092A1/en
Publication of WO2002000613A2 publication Critical patent/WO2002000613A2/fr
Publication of WO2002000613A3 publication Critical patent/WO2002000613A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne des inhibiteurs d'infections par le VHB. On décrit une classe de guanyl hydrazones qui sont des inhibiteurs puissants d'infections par le VHB. Ce type de composé est utile pour le traitement d'une infection par le VHB, en particulier l'infection chronique par le VHB, et pour le traitement d'infections et de maladies opportunistes engendrées par l'infection en question. L'invention concerne également des compositions pharmaceutiques utiles pour la prophylaxie et/ou le traitement des infections par le VHB, y compris les infections opportunistes, et des maladies résultant d'infections par le VHB.
PCT/EP2001/007260 2000-06-27 2001-06-26 Inhibiteurs d'infections par le virus de l'hepatite b (vhb) WO2002000613A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001269092A AU2001269092A1 (en) 2000-06-27 2001-06-26 Inhibitors of hepatitis b virus infection

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21455600P 2000-06-27 2000-06-27
US60/214,556 2000-06-27

Publications (2)

Publication Number Publication Date
WO2002000613A2 WO2002000613A2 (fr) 2002-01-03
WO2002000613A3 true WO2002000613A3 (fr) 2002-11-07

Family

ID=22799534

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/007260 WO2002000613A2 (fr) 2000-06-27 2001-06-26 Inhibiteurs d'infections par le virus de l'hepatite b (vhb)

Country Status (2)

Country Link
AU (1) AU2001269092A1 (fr)
WO (1) WO2002000613A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9034841B2 (en) 2011-04-21 2015-05-19 Isis Pharmaceuticals, Inc. Modulation of hepatitis B virus (HBV) expression

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003006426A1 (fr) * 2001-07-13 2003-01-23 Axxima Pharmaceuticals Ag Guanylhydrazones aromatiques utilises comme composes efficaces contre les maladies nerveuses
WO2003024407A2 (fr) 2001-09-21 2003-03-27 Message Pharmaceuticals, Inc. Inhibiteurs des proteines rnase p servant de composes antibacteriens
SI1572095T1 (sl) 2002-09-13 2015-12-31 Novartis Ag Beta-l-2'-deoksinukleozidi za uporabo pri zdravljenju odpornih sevov hbv
US7244765B2 (en) * 2004-06-25 2007-07-17 Cytokine Pharmasciences, Inc Guanylhydrazone salts, compositions, processes of making and methods of using
CN102936212A (zh) 2004-08-17 2013-02-20 辉凌公司 脒腙化合物、组合物、制备方法及使用方法
WO2006130697A1 (fr) * 2005-06-01 2006-12-07 Cytokine Pharmasciences, Inc. Expression de hmgb1 et role protecteur de semapimod dans nec
EP2155675B1 (fr) 2007-06-12 2014-02-19 Provid Pharmaceuticals, Inc. Inhibiteurs de kinases, leurs compositions et procédés d'utilisation
CN110642741A (zh) * 2012-12-06 2020-01-03 巴鲁克斯布隆伯格研究所 作为抗hbv感染的抗病毒剂的官能化苯甲酰胺衍生物
CN113134002B (zh) * 2021-04-26 2023-12-19 北京慧宝源生物技术股份有限公司 克来夫定的应用

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB923398A (en) * 1960-08-09 1963-04-10 Vismara Francesco Spa Diphenyl mono-and bis-formyl guanylhydrazones
US3560557A (en) * 1965-11-19 1971-02-02 Ciba Geigy Corp Diphenyl-ureas,-thioureas,-guanidines and -parabanic acids
US5689563A (en) * 1993-06-29 1997-11-18 Motorola, Inc. Method and apparatus for efficient real-time authentication and encryption in a communication system
WO1998020868A1 (fr) * 1996-11-15 1998-05-22 The Picower Institute For Medical Research Guanylhydrazones utiles dans le traitement de maladies associees a l'activation des cellules t
WO1998030583A1 (fr) * 1997-01-08 1998-07-16 The Picower Institute For Medical Research Complexes et combinaisons de fetuine et d'agents therapeutiques
US5854289A (en) * 1994-01-21 1998-12-29 The Picower Institute For Medical Research Guanylhydrazones and their use to treat inflammatory conditions
WO2001025192A1 (fr) * 1999-10-06 2001-04-12 Melacure Therapeutics Ab Derives de guanidine et leur utilisation dans la production d'un medicament destine a bloquer les xanthine oxydases/deshydrogenases
WO2001056553A2 (fr) * 2000-02-02 2001-08-09 Axxima Pharmaceuticals Ag Guanylhydrazones aromatiques, actives sur le plan pharmacologique
WO2002011715A2 (fr) * 2000-08-07 2002-02-14 Melacure Therapeutics Ab Benzylideneaminoguanidines et hydroxyguanidines utilisees comme ligands des recepteur de la melanocortine

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB923398A (en) * 1960-08-09 1963-04-10 Vismara Francesco Spa Diphenyl mono-and bis-formyl guanylhydrazones
US3560557A (en) * 1965-11-19 1971-02-02 Ciba Geigy Corp Diphenyl-ureas,-thioureas,-guanidines and -parabanic acids
US5689563A (en) * 1993-06-29 1997-11-18 Motorola, Inc. Method and apparatus for efficient real-time authentication and encryption in a communication system
US5854289A (en) * 1994-01-21 1998-12-29 The Picower Institute For Medical Research Guanylhydrazones and their use to treat inflammatory conditions
WO1998020868A1 (fr) * 1996-11-15 1998-05-22 The Picower Institute For Medical Research Guanylhydrazones utiles dans le traitement de maladies associees a l'activation des cellules t
WO1998030583A1 (fr) * 1997-01-08 1998-07-16 The Picower Institute For Medical Research Complexes et combinaisons de fetuine et d'agents therapeutiques
WO2001025192A1 (fr) * 1999-10-06 2001-04-12 Melacure Therapeutics Ab Derives de guanidine et leur utilisation dans la production d'un medicament destine a bloquer les xanthine oxydases/deshydrogenases
WO2001056553A2 (fr) * 2000-02-02 2001-08-09 Axxima Pharmaceuticals Ag Guanylhydrazones aromatiques, actives sur le plan pharmacologique
WO2002011715A2 (fr) * 2000-08-07 2002-02-14 Melacure Therapeutics Ab Benzylideneaminoguanidines et hydroxyguanidines utilisees comme ligands des recepteur de la melanocortine

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CAVALLINI G ET AL: "ANTIBACTERIAL AGENTS. SOME NEW GUANYLHYDRAZONE DERIVATIVES", JOURNAL OF MEDICINAL AND PHARMACEUTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, vol. 4, no. 1, 1 July 1961 (1961-07-01), pages 177 - 182, XP001021572 *
CERAMI, CARLA ET AL: "High-performance liquid chromatographic method for guanylhydrazone compounds", J. CHROMATOGR., B: BIOMED. APPL. (1996), 675(1), 71-5, XP002206329 *
COHEN P S ET AL: "The critical role of p38 MAP kinase in T cell HIV -1 replication.", MOLECULAR MEDICINE, vol. 3, no. 5, May 1997 (1997-05-01), pages 339 - 346, XP001018447 *
KORYTNYK, W. ET AL: "Guanylhydrazones with potential antileukemic activity. 2. Synthesis and structure-activity relationships of analogs of 4,4'-diacetyl-N,N'-diphenylurea bis(guanylhydrazone)", J. MED. CHEM. (1978), 21(6), 507-13, XP002206328 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9034841B2 (en) 2011-04-21 2015-05-19 Isis Pharmaceuticals, Inc. Modulation of hepatitis B virus (HBV) expression
US9127278B2 (en) 2011-04-21 2015-09-08 Isis Pharmaceuticals, Inc. Modulation of hepatitis B virus (HBV) expression

Also Published As

Publication number Publication date
WO2002000613A2 (fr) 2002-01-03
AU2001269092A1 (en) 2002-01-08

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