WO2002000613A3 - Inhibiteurs d'infections par le virus de l'hepatite b (vhb) - Google Patents
Inhibiteurs d'infections par le virus de l'hepatite b (vhb) Download PDFInfo
- Publication number
- WO2002000613A3 WO2002000613A3 PCT/EP2001/007260 EP0107260W WO0200613A3 WO 2002000613 A3 WO2002000613 A3 WO 2002000613A3 EP 0107260 W EP0107260 W EP 0107260W WO 0200613 A3 WO0200613 A3 WO 0200613A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- hbv
- inhibitors
- infections
- hepatitis
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
- C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2001269092A AU2001269092A1 (en) | 2000-06-27 | 2001-06-26 | Inhibitors of hepatitis b virus infection |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21455600P | 2000-06-27 | 2000-06-27 | |
US60/214,556 | 2000-06-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002000613A2 WO2002000613A2 (fr) | 2002-01-03 |
WO2002000613A3 true WO2002000613A3 (fr) | 2002-11-07 |
Family
ID=22799534
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2001/007260 WO2002000613A2 (fr) | 2000-06-27 | 2001-06-26 | Inhibiteurs d'infections par le virus de l'hepatite b (vhb) |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU2001269092A1 (fr) |
WO (1) | WO2002000613A2 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9034841B2 (en) | 2011-04-21 | 2015-05-19 | Isis Pharmaceuticals, Inc. | Modulation of hepatitis B virus (HBV) expression |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003006426A1 (fr) * | 2001-07-13 | 2003-01-23 | Axxima Pharmaceuticals Ag | Guanylhydrazones aromatiques utilises comme composes efficaces contre les maladies nerveuses |
WO2003024407A2 (fr) | 2001-09-21 | 2003-03-27 | Message Pharmaceuticals, Inc. | Inhibiteurs des proteines rnase p servant de composes antibacteriens |
SI1572095T1 (sl) | 2002-09-13 | 2015-12-31 | Novartis Ag | Beta-l-2'-deoksinukleozidi za uporabo pri zdravljenju odpornih sevov hbv |
US7244765B2 (en) * | 2004-06-25 | 2007-07-17 | Cytokine Pharmasciences, Inc | Guanylhydrazone salts, compositions, processes of making and methods of using |
CN102936212A (zh) | 2004-08-17 | 2013-02-20 | 辉凌公司 | 脒腙化合物、组合物、制备方法及使用方法 |
WO2006130697A1 (fr) * | 2005-06-01 | 2006-12-07 | Cytokine Pharmasciences, Inc. | Expression de hmgb1 et role protecteur de semapimod dans nec |
EP2155675B1 (fr) | 2007-06-12 | 2014-02-19 | Provid Pharmaceuticals, Inc. | Inhibiteurs de kinases, leurs compositions et procédés d'utilisation |
CN110642741A (zh) * | 2012-12-06 | 2020-01-03 | 巴鲁克斯布隆伯格研究所 | 作为抗hbv感染的抗病毒剂的官能化苯甲酰胺衍生物 |
CN113134002B (zh) * | 2021-04-26 | 2023-12-19 | 北京慧宝源生物技术股份有限公司 | 克来夫定的应用 |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB923398A (en) * | 1960-08-09 | 1963-04-10 | Vismara Francesco Spa | Diphenyl mono-and bis-formyl guanylhydrazones |
US3560557A (en) * | 1965-11-19 | 1971-02-02 | Ciba Geigy Corp | Diphenyl-ureas,-thioureas,-guanidines and -parabanic acids |
US5689563A (en) * | 1993-06-29 | 1997-11-18 | Motorola, Inc. | Method and apparatus for efficient real-time authentication and encryption in a communication system |
WO1998020868A1 (fr) * | 1996-11-15 | 1998-05-22 | The Picower Institute For Medical Research | Guanylhydrazones utiles dans le traitement de maladies associees a l'activation des cellules t |
WO1998030583A1 (fr) * | 1997-01-08 | 1998-07-16 | The Picower Institute For Medical Research | Complexes et combinaisons de fetuine et d'agents therapeutiques |
US5854289A (en) * | 1994-01-21 | 1998-12-29 | The Picower Institute For Medical Research | Guanylhydrazones and their use to treat inflammatory conditions |
WO2001025192A1 (fr) * | 1999-10-06 | 2001-04-12 | Melacure Therapeutics Ab | Derives de guanidine et leur utilisation dans la production d'un medicament destine a bloquer les xanthine oxydases/deshydrogenases |
WO2001056553A2 (fr) * | 2000-02-02 | 2001-08-09 | Axxima Pharmaceuticals Ag | Guanylhydrazones aromatiques, actives sur le plan pharmacologique |
WO2002011715A2 (fr) * | 2000-08-07 | 2002-02-14 | Melacure Therapeutics Ab | Benzylideneaminoguanidines et hydroxyguanidines utilisees comme ligands des recepteur de la melanocortine |
-
2001
- 2001-06-26 WO PCT/EP2001/007260 patent/WO2002000613A2/fr active Application Filing
- 2001-06-26 AU AU2001269092A patent/AU2001269092A1/en not_active Abandoned
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB923398A (en) * | 1960-08-09 | 1963-04-10 | Vismara Francesco Spa | Diphenyl mono-and bis-formyl guanylhydrazones |
US3560557A (en) * | 1965-11-19 | 1971-02-02 | Ciba Geigy Corp | Diphenyl-ureas,-thioureas,-guanidines and -parabanic acids |
US5689563A (en) * | 1993-06-29 | 1997-11-18 | Motorola, Inc. | Method and apparatus for efficient real-time authentication and encryption in a communication system |
US5854289A (en) * | 1994-01-21 | 1998-12-29 | The Picower Institute For Medical Research | Guanylhydrazones and their use to treat inflammatory conditions |
WO1998020868A1 (fr) * | 1996-11-15 | 1998-05-22 | The Picower Institute For Medical Research | Guanylhydrazones utiles dans le traitement de maladies associees a l'activation des cellules t |
WO1998030583A1 (fr) * | 1997-01-08 | 1998-07-16 | The Picower Institute For Medical Research | Complexes et combinaisons de fetuine et d'agents therapeutiques |
WO2001025192A1 (fr) * | 1999-10-06 | 2001-04-12 | Melacure Therapeutics Ab | Derives de guanidine et leur utilisation dans la production d'un medicament destine a bloquer les xanthine oxydases/deshydrogenases |
WO2001056553A2 (fr) * | 2000-02-02 | 2001-08-09 | Axxima Pharmaceuticals Ag | Guanylhydrazones aromatiques, actives sur le plan pharmacologique |
WO2002011715A2 (fr) * | 2000-08-07 | 2002-02-14 | Melacure Therapeutics Ab | Benzylideneaminoguanidines et hydroxyguanidines utilisees comme ligands des recepteur de la melanocortine |
Non-Patent Citations (4)
Title |
---|
CAVALLINI G ET AL: "ANTIBACTERIAL AGENTS. SOME NEW GUANYLHYDRAZONE DERIVATIVES", JOURNAL OF MEDICINAL AND PHARMACEUTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, vol. 4, no. 1, 1 July 1961 (1961-07-01), pages 177 - 182, XP001021572 * |
CERAMI, CARLA ET AL: "High-performance liquid chromatographic method for guanylhydrazone compounds", J. CHROMATOGR., B: BIOMED. APPL. (1996), 675(1), 71-5, XP002206329 * |
COHEN P S ET AL: "The critical role of p38 MAP kinase in T cell HIV -1 replication.", MOLECULAR MEDICINE, vol. 3, no. 5, May 1997 (1997-05-01), pages 339 - 346, XP001018447 * |
KORYTNYK, W. ET AL: "Guanylhydrazones with potential antileukemic activity. 2. Synthesis and structure-activity relationships of analogs of 4,4'-diacetyl-N,N'-diphenylurea bis(guanylhydrazone)", J. MED. CHEM. (1978), 21(6), 507-13, XP002206328 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9034841B2 (en) | 2011-04-21 | 2015-05-19 | Isis Pharmaceuticals, Inc. | Modulation of hepatitis B virus (HBV) expression |
US9127278B2 (en) | 2011-04-21 | 2015-09-08 | Isis Pharmaceuticals, Inc. | Modulation of hepatitis B virus (HBV) expression |
Also Published As
Publication number | Publication date |
---|---|
WO2002000613A2 (fr) | 2002-01-03 |
AU2001269092A1 (en) | 2002-01-08 |
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