WO2002048116A3 - Inhibiteurs de la protease ns3 du virus de l'hepatite c - Google Patents
Inhibiteurs de la protease ns3 du virus de l'hepatite c Download PDFInfo
- Publication number
- WO2002048116A3 WO2002048116A3 PCT/US2001/047911 US0147911W WO0248116A3 WO 2002048116 A3 WO2002048116 A3 WO 2002048116A3 US 0147911 W US0147911 W US 0147911W WO 0248116 A3 WO0248116 A3 WO 0248116A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- hepatitis
- virus
- inhibitors
- protease
- protease inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
- C07F5/02—Boron compounds
- C07F5/04—Esters of boric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2002230763A AU2002230763A1 (en) | 2000-12-13 | 2001-12-12 | Inhibitors of hepatitis c virus ns3 protease |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25529000P | 2000-12-13 | 2000-12-13 | |
US60/255,290 | 2000-12-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002048116A2 WO2002048116A2 (fr) | 2002-06-20 |
WO2002048116A3 true WO2002048116A3 (fr) | 2007-10-25 |
Family
ID=22967659
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/047911 WO2002048116A2 (fr) | 2000-12-13 | 2001-12-12 | Inhibiteurs de la protease ns3 du virus de l'hepatite c |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU2002230763A1 (fr) |
WO (1) | WO2002048116A2 (fr) |
Cited By (9)
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---|---|---|---|---|
US8841275B2 (en) | 2010-11-30 | 2014-09-23 | Gilead Pharmasset Llc | 2′-spiro-nucleosides and derivatives thereof useful for treating hepatitis C virus and dengue virus infections |
US8957046B2 (en) | 2007-03-30 | 2015-02-17 | Gilead Pharmasset Llc | Nucleoside phosphoramidate prodrugs |
US8993595B2 (en) | 2009-04-08 | 2015-03-31 | Idenix Pharmaceuticals, Inc. | Macrocyclic serine protease inhibitors |
US9045520B2 (en) | 2008-12-23 | 2015-06-02 | Gilead Pharmasset Llc | Synthesis of purine nucleosides |
US9186369B2 (en) | 2003-07-25 | 2015-11-17 | Idenix Pharmaceuticals, Llc | Purine nucleoside analogues for treating flaviviridae including hepatitis C |
US9243025B2 (en) | 2011-03-31 | 2016-01-26 | Idenix Pharmaceuticals, Llc | Compounds and pharmaceutical compositions for the treatment of viral infections |
US9284307B2 (en) | 2009-08-05 | 2016-03-15 | Idenix Pharmaceuticals Llc | Macrocyclic serine protease inhibitors |
US9353100B2 (en) | 2011-02-10 | 2016-05-31 | Idenix Pharmaceuticals Llc | Macrocyclic serine protease inhibitors, pharmaceutical compositions thereof, and their use for treating HCV infections |
US9549941B2 (en) | 2011-11-29 | 2017-01-24 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
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PL373399A1 (en) | 2002-04-11 | 2005-08-22 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease |
EP2332952B1 (fr) | 2002-06-28 | 2015-04-29 | IDENIX Pharmaceuticals, Inc. | Promédicaments à base de nucléosides modifiés en 2' et 3' pour le traitement d'infections par flavivirus |
SI2604620T1 (sl) | 2003-05-30 | 2016-10-28 | Gilead Pharmasset LLC c/o Gilead Sciences, Inc. | Modificirani fluorirani nukleozidni analogi |
MY148123A (en) | 2003-09-05 | 2013-02-28 | Vertex Pharma | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease |
CN101857631A (zh) | 2003-10-10 | 2010-10-13 | 沃泰克斯药物股份有限公司 | 丝氨酸蛋白酶、特别是hcv ns3-ns4a蛋白酶的抑制剂 |
WO2005043118A2 (fr) | 2003-10-27 | 2005-05-12 | Vertex Pharmaceuticals Incorporated | Methode de decouverte de medicament |
EP1944042A1 (fr) | 2003-10-27 | 2008-07-16 | Vertex Pharmceuticals Incorporated | Combinaisons pour le traitement HCV |
GB0500020D0 (en) | 2005-01-04 | 2005-02-09 | Novartis Ag | Organic compounds |
EP1711515A2 (fr) | 2004-02-04 | 2006-10-18 | Vertex Pharmaceuticals Incorporated | Inhibiteurs de proteases serines, en particulier de la protease hcv ns3-ns4a |
US20050182252A1 (en) | 2004-02-13 | 2005-08-18 | Reddy K. R. | Novel 2'-C-methyl nucleoside derivatives |
JP5055564B2 (ja) | 2004-06-15 | 2012-10-24 | メルク・シャープ・エンド・ドーム・コーポレイション | Rna依存性rnaウイルスポリメラーゼの阻害剤としてのc−プリンヌクレオシド類似体 |
AU2005267421B2 (en) | 2004-06-24 | 2010-06-03 | Merck Sharp & Dohme Corp. | Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection |
EP1809301B1 (fr) | 2004-09-14 | 2019-11-06 | Gilead Pharmasset LLC | Intermédiaires de d-ribonolactone à substitution 2-fluoro-2-alkyl |
US7879797B2 (en) | 2005-05-02 | 2011-02-01 | Merck Sharp & Dohme Corp. | HCV NS3 protease inhibitors |
WO2006126730A1 (fr) * | 2005-05-26 | 2006-11-30 | Ajinomoto Co., Inc. | Dérivés bicycliques de pyrimidine et procédé de synthèse desdits dérivés |
US20090221598A1 (en) | 2005-06-17 | 2009-09-03 | Kai Lin | Use of Sanglifehrin in HCV |
AR057456A1 (es) | 2005-07-20 | 2007-12-05 | Merck & Co Inc | Inhibidores de la proteasa ns3 del vhc |
KR20080036598A (ko) | 2005-08-01 | 2008-04-28 | 머크 앤드 캄파니 인코포레이티드 | Hcv ns3 프로테아제 억제제로서의 마크로사이클릭펩티드 |
JP2009505966A (ja) | 2005-08-02 | 2009-02-12 | バーテックス ファーマシューティカルズ インコーポレイテッド | セリンプロテアーゼのインヒビター |
AU2006280175B2 (en) | 2005-08-09 | 2011-09-01 | Merck Sharp & Dohme Corp. | Ribonucleoside cyclic acetal derivatives for the treatment of RNA-dependent RNA viral infection |
EP1934179B1 (fr) | 2005-08-19 | 2010-04-07 | Vertex Pharmaceuticals Incorporated | Procedes et intermediaires |
AR055395A1 (es) | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
AU2006315438A1 (en) | 2005-11-11 | 2007-05-24 | Vertex Pharmaceuticals Incorporated | Hepatitis C virus variants |
US7705138B2 (en) | 2005-11-11 | 2010-04-27 | Vertex Pharmaceuticals Incorporated | Hepatitis C virus variants |
JP5167244B2 (ja) | 2006-04-11 | 2013-03-21 | ノバルティス アーゲー | Hcv/hiv阻害剤およびそれらの使用 |
GB0609492D0 (en) | 2006-05-15 | 2006-06-21 | Angeletti P Ist Richerche Bio | Therapeutic agents |
GB0612423D0 (en) | 2006-06-23 | 2006-08-02 | Angeletti P Ist Richerche Bio | Therapeutic agents |
EP2079479B1 (fr) | 2006-10-24 | 2014-11-26 | Merck Sharp & Dohme Corp. | Inhibiteurs de la protéase ns3 du vhc |
JP5345941B2 (ja) | 2006-10-24 | 2013-11-20 | メルク・シャープ・アンド・ドーム・コーポレーション | Hcvns3プロテアーゼ阻害剤 |
AU2007309546A1 (en) | 2006-10-24 | 2008-05-02 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | HCV NS3 protease inhibitors |
US8377874B2 (en) | 2006-10-27 | 2013-02-19 | Merck Sharp & Dohme Corp. | HCV NS3 protease inhibitors |
MY164469A (en) | 2006-10-27 | 2017-12-15 | Msd Italia Srl | Hcv ns3 protease inhibitors |
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GB0625349D0 (en) | 2006-12-20 | 2007-01-31 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
US8101595B2 (en) | 2006-12-20 | 2012-01-24 | Istituto di Ricerche di Biologia Molecolare P. Angletti SpA | Antiviral indoles |
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WO2009010804A1 (fr) | 2007-07-19 | 2009-01-22 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Composes macrocycliques servant d'agents antiviraux |
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WO2015061683A1 (fr) | 2013-10-25 | 2015-04-30 | Idenix Pharmaceuticals, Inc. | Pronucléotides thiophosphoramidates à acide aminé d et pronucléotides thiophosphoramidates à d-analine de composés de nucléoside utiles pour le traitement du vhc |
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EP3113763A1 (fr) | 2014-03-05 | 2017-01-11 | Idenix Pharmaceuticals LLC | Formes solides de promédicaments de 2'-chloro-2'-méthyl uridine pour lutter contre le vhc |
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EP3131914B1 (fr) | 2014-04-16 | 2023-05-10 | Idenix Pharmaceuticals LLC | Nucléosides méthyle ou alcynyle substitués en position 3 pour le traitement du virus de l'hépatite c |
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WO1995035308A1 (fr) * | 1994-06-17 | 1995-12-28 | Vertex Pharmaceuticals Incorporated | INHIBITEURS DE L'ENZYME DE CONVERSION D'INTERLEUKINE-1$g(b) |
WO2000020400A1 (fr) * | 1998-10-05 | 2000-04-13 | Axys Pharmaceuticals, Inc. | Nouveaux composes et compositions pour le traitement de l'hepatite c |
WO2001002424A2 (fr) * | 1999-07-07 | 2001-01-11 | Du Pont Pharmaceuticals Company | Inhibiteurs de la protease du virus de l'hepatite c a base d'acide boronique peptide |
WO2001007407A1 (fr) * | 1999-07-26 | 2001-02-01 | Bristol-Myers Squibb Pharma Company | Inhibiteurs lactame de la protease ns3 du virus de l'hepatite c |
-
2001
- 2001-12-12 AU AU2002230763A patent/AU2002230763A1/en not_active Abandoned
- 2001-12-12 WO PCT/US2001/047911 patent/WO2002048116A2/fr not_active Application Discontinuation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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WO1995035308A1 (fr) * | 1994-06-17 | 1995-12-28 | Vertex Pharmaceuticals Incorporated | INHIBITEURS DE L'ENZYME DE CONVERSION D'INTERLEUKINE-1$g(b) |
WO2000020400A1 (fr) * | 1998-10-05 | 2000-04-13 | Axys Pharmaceuticals, Inc. | Nouveaux composes et compositions pour le traitement de l'hepatite c |
WO2001002424A2 (fr) * | 1999-07-07 | 2001-01-11 | Du Pont Pharmaceuticals Company | Inhibiteurs de la protease du virus de l'hepatite c a base d'acide boronique peptide |
WO2001007407A1 (fr) * | 1999-07-26 | 2001-02-01 | Bristol-Myers Squibb Pharma Company | Inhibiteurs lactame de la protease ns3 du virus de l'hepatite c |
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US8957046B2 (en) | 2007-03-30 | 2015-02-17 | Gilead Pharmasset Llc | Nucleoside phosphoramidate prodrugs |
US9585906B2 (en) | 2007-03-30 | 2017-03-07 | Gilead Pharmasset Llc | Nucleoside phosphoramidate prodrugs |
US9045520B2 (en) | 2008-12-23 | 2015-06-02 | Gilead Pharmasset Llc | Synthesis of purine nucleosides |
US8993595B2 (en) | 2009-04-08 | 2015-03-31 | Idenix Pharmaceuticals, Inc. | Macrocyclic serine protease inhibitors |
US9284307B2 (en) | 2009-08-05 | 2016-03-15 | Idenix Pharmaceuticals Llc | Macrocyclic serine protease inhibitors |
US8841275B2 (en) | 2010-11-30 | 2014-09-23 | Gilead Pharmasset Llc | 2′-spiro-nucleosides and derivatives thereof useful for treating hepatitis C virus and dengue virus infections |
US9394331B2 (en) | 2010-11-30 | 2016-07-19 | Gilead Pharmasset Llc | 2′-spiro-nucleosides and derivatives thereof useful for treating hepatitis C virus and dengue virus infections |
US9353100B2 (en) | 2011-02-10 | 2016-05-31 | Idenix Pharmaceuticals Llc | Macrocyclic serine protease inhibitors, pharmaceutical compositions thereof, and their use for treating HCV infections |
US9243025B2 (en) | 2011-03-31 | 2016-01-26 | Idenix Pharmaceuticals, Llc | Compounds and pharmaceutical compositions for the treatment of viral infections |
US9549941B2 (en) | 2011-11-29 | 2017-01-24 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
Also Published As
Publication number | Publication date |
---|---|
WO2002048116A2 (fr) | 2002-06-20 |
AU2002230763A8 (en) | 2002-06-24 |
AU2002230763A1 (en) | 2008-01-03 |
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