WO2001095726A1 - Composition antiparasitaire - Google Patents

Composition antiparasitaire Download PDF

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Publication number
WO2001095726A1
WO2001095726A1 PCT/GB2001/002609 GB0102609W WO0195726A1 WO 2001095726 A1 WO2001095726 A1 WO 2001095726A1 GB 0102609 W GB0102609 W GB 0102609W WO 0195726 A1 WO0195726 A1 WO 0195726A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
composition according
terpene
derivative
alcohol
Prior art date
Application number
PCT/GB2001/002609
Other languages
English (en)
Inventor
Ian Whelan
Original Assignee
Ssl International Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0014666A external-priority patent/GB0014666D0/en
Priority claimed from GB0015109A external-priority patent/GB0015109D0/en
Application filed by Ssl International Plc filed Critical Ssl International Plc
Priority to AU2001264109A priority Critical patent/AU2001264109A1/en
Publication of WO2001095726A1 publication Critical patent/WO2001095726A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08—Magnoliopsida [dicotyledons]

Definitions

  • the invention relates to a parasiticidal composition and in particular to a composition for controlling headlice infestation in humans.
  • Lice infestation in man is generally caused by insects from the families Pediculidae and Pthiridae, in particular Pediculus humanus species and Pthirus pubis.
  • Terpenes are classed as a group of hydrocarbons that are made up of building blocks of isoprene or similar five-carbon units, with a monoterpene made up of two units (example: limonene and pinene), a sesquiterpene made up of three units (example: humulene,), and a diterpene made up of four units (example: phytol).
  • Isoprene The Isoprene rule was first pointed out by Wallach (1887) and it was later elucidated by Ingold (1925) who discussed that isoprene units in natural terpenes were joined "head-to-tail".
  • the terpenes in our context, are the primary constituents in the aromatic fractions of scented plants, generally essential oils, flavours and fragrances.
  • the extraction and synthesis of compounds such as these is the basis for the perfumery industry and they find a variety of uses in the feed and pharmaceutical industry as flavour and odour improvers, such as Limonene and Terpineol.
  • Saponin molecules are a combination of a sugar chain attached to either a sterol or a triterpene. Their name is derived from their ability to form foams in water, which is a function of a molecule containing both water (sugar) and fat soluble (triterpene) components. They are found in many plants, but get their name from the soapwort plant. Saponins at a concentration of about 5.6% are frequently employed in soap, shampoo and bath salt formulation.
  • a parasiticidal composition comprising a terpene or derivative thereof having parasiticidal activity, a naturally occurring plant saponin, and a plysiologically acceptable carrier.
  • the terpene or derivative may comprise one or more of d-limonene, geranyl acetate and eugenol, and the plant saponin may comprise one or more from the group consisting of Peru balsam, yucca, soapwort, ginseng and quillija. It is preferred that the composition is adapted for topical application to a subject. It is particularly preferred that the composition is adapted for application as a lotion or mousse for the hair.
  • composition may comprise an alcohol, such as isopropanol and/or ethanol, and the physiologically acceptable carrier may comprise the alcohol.
  • alcohol such as isopropanol and/or ethanol
  • physiologically acceptable carrier may comprise the alcohol.
  • composition may comprise at least about 1.0% v/v terpene or derivative.
  • composition is for use in the treatment and/or prevention of human infestation by parasites from the families Pediculidae and Pthiridae.
  • a process for preparing a parasiticidal composition which comprises bringing a terpene or derivative thereof and a naturally occurring plant saponin into association with at least one physiologically acceptable carrier therefor.
  • a terpene or derivative thereof and a plant saponin in the manufacture of a composition for use in controlling parasite infestations in humans, in particular infestation by parasites from the families Pediculidae and Pthiridae.
  • a composition comprising eugenol and the saponin soapwort was prepared.
  • the stock chemicals were diluted to the appropriate level using 60% propan-2-ol (isopropyl alcohol, isopropanol) diluted with 40% distilled water.
  • Solutions of the eugenol and soapwort were made on a weight for weight basis (w/w) in the alcohol vehicle.
  • Human lice pediculus humanus, were obtained from the culture colony maintained by the Medical Entomology Centre. Adult female and male lice, in approximately equal numbers, were used for each test. The lice were fed on the morning of the test and allowed a minimum of 4 hours to recover, during which time they were able to excrete excess water imbibed with their blood meal. Lice were counted into batches that were provided with squares of an open meshed nylon gauze (tulle), as a substrate upon which to stand, and each batch allocated to a marked 30 millimetre plastic Petri dish.
  • tulle open meshed nylon gauze
  • Gauze squares bearing lice were incubated under normal maintenance conditions (30° ⁇ 2° Celsius and 50% + 15% relative humidity) for the remainder of the test period.
  • the insects and gauze were washed using a bland toiletry shampoo (Boots frequent wash shampoo) diluted one part shampoo with fourteen parts water (FWS 1:15) after which they were rinsed three times using 250 millilitres of warm (34° Celsius) tap water poured through and over the gauze squares. They were then blotted dry using medical wipe tissue and incubated under normal maintenance conditions in clean plastic Petri dishes of the appropriate size until the results were recorded.
  • Mortality percentages were corrected by Abbott's formula. The percent of mortality in a control was subtracted from the percent mortality in the test and then divided by the percent mortality in the test.
  • formulations having parasiticidal activity were prepared as follows:
  • formulations which can be prepared in accordance with this invention include lotions and mousses as well as, potentially, other hair treatments.
  • additional constituents which are required will vary according to the desired properties of the final product.
  • the skilled worker will be familiar with such constituents and their usage, which can include, for example, surfactants, silicone compounds, suspending agents colourings and perfumes.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Agronomy & Crop Science (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Pest Control & Pesticides (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

La présente invention concerne une composition antiparasitaire qui comprend un terpène ou un dérivé de terpène possédant une activité antiparasitaire, une saponine végétale naturelle et un véhicule physiologiquement acceptable.
PCT/GB2001/002609 2000-06-15 2001-06-14 Composition antiparasitaire WO2001095726A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001264109A AU2001264109A1 (en) 2000-06-15 2001-06-14 Parasiticidal composition

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0014666.2 2000-06-15
GB0014666A GB0014666D0 (en) 2000-06-15 2000-06-15 Parasiticidal composition
GB0015109.2 2000-06-20
GB0015109A GB0015109D0 (en) 2000-06-20 2000-06-20 Parasitical composition

Publications (1)

Publication Number Publication Date
WO2001095726A1 true WO2001095726A1 (fr) 2001-12-20

Family

ID=26244493

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2001/002609 WO2001095726A1 (fr) 2000-06-15 2001-06-14 Composition antiparasitaire

Country Status (2)

Country Link
AU (1) AU2001264109A1 (fr)
WO (1) WO2001095726A1 (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6891079B2 (en) 2001-12-20 2005-05-10 Kimberly-Clark Worldwide, Inc. Wipe
US7154018B2 (en) 2001-12-20 2006-12-26 Kimberly-Clark Worldwide, Inc. Absorbent article
WO2007023028A2 (fr) * 2005-07-12 2007-03-01 Schneider, Frank Melange
NL1033969C2 (nl) * 2007-06-11 2008-12-12 Denka Internat Holding B V Carvacrol en Saponine.
US7485110B2 (en) 2001-12-20 2009-02-03 Kimberly Clark Worldwide, Inc. Wipe comprising a pathogen selective antimicrobial
US20130102471A1 (en) * 2011-10-19 2013-04-25 Huu Tieu Formula composition as delivery system used in pharmaceutical and pesticide applications
US8968757B2 (en) 2010-10-12 2015-03-03 Ecolab Usa Inc. Highly wettable, water dispersible, granules including two pesticides
CN105746585A (zh) * 2016-05-09 2016-07-13 福建省农业科学院植物保护研究所 一种蚜虫捕食性天敌昆虫的引诱剂
US9675068B2 (en) 2008-06-05 2017-06-13 Ecolab Usa Inc. Solid form sodium lauryl sulfate (SLS) crawling pest elimination composition
WO2024057304A1 (fr) 2022-09-12 2024-03-21 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Compositions pour une administration dermique/transdermique et utilisation cosmétique

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1467419A (en) * 1973-03-21 1977-03-16 Inchcape Chemco Ltd Pesticidal compositions
EP0495684A1 (fr) * 1991-01-18 1992-07-22 Clilco, Ltd. Compositions répulsives aux poux
WO1998027812A1 (fr) * 1996-12-24 1998-07-02 Proguard, Inc. Compositions repulsives contenant des aldehydes aromatiques
US5977186A (en) * 1998-01-27 1999-11-02 Ximed Group Plc Terpene treatments for killing lice and lice eggs

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1467419A (en) * 1973-03-21 1977-03-16 Inchcape Chemco Ltd Pesticidal compositions
EP0495684A1 (fr) * 1991-01-18 1992-07-22 Clilco, Ltd. Compositions répulsives aux poux
WO1998027812A1 (fr) * 1996-12-24 1998-07-02 Proguard, Inc. Compositions repulsives contenant des aldehydes aromatiques
US5977186A (en) * 1998-01-27 1999-11-02 Ximed Group Plc Terpene treatments for killing lice and lice eggs

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
A.Y.LEUNG,S.FOSTER: "Encyclopedia of Common Natural Ingredients used in food, drugs and cosmetics", 1996, JOHN WILEY & SONS, INC., XP002173347 *
S.DHARMANANDA: "Platycodon and other Chinees herbs with triterpene glycosides", INTERNET ARTICLE, XP002173346, Retrieved from the Internet <URL:http://www.itmonline.org/pdf/platygly.pdf> [retrieved on 20010727] *

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6891079B2 (en) 2001-12-20 2005-05-10 Kimberly-Clark Worldwide, Inc. Wipe
US7154018B2 (en) 2001-12-20 2006-12-26 Kimberly-Clark Worldwide, Inc. Absorbent article
US7485110B2 (en) 2001-12-20 2009-02-03 Kimberly Clark Worldwide, Inc. Wipe comprising a pathogen selective antimicrobial
WO2007023028A2 (fr) * 2005-07-12 2007-03-01 Schneider, Frank Melange
WO2007023028A3 (fr) * 2005-07-12 2007-08-02 Schneider Frank Melange
EP2002721A3 (fr) * 2007-06-11 2008-12-31 Denka International Holding B.V. Résidus de graines de thé et produits naturels de saponines de thé
EP2002721A2 (fr) 2007-06-11 2008-12-17 Denka International Holding B.V. Résidus de graines de thé et produits naturels de saponines de thé
NL1033969C2 (nl) * 2007-06-11 2008-12-12 Denka Internat Holding B V Carvacrol en Saponine.
US9675068B2 (en) 2008-06-05 2017-06-13 Ecolab Usa Inc. Solid form sodium lauryl sulfate (SLS) crawling pest elimination composition
US8968757B2 (en) 2010-10-12 2015-03-03 Ecolab Usa Inc. Highly wettable, water dispersible, granules including two pesticides
US9578876B2 (en) 2010-10-12 2017-02-28 Ecolab Usa Inc. Highly wettable, water dispersible, granules including two pesticides
US20130102471A1 (en) * 2011-10-19 2013-04-25 Huu Tieu Formula composition as delivery system used in pharmaceutical and pesticide applications
CN105746585A (zh) * 2016-05-09 2016-07-13 福建省农业科学院植物保护研究所 一种蚜虫捕食性天敌昆虫的引诱剂
CN105746585B (zh) * 2016-05-09 2018-11-30 福建省农业科学院植物保护研究所 一种蚜虫捕食性天敌昆虫的引诱剂
WO2024057304A1 (fr) 2022-09-12 2024-03-21 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Compositions pour une administration dermique/transdermique et utilisation cosmétique

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Publication number Publication date
AU2001264109A1 (en) 2001-12-24

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