WO2001090720A3 - Verfahren für die bestimmung von substrat- und produktkonzentrationen in einem medium - Google Patents

Verfahren für die bestimmung von substrat- und produktkonzentrationen in einem medium Download PDF

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Publication number
WO2001090720A3
WO2001090720A3 PCT/EP2001/005891 EP0105891W WO0190720A3 WO 2001090720 A3 WO2001090720 A3 WO 2001090720A3 EP 0105891 W EP0105891 W EP 0105891W WO 0190720 A3 WO0190720 A3 WO 0190720A3
Authority
WO
WIPO (PCT)
Prior art keywords
medium
diffusion
time
analyte
detector
Prior art date
Application number
PCT/EP2001/005891
Other languages
English (en)
French (fr)
Other versions
WO2001090720A2 (de
Inventor
Evelyn Wolfram
Matthias Arnold
Andreas Franz
Dirk Weuster-Botz
Christian Wandrey
Original Assignee
Forschungszentrum Juelich Gmbh
Dasgip Drescher Arnold & Schne
Evelyn Wolfram
Matthias Arnold
Andreas Franz
Weuster Botz Dirk
Christian Wandrey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forschungszentrum Juelich Gmbh, Dasgip Drescher Arnold & Schne, Evelyn Wolfram, Matthias Arnold, Andreas Franz, Weuster Botz Dirk, Christian Wandrey filed Critical Forschungszentrum Juelich Gmbh
Priority to EP01934003A priority Critical patent/EP1287329A2/de
Publication of WO2001090720A2 publication Critical patent/WO2001090720A2/de
Publication of WO2001090720A3 publication Critical patent/WO2001090720A3/de
Priority to US10/301,851 priority patent/US20030119201A1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/34—Purifying; Cleaning
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4005—Concentrating samples by transferring a selected component through a membrane
    • G01N2001/4016—Concentrating samples by transferring a selected component through a membrane being a selective membrane, e.g. dialysis or osmosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

Verfahren für die Bestimmung von Substrat- und Produktkonzentrationen in flüssigen und/oder gasförmigen Medien, bei dem mehrere Proben wenigstens einer zu analysierenden Substanz - dem Analyt - in wenigstens einer Probenahmestrecke (3) durch zeitgesteuerte Diffusion des wenigstens einen Analyts zwischen dem jeweiligen Medium und einem Diffusionsmedium, das den Probenahmestrecken (3) durch Fluidleitungen (5a, 5b) mittels wenigstens einer Pumpe (6) zugeführt wird, über semipermeable Membranen (2) entnommen werden und anschließend das Diffusionsmedium unter gleichzeitiger Zuführung neuen Diffusionsmediums von der Probenahmestrecke (3) zu wenigstens einem Detektor (7) transportiert und von diesem zur Bestimmung der Analytkonzentrationen analysiert wird. Der Detektor liefert eine zeitliche Konzentrationsverteilung oder eine zeitliche Verteilung eines zur Konzentration proportionalen Signals, daß eine Veränderung des Verhältnisses vom Signalmaximum zur Basislinie im Abstrom des Detektorsignals ermittelt und daraus auf eine Veränderung der Diffusionseigenschaften der semipermeablen Membranen geschlossen und ein Korrekturfaktor ermittelt wird.
PCT/EP2001/005891 2000-05-22 2001-05-22 Verfahren für die bestimmung von substrat- und produktkonzentrationen in einem medium WO2001090720A2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP01934003A EP1287329A2 (de) 2000-05-22 2001-05-22 Verfahren für die bestimmung von substrat- und produktkonzentrationen in einem medium
US10/301,851 US20030119201A1 (en) 2000-05-22 2002-11-22 Method for determination of product and substrate concentrations in a medium

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10024969A DE10024969A1 (de) 2000-05-22 2000-05-22 Verfahren für die Bestimmung von Substrat- und Produktkonzentrationen in einem Medium
DE10024969.8 2000-05-22

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/301,851 Continuation US20030119201A1 (en) 2000-05-22 2002-11-22 Method for determination of product and substrate concentrations in a medium

Publications (2)

Publication Number Publication Date
WO2001090720A2 WO2001090720A2 (de) 2001-11-29
WO2001090720A3 true WO2001090720A3 (de) 2002-05-23

Family

ID=7642896

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/005891 WO2001090720A2 (de) 2000-05-22 2001-05-22 Verfahren für die bestimmung von substrat- und produktkonzentrationen in einem medium

Country Status (4)

Country Link
US (1) US20030119201A1 (de)
EP (1) EP1287329A2 (de)
DE (1) DE10024969A1 (de)
WO (1) WO2001090720A2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190357827A1 (en) 2003-08-01 2019-11-28 Dexcom, Inc. Analyte sensor
US8626257B2 (en) 2003-08-01 2014-01-07 Dexcom, Inc. Analyte sensor
US8364231B2 (en) 2006-10-04 2013-01-29 Dexcom, Inc. Analyte sensor
US8532730B2 (en) * 2006-10-04 2013-09-10 Dexcom, Inc. Analyte sensor
DE102007063440B4 (de) 2007-12-21 2011-02-17 Thomas Grimm Screeningsystem zur Durchführung und direkten Analyse von biologischen, biochemischen und chemischen Synthese- und Umsetzungsreaktionen
US9149220B2 (en) 2011-04-15 2015-10-06 Dexcom, Inc. Advanced analyte sensor calibration and error detection
JP5148465B2 (ja) * 2008-12-08 2013-02-20 東京エレクトロン株式会社 液処理方法、液処理装置および記憶媒体
CN103975055B (zh) 2011-10-10 2016-05-04 德国达斯其普信息与程序技术有限公司 包括生物反应器的生物技术装置、用于生物反应器的排出气体温度控制装置以及用于处理生物技术装置中的排出气流的方法
WO2013053778A1 (en) 2011-10-10 2013-04-18 DASGIP Information and Process Technology GmbH Method for controlled operation of a biotechnological apparatus and bioreactor systems
SE536739C2 (sv) * 2012-11-06 2014-07-08 Scania Cv Ab Svavelhaltsindikator för bränsle, fordon som innefattar en sådan indikator samt ett förfarande för indikering av svavelhalt i ett bränsle
EP3199616A1 (de) 2016-01-29 2017-08-02 Eppendorf Ag Einweg-anschlusseinrichtung

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4819478A (en) * 1988-03-04 1989-04-11 The Dow Chemical Company Membrane assisted flow injection analysis
EP0445675A2 (de) * 1990-03-08 1991-09-11 Forschungszentrum Jülich Gmbh Durchfluss-Analysenverfahren und -vorrichtung
DE19517572A1 (de) * 1995-05-12 1996-11-14 Hitzmann Bernd Vorrichtung und Verfahren zur Meßsignalauswertung in Fließanalysesystemen
US5672319A (en) * 1993-04-29 1997-09-30 Danfoss A/S Device for analyzing a fluid medium
US5773713A (en) * 1994-07-26 1998-06-30 Crc For Waste Management & Pollution Control Limited Environmental monitoring of organic compounds
DE19729492A1 (de) * 1997-07-10 1999-02-11 Forschungszentrum Juelich Gmbh Verfahren und Vorrichtung zur Serienprobenahme

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5766959A (en) * 1996-05-24 1998-06-16 The Dow Chemical Company Method for determining a component using a liquid film or droplet

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4819478A (en) * 1988-03-04 1989-04-11 The Dow Chemical Company Membrane assisted flow injection analysis
EP0445675A2 (de) * 1990-03-08 1991-09-11 Forschungszentrum Jülich Gmbh Durchfluss-Analysenverfahren und -vorrichtung
US5672319A (en) * 1993-04-29 1997-09-30 Danfoss A/S Device for analyzing a fluid medium
US5773713A (en) * 1994-07-26 1998-06-30 Crc For Waste Management & Pollution Control Limited Environmental monitoring of organic compounds
DE19517572A1 (de) * 1995-05-12 1996-11-14 Hitzmann Bernd Vorrichtung und Verfahren zur Meßsignalauswertung in Fließanalysesystemen
DE19729492A1 (de) * 1997-07-10 1999-02-11 Forschungszentrum Juelich Gmbh Verfahren und Vorrichtung zur Serienprobenahme

Also Published As

Publication number Publication date
WO2001090720A2 (de) 2001-11-29
US20030119201A1 (en) 2003-06-26
DE10024969A1 (de) 2001-12-06
EP1287329A2 (de) 2003-03-05

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