WO2001089681A3 - Systeme de production chimique modulaire utilisant un microreacteur - Google Patents

Systeme de production chimique modulaire utilisant un microreacteur Download PDF

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Publication number
WO2001089681A3
WO2001089681A3 PCT/US2001/015738 US0115738W WO0189681A3 WO 2001089681 A3 WO2001089681 A3 WO 2001089681A3 US 0115738 W US0115738 W US 0115738W WO 0189681 A3 WO0189681 A3 WO 0189681A3
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WO
WIPO (PCT)
Prior art keywords
product
modules
produce
microreactor
reactants
Prior art date
Application number
PCT/US2001/015738
Other languages
English (en)
Other versions
WO2001089681A2 (fr
Inventor
Thomas Schwalbe
Sebastian Oberbeck
Klaus Golbig
Michael Hohmann
Andreas Oberbeck
Original Assignee
Cellular Process Chemistry Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/578,224 external-priority patent/US7056477B1/en
Application filed by Cellular Process Chemistry Inc filed Critical Cellular Process Chemistry Inc
Priority to EP01935559A priority Critical patent/EP1286761A2/fr
Priority to JP2001585914A priority patent/JP2004508919A/ja
Publication of WO2001089681A2 publication Critical patent/WO2001089681A2/fr
Publication of WO2001089681A3 publication Critical patent/WO2001089681A3/fr

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00801—Means to assemble
    • B01J2219/0081—Plurality of modules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00835—Comprising catalytically active material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00867—Microreactors placed in series, on the same or on different supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00869—Microreactors placed in parallel, on the same or on different supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00871—Modular assembly
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00873—Heat exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00889—Mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00891—Feeding or evacuation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00984—Residence time

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

L'invention concerne un système de production chimique modulaire comprenant un microréacteur, destiné à la production d'un produit par mise en réaction d'au moins deux réactifs. La modularisation permet d'ajouter et d'enlever des composants, tels que des contrôleurs, des pompes, des soupapes, des microréacteurs, et des modules de traitement, selon les besoins, pour obtenir un produit désiré. Ce système comprend un module de commande et un module de réaction renfermant un volume de mélange et un volume de réaction. Plusieurs modules de pompage et de séjour peuvent également être inclus dans le système. Des raccords à engagement/dégagement rapide permettent un changement rapide des modules en cas de dysfonctionnement ou pour produire un produit ou une quantité différent. Une base de données comprend les paramètres optimaux pour une pluralité de réactions différentes permettant de produire différents produits chimiques. L'utilisateur sélectionne un produit et une quantité désirés, fournit les réactifs, les solvants et les agents caloporteurs, et le module de commande gère le système pour produire automatiquement le produit, jusqu'à obtention de la quantité désirée.
PCT/US2001/015738 2000-05-24 2001-05-15 Systeme de production chimique modulaire utilisant un microreacteur WO2001089681A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP01935559A EP1286761A2 (fr) 2000-05-24 2001-05-15 Systeme de production chimique modulaire utilisant un microreacteur
JP2001585914A JP2004508919A (ja) 2000-05-24 2001-05-15 マイクロリアクタを組み入れたモジュラ式化学生産システム

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/578,224 2000-05-24
US09/578,224 US7056477B1 (en) 2000-02-03 2000-05-24 Modular chemical production system incorporating a microreactor

Publications (2)

Publication Number Publication Date
WO2001089681A2 WO2001089681A2 (fr) 2001-11-29
WO2001089681A3 true WO2001089681A3 (fr) 2003-01-03

Family

ID=24311932

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/015738 WO2001089681A2 (fr) 2000-05-24 2001-05-15 Systeme de production chimique modulaire utilisant un microreacteur

Country Status (3)

Country Link
EP (1) EP1286761A2 (fr)
JP (1) JP2004508919A (fr)
WO (1) WO2001089681A2 (fr)

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US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
US8883490B2 (en) 2006-03-24 2014-11-11 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US8894947B2 (en) 2001-03-28 2014-11-25 Handylab, Inc. Systems and methods for thermal actuation of microfluidic devices
US9028773B2 (en) 2001-09-12 2015-05-12 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US9051604B2 (en) 2001-02-14 2015-06-09 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
USD742027S1 (en) 2011-09-30 2015-10-27 Becton, Dickinson And Company Single piece reagent holder
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9217143B2 (en) 2007-07-13 2015-12-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US9222954B2 (en) 2011-09-30 2015-12-29 Becton, Dickinson And Company Unitized reagent strip
US9238223B2 (en) 2007-07-13 2016-01-19 Handylab, Inc. Microfluidic cartridge
US9259734B2 (en) 2007-07-13 2016-02-16 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9259735B2 (en) 2001-03-28 2016-02-16 Handylab, Inc. Methods and systems for control of microfluidic devices
US9347586B2 (en) 2007-07-13 2016-05-24 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
US12030050B2 (en) 2020-11-04 2024-07-09 Handylab, Inc. Microfluidic cartridge and method of making same

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DE10032059A1 (de) * 2000-07-05 2002-01-17 Mir Chem Gmbh Vorrichtung zum Ausführen einer katalytischen Rohrreaktion
AU2001281121B2 (en) 2000-08-08 2007-08-23 Ortho-Mcneil Pharmaceutical, Inc. Non-imidazole aryloxypiperidines as H3 receptor ligands
PT1313721E (pt) 2000-08-08 2006-06-30 Ortho Mcneil Pharm Inc Ariloxialquilaminas nao imidazoles como ligandos de receptor h3
DE10143189A1 (de) * 2001-09-04 2003-03-20 Clariant Gmbh Verfahren und Vorrichtung zur prozeßbegleitenden Reinigung von Mikro-und Minireaktoren
DE10209897A1 (de) * 2002-03-08 2003-09-25 Merck Patent Gmbh Mikrokomponenten-Anschlusssystem
WO2004011134A1 (fr) * 2002-07-26 2004-02-05 Avantium International B.V. Systeme permettant de mettre en oeuvre une reaction chimique dans une pluralite de microreacteurs differents
GB0307999D0 (en) * 2003-04-07 2003-05-14 Glaxo Group Ltd A system
JP2006526492A (ja) * 2003-05-09 2006-11-24 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング マイクロ処理制御用コンポーネント
EP3718635A1 (fr) 2003-07-31 2020-10-07 Handylab, Inc. Traitement d'échantillons contenant des particules
DE102005013915A1 (de) * 2005-03-24 2006-09-28 Siemens Ag Verfahrenstechnische, insbesondere mikroverfahrenstechnische Anlage
KR101004487B1 (ko) 2005-09-08 2010-12-31 가시오게산키 가부시키가이샤 이동형 전자 장치의 전원공급용 개질기
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
ES2587007T3 (es) 2006-03-24 2016-10-20 Handylab, Inc. Sistema integrado para procesar muestras microfluídicas, y métodos de uso del mismo
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
TW200738328A (en) 2006-03-31 2007-10-16 Lonza Ag Micro-reactor system assembly
US8709787B2 (en) 2006-11-14 2014-04-29 Handylab, Inc. Microfluidic cartridge and method of using same
EP2167233B1 (fr) * 2007-06-26 2013-01-23 Micronit Microfluidics B.V. Dispositif et procédé permettant le couplage fluidique de conduits fluidiques à une puce microfluidique et leur découplage
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
WO2009092392A1 (fr) * 2008-01-22 2009-07-30 Siemens Aktiengesellschaft Module de processus pour réaliser une fonction industrielle prédéterminée
DE102008041950A1 (de) * 2008-09-10 2010-03-11 Evonik Degussa Gmbh System zur Bereitstellung einer universellen Infrastruktur für chemische Prozesse
EP2223741A1 (fr) * 2009-02-13 2010-09-01 Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO Système micro fluidique, incluant un amas de modules de procédé et modules d'échange thermique
JP4904374B2 (ja) * 2009-03-30 2012-03-28 東レエンジニアリング株式会社 マイクロリアクタ
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DE202010000262U1 (de) 2009-05-12 2010-05-20 Lonza Ag Strömungsreaktor mit Mikrokanalsystem
DE202009017416U1 (de) 2009-05-12 2010-04-15 Lonza Ag Reaktor und Satz aus Reaktoren
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EP3159697B1 (fr) 2011-04-15 2019-12-25 Becton, Dickinson and Company Balayage de thermocycleur microfluidique en temps réel
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US11185839B2 (en) 2016-05-02 2021-11-30 Massachusetts Institute Of Technology Reconfigurable multi-step chemical synthesis system and related components and methods
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Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9051604B2 (en) 2001-02-14 2015-06-09 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US9528142B2 (en) 2001-02-14 2016-12-27 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US8894947B2 (en) 2001-03-28 2014-11-25 Handylab, Inc. Systems and methods for thermal actuation of microfluidic devices
US9259735B2 (en) 2001-03-28 2016-02-16 Handylab, Inc. Methods and systems for control of microfluidic devices
US9028773B2 (en) 2001-09-12 2015-05-12 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
US8883490B2 (en) 2006-03-24 2014-11-11 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US9217143B2 (en) 2007-07-13 2015-12-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US9238223B2 (en) 2007-07-13 2016-01-19 Handylab, Inc. Microfluidic cartridge
US9259734B2 (en) 2007-07-13 2016-02-16 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9347586B2 (en) 2007-07-13 2016-05-24 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US11845081B2 (en) 2007-07-13 2023-12-19 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
US9222954B2 (en) 2011-09-30 2015-12-29 Becton, Dickinson And Company Unitized reagent strip
US9480983B2 (en) 2011-09-30 2016-11-01 Becton, Dickinson And Company Unitized reagent strip
USD742027S1 (en) 2011-09-30 2015-10-27 Becton, Dickinson And Company Single piece reagent holder
US12030050B2 (en) 2020-11-04 2024-07-09 Handylab, Inc. Microfluidic cartridge and method of making same

Also Published As

Publication number Publication date
EP1286761A2 (fr) 2003-03-05
WO2001089681A2 (fr) 2001-11-29
JP2004508919A (ja) 2004-03-25

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