WO2001085788A3 - Human ion channels - Google Patents

Human ion channels Download PDF

Info

Publication number
WO2001085788A3
WO2001085788A3 PCT/US2001/014965 US0114965W WO0185788A3 WO 2001085788 A3 WO2001085788 A3 WO 2001085788A3 US 0114965 W US0114965 W US 0114965W WO 0185788 A3 WO0185788 A3 WO 0185788A3
Authority
WO
WIPO (PCT)
Prior art keywords
ion channels
provides
ion channel
human ion
methods
Prior art date
Application number
PCT/US2001/014965
Other languages
French (fr)
Other versions
WO2001085788A2 (en
Inventor
Steven L Roberds
Christopher W Benjamin
Alla M Karnovsky
Cara L Ruble
Original Assignee
Upjohn Co
Steven L Roberds
Christopher W Benjamin
Alla M Karnovsky
Cara L Ruble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co, Steven L Roberds, Christopher W Benjamin, Alla M Karnovsky, Cara L Ruble filed Critical Upjohn Co
Priority to EP01931099A priority Critical patent/EP1280824A2/en
Priority to AU2001257570A priority patent/AU2001257570A1/en
Publication of WO2001085788A2 publication Critical patent/WO2001085788A2/en
Publication of WO2001085788A3 publication Critical patent/WO2001085788A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Abstract

The present invention provides novel ion channel polypeptides and polynucleotides that identify and encode them. In addition, the invention provides expression vectors, host cells and methods for their production. The inventin also provides methods for the identification of ion channel agonists/antagonists, useful for the treatment of human diseases and conditions.
PCT/US2001/014965 2000-05-10 2001-05-10 Human ion channels WO2001085788A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP01931099A EP1280824A2 (en) 2000-05-10 2001-05-10 Human ion channels
AU2001257570A AU2001257570A1 (en) 2000-05-10 2001-05-10 Human ion channels

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US20330500P 2000-05-10 2000-05-10
US60/203,305 2000-05-10
US20652600P 2000-05-23 2000-05-23
US60/206,526 2000-05-23
US20703300P 2000-05-25 2000-05-25
US20709200P 2000-05-25 2000-05-25
US20709300P 2000-05-25 2000-05-25
US60/207,093 2000-05-25
US60/207,092 2000-05-25
US60/207,033 2000-05-25
US21689300P 2000-07-07 2000-07-07
US60/216,893 2000-07-07
US22324500P 2000-08-04 2000-08-04
US60/223,245 2000-08-04
US23787300P 2000-10-04 2000-10-04
US60/237,873 2000-10-04

Publications (2)

Publication Number Publication Date
WO2001085788A2 WO2001085788A2 (en) 2001-11-15
WO2001085788A3 true WO2001085788A3 (en) 2002-07-18

Family

ID=27575170

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/014965 WO2001085788A2 (en) 2000-05-10 2001-05-10 Human ion channels

Country Status (3)

Country Link
EP (1) EP1280824A2 (en)
AU (1) AU2001257570A1 (en)
WO (1) WO2001085788A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030113888A1 (en) * 2000-05-26 2003-06-19 Benjamin Christopher W. Human ion channels
CA2413747A1 (en) * 2000-06-27 2002-01-03 Centre National De La Recherche Scientifique Mammal 2p domain mechano-sensitive k+ channel, cloning and applications thereof
US20020103115A1 (en) * 2000-09-19 2002-08-01 Karl Guegler Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof
EP1347049A4 (en) * 2000-12-26 2004-08-04 Yamanouchi Pharma Co Ltd Novel potassium channel

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999037762A1 (en) * 1998-01-27 1999-07-29 Smithkline Beecham Plc Trek-1 like two pore potassium channel
WO1999043696A1 (en) * 1998-02-25 1999-09-02 Icagen Inc. Human potassium channel genes
WO1999045108A2 (en) * 1998-03-05 1999-09-10 Centre National De La Recherche Scientifique (Cnrs) Novel mechanically sensitive mammal potassium channel family activated by polyunsaturated fatty acids and their use particularly for screening medicines

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999037762A1 (en) * 1998-01-27 1999-07-29 Smithkline Beecham Plc Trek-1 like two pore potassium channel
WO1999043696A1 (en) * 1998-02-25 1999-09-02 Icagen Inc. Human potassium channel genes
WO1999045108A2 (en) * 1998-03-05 1999-09-10 Centre National De La Recherche Scientifique (Cnrs) Novel mechanically sensitive mammal potassium channel family activated by polyunsaturated fatty acids and their use particularly for screening medicines

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE GENEMBL 20 September 2000 (2000-09-20), LESAGE, F. ET AL.: "Homo sapiens domain potassium channel TREK2 (KCNK10) mRNA, complete cds", XP002187800 *
LESAGE, F. ET AL.: "Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 37, 15 September 2000 (2000-09-15), pages 28398 - 28405, XP002187799 *
See also references of EP1280824A2 *

Also Published As

Publication number Publication date
WO2001085788A2 (en) 2001-11-15
EP1280824A2 (en) 2003-02-05
AU2001257570A1 (en) 2001-11-20

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