WO2001044283A3 - Human ion channels - Google Patents

Human ion channels Download PDF

Info

Publication number
WO2001044283A3
WO2001044283A3 PCT/US2000/033829 US0033829W WO0144283A3 WO 2001044283 A3 WO2001044283 A3 WO 2001044283A3 US 0033829 W US0033829 W US 0033829W WO 0144283 A3 WO0144283 A3 WO 0144283A3
Authority
WO
WIPO (PCT)
Prior art keywords
ion channels
provides
human ion
ion channel
methods
Prior art date
Application number
PCT/US2000/033829
Other languages
French (fr)
Other versions
WO2001044283A2 (en
Inventor
Steven L Roberds
Alla M Karnovsky
Cara L Ruble
Christopher W Benjamin
Original Assignee
Upjohn Co
Steven L Roberds
Alla M Karnovsky
Cara L Ruble
Christopher W Benjamin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co, Steven L Roberds, Alla M Karnovsky, Cara L Ruble, Christopher W Benjamin filed Critical Upjohn Co
Priority to AU20975/01A priority Critical patent/AU784644B2/en
Priority to CA002393538A priority patent/CA2393538A1/en
Priority to EP00984339A priority patent/EP1237923A2/en
Priority to US10/149,930 priority patent/US20030215813A1/en
Publication of WO2001044283A2 publication Critical patent/WO2001044283A2/en
Publication of WO2001044283A3 publication Critical patent/WO2001044283A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid

Abstract

The present invention provides novel ion channel polypeptides and polynucleotides which identify and encode them. In addition, the invention provides expression vectors, host cells and methods for their production. The invention also provides methods for the identification of ion channel agonists/antagonists, useful for the treatment of human diseases and conditions.
PCT/US2000/033829 1999-12-14 2000-12-14 Human ion channels WO2001044283A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU20975/01A AU784644B2 (en) 1999-12-14 2000-12-14 Human ion channels
CA002393538A CA2393538A1 (en) 1999-12-14 2000-12-14 Human ion channels
EP00984339A EP1237923A2 (en) 1999-12-14 2000-12-14 Human ion channels
US10/149,930 US20030215813A1 (en) 2000-12-14 2000-12-14 Human ion channels

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46060299A 1999-12-14 1999-12-14
US09/460,602 1999-12-14

Publications (2)

Publication Number Publication Date
WO2001044283A2 WO2001044283A2 (en) 2001-06-21
WO2001044283A3 true WO2001044283A3 (en) 2002-02-21

Family

ID=23829374

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/033829 WO2001044283A2 (en) 1999-12-14 2000-12-14 Human ion channels

Country Status (4)

Country Link
EP (1) EP1237923A2 (en)
AU (1) AU784644B2 (en)
CA (1) CA2393538A1 (en)
WO (1) WO2001044283A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001068849A2 (en) * 2000-03-10 2001-09-20 Pharmacia & Upjohn Company Human ion channels
EP1287022A2 (en) * 2000-05-26 2003-03-05 PHARMACIA & UPJOHN COMPANY Human ion channels
EP1307551A2 (en) 2000-07-05 2003-05-07 PHARMACIA & UPJOHN COMPANY Human ion channels
DE10164139A1 (en) 2001-12-27 2003-07-10 Bayer Ag 2-heteroaryl carboxamides
PT2540297E (en) 2008-11-19 2015-08-26 Forum Pharmaceuticals Inc Treatment of cognitive disorders with (r)-7-chloro-n-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide and pharmaceutically acceptable salts thereof
SA111320455B1 (en) 2010-05-17 2014-10-16 Envivo Pharmaceuticals Inc Acrystalline form of (R)-7-chloro-N-(quinuclidin-3-‎Yl)benzo[B]thiophene-2-carboxamide hydrochloride ‎monohydrate
EP3666272A1 (en) 2012-05-08 2020-06-17 Forum Pharmaceuticals Inc. Use of encenicline in the treatment of cognitive impairment, alzheimer's disease, memory deficit

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996041876A1 (en) * 1995-06-07 1996-12-27 Sibia Neurosciences, Inc. Human neuronal nicotinic acetylcholine receptor compositions and methods employing same
WO2000073431A2 (en) * 1999-05-27 2000-12-07 Pharmacia & Upjohn Company Methods and compositions for measuring ion channel conductance

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996041876A1 (en) * 1995-06-07 1996-12-27 Sibia Neurosciences, Inc. Human neuronal nicotinic acetylcholine receptor compositions and methods employing same
WO2000073431A2 (en) * 1999-05-27 2000-12-07 Pharmacia & Upjohn Company Methods and compositions for measuring ion channel conductance

Non-Patent Citations (14)

* Cited by examiner, † Cited by third party
Title
A V MARICQ ET AL: "Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel", SCIENCE,AAAS. LANCASTER, PA,US, vol. 254, 18 October 1991 (1991-10-18), pages 432 - 437, XP002157173, ISSN: 0036-8075 *
ANAND R ET AL: "CHROMOSOMAL LOCALIZATION OF SEVEN NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR SUBUNIT GENES IN HUMANS", GENOMICS,US,ACADEMIC PRESS, SAN DIEGO, vol. 13, no. 4, 1 August 1992 (1992-08-01), pages 962 - 967, XP000611273, ISSN: 0888-7543 *
BAILEY MARK E S ET AL: "Genetic linkage and radiation hybrid mapping of the three human GABAC receptor rho subunit genes: GABRR1, GABRR2 and GABRR3.", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1447, no. 2-3, 28 October 1999 (1999-10-28), pages 307 - 312, XP000926470, ISSN: 0006-3002 *
CHEBIB MARY ET AL: "The 'ABC' of GABA receptors: A brief review.", CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, vol. 26, no. 11, November 1999 (1999-11-01), pages 937 - 940, XP002168993, ISSN: 0305-1870 *
DATABASE EMBL 1 January 1900 (1900-01-01), MUZNY D M, ET AL: "HOMO SAPIENS CHROMOSOME 3 CLONE RP11-315J22, WORKING DRAFT SEQUENCE, 21 UNORDERED PIECES", XP002168999, Database accession no. AC068644 *
DATABASE SWISSPROT SWALL 1 January 1900 (1900-01-01), CAULEY K, AGRANOFF B W, GOLDMAN D: "NEURONAL ACETYLCHOLINE RECEPTOR PROTEIN, NON-ALPHA-2 CHAIN PRECURSOR (GFN-ALPHA-2)", XP002168997, Database accession no. P13908 *
DATABASE SWISSPROT SWALL 1 January 1900 (1900-01-01), MIYAKE A, ET AL: "5-HYDROXYTRYPTAMINE 3 RECEPTOR PRECURSOR (5-HT-3) (SEROTONIN-GATED ION CHANNEL RECEPTOR) (5-HT3R)", XP002168995, Database accession no. P46098 *
DATABASE TREMBL 1 January 1900 (1900-01-01), WERNER P, ET AL: "5HT3 RECEPTOR", XP002168996, Database accession no. Q61225 *
DATABASE TREMBL SWALL 1 January 1900 (1900-01-01), SGARD F, ET AL: "NEURONAL NICOTINIC ACETYLCHOLINE ALPHA10 SUBUNIT PRECURSOR (NICOTINIC ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA 10) (NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA 10 PRECURSOR)", XP002168998, Database accession no. Q9GZZ6 *
J -L EISELE ET AL: "CHIMAERIC NICOTINIC-SEROTONERGIC RECEPTOR COMBINES DISTINCT LIGAND BINDING AND CHANNEL SPECIFICITIES", NATURE,MACMILLAN JOURNALS LTD. LONDON,GB, vol. 366, 2 December 1993 (1993-12-02), pages 479 - 483, XP002157172, ISSN: 0028-0836 *
LE NOVERE NICOLAS ET AL: "The ligand gated ion channel database.", NUCLEIC ACIDS RESEARCH, vol. 27, no. 1, 1 January 1999 (1999-01-01), pages 340 - 342, XP002168994, ISSN: 0305-1048 *
LUKAS RONALD J ET AL: "International union of pharmacology. XX. Current status of the nomenclature for nicotinic acetylcholine receptors and their subunits.", PHARMACOLOGICAL REVIEWS, vol. 51, no. 2, June 1999 (1999-06-01), pages 397 - 401, XP000926477, ISSN: 0031-6997 *
QIAN HAOHUA ET AL: "Response kinetics and pharmacological properties of heteromeric receptors formed by coassembly of GABA rho- and gamma2-subunits.", PROCEEDINGS OF THE ROYAL SOCIETY BIOLOGICAL SCIENCES SERIES B, vol. 266, no. 1436, 7 December 1999 (1999-12-07), pages 2419 - 2425, XP000926469, ISSN: 0962-8452 *
WHITING P J ET AL: "EXPRESSION OF NICOTINIC ACETYLCHOLINE RECEPTOR SUBTYPES IN BRAIN AND RETINA", MOLECULAR BRAIN RESEARCH, vol. 10, no. 1, 1991, pages 61 - 70, XP000926478, ISSN: 0169-328X *

Also Published As

Publication number Publication date
WO2001044283A2 (en) 2001-06-21
CA2393538A1 (en) 2001-06-21
EP1237923A2 (en) 2002-09-11
AU784644B2 (en) 2006-05-18
AU2097501A (en) 2001-06-25

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