WO2001077125A3 - Haplotypes du gene ccr5 - Google Patents

Haplotypes du gene ccr5 Download PDF

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Publication number
WO2001077125A3
WO2001077125A3 PCT/US2001/010708 US0110708W WO0177125A3 WO 2001077125 A3 WO2001077125 A3 WO 2001077125A3 US 0110708 W US0110708 W US 0110708W WO 0177125 A3 WO0177125 A3 WO 0177125A3
Authority
WO
WIPO (PCT)
Prior art keywords
ccr5
haplotypes
gene
ccr5 gene
disclosed
Prior art date
Application number
PCT/US2001/010708
Other languages
English (en)
Other versions
WO2001077125A2 (fr
Inventor
Julie Y Choi
Stefanie E Kliem
Beena Koshy
Original Assignee
Genaissance Pharmaceuticals
Julie Y Choi
Stefanie E Kliem
Beena Koshy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaissance Pharmaceuticals, Julie Y Choi, Stefanie E Kliem, Beena Koshy filed Critical Genaissance Pharmaceuticals
Priority to AU2001249798A priority Critical patent/AU2001249798A1/en
Publication of WO2001077125A2 publication Critical patent/WO2001077125A2/fr
Publication of WO2001077125A3 publication Critical patent/WO2001077125A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7158—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne des nouveaux polymorphismes de nucléotide simple dans le gène récepteur 5 (présentant le motif C-C) (CCR5) de la chimiokine de l'homme. De plus, l'invention concerne divers génotypes, divers haplotypes et diverses paires d'haplotypes destinés au gène CCR5 existant dans la population. L'invention concerne également des compositions et des procédés permettant d'haplotyper et/ou de génotyper le gène CCR5 dans un individu. On décrit également des polynucléotides renfermant au moins un des polymorphismes du gène CCR5.
PCT/US2001/010708 2000-04-05 2001-04-04 Haplotypes du gene ccr5 WO2001077125A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001249798A AU2001249798A1 (en) 2000-04-05 2001-04-04 Haplotypes of the ccr5 gene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19436100P 2000-04-05 2000-04-05
US60/194,361 2000-04-05

Publications (2)

Publication Number Publication Date
WO2001077125A2 WO2001077125A2 (fr) 2001-10-18
WO2001077125A3 true WO2001077125A3 (fr) 2002-02-28

Family

ID=22717284

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/010708 WO2001077125A2 (fr) 2000-04-05 2001-04-04 Haplotypes du gene ccr5

Country Status (2)

Country Link
AU (1) AU2001249798A1 (fr)
WO (1) WO2001077125A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7393634B1 (en) * 1999-10-12 2008-07-01 United States Of America As Represented By The Secretary Of The Air Force Screening for disease susceptibility by genotyping the CCR5 and CCR2 genes

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CARRINGTON ET AL.: "Novel alleles of the chemokine-receptor gene CCR5", AMERICAN J. OF HUMAN GENETICS, vol. 61, 1997, pages 1261 - 1267, XP002948878 *
KOSTRIKIS ET AL.: "A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation", NATURE MEDICINE, vol. 4, no. 3, March 1998 (1998-03-01), pages 350 - 353, XP002948876 *
KOSTRIKIS ET AL.: "A polymorphism in the regulatory region of the CC-chemokine receptor 5 gene influences perinatal transmission of HIV-1 to African-American infants", J. OF VIROLOGY, vol. 73, no. 12, December 1999 (1999-12-01), pages 10264 - 10271, XP002948875 *
MARTIN ET AL.: "Genetic acceleration of AIDS progression by a promoter variant of CCR5", SCIENCE, vol. 282, pages 1907 - 1911, XP002948877 *
MCDERMOTT ET AL.: "CCR5 promoter polymorphism and HIV-1 disease progression", THE LANCET, vol. 352, 12 September 1998 (1998-09-12), pages 866 - 870, XP002948874 *

Also Published As

Publication number Publication date
WO2001077125A2 (fr) 2001-10-18
AU2001249798A1 (en) 2001-10-23

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