WO2001054816A1 - Recipient pour contenir des liquides - Google Patents

Recipient pour contenir des liquides Download PDF

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Publication number
WO2001054816A1
WO2001054816A1 PCT/AT2001/000018 AT0100018W WO0154816A1 WO 2001054816 A1 WO2001054816 A1 WO 2001054816A1 AT 0100018 W AT0100018 W AT 0100018W WO 0154816 A1 WO0154816 A1 WO 0154816A1
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WO
WIPO (PCT)
Prior art keywords
container
container according
polymer
mbar
maximum
Prior art date
Application number
PCT/AT2001/000018
Other languages
German (de)
English (en)
Inventor
Franz Konrad
Original Assignee
Greiner Bio-One Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Greiner Bio-One Gmbh filed Critical Greiner Bio-One Gmbh
Priority to AU2001229866A priority Critical patent/AU2001229866A1/en
Publication of WO2001054816A1 publication Critical patent/WO2001054816A1/fr

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se

Definitions

  • the invention relates to a container for holding liquids according to the features of the preambles of claims 1, 39 and 40, respectively.
  • containers are used for taking blood, which are either evacuated or by appropriate devices, e.g. generate a negative pressure by means of displaceable piston rods in the interior of the container.
  • an automatic suction of the blood into these blood collection tubes is achieved, as a result of which the overall process of blood collection can be improved overall.
  • the containers used are usually either made of glass or plastic, with the latter recently being preferred because they have the advantage of reduced risk of breakage over glass, i.e. that the blood samples, which are sometimes contaminated with potentially dangerous viruses, even if the
  • Plastics the problem that they have a poorer diffusion or permeation coefficient for e.g. Have water vapor or gases, which means that the concentrations of these solutions, which may be set very precisely, change significantly with prolonged storage of the blood collection tubes. This can sometimes lead to the extent that individual constituents of the solutions crystallize again and thus the solid phase
  • EP 0 512 612 A for example, to provide a sample container made of plastic on its outer surface with a so-called barrier label, which has a multi-layer design.
  • this adhesive labels are extremely difficult to attach to the sample containers with semicircular bottoms and, as a result, this label can detach itself from the sample container at least in some areas during long storage or during transport.
  • Design variants have therefore also been proposed in which the adhesive label does not extend over the entire outer surface of the sample container and is open in particular in the region of the semicircular base.
  • the adhesive label can only be effective to a limited extent.
  • this adhesive label does not completely detach from the sample container, but rather only individual gaps occur between the sample container and the label, there is a risk that, for example, water vapor diffuses from the inside of the sample container into the intermediate space, which has negative effects on the concentration of the Liquids presented to sample containers are expected.
  • this adhesive label may first have to be attached to the sample container by the user, as a result of which the user-friendliness is greatly reduced.
  • this adhesive label must always be attached to the outer surface of the sample container, as a result of which transport damage to the adhesive label that may occur cannot be prevented, and the function of the adhesive label may in turn be severely restricted.
  • a blood collection tube is known from EP 0 735 921 A, which is formed by a liquid-tight container inserted into a gas-tight outer housing. With this blood collection tube too there is a risk that a space is formed between the container and the outer housing, which in turn makes it possible for e.g. a solvent present in the interior of the blood collection tube diffuses into this intermediate space and the concentration stability cannot be guaranteed.
  • the invention is based on the object of creating a container for holding liquids which enables the stable storage of liquids or reagent formulations over a longer period of time.
  • Formations according to claims 2 and 3 are also advantageous, since they can further reduce environmental influences on the container contents.
  • Embodiments according to claims 4 and 5 are also advantageous, since the choice of at least one of these polymers enables simple and cost-effective production of the container, since these polymers can be obtained as commercially available materials.
  • an embodiment according to claim 6 is also possible, with which not only the permeation of the water vapor through the container wall can be reduced, but also the water vapor or water storage position in the wall.
  • spoke 9 advantageous, according to which the permeation coefficient of the container for water vapor can be further reduced.
  • spoke 10 has the advantage that multilayered containers with the desired properties can be formed from commercially available materials.
  • Another advantage is a configuration according to spoke 14, with which the first polymer for a special application can be selected without having to take into account the other required characteristics of the container.
  • the water absorption can advantageously be reduced even further.
  • Embodiments according to claims 16 and 17 are also advantageous, since the polymer selected in this way can fulfill a support function for the container and thus the polymer required for the characteristics of the container can have reduced strength properties.
  • spoke 21 it is advantageously provided that the amount of water absorbed by the polymer is indicated optically.
  • spoke 22 it is advantageous if the indicator for the optical display is arranged in the first inner polymer, since this allows a conclusion to be drawn about a possible change in concentration of a fluid placed in the container.
  • the indicator changes color according to spoke 24, since this means that no additional facilities are required for the qualitative detection of water taken up.
  • spoke 25 is also advantageous, according to which, on the one hand, the contamination of the container contents with substances from the container wall can be avoided or reduced and, on the other hand, the formation of channels which promote permeation can thereby be reduced.
  • at least one polymer contains at least one filler to reduce permeation, whereby the advantage can be achieved that less expensive polymer materials can be used while maintaining the required characteristics of the container.
  • the advantage can be achieved that, on the one hand, water vapor permeation is reduced by reduced wettability and, on the other hand, the permeation of apolar gases is reduced by selecting a polymer of higher polarity.
  • An embodiment according to claims 33 to 37 is also advantageous, since it enables the user to be provided with a container which on the one hand is securely closed and thus largely prevents contamination of the environment and on the other hand simple filling of the container or a simple one Removal of liquids from the container is made possible.
  • the advantage can be achieved that it can be used as a self-absorbing device for liquids.
  • the advantage here is that the container according to the invention can already be factory-equipped so that the user of this container usually has individual additional steps, e.g. are required when using the container as a blood collection vessel, can be removed and thus the blood draw can be shortened overall. It is also advantageous if the fluid is composed, for example, as an analysis reagent, which in turn enables shorter analysis times to be achieved on site.
  • the object of the invention is achieved by the features in the characterizing part of claim 40.
  • the advantage here is that the container according to the invention is composed of several individual containers, which on the one hand enables simple manufacture of the individual containers without the need for laminate formation, and on the other hand also makes it possible to recycle individual containers, which means that appropriate resource conservation can be achieved.
  • an embodiment according to claim 43 is advantageous, whereby the examination of biological cells can be simplified or accelerated, since the cell wall is already destroyed when a liquid to be analyzed is poured into the container according to the invention.
  • the fluid serves to stabilize nucleic acids according to claim 44, since degradative degradation of the nucleic acids can be prevented over a longer period of time.
  • the fluid contains at least one substance according to the embodiments of claims 45 to 48, since on the one hand rapid and efficient lysis of biological cells can be achieved and on the other hand the yield of analytes
  • Nucleic acids in subsequent analysis systems such as in PCR synthesis, can be improved.
  • the container according to the invention is used as a blood collection vessel.
  • Figure 1 schematically simplified a container according to the invention in side view.
  • FIG. 2 shows a schematically simplified top view of the open end region of the invention. container according to the invention.
  • FIG. 3 shows the end region according to FIG. 2 in a side view, cut away and schematically simplified
  • FIG. 4 shows a further embodiment variant of the container according to the invention, cut in a side view
  • FIG. 5 shows a schematically simplified illustration of a further exemplary embodiment of the container according to the invention, cut in a side view;
  • FIG. 6 shows a container according to the invention in a schematically simplified illustration with two open end regions arranged opposite one another.
  • a container 1 according to the invention is shown schematically simplified in different sections.
  • This container 1 which is primarily designed to hold liquids, for example blood, and in particular can also be used as a blood sampling device, has a container wall 3 surrounding an interior 2.
  • This container wall 3 is delimited in the direction of a central axis 4 by end faces 5, wherein in the exemplary embodiment according to FIG. 1 only one of these end faces 5 forms an open end 6 and the end face 5 opposite this open end 6 is connected to a container bottom 7.
  • This container bottom 7 can be formed directly on the container wall 3, so that the container 1 can be manufactured in one production step, for example by injection molding, deep drawing or the like.
  • suitable means for example adhesive points, plug connections or the like.
  • the container wall 3 and / or the container base 7 consist of a first polymer which, under standard conditions, ie 273.15 K and 1013 mbar, has a permeation coefficient for water vapor of a maximum of 10 ⁇ 10 "9 g / (cm h mbar), preferably of a maximum of 5 ⁇ 10 " 9 g / (cm h mbar), in particular of a maximum of 2x10 "9 g / (cm h mbar) and / or for oxygen of a maximum of 15xl0 " 12 cm 3 / (cm s mbar), preferably of a maximum of 8xl0 "12 cm 3 / (cm s mbar), in particular of a maximum of 2xl0 "12 cm 3 / (cm s mbar), for example of a maximum of 0.15xl0 " 12 cm 3 / (cm s mbar) and / or for carbon dioxide of a maximum of 25x10 "12 cm 3
  • this first polymer can be designed as a so-called barrier polymer and, for example, from a polyvinylidene chloride (PVDC), polyvinyl alcohol (PVA), ethylene-vinyl alcohol copolymer (EVOH), polyamide (PA) and polyacrylonitrile (PAN), polyethylene naphthalate (PEN), polypropylene (PP) and polyethylene terephthalate (PET) containing group.
  • PVDC polyvinylidene chloride
  • PVA polyvinyl alcohol
  • EVOH ethylene-vinyl alcohol copolymer
  • PA polyamide
  • PAN polyacrylonitrile
  • PEN polyethylene naphthalate
  • PP polypropylene
  • PET polyethylene terephthalate
  • this first polymer has a water absorption under standard conditions of at most 0.5%, preferably at most 0.05%, in particular at most 0.02%, for example at most 0.01%.
  • the first polymer has a permeation coefficient of mmaaxxiimmaall 55xx1100 "" ccmm // ((ccmm ss mmbbaarr)) ,, for oxygen from a maximum of 3x10 " cm / (cm s mbar), in particular 0.13xl0 " 12 cm 3 / (cm s mbar).
  • the specified characteristic values are to be regarded as generally valid average values, which may vary slightly.
  • the experimental determination of the gas permeability was carried out according to DIN 53 380, the water vapor permeability according to DIN 53 122 for plastic films.
  • the water absorption of the polymer was determined in accordance with DIN 53 495 and DIN 53 471.
  • the above conditions for the first polymer should above all be met in order to avoid any subsequent change in this liquid over the duration of storage after loading the container 1 with the liquid to be collected, for example blood, these changes being caused by gases such as, for example Oxygen, but also water vapor, which can serve as a carrier material for a wide variety of oxidizing agents, are caused, these gases or the water vapor being able to penetrate into the interior 2 from the outside via the container wall 3 and / or the container bottom 7 if the polymer is selected incorrectly.
  • container 1 is particularly important when a wide variety of reagents, for example in the form of solutions, are provided in container 1, which react with the respective sample liquid to be collected, in particular already during the filling process the liquid to be stored, e.g. Blood, should initiate.
  • reagents for example in the form of solutions
  • these reagents are usually presented in defined concentrations or concentration ranges, so that one
  • Modification of these reagents for example by concentration due to the permeation of water vapor through the container wall 3 and / or the container bottom 7 or by water absorption by the first polymer, or by undesirable reactions, for example oxidation during storage, in the container 1 until its use is undesirable.
  • the morphology of the polymer plays a decisive role for the permeation of a, in particular, low-molecular-weight permient into a polymeric material.
  • permeation i.e. the permeation coefficient, which results from the product of the diffusion coefficient and the solubility coefficient of the permient in the polymer, increases with increasing
  • the residual monomer content of the polymer in particular of the first polymer, or, as will be explained below, the polymer has a certain quantitative proportion of max. 25 ppm, preferably not more than 13 ppm, in particular not more than 9 ppm, for example not more than 5 ppm.
  • this can prevent large amounts of monomer from being dissolved out of the polymer, which not only causes contamination of the reagent formulation or the sample liquid contained therein, but also, that channels of larger diameter are formed in the polymer, which in turn promote permeation. Consequently, by maintaining certain maximum residual monomer contents, it is difficult for a permeate to penetrate into the polymer, for example due to the increased space requirement of the preferably branched polymer chains.
  • entanglements of the individual polymer threads can also counteract permeation and the selection of polymers or the targeted production according to these criteria has proven to be an advantage.
  • fillers to the polymer in particular the first polymer, can also have a favorable effect on the reduced permeation. As a result, not only can the density of the respective polymer increase, but the space available for a permient in the polymer can also be reduced.
  • the water absorption of the polymer can also be reduced by a suitable choice of the filler.
  • minerals such as e.g. Mica, talc or calcined clay are used, whereby an appropriate particle size distribution must be ensured so that the optical properties of the polymers are not impaired and these fillers should therefore have a corresponding fineness.
  • the first polymer Decreasing the wetting of the polymer, in particular the first polymer, by a liquid permient can also counteract the permeation.
  • the first polymer it is advantageous for the first polymer to select, in particular, those materials which have a low polarity, for example a relative dielectric constant at 800 Hz of less than 3.5, preferably less than 3, in particular less than 2.6 (DIN 53483), because that means the wetting by water or by water vapor is reduced due to the strong dipole moment of the water molecules.
  • corresponding, preferably non-polar side groups can also be introduced into the polymer.
  • the container 1 is formed from at least two layers of different composition.
  • the container 1 can have a closure device 8. This not only prevents the escape of substances from the interior 2, but also makes it possible to evacuate the container 1 and to maintain this vacuum over a longer period of time if the closure device 8 is designed accordingly.
  • Evacuated containers 1 are advantageously used, for example, for taking blood.
  • the closure device 8 comprises a cap 9, for example made of plastic, into which a sealing plug 10 is inserted, which is held in position in the cap 9 by means of a retaining ring 11.
  • the sealing plug 10 is preferably pierceable from a highly elastic and self-sealing material, e.g. Pharmaceutical rubber, silicone rubber, bromobutyl rubber or the like.
  • a cannula 12 can be inserted into the interior 2 through this sealing plug in order to fill various sample liquids into the container 1 and the interior 2 is sealed again when the cannula 12 is removed.
  • the retaining ring 11 which may also be made of plastic, preferably has a concentric opening for the cannula 12 to pass through.
  • the maximum diameter of the retaining ring 11 is chosen such that it is larger than an inner diameter in an upper region 13 of the cap 9.
  • the cap 9 can have a corresponding one in this region 13
  • the cap 9 is preferably also concentric with the central axis 4.
  • a minimum diameter of the sealing plug 10 can be selected to be slightly larger than an inner diameter 14 of the container 1 in the region of the cap 9. Due to the elastic material of the sealing plug 10 even in this embodiment, the sealing plug 10 can be pushed in with the cap 9, and the sealing plug 10 is also moved, inter alia, by frictional forces between it and an inner surface 15 of the container. ters 1 held.
  • the cap 9 On its surface facing the container wall 3, the cap 9 has a preferably concentric web 16 which can be used to hold the sealing plug 10 in the cap 9.
  • the sealing plug 10 is designed such that it has a larger diameter above this web 16 than below and this diameter can correspond approximately to the inner diameter 14 of the container 1.
  • the cap 9 has locking devices 17 on the surface facing the container wall 3. These can be designed, for example, in the form of a screw thread.
  • the container wall 3 can have means for coupling, for example coupling webs 19, on an outer surface 18, which engage in the locking device 17.
  • FIGS. 2 and 3 An embodiment variant of this coupling webs 19 is shown in detail in FIGS. 2 and 3. For example, it is possible to arrange at least approximately symmetrically three web-like extensions 21 over a cross section 20 of the container 1, in particular in the region of the open end 6, preferably on the end face 5. To facilitate the intervention of the
  • these coupling webs 19 or extensions 21 can be formed on the one hand in a plane 22 of the cross section 20 at the transition from the container wall 3 to the extensions 21 with rounded corners 23.
  • an extension cross section 24 can also have rounded corners 25 parallel to a plane in the direction of the central axis 4.
  • the advantage of this variant is that not only is it easier to connect the cap 9 to the container wall 3, but also that the cap 9 can be replaced and removed several times without the locking devices or coupling devices 17 or coupling webs 19 being damaged in this way be that the cap 9 is only loosely attached to the container 1.
  • the sealing plug 10 can have a concentrically arranged recess 26, with the aid of which the insertion of the cannula 12 can be facilitated.
  • the sealing plug 19 can also be arranged in the cap 9 so that an annular free space is formed between the locking device 17 on the inside of the cap and the sealing plug 10, the width of which approximately corresponds to the wall thickness of the container wall 3, so that the sealing plug 10 can be laterally expanded is.
  • FIG. 4 an embodiment variant of the container 1 according to the invention is shown schematically simplified as a longitudinal section. All of the statements relating to the closure device 8 according to FIG. 1 can also relate to this and the embodiment variants described below, it being noted at this point that the container 1 independently achieves the object of the invention even without the closure device 8. Training the statements relating to the closure device 8 according to FIG. 1 can also relate to this and the embodiment variants described below, it being noted at this point that the container 1 independently achieves the object of the invention even without the closure device 8. Training the
  • Closure device 8 can rather depend on the intended use of the container 1, so that other closure devices can also be used, for example conventional screw closures without sealing plug 10 or the like.
  • this container wall 3 has a two-layer container wall 3 and this comprises a further layer 27, preferably a second polymer different from the first polymer.
  • This further layer 27 can, for example, be molded onto the first polymer, in particular at least partially surround the outer surface of the first polymer facing away from the interior 2.
  • this laminate like the two-layer structure according to FIG. 4, being able to form the container wall 3 and / or the container bottom 7.
  • a reason for such a multilayer construction or such a laminate can e.g. be that a single polymer does not meet all the requirements of such containers
  • the further layer 27 can perform a supporting function for the container 1 and consist, for example, of a thermoplastic selected from a polyvinyl chloride (PVC), polyethylene (PE), polypropylene (PP), polyethylene terephthalate (PET), polycarbonate (PC) or the like. containing group.
  • a thermoplastic selected from a polyvinyl chloride (PVC), polyethylene (PE), polypropylene (PP), polyethylene terephthalate (PET), polycarbonate (PC) or the like. containing group.
  • translucent thermoplastics are preferably used to provide an unimpeded view of the interior 2 of the container 1 to enable.
  • this multi-layer structure can e.g. also be that one of the layers fulfills the task of reduced gas permeation and another layer, for example the second layer 27, fulfills the task of reduced water absorption.
  • this further layer 27 can enclose the first polymer on the surface 18 on a container outer side 28 facing away from the interior 2 (see FIG. 1) or the interior 2 with respect to the first Polymer be arranged closer.
  • the first polymer is arranged between two layers of this further layer 27. , • ⁇
  • the permeation coefficients for gases or for water vapor for such a multilayer structure of the container 1 which can also be made conical in the direction of the central axis 4, for example in the direction of the container bottom 7, it should be noted that in In this case, add the reciprocal values of the gas permeability of the individual layers, the reciprocal value of the total gas permeability being equal to the sum of the reciprocal values of the individual gas permeabilities.
  • the laminate can have a permeation coefficient under standard conditions for water vapor of at most 3.5 ⁇ 10 9 g / (cm h mbar), preferably of at most 1.25 ⁇ 10 9 g / (cm h mbar), in particular of at most 0.9 ⁇ 10 0 "9 g / (cm h mbar) and / or for oxygen of a maximum of 7xl0 " 12 cm 3 / (cm s mbar), preferably of a maximum of 4xl0 "12 cm 3 / (cm s mbar), in particular of a maximum of l, 2xl0 " 12 cm 3 / (cm s mbar), for example of a maximum of 0.12xl0 "12 cm 3 / (cm s mbar) and / or for carbon dioxide of a maximum of 12x10 " cm / (cm s mbar), preferably of a maximum of 6x10 " cm / (cm mbar).
  • the further layer 27 should face the interior 2 such that this additional layer 27 absorbs water under standard conditions of a maximum of 0.04%, preferably a maximum of 0.018%. in particular of a maximum of 0.01%.
  • at least one additional layer 29, preferably made of a further polymer, can be arranged between the first and the second polymer, FIG. 5 showing a three-layer structure in particular.
  • This additional layer 29 can in turn be a thermoplastic, for example, selected from a group containing PVC, PE, PP, PET, PC, etc.
  • This additional layer 29 can act, for example, as an adhesion promoter between the first and the second polymer, should these polymers be chemically very different from one another.
  • this makes it possible to allow an increased permeation coefficient for gases and / or water vapor for the first polymer, so that e.g. Water can penetrate into the first polymer and subsequently this further layer 29, which can also be designed as a barrier polymer, as a barrier for e.g. Water vapor occurs.
  • this further layer 29 which can also be designed as a barrier polymer, as a barrier for e.g. Water vapor occurs.
  • the water absorption by the first polymer must also be calculated for the concentration of these solutions in the case of aqueous solutions presented in the interior 2.
  • one of the layers 27 and / or 29 is not made of a polymer, but of another material, for example of metal, in which case it is also possible to provide an insight into the interior 2 , one of these layers 27, 29 - or both - has a corresponding window.
  • the start of photosensitized reactions can be delayed or prevented, for example, if the cap 9 is designed accordingly.
  • FIG. 6 shows a further exemplary embodiment of the container 1 according to the invention in longitudinal section without caps 9. Contrary to the previous design variants, this container 1 has two open ends 6 and, for the sake of simplicity, only a single-layer structure is shown. Of course, multilayered container walls 3 corresponding to the above explanations are also possible for these variants.
  • the advantage of this variant is that the interior 2 has two openings can be achieved so that in the event of any separations of the sample liquid to be collected therein into individual components, for example by centrifugation, sedimentation or the like, the components or the component mixtures can be separated off without re-vortexing.
  • a device for separating constituents of the liquid according to the density can be arranged in the interior 2 - as in any other embodiment variant.
  • this device can have a density that lies between the density of the individual components.
  • blood plasma can be separated from the serum in this way.
  • This device can be designed, for example, as a gel or as a so-called sink plug known from the prior art.
  • the container 1 instead of the previously described two-layer structure or multilayer laminate, it is also possible for the container 1 to enclose a further individual container or to be surrounded by one. These two containers - it is of course also possible to push several containers into one another - can be connected to one another in such a way that subsequent separation is no longer possible. On the other hand, it is possible for the two containers to be arranged at a distance from one another in order to enable subsequent separation of the containers and, for example, to reuse one of the individual containers and thus to reduce the amount of waste which arises. For mutual locking, the individual containers can have appropriate devices, e.g. Tongue and groove or the like. Have.
  • a polymer with reduced liquid absorption can be dispensed with under certain circumstances, especially if the the reagent liquid presented in the interior 2 simply cannot be concentrated the should and a dilution is irrelevant for a later reaction with sample liquids, since in this case the permeation of these liquids can be controlled by the polymers so that this takes place from the space between the two individual containers in the direction of the interior 2.
  • each individual container is constructed from both a container base 7 and a container wall 3.
  • a container base 7 there is also the possibility that only one of the two individual containers has a container base 7. This can be arranged as an inner or as an outer individual container.
  • An indicator for indicating the amount of water absorbed can be contained in at least one of the polymers.
  • This indicator can be contained, for example, in the first or in the second polymer.
  • the indicator can be chosen so that it changes color after absorbing a certain amount of water. With the aid of such an indicator, simple means can be used to visually check whether, for example, a change, in particular concentration due to loss of solvent, occurs in the interior 2 of FIG. Container 1 presented reagent solutions has taken place and such an indicator can therefore be used for quality control after long storage.
  • a reagent or a reagent solution and / or mixture can be provided in the interior 2, which preferably reacts immediately after contact with the respective sample liquid.
  • the fluid arranged in the interior 2 can also be a gas.
  • this fluid causes the lysis of biological cells and thus e.g. can stabilize nucleic acids (DNA, RNA).
  • nucleic acids DNA, RNA
  • the fluid may contain a guanidinium salt, e.g. a guanidium halide such as e.g. Guanidinium chloride, guanidinium thiocyanate, guanidinium carbonate, guanidinium nitrate, guanidinium acetate, guanidinium sulfate, guanidium stearate, guanidium hydrogen or dihydrogen phosphate or the like.
  • a guanidinium salt e.g. a guanidium halide such as e.g. Guanidinium chloride, guanidinium thiocyanate, guanidinium carbonate, guanidinium nitrate, guanidinium acetate, guanidinium sulfate, guanidium stearate, guanidium hydrogen or dihydrogen phosphate or the like.
  • a guanidinium salt e.g. a guanidium halide such as
  • this fluid furthermore buffer substances and / or detergents such as, for example, tris (2,3-dibromopropyl) phosphate, tris (hydroxymethyl) aminomethane, ethoxylates of 4- (l , l, 3,3-tetramethylbutyl) phenol, benzyltrimethylammonium hydroxide, (4- (2-hydroxyethyl) piperazino) ethanesulfonic acid, 3-morpholino-l- propane sulfonic acid, polyoxyethylene derivatives of sorbitan esters such as -laurate, -palmitate, -stearate, -tristearate or -oleate.
  • reducing agents such as, for example, b-mercaptoethanol may also be present.
  • the guanidinium salts can be used in a concentration of up to 10 M, preferably up to 8
  • M for example up to 5 M.
  • citrate and / or phosphate buffers can of course also be used.
  • concentration of the buffers can be between 1 and 400 mM, preferably between 20 and 300 mM, for example between 30 and 200 mM.
  • the detergents used can have a proportion of up to 40% by weight, preferably up to 30% by weight, for example up to 20% by weight, of the total mixture.
  • the fluid contains a reducing agent, e.g. TCEP, Dithiothreitol im
  • the pH of the fluid introduced can be between 3 and 9, preferably between 4 and 8, for example between 5 and 7.
  • the inner surface 15 is coated with reagents in the solid state, e.g. with anticoagulants such as EDTA, the latter can also be presented as a solution.
  • reagents in the solid state e.g. with anticoagulants such as EDTA
  • the container 1 according to the invention has been associated essentially with blood collection tubes, there are of course a number of other possible uses for this container 1 and these should not be excluded from the scope of protection. There are also a number of other possible combinations of the individual polymer layers.
  • FIGS. 1, 2, 3; 4; 5; 6 embodiments shown form the subject of independent solutions according to the invention.
  • the tasks and solutions according to the invention in this regard can be found in the detailed descriptions of these figures.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Packages (AREA)

Abstract

L'invention concerne un récipient (1) prévu pour contenir des liquides, à base d'au moins un premier polymère, avec une paroi (3) entourant un espace intérieur (2). Dans des conditions normales, le premier polymère prévu pour la paroi du récipient (3) et/ou le fond du récipient (7) présentent un coefficient de perméation pour la vapeur d'eau n'excédant pas 10x10-9 g/(cm h mbar) et/ou pour l'oxygène, n'excédant pas 15x10-12 cm3/c(cm s mbar).
PCT/AT2001/000018 2000-01-27 2001-01-23 Recipient pour contenir des liquides WO2001054816A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001229866A AU2001229866A1 (en) 2000-01-27 2001-01-23 Container for holding fluids

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Application Number Priority Date Filing Date Title
AT1162000 2000-01-27
ATA116/2000 2000-01-27

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WO2001054816A1 true WO2001054816A1 (fr) 2001-08-02

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Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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US7959866B2 (en) 2002-09-04 2011-06-14 Becton, Dickinson And Company Collection assembly
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US8894951B2 (en) 2010-01-19 2014-11-25 Becton, Dickinson And Company Specimen collection container having a transitional fill-volume indicator indicating extraction method
US9272095B2 (en) 2011-04-01 2016-03-01 Sio2 Medical Products, Inc. Vessels, contact surfaces, and coating and inspection apparatus and methods
US9458536B2 (en) 2009-07-02 2016-10-04 Sio2 Medical Products, Inc. PECVD coating methods for capped syringes, cartridges and other articles
US9545360B2 (en) 2009-05-13 2017-01-17 Sio2 Medical Products, Inc. Saccharide protective coating for pharmaceutical package
US9554968B2 (en) 2013-03-11 2017-01-31 Sio2 Medical Products, Inc. Trilayer coated pharmaceutical packaging
US9662450B2 (en) 2013-03-01 2017-05-30 Sio2 Medical Products, Inc. Plasma or CVD pre-treatment for lubricated pharmaceutical package, coating process and apparatus
US9664626B2 (en) 2012-11-01 2017-05-30 Sio2 Medical Products, Inc. Coating inspection method
US9764093B2 (en) 2012-11-30 2017-09-19 Sio2 Medical Products, Inc. Controlling the uniformity of PECVD deposition
US9863042B2 (en) 2013-03-15 2018-01-09 Sio2 Medical Products, Inc. PECVD lubricity vessel coating, coating process and apparatus providing different power levels in two phases
US9878101B2 (en) 2010-11-12 2018-01-30 Sio2 Medical Products, Inc. Cyclic olefin polymer vessels and vessel coating methods
US9903782B2 (en) 2012-11-16 2018-02-27 Sio2 Medical Products, Inc. Method and apparatus for detecting rapid barrier coating integrity characteristics
US9937099B2 (en) 2013-03-11 2018-04-10 Sio2 Medical Products, Inc. Trilayer coated pharmaceutical packaging with low oxygen transmission rate
US10189603B2 (en) 2011-11-11 2019-01-29 Sio2 Medical Products, Inc. Passivation, pH protective or lubricity coating for pharmaceutical package, coating process and apparatus
US10201660B2 (en) 2012-11-30 2019-02-12 Sio2 Medical Products, Inc. Controlling the uniformity of PECVD deposition on medical syringes, cartridges, and the like
US11066745B2 (en) 2014-03-28 2021-07-20 Sio2 Medical Products, Inc. Antistatic coatings for plastic vessels
US11077233B2 (en) 2015-08-18 2021-08-03 Sio2 Medical Products, Inc. Pharmaceutical and other packaging with low oxygen transmission rate
US11116695B2 (en) 2011-11-11 2021-09-14 Sio2 Medical Products, Inc. Blood sample collection tube
US11624115B2 (en) 2010-05-12 2023-04-11 Sio2 Medical Products, Inc. Syringe with PECVD lubrication
US11944434B2 (en) 2008-03-05 2024-04-02 Becton, Dickinson And Company Capillary action collection device and container assembly

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US6749078B2 (en) 2000-07-25 2004-06-15 Becton, Dickinson And Company Collection assembly
EP1285694A1 (fr) * 2001-08-21 2003-02-26 Becton Dickinson and Company Dispositif avec récipient de prélèvement
US7959866B2 (en) 2002-09-04 2011-06-14 Becton, Dickinson And Company Collection assembly
US9409176B2 (en) 2006-09-08 2016-08-09 Becton, Dickinson And Company Sample container with physical fill-line indicator
WO2008031036A1 (fr) * 2006-09-08 2008-03-13 Becton, Dickinson And Company Contenant d'échantillon pourvu d'un indicateur de remplissage physique
JP2010502994A (ja) * 2006-09-08 2010-01-28 ベクトン・ディキンソン・アンド・カンパニー 物理的な充填ライン指標を備える試料容器
US11944434B2 (en) 2008-03-05 2024-04-02 Becton, Dickinson And Company Capillary action collection device and container assembly
US7985188B2 (en) 2009-05-13 2011-07-26 Cv Holdings Llc Vessel, coating, inspection and processing apparatus
US8834954B2 (en) 2009-05-13 2014-09-16 Sio2 Medical Products, Inc. Vessel inspection apparatus and methods
US9545360B2 (en) 2009-05-13 2017-01-17 Sio2 Medical Products, Inc. Saccharide protective coating for pharmaceutical package
US8512796B2 (en) 2009-05-13 2013-08-20 Si02 Medical Products, Inc. Vessel inspection apparatus and methods
US9572526B2 (en) 2009-05-13 2017-02-21 Sio2 Medical Products, Inc. Apparatus and method for transporting a vessel to and from a PECVD processing station
US10390744B2 (en) 2009-05-13 2019-08-27 Sio2 Medical Products, Inc. Syringe with PECVD lubricity layer, apparatus and method for transporting a vessel to and from a PECVD processing station, and double wall plastic vessel
US10537273B2 (en) 2009-05-13 2020-01-21 Sio2 Medical Products, Inc. Syringe with PECVD lubricity layer
US9458536B2 (en) 2009-07-02 2016-10-04 Sio2 Medical Products, Inc. PECVD coating methods for capped syringes, cartridges and other articles
US8894951B2 (en) 2010-01-19 2014-11-25 Becton, Dickinson And Company Specimen collection container having a transitional fill-volume indicator indicating extraction method
US11624115B2 (en) 2010-05-12 2023-04-11 Sio2 Medical Products, Inc. Syringe with PECVD lubrication
US11123491B2 (en) 2010-11-12 2021-09-21 Sio2 Medical Products, Inc. Cyclic olefin polymer vessels and vessel coating methods
US9878101B2 (en) 2010-11-12 2018-01-30 Sio2 Medical Products, Inc. Cyclic olefin polymer vessels and vessel coating methods
US9272095B2 (en) 2011-04-01 2016-03-01 Sio2 Medical Products, Inc. Vessels, contact surfaces, and coating and inspection apparatus and methods
US11116695B2 (en) 2011-11-11 2021-09-14 Sio2 Medical Products, Inc. Blood sample collection tube
US11884446B2 (en) 2011-11-11 2024-01-30 Sio2 Medical Products, Inc. Passivation, pH protective or lubricity coating for pharmaceutical package, coating process and apparatus
US10189603B2 (en) 2011-11-11 2019-01-29 Sio2 Medical Products, Inc. Passivation, pH protective or lubricity coating for pharmaceutical package, coating process and apparatus
US11724860B2 (en) 2011-11-11 2023-08-15 Sio2 Medical Products, Inc. Passivation, pH protective or lubricity coating for pharmaceutical package, coating process and apparatus
US10577154B2 (en) 2011-11-11 2020-03-03 Sio2 Medical Products, Inc. Passivation, pH protective or lubricity coating for pharmaceutical package, coating process and apparatus
US11148856B2 (en) 2011-11-11 2021-10-19 Sio2 Medical Products, Inc. Passivation, pH protective or lubricity coating for pharmaceutical package, coating process and apparatus
US9664626B2 (en) 2012-11-01 2017-05-30 Sio2 Medical Products, Inc. Coating inspection method
US9903782B2 (en) 2012-11-16 2018-02-27 Sio2 Medical Products, Inc. Method and apparatus for detecting rapid barrier coating integrity characteristics
US9764093B2 (en) 2012-11-30 2017-09-19 Sio2 Medical Products, Inc. Controlling the uniformity of PECVD deposition
US10201660B2 (en) 2012-11-30 2019-02-12 Sio2 Medical Products, Inc. Controlling the uniformity of PECVD deposition on medical syringes, cartridges, and the like
US10363370B2 (en) 2012-11-30 2019-07-30 Sio2 Medical Products, Inc. Controlling the uniformity of PECVD deposition
US11406765B2 (en) 2012-11-30 2022-08-09 Sio2 Medical Products, Inc. Controlling the uniformity of PECVD deposition
US9662450B2 (en) 2013-03-01 2017-05-30 Sio2 Medical Products, Inc. Plasma or CVD pre-treatment for lubricated pharmaceutical package, coating process and apparatus
US11298293B2 (en) 2013-03-11 2022-04-12 Sio2 Medical Products, Inc. PECVD coated pharmaceutical packaging
US9937099B2 (en) 2013-03-11 2018-04-10 Sio2 Medical Products, Inc. Trilayer coated pharmaceutical packaging with low oxygen transmission rate
US11344473B2 (en) 2013-03-11 2022-05-31 SiO2Medical Products, Inc. Coated packaging
US10912714B2 (en) 2013-03-11 2021-02-09 Sio2 Medical Products, Inc. PECVD coated pharmaceutical packaging
US10537494B2 (en) 2013-03-11 2020-01-21 Sio2 Medical Products, Inc. Trilayer coated blood collection tube with low oxygen transmission rate
US11684546B2 (en) 2013-03-11 2023-06-27 Sio2 Medical Products, Inc. PECVD coated pharmaceutical packaging
US10016338B2 (en) 2013-03-11 2018-07-10 Sio2 Medical Products, Inc. Trilayer coated pharmaceutical packaging
US9554968B2 (en) 2013-03-11 2017-01-31 Sio2 Medical Products, Inc. Trilayer coated pharmaceutical packaging
US9863042B2 (en) 2013-03-15 2018-01-09 Sio2 Medical Products, Inc. PECVD lubricity vessel coating, coating process and apparatus providing different power levels in two phases
US11066745B2 (en) 2014-03-28 2021-07-20 Sio2 Medical Products, Inc. Antistatic coatings for plastic vessels
US11077233B2 (en) 2015-08-18 2021-08-03 Sio2 Medical Products, Inc. Pharmaceutical and other packaging with low oxygen transmission rate

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