WO2001046147A8 - Procede de preparation de piperidines 4 substituees - Google Patents

Procede de preparation de piperidines 4 substituees

Info

Publication number
WO2001046147A8
WO2001046147A8 PCT/US2000/032429 US0032429W WO0146147A8 WO 2001046147 A8 WO2001046147 A8 WO 2001046147A8 US 0032429 W US0032429 W US 0032429W WO 0146147 A8 WO0146147 A8 WO 0146147A8
Authority
WO
WIPO (PCT)
Prior art keywords
substituted
heterocycle
preparing
aryl
alkenyl
Prior art date
Application number
PCT/US2000/032429
Other languages
English (en)
Other versions
WO2001046147A1 (fr
Inventor
Alexander Glenn Godfrey
Steven Wayne Pedersen
Original Assignee
Lilly Co Eli
Alexander Glenn Godfrey
Steven Wayne Pedersen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli, Alexander Glenn Godfrey, Steven Wayne Pedersen filed Critical Lilly Co Eli
Priority to AU19307/01A priority Critical patent/AU1930701A/en
Priority to EP00982251A priority patent/EP1244623A1/fr
Publication of WO2001046147A1 publication Critical patent/WO2001046147A1/fr
Publication of WO2001046147A8 publication Critical patent/WO2001046147A8/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/12—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with only hydrogen atoms attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La présente invention porte sur un procédé de préparation de 4 N piperidines substituées protégées de formule (I) dans laquelle Pg représente un groupe de protection approprié de l'azote; X représente un hétérocycle, un hétérocycle substitué, un alcényle substitué ou un aryle substitué dans lequel l'hétérocycle substitué, l'alcényle substitué ou l'aryle substitué sont substitués par 1 à 3 groupes d'activation appropriés; et R?1, R2, R3, R4, R5,R6, R7 et R8¿ représentent chacun de manière indépendante un alkyle, un alcényle, un cycloalklye, un aryle, un aryle substitué, un hétérocycle ou un hétérocycle substitué. Ce procédé consiste à traiter avec du triéthylsilane et de l'acide trifluoroacétique un composé de formule (II) dans laquelle les substituants sont définis comme précédemment.
PCT/US2000/032429 1999-12-20 2000-12-06 Procede de preparation de piperidines 4 substituees WO2001046147A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU19307/01A AU1930701A (en) 1999-12-20 2000-12-06 A process for preparing 4-substituted piperidines
EP00982251A EP1244623A1 (fr) 1999-12-20 2000-12-06 Procede de preparation de piperidines 4 substituees

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17272499P 1999-12-20 1999-12-20
US60/172,724 1999-12-20

Publications (2)

Publication Number Publication Date
WO2001046147A1 WO2001046147A1 (fr) 2001-06-28
WO2001046147A8 true WO2001046147A8 (fr) 2002-06-06

Family

ID=22628944

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2000/032428 WO2001046143A1 (fr) 1999-12-20 2000-12-06 Procede de preparation de piperidines trans-2,4-disubstituees
PCT/US2000/032429 WO2001046147A1 (fr) 1999-12-20 2000-12-06 Procede de preparation de piperidines 4 substituees

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2000/032428 WO2001046143A1 (fr) 1999-12-20 2000-12-06 Procede de preparation de piperidines trans-2,4-disubstituees

Country Status (3)

Country Link
EP (2) EP1244623A1 (fr)
AU (1) AU1805701A (fr)
WO (2) WO2001046143A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005038706A2 (fr) 2003-10-14 2005-04-28 Amfit, Inc. Procede de saisie et de reproduction d'un contour 3d
UA98698C2 (en) 2008-03-03 2012-06-11 Х. Луннбек А/С Phenylsulfanylphenyl-piperidines and process for the preparation thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5846982A (en) * 1996-06-14 1998-12-08 Eli Lilly And Company Inhibition of serotonin reuptake
US6303627B1 (en) * 1998-06-19 2001-10-16 Eli Lilly And Company Inhibitors of serotonin reuptake
DE60015146T2 (de) * 1999-07-29 2006-02-16 Eli Lilly And Co., Indianapolis Serotonerge benzothiophene

Also Published As

Publication number Publication date
EP1244622A1 (fr) 2002-10-02
AU1805701A (en) 2001-07-03
EP1244623A1 (fr) 2002-10-02
WO2001046143A1 (fr) 2001-06-28
WO2001046147A1 (fr) 2001-06-28

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