NO964533L - Nye kinolon 5-(N-heterosubstituert amino) antimikrobielle forbindelser - Google Patents
Nye kinolon 5-(N-heterosubstituert amino) antimikrobielle forbindelserInfo
- Publication number
- NO964533L NO964533L NO964533A NO964533A NO964533L NO 964533 L NO964533 L NO 964533L NO 964533 A NO964533 A NO 964533A NO 964533 A NO964533 A NO 964533A NO 964533 L NO964533 L NO 964533L
- Authority
- NO
- Norway
- Prior art keywords
- compounds
- hetero
- substituted amino
- quinolone
- antimicrobial compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Oppfinnelsen vedrører antimikrobielle 5-(N-heterosubstituert amino)kinolonforbindelser som har en struktur i samsvar med formel (I) eller (II), hvori: (1) R1, R2, R3, R9 og R10 danner hvilken eller hvilke som helst av en rekke forskjellige kinolon- og beslektede heterocykliske strukturer lignende dem som er kjent innen fagområdet til å ha antimikrobiell aktivi- tet, og (2) (a) R4 og R5 er uavhengig hydrogen, lavere alkyl, cykloalkyl, heteroalkyl, eller -C(=0)-X-R8, hvor X er en kova- lent binding. N, O eller S, og R8 er lavere alkyl, lavere alkenyl, arylalkyl, en karbocyklisk ring, eller en hetero- cyklisk ring, eller (b) R4 og R5 sammen utgjør en hetero- cyklisk ring som inkluderer det nitrogen hvortil de er bundet, og de farmasøytisk akseptable salter, biohydrolyserbare estere, biohydrolyserbare amider, og solvater derav. Oppfin- nelsen vedrører også preparater omfattende disse forbindelser, såvel som metoder for behandling av infeksiøse lidelser ved anvendelse av forbindelsene og/eller preparatene i samsvar med den foreliggende oppfinnelse.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/235,003 US5646163A (en) | 1992-10-30 | 1994-04-28 | Quinolone 5-(N-heterosubstituted amino) antimicrobials |
PCT/US1995/004495 WO1995029894A1 (en) | 1994-04-28 | 1995-04-11 | Novel quinolone 5-(n-heterosubstituted amino) antimicrobials |
Publications (2)
Publication Number | Publication Date |
---|---|
NO964533D0 NO964533D0 (no) | 1996-10-25 |
NO964533L true NO964533L (no) | 1996-12-23 |
Family
ID=22883653
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO964533A NO964533L (no) | 1994-04-28 | 1996-10-25 | Nye kinolon 5-(N-heterosubstituert amino) antimikrobielle forbindelser |
Country Status (11)
Country | Link |
---|---|
US (1) | US5646163A (no) |
EP (1) | EP0757675A1 (no) |
JP (1) | JPH09512549A (no) |
KR (1) | KR100244992B1 (no) |
CN (1) | CN1157611A (no) |
AU (1) | AU2246695A (no) |
BR (1) | BR9507553A (no) |
CA (1) | CA2188918A1 (no) |
FI (1) | FI964318A (no) |
NO (1) | NO964533L (no) |
WO (1) | WO1995029894A1 (no) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1650203B1 (en) * | 2000-09-11 | 2008-02-20 | Novartis Vaccines and Diagnostics, Inc. | Process of preparation of benzimidazol-2-yl quinolinone derivatives |
EP1664062B1 (en) * | 2003-08-12 | 2013-03-13 | Achillion Pharmaceuticals, Inc. | Isothiazoloquinolones and related compounds as anti-infective agents |
PL1666477T3 (pl) | 2003-09-10 | 2013-11-29 | Kyorin Seiyaku Kk | Pochodna kwasu 7-(4-podstawionego-3-cyklopropyloaminometylo-1- pirolidynylo)chinolonokarboksylowego |
WO2006020573A2 (en) * | 2004-08-11 | 2006-02-23 | Barbeau Donald L | Noncardiotoxic pharmaceutical compounds |
KR101289115B1 (ko) * | 2004-08-13 | 2013-07-23 | 엠에스디 인터내셔널 홀딩즈 게엠베하 | 항생제인 트리아졸 및 코르티코스테로이드를 포함하는약제학적 제형 |
US7652134B2 (en) * | 2004-09-17 | 2010-01-26 | Cylene Pharmaceuticals, Inc. | Methods for converting quinolone esters into quinolone amides |
US7816406B2 (en) * | 2004-09-17 | 2010-10-19 | Cylene Pharmaceuticals, Inc. | Quinolone analogs |
EP1809639B1 (en) * | 2004-11-11 | 2009-10-14 | Achillion Pharmaceuticals, Inc. | 8a, 9-dihydro-4a-h-isothiazolo[5,4-b] quinoline-3, 4-diones and related compounds as anti-infective agents |
WO2006074317A1 (en) * | 2005-01-05 | 2006-07-13 | Achillion Pharmaceuticals, Inc. | 1-thia-2,4a-diaza-cyclopenta[b]naphthalene-3,4-diones and related compounds as anti-infective agents |
US7199128B2 (en) | 2005-02-02 | 2007-04-03 | Achillion Pharmaceuticals, Inc. | 8-N-substituted-2H-isothiazolo[5,4-b]quinolizine-3,4-diones and related compounds as antiinfective agents |
US8114888B2 (en) * | 2005-02-16 | 2012-02-14 | Achillion Pharmaceuticals, Inc. | Isothiazoloquinolones and related compounds as anti-infective agents |
EP1913004B1 (en) | 2005-07-27 | 2010-09-22 | Achillion Pharmaceuticals, Inc. | 8-methoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents |
PL1928887T3 (pl) * | 2005-08-05 | 2015-05-29 | Senhwa Biosciences Inc | Sposoby otrzymywania analogów chinolonowych |
CL2007003332A1 (es) * | 2006-11-24 | 2008-06-20 | Actelion Pharmaceuticals Ltd | Compuestos derivados de heterociclos condensados; compuestos intermediarios; composicion farmaceutica; y uso en la prevencion o tratamiento de infecciones bacterianas. |
US8183236B2 (en) * | 2007-04-12 | 2012-05-22 | University Of Southern California | Compounds with HIV-1 integrase inhibitory activity and use thereof as anti-HIV/AIDS therapeutics |
WO2008143343A1 (ja) * | 2007-05-24 | 2008-11-27 | Kyorin Pharmaceutical Co., Ltd. | 14位置換基に複素芳香環カルボン酸構造を有するムチリン誘導体 |
EP2145891A1 (en) * | 2008-07-09 | 2010-01-20 | Vetoquinol S.A. | 9-substituted-5-carboxy-oxadiazino-quinolone derivatives, their preparation and their application as anti-bacterials |
CA2756701A1 (en) * | 2009-04-03 | 2010-10-07 | Achillion Pharmaceuticals, Inc. | Hydroxythienoquinolones and related compounds as anti-infective agents |
WO2011031745A1 (en) | 2009-09-09 | 2011-03-17 | Achaogen, Inc. | Antibacterial fluoroquinolone analogs |
WO2011047323A2 (en) | 2009-10-16 | 2011-04-21 | Rib-X Pharmaceuticals, Inc. | Antimicrobial compounds and methods of making and using the same |
EP3421476A1 (en) | 2009-10-16 | 2019-01-02 | Melinta Therapeutics, Inc. | Antimicrobial compounds and methods of making and using the same |
TWI618707B (zh) * | 2009-10-16 | 2018-03-21 | 梅林塔療法公司 | 抗微生物性化合物,及製法及其用途 |
MX2016003046A (es) | 2013-09-09 | 2016-09-08 | Melinta Therapeutics Inc | Compuestos antimicrobianos y métodos de fabricación y utilización de los mismos. |
SG11201601654TA (en) | 2013-09-09 | 2016-04-28 | Melinta Therapeutics Inc | Antimicrobial compunds and methods of making and using the same |
CA2979342A1 (en) | 2015-03-11 | 2016-09-15 | Melinta Therapeutics, Inc. | Antimicrobial compounds and methods of making and using the same |
WO2017193016A1 (en) | 2016-05-06 | 2017-11-09 | Melinta Therapeutics, Inc. | Antimicrobials and methods of making and using same |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4665079A (en) * | 1984-02-17 | 1987-05-12 | Warner-Lambert Company | Antibacterial agents |
IE58742B1 (en) * | 1984-07-20 | 1993-11-05 | Warner Lambert Co | Substituted-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7h-pyrido[1,2,3-de] [1,4]benzoxauine-6-carboxylic acids; sibstituted-5-amino-6-6fluoro-4-oxo.1,4-dihydroquinoline-3 carboxylic acids; substituted-5-amino-6-fluoro-1,4-dihydro-4-oxo-1.8-naphthyridine-3-carboxylic acids; derivatives thereof; pharmaceutical compositions comprising the compounds; and processes for producing the compounds |
US4822801A (en) * | 1984-07-20 | 1989-04-18 | Warner-Lambert Company | 4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivative as antibacterial agents |
US4623650A (en) * | 1984-12-06 | 1986-11-18 | Pfizer Inc. | Antibiotic derivatives of 7-phenyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids |
AU594983B2 (en) * | 1985-10-29 | 1990-03-22 | Dainippon Pharmaceutical Co. Ltd. | Novel quinoline derivatives and processes for preparation thereof |
US4954507A (en) * | 1986-10-08 | 1990-09-04 | Bristol-Myers Company | 1-tertiary-alkyl-substituted naphthyridine carboxylic acid antibacterial agents |
DE3711193A1 (de) * | 1987-04-02 | 1988-10-13 | Bayer Ag | 5-substituierte chinolon- und naphthyridoncarbonsaeure-derivate |
AU609974B2 (en) * | 1988-05-18 | 1991-05-09 | Warner-Lambert Company | Improved process for the preparation of 5-amino-7- (substituted amino)-quinoline-3-carboxylic acids |
JP2664950B2 (ja) * | 1988-08-31 | 1997-10-22 | 日本電気株式会社 | 入出力処理装置 |
US4945160A (en) * | 1988-11-22 | 1990-07-31 | Warner-Lambert Company | Preparation of certain 7-substituted quinolones |
DK0525057T3 (da) * | 1990-04-18 | 2000-07-31 | Procter & Gamble Pharma | Antimikrobielle quinolonyllactamer |
ES2101119T3 (es) * | 1991-10-01 | 1997-07-01 | Procter & Gamble Pharma | Procedimiento para preparar quinolonil-lactamas antimicrobianas. |
EG20543A (en) * | 1992-10-30 | 1999-07-31 | Procter & Gamble | Process for preparing of novel antimicrobial -5- (n-heterosubstituted amino) quinolones |
-
1994
- 1994-04-28 US US08/235,003 patent/US5646163A/en not_active Expired - Fee Related
-
1995
- 1995-04-11 CN CN95193457A patent/CN1157611A/zh active Pending
- 1995-04-11 WO PCT/US1995/004495 patent/WO1995029894A1/en not_active Application Discontinuation
- 1995-04-11 CA CA002188918A patent/CA2188918A1/en not_active Abandoned
- 1995-04-11 KR KR1019960706138A patent/KR100244992B1/ko not_active IP Right Cessation
- 1995-04-11 BR BR9507553A patent/BR9507553A/pt not_active Application Discontinuation
- 1995-04-11 EP EP95915652A patent/EP0757675A1/en not_active Withdrawn
- 1995-04-11 AU AU22466/95A patent/AU2246695A/en not_active Abandoned
- 1995-04-11 JP JP7528255A patent/JPH09512549A/ja active Pending
-
1996
- 1996-10-25 FI FI964318A patent/FI964318A/fi unknown
- 1996-10-25 NO NO964533A patent/NO964533L/no unknown
Also Published As
Publication number | Publication date |
---|---|
JPH09512549A (ja) | 1997-12-16 |
CN1157611A (zh) | 1997-08-20 |
KR970702849A (ko) | 1997-06-10 |
FI964318A (fi) | 1996-12-23 |
FI964318A0 (fi) | 1996-10-25 |
EP0757675A1 (en) | 1997-02-12 |
WO1995029894A1 (en) | 1995-11-09 |
NO964533D0 (no) | 1996-10-25 |
KR100244992B1 (ko) | 2000-03-02 |
AU2246695A (en) | 1995-11-29 |
US5646163A (en) | 1997-07-08 |
CA2188918A1 (en) | 1995-11-09 |
BR9507553A (pt) | 1997-08-05 |
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