WO2001030140A2 - Atoxic insecticide, bactericide, fungicide and antimicotic agent - Google Patents

Atoxic insecticide, bactericide, fungicide and antimicotic agent Download PDF

Info

Publication number
WO2001030140A2
WO2001030140A2 PCT/MX2000/000039 MX0000039W WO0130140A2 WO 2001030140 A2 WO2001030140 A2 WO 2001030140A2 MX 0000039 W MX0000039 W MX 0000039W WO 0130140 A2 WO0130140 A2 WO 0130140A2
Authority
WO
WIPO (PCT)
Prior art keywords
shampoo
formulation
bactericide
fungicide
insecticide
Prior art date
Application number
PCT/MX2000/000039
Other languages
Spanish (es)
French (fr)
Other versions
WO2001030140A3 (en
Inventor
María Teresa DELGADILLO GUILLEN
Original Assignee
Delgadillo Guillen Maria Teres
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from MXPA/A/1999/009657A external-priority patent/MXPA99009657A/en
Application filed by Delgadillo Guillen Maria Teres filed Critical Delgadillo Guillen Maria Teres
Priority to AU14219/01A priority Critical patent/AU1421901A/en
Publication of WO2001030140A2 publication Critical patent/WO2001030140A2/en
Publication of WO2001030140A3 publication Critical patent/WO2001030140A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Definitions

  • INSECTICIDE BACTERICIDE
  • FUNGICIDE ANTIMICOTICO AT ⁇ XICOS.
  • Pediculosis is recognized as a public health problem that affects not only humans but also animals, both domestic and breeding. This problem has been tackled with the production of mainly chlorinated synthetic compounds, which, although used as an effective treatment, also represents a high cost, in addition to an environmental risk, due to their toxicity, and damage to health.
  • Lindane is insoluble in water, neurotoxic and is more active than DDT; high toxicity in plants, animals and humans, causing irreversible damage to health, including seizures, seizures, mental retardation and cancer among others, in addition, its toxicity and high manufacturing cost is not feasible for treatments massive in the population.
  • This active substance has a wide biological activity documented mainly as: insecticide, bactericide, fungicide and non-toxic antifungal; however, its effectiveness as a pediculicide had not been demonstrated so far, since it had not been formulated to be applied to both the scalp and the human body, to allow a total insecticidal action without an irritating or collateral effect on the skin of the affected people.
  • This product is an innovation compared to any other product when valued in the human species. It has been proven to be 100% effective, without causing irritation, or dermal lesions, or any adverse reactions, I have documented all this to guarantee its use.
  • the plant is weighed (5 grams) and disinfected for a period not exceeding 10 minutes.
  • the final point is marked by the slow decrease in foam that the mixing process presents, thus concluding the formulation.

Abstract

The invention relates to a pediculicidal product containing ascaridole. An active substance identified as ascaridole having pediculicidal activity is obtained from the leaves of Chenopodium graveolens Wild (or Teloxis graveolens Wild). It is formulated as a shampoo and applied in humans for the elimination of lice of the species Pediculus humanus of type capitis and Phthirus pubis. The product can also be formulated as a cream, ointment, liquid soap, paste soap, lotion, gel, talcum powder and spray, which are applied topically. The preparation of active substance ascaridole is not toxic in very low doses. It can therefore be used not only as a pediculicidal agent, but also as atoxic insecticide, bactericide, fungicide and antimicotic agent.

Description

INSECTICIDA, BACTERICIDA, FUNGICIDA Y ANTIMICOTICO ATÓXICOS.INSECTICIDE, BACTERICIDE, FUNGICIDE AND ANTIMICOTICO ATÓXICOS.
CAMPO TÉCNICOTECHNICAL FIELD
BIOTECNOLOGÍABIOTECHNOLOGY
ANTECEDENTES.BACKGROUND.
En México, así como en muchos países independientemente del nivel de desarrollo, se reconoce como un problema de sanidad pública la Pediculosis que afecta no únicamente a humanos sino también a los animales, tanto en los domésticos como los de cría. Este problema se ha abordado con la producción de compuestos sintéticos clorados principalmente, que si bien, se usan como tratamiento eficaz, también representa un alto costo, además un riesgo ambiental, por su toxicidad, y daños a la salud.In Mexico, as well as in many countries, regardless of the level of development, Pediculosis is recognized as a public health problem that affects not only humans but also animals, both domestic and breeding. This problem has been tackled with the production of mainly chlorinated synthetic compounds, which, although used as an effective treatment, also represents a high cost, in addition to an environmental risk, due to their toxicity, and damage to health.
Durante años el tratamiento más común para este problema, ha sido el uso de loción y champú que contienen lindano. El lindano es un pesticida potente que daña de manera permanente el sistema nervioso central; demostrado y ampliamente documentado. Los productos que contienen este principio activo son absorbidos por la piel humana y animal aumentando así su potencial tóxico.For years the most common treatment for this problem has been the use of lotion and shampoo that contain lindane. Lindane is a potent pesticide that permanently damages the central nervous system; Proven and widely documented. Products that contain this active substance are absorbed by human and animal skin thus increasing their toxic potential.
El lindano es insoluble en agua, neurotóxico y es más activo que el DDT; de alta toxicidad en plantas, animales y en el ser humano, causando daños irreversibles a la salud, entre ellos: convulsiones, ataques epilépticos, retraso mental y cáncer entre otros, además, de su toxicidad y alto costo de fabricación no es viable para tratamientos masivos en la población.Lindane is insoluble in water, neurotoxic and is more active than DDT; high toxicity in plants, animals and humans, causing irreversible damage to health, including seizures, seizures, mental retardation and cancer among others, in addition, its toxicity and high manufacturing cost is not feasible for treatments massive in the population.
En la actualidad estos pediculicidas no son biodegradables, acumulándose en el medio ambiente y en los individuos que los usan, los cuales sufren efectos a corto mediano y largo plazo, dependiendo del tiempo de tratamiento.At present these pediculicides are not biodegradable, accumulating in the environment and in the individuals who use them, which suffer effects in the short and medium term, depending on the time of treatment.
Es un producto de origen vegetal, que tanto en su proceso como en su formulación para uso humano, veterinario, agrícola y uso domestico, se utiliza tecnología de muy bajo costo, dado que en este país México se requiere para su industrialización, además no se requieren solventes tóxicos, garantizando un producto de estabilidad, seguridad y eficacia; el producto cumple los requisitos de la SECRETARIA DE COMERCIO Y FOMENTO INDUSTRIAL, así como las NORMAS MEXICANAS, para su Formulación en champú. Contiene un principio activo identificado como ASCARIDOL, el cual se encuentra en el follaje del Chenopodium graveóles Willd o Teloxis graveóles Willd. Este principio activo tiene una amplia actividad biológica documentada principalmente como: insecticida, bactericida, fungicida y antimicótico atóxico; sin embargo no se había demostrado hasta ahora su eficacia como pediculicida, dado que no se había formulado para ser aplicado tanto en el cuero cabelludo como en el cuerpo humano, para permitir una acción insecticida total sin un efecto irritante o colateral sobre la piel de las personas afectadas.It is a product of plant origin, that both in its process and in its formulation for human, veterinary, agricultural and domestic use, very low cost technology is used, since in this country Mexico is required for its industrialization, in addition it is not they require toxic solvents, guaranteeing a product of stability, safety and efficacy; The product meets the requirements of the SECRETARY OF COMMERCE AND INDUSTRIAL DEVELOPMENT, as well as the MEXICAN RULES, for its formulation in shampoo. It contains an active substance identified as ASCARIDOL, which is found in the foliage of the Chenopodium graveóles Willd or Teloxis graveóles Willd. This active substance has a wide biological activity documented mainly as: insecticide, bactericide, fungicide and non-toxic antifungal; however, its effectiveness as a pediculicide had not been demonstrated so far, since it had not been formulated to be applied to both the scalp and the human body, to allow a total insecticidal action without an irritating or collateral effect on the skin of the affected people.
Este producto es una innovación frente a cualquier otro producto al valorarlo en la especie humana. Se ha comprobado ser 100% eficaz, sin producir irritación, o lesiones dérmicas, ni ninguna reacción adversa, todo esto lo he documentado para garantizar su uso.This product is an innovation compared to any other product when valued in the human species. It has been proven to be 100% effective, without causing irritation, or dermal lesions, or any adverse reactions, I have documented all this to guarantee its use.
PROCESO DE OBTENCIÓN.OBTAINING PROCESS.
1.- El follaje del (Chenopodium graveolens Willd o Teloxis graveóles Willd. ); obtenido en fresco se lava al chorro del agua dos veces, se elimina el agua, se seca, y se fragmenta para su uso posterior.1.- The foliage of the (Chenopodium graveolens Willd or Teloxis graveóles Willd.); Freshly obtained, it is washed twice with water, the water is removed, dried, and fragmented for later use.
2.- Se pesa la planta (5 gramos) y se desinfecta por un periodo no mayor de 10 minutos.2.- The plant is weighed (5 grams) and disinfected for a period not exceeding 10 minutes.
Se enjuaga con agua destilada o purificada y se coloca en un matraz de vidrio Pyrex. En un recipiente de vidrio se pone un volumen de 200 mL de agua a temperatura de ebullición durante 5 minutos se incorpora la planta y se deja a temperatura de ebullición durante 10 minutos tapando el matraz con un vidrio de reloj. Se enfría a temperatura ambiente.It is rinsed with distilled or purified water and placed in a Pyrex glass flask. In a glass container, a volume of 200 mL of water is boiled at boiling temperature for 5 minutes, the plant is incorporated and left at boiling temperature for 10 minutes, covering the flask with a watch glass. It cools to room temperature.
3.- Se filtra con papel filtro por dos ocasiones y el matraz se tapa nuevamente.3.- Filter with filter paper twice and the flask is covered again.
4.- Se checa el Ph, y que la solución sea completamente cristalina.4.- The Ph is checked, and the solution is completely crystalline.
II.- FORMULACIÓN DEL CHAMPÚ.II.- FORMULATION OF THE SHAMPOO.
Se prepara de la siguiente manera para (1 litro), obteniendo aproximadamente un total de 1200 mL de champú, utilizando agua destilada o purificada.It is prepared as follows for (1 liter), obtaining approximately a total of 1200 mL of shampoo, using distilled or purified water.
1.- DIETANOLAMIDA DE ÁCIDOS GRASOS DE COCO, se prepara al 2% en 1 litro de agua a temperatura de 100X se incorpora, lentamente hasta su total incorporación, estando a temperatura de 80°C mínimo, se agrega LAURIL ÉTER SULFATO DE SODIO al 20% con agitación continua, se incorpora COCOAMIDA1.- DIETANOLAMIDE OF COCONUT FATTY ACIDS, it is prepared at 2% in 1 liter of water at a temperature of 100X it is incorporated, slowly until its total incorporation, being at a temperature of 80 ° C minimum, LAURIL Ether is added 20% SODIUM SULFATE with continuous agitation, COCOAMIDA is incorporated
PROPIL BETAÍNA, al 6% sin dejar de agitar, y antes de que disminuya la temperatura más de 5o OBETAINE PROPIL, at 6% while stirring, and before the temperature drops more than 5 or O
2.- En otro recipiente de vidrio se mezcla, DIESTERATO POLIETILENGLICOL, al 0.3% en 100 mL. agua de 60°C a 80°C, sin exceder este rango hasta que se disuelva, luego se incorpora inmediatamente a la mezcla anterior.2.- In another glass container, 0.3% POLYETHYLENE GLYCOL DIESTERATE is mixed in 100 mL. water from 60 ° C to 80 ° C, without exceeding this range until dissolved, then immediately incorporated into the previous mixture.
3.- Se calienta 100 mL de agua destilada en otro matraz de vidrio. A temperatura de 60°C a 80°C, se incorpora el PROPILPARABENO al 0.5%, una vez disuelto se incorpora a la mezcla, agitando continuamente.3.- 100 mL of distilled water is heated in another glass flask. At a temperature of 60 ° C to 80 ° C, 0.5% PROPILPARABEN is incorporated, once dissolved it is incorporated into the mixture, stirring continuously.
4.- Finalmente se agrega a la mezcla la fragancia para el champú al 0.2%.4.- Finally, the fragrance for the 0.2% shampoo is added to the mixture.
El punto final lo marca la lenta disminución de espuma que presenta el proceso de mezclado, concluyendo así la formulación. The final point is marked by the slow decrease in foam that the mixing process presents, thus concluding the formulation.

Claims

REIVINDICACIONES. Reclamo como de mí propiedad: CLAIMS. Claim as my property:
1.- La formulación del insecticida, bactericida, fungicida y antimicótico en humanos, tanto como para la cabeza como para el cuerpo, como los productos derivados, dado que nunca se han usado con este propósito.1.- The formulation of insecticide, bactericide, fungicide and antifungal in humans, both for the head and for the body, as derived products, since they have never been used for this purpose.
2.-La formulación del champú para caspa y seborrea en humanos, como los productos que se puedan derivar de este.2.-The formulation of shampoo for dandruff and seborrhea in humans, as the products that can be derived from it.
3.-La formulación del champú para evitar la caída del pelo, lavar heridas y cicratrizarlas.3.-The shampoo formulation to prevent hair loss, wash wounds and cycle them.
4.-La formulación de champú para uso en piel en humanos en casos de bacterias, hogos y virus así también lavar heridas y cicratizarlas.4.-The formulation of shampoo for use on skin in humans in cases of bacteria, fungi and viruses, as well as washing wounds and cycling them.
5.-Laforτnulación del champú en piojos pulgas y garrapatas de uso veterinario así como en otras presentaciones las cuales pueden ser formuladas por esta mezcla como también en otros usos Veterinarios como son contra la cucaracha ( periplaneta americano) etc.5.-Laforτnulation of shampoo in fleas and ticks for veterinary use as well as in other presentations which can be formulated by this mixture as well as in other Veterinary uses such as against cockroaches (American periplanet) etc.
6.-EI uso del principio activo en la agricultura contra plagas como lo son hongos, insectos, etc.6.-The use of the active substance in agriculture against pests such as fungi, insects, etc.
7.-Uso en el hogar como insecticida, bactericida o fungicida.7.-Use at home as an insecticide, bactericide or fungicide.
8. -La preparación del principio activo con la dosis manejada según la farmacopea de Estado Unidos Mexicanos S.S.A. Respecto a la valoración de ASCARIDOL resultando de estas pruebas 10,000 veces abajo de la dosis letal establecida.8. -The preparation of the active substance with the dose managed according to the pharmacopoeia of Estado Unidos Mexicanos S.S.A. Regarding the evaluation of ASCARIDOL resulting from these tests 10,000 times below the established lethal dose.
9.-EI uso de esta planta nativa de México esta considerada como tóxica que bajo esta dosis permite ser atóxica (no tóxica). La planta lleva el nombre científico (Chenopodium graveolens Willd o Teloxis graveóles Willd.) 9.-The use of this plant native to Mexico is considered to be toxic which, under this dose, can be toxic (non-toxic). The plant is named after the scientific name (Chenopodium graveolens Willd or Teloxis graveóles Willd.)
PCT/MX2000/000039 1999-10-21 2000-10-20 Atoxic insecticide, bactericide, fungicide and antimicotic agent WO2001030140A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU14219/01A AU1421901A (en) 1999-10-21 2000-10-20 Atoxic insecticide, bactericide, fungicide and antimicotic agent

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
MX999657 1999-10-21
MXPA/A/1999/009657A MXPA99009657A (en) 1999-10-21 Process for the obtaining of the formulation of a new product insecticide, bactericide, fungicide and antimicotico atóxi

Publications (2)

Publication Number Publication Date
WO2001030140A2 true WO2001030140A2 (en) 2001-05-03
WO2001030140A3 WO2001030140A3 (en) 2002-02-28

Family

ID=19745123

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/MX2000/000039 WO2001030140A2 (en) 1999-10-21 2000-10-20 Atoxic insecticide, bactericide, fungicide and antimicotic agent

Country Status (2)

Country Link
AU (1) AU1421901A (en)
WO (1) WO2001030140A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6663876B2 (en) 2002-04-29 2003-12-16 Piedmont Pharmaceuticals, Llc Methods and compositions for treating ectoparasite infestation

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KLIKS M M: "STUDIES ON THE TRADITIONAL HERBAL ANTHELMINTIC CHENOPODIUM AMBROSIOIDES L.: ETHNOPHARMACOLOGICAL EVALUATION AND CLINICAL FIELD TRIALS" SOCIAL SCIENCE & MEDICINE, vol. 21, num. 8, 1985, páginas 879 879-886, XP002901597 *
MATA R ET AL: "FLAVONOIDS AND TERPENOIDS OF CHENOPODIUM GRAVEOLENS" PHYTOCHEMISTRY, vol. 26, num. 1, 1987, páginas 191-193, XP002901595 *
MONTAYA-CABRERA M A ET AL: "ENVENENAMIENTO MORTAL CAUSADO POR EL ACEITE DE EPAZOTE,CHENOPODIUM GRAVEOLENS" GACETA MEDICA DE MEXICO, vol. 132, num. 4, Julio 1996 (1996-07) - Agosto 1996 (1996-08), páginas 433-437, XP002901596 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6663876B2 (en) 2002-04-29 2003-12-16 Piedmont Pharmaceuticals, Llc Methods and compositions for treating ectoparasite infestation
US8178116B2 (en) 2002-04-29 2012-05-15 Piedmont Pharmaceuticals, Llc Methods and compositions for treating ectoparasite infestation

Also Published As

Publication number Publication date
WO2001030140A3 (en) 2002-02-28
AU1421901A (en) 2001-05-08

Similar Documents

Publication Publication Date Title
KR20010079812A (en) Insecticidal composition
CN110537555A (en) Preparation of mosquito repellent liquid with bactericidal effect based on natural plant extract
ES2224386T3 (en) COMPOSITION FOR SPRAYER AGAINST ANTS CONTAINING D-LIMONENE AND PROCEDURES FOR THEIR PREPARATION AND USE OF THE SAME.
WO2001030140A2 (en) Atoxic insecticide, bactericide, fungicide and antimicotic agent
US5093326A (en) Repellant compositions
PT774903E (en) PESTICIDE COMPOSITIONS CONTAINING ETOXILATED FAT AMINES TO INCREASE THE EFFECTIVENESS OF "ENDOTHALL" AND ITS SALTS
US6784211B1 (en) Ant spray containing d-limonene and methods of making and using the same
CN107455390A (en) Composition pesticide of environment-protecting pesticide sterilization and preparation method thereof
JP3127289B2 (en) Topical antifungal and insecticidal products
US20170071202A1 (en) Compositions comprising flavonoid-containing extracts from plants of the genus citrus and/or isolated citrus flavonoids and specific cationic surface active agents, and said composition for use as an agent for treating infestations with head lice
CN106417341A (en) Indoxacarb-containing cockroach killing preparation
RU2285405C2 (en) Method for controlling of arthropod pests, composition for insecticidal and arachnicidal application, methods for controlling of sucking lice, flies, mites, and cockroaches
HU188391B (en) Insecticide composition containing salicylic acid derivatives as activators
BG63027B1 (en) Method for the destruction of harmful insect eggs and the application of ovocidal compositions to this end
Jadhav et al. Anticockroach Activity of Fruit Extract of Luffa acutangula var. amara Anticockroach Activity of Luffa amara
KR100604092B1 (en) Composition For Treating Skin Disease of Pet Animals Comprising 6-Pentyl-Alpha-Pyrone as Active Ingredient
ES2718390B2 (en) USE OF A FUNGICIDE COMPOSITION AS A TREATMENT
GB2533773A (en) Compositions for the treatment of pediculosis
BR112021007600A2 (en) new composition of soluble concentrate of abamectin (sl)
MXPA97003021A (en) Product ectoparasiticida antimicotico de uso exte
RU2232507C1 (en) "aut" pesticide preparation against insects
JP4602491B2 (en) Pest control agent
JPS5988403A (en) Herbicide for plowed land or horticultural use
JPS6136482B2 (en)
Ginsburg et al. The effect of soap sprays on plants

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

NENP Non-entry into the national phase

Ref country code: JP