WO2001027127A1 - Glycosides de tamoxifene et d'analogues de tamoxifene et leurs utilisations - Google Patents

Glycosides de tamoxifene et d'analogues de tamoxifene et leurs utilisations Download PDF

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Publication number
WO2001027127A1
WO2001027127A1 PCT/GB2000/003865 GB0003865W WO0127127A1 WO 2001027127 A1 WO2001027127 A1 WO 2001027127A1 GB 0003865 W GB0003865 W GB 0003865W WO 0127127 A1 WO0127127 A1 WO 0127127A1
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WO
WIPO (PCT)
Prior art keywords
alkyl
compound according
group
phenyl
integer
Prior art date
Application number
PCT/GB2000/003865
Other languages
English (en)
Inventor
Michael Francis Holick
Halasya Ramanathan
Original Assignee
Strakan Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Strakan Group Plc filed Critical Strakan Group Plc
Priority to AU76740/00A priority Critical patent/AU7674000A/en
Publication of WO2001027127A1 publication Critical patent/WO2001027127A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Abstract

L'invention porte sur des glycosides et des orthoesters glycosides de tamoxifène et leurs analogues présentant des niveaux plus élevés de plasma que le tamoxifène après administration orale.
PCT/GB2000/003865 1999-10-08 2000-10-06 Glycosides de tamoxifene et d'analogues de tamoxifene et leurs utilisations WO2001027127A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU76740/00A AU7674000A (en) 1999-10-08 2000-10-06 Tamoxifen and tamoxifen analogue glycosides and uses thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US15814199P 1999-10-08 1999-10-08
US60/158,141 1999-10-08
US21066900P 2000-06-09 2000-06-09
US60/210,669 2000-06-09

Publications (1)

Publication Number Publication Date
WO2001027127A1 true WO2001027127A1 (fr) 2001-04-19

Family

ID=26854777

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2000/003865 WO2001027127A1 (fr) 1999-10-08 2000-10-06 Glycosides de tamoxifene et d'analogues de tamoxifene et leurs utilisations

Country Status (2)

Country Link
AU (1) AU7674000A (fr)
WO (1) WO2001027127A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005000834A1 (fr) * 2003-06-10 2005-01-06 Eli Lilly And Company Pentafluoroalcanesulfinyl naphtalenes et modulateurs du recepteur d'oestrogene apparentes
US9675546B2 (en) 2006-06-02 2017-06-13 Bernadette KLAMERUS Method of treating atrophic vaginitis
CN107674051A (zh) * 2017-09-20 2018-02-09 南京医科大学 4‑羟基他莫昔酚环状衍生物乏氧活化前药及其药物用途
KR20180016108A (ko) * 2016-08-05 2018-02-14 고려대학교 산학협력단 당 부가된 엔클로미펜, 이의 제조방법 및 이를 포함하는 약학적 조성물

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0683170A1 (fr) * 1994-05-20 1995-11-22 Eli Lilly And Company Benzothiophènes de glucopyranoside
WO1996003995A1 (fr) * 1994-08-04 1996-02-15 Holick Michael F Procede d'administration d'×strogene
US5508392A (en) * 1992-12-29 1996-04-16 Holick; Michael F. Use of vitamin D glycosides, vitamin D orthoester glycosides, vitamin D analog glycosides and vitamin D analog orthoester glycosides for the treatment of osteoporosis
EP0735141A2 (fr) * 1995-03-31 1996-10-02 Eli Lilly And Company Procédé de préparation de benzo(b)thiophène glucuronides
WO1999007693A1 (fr) * 1997-08-11 1999-02-18 Eli Lilly And Company Benzothiophenes

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5508392A (en) * 1992-12-29 1996-04-16 Holick; Michael F. Use of vitamin D glycosides, vitamin D orthoester glycosides, vitamin D analog glycosides and vitamin D analog orthoester glycosides for the treatment of osteoporosis
EP0683170A1 (fr) * 1994-05-20 1995-11-22 Eli Lilly And Company Benzothiophènes de glucopyranoside
US5567820A (en) * 1994-05-20 1996-10-22 Eli Lilly And Company Glucopyranoside benzothiophenes
WO1996003995A1 (fr) * 1994-08-04 1996-02-15 Holick Michael F Procede d'administration d'×strogene
EP0735141A2 (fr) * 1995-03-31 1996-10-02 Eli Lilly And Company Procédé de préparation de benzo(b)thiophène glucuronides
WO1999007693A1 (fr) * 1997-08-11 1999-02-18 Eli Lilly And Company Benzothiophenes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DODGE J A ET AL: "Synthesis and estrogen receptor binding affinities of the major human metabolites of raloxifene (LY139481)", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,GB,OXFORD, vol. 7, no. 8, 22 April 1997 (1997-04-22), pages 993 - 996, XP004136171, ISSN: 0960-894X *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005000834A1 (fr) * 2003-06-10 2005-01-06 Eli Lilly And Company Pentafluoroalcanesulfinyl naphtalenes et modulateurs du recepteur d'oestrogene apparentes
US7462647B2 (en) 2003-06-10 2008-12-09 Eli Lilly And Company Pentalfluoroalkanesulfinyl naphthalenes and related estrogen receptor modulators
US9675546B2 (en) 2006-06-02 2017-06-13 Bernadette KLAMERUS Method of treating atrophic vaginitis
US9693953B2 (en) 2006-06-02 2017-07-04 Janet A. Chollet Method of treating atrophic vaginitis
KR20180016108A (ko) * 2016-08-05 2018-02-14 고려대학교 산학협력단 당 부가된 엔클로미펜, 이의 제조방법 및 이를 포함하는 약학적 조성물
WO2018026087A3 (fr) * 2016-08-05 2018-08-09 고려대학교 산학협력단 Enclomiphène avec sucre ajouté, son procédé de préparation et composition pharmaceutique le comprenant
KR101970326B1 (ko) * 2016-08-05 2019-04-18 고려대학교 산학협력단 당 부가된 엔클로미펜, 이의 제조방법 및 이를 포함하는 약학적 조성물
CN107674051A (zh) * 2017-09-20 2018-02-09 南京医科大学 4‑羟基他莫昔酚环状衍生物乏氧活化前药及其药物用途

Also Published As

Publication number Publication date
AU7674000A (en) 2001-04-23

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