WO2001025245A3 - Isogenes de ciblage de medicament: polymorphismes du gene de la proteine 6 associe a l'apoptose - Google Patents

Isogenes de ciblage de medicament: polymorphismes du gene de la proteine 6 associe a l'apoptose Download PDF

Info

Publication number
WO2001025245A3
WO2001025245A3 PCT/US2000/027487 US0027487W WO0125245A3 WO 2001025245 A3 WO2001025245 A3 WO 2001025245A3 US 0027487 W US0027487 W US 0027487W WO 0125245 A3 WO0125245 A3 WO 0125245A3
Authority
WO
WIPO (PCT)
Prior art keywords
gene
polymorphisms
associated protein
death
drug target
Prior art date
Application number
PCT/US2000/027487
Other languages
English (en)
Other versions
WO2001025245A2 (fr
Inventor
Anne Chew
Julie Y Choi
Richard Rex Denton
Krishnan Nandabalan
Joel Claiborne Stephens
Original Assignee
Genaissance Pharmaceuticals
Anne Chew
Julie Y Choi
Richard Rex Denton
Krishnan Nandabalan
Joel Claiborne Stephens
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaissance Pharmaceuticals, Anne Chew, Julie Y Choi, Richard Rex Denton, Krishnan Nandabalan, Joel Claiborne Stephens filed Critical Genaissance Pharmaceuticals
Priority to AU2000278606A priority Critical patent/AU2000278606A1/en
Publication of WO2001025245A2 publication Critical patent/WO2001025245A2/fr
Publication of WO2001025245A3 publication Critical patent/WO2001025245A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
    • C12Q2535/131—Allele specific probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne des polynucléotides comprenant un ou plusieurs parmi 19 nouveaux polymorphismes nucléotidiques simples dans le gène humain de la protéine 6 associé à l'apoptose (DAXX). L'invention concerne des compositions et des méthodes qui permettent de détecter un ou plusieurs de ces polymorphismes. Elle concerne en outre divers génotypes et halotypes du gène DAXX existant dans la population.
PCT/US2000/027487 1999-10-06 2000-10-05 Isogenes de ciblage de medicament: polymorphismes du gene de la proteine 6 associe a l'apoptose WO2001025245A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2000278606A AU2000278606A1 (en) 1999-10-06 2000-10-05 Drug target isogenes: polymorphisms in the death-associated protein 6 gene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15790999P 1999-10-06 1999-10-06
US60/157,909 1999-10-06

Publications (2)

Publication Number Publication Date
WO2001025245A2 WO2001025245A2 (fr) 2001-04-12
WO2001025245A3 true WO2001025245A3 (fr) 2001-10-18

Family

ID=22565840

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/027487 WO2001025245A2 (fr) 1999-10-06 2000-10-05 Isogenes de ciblage de medicament: polymorphismes du gene de la proteine 6 associe a l'apoptose

Country Status (2)

Country Link
AU (1) AU2000278606A1 (fr)
WO (1) WO2001025245A2 (fr)

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CYTOMETRY, vol. 40, no. 2, 2000, pages 102 - 108 *
DATABASE CAPLUS [online] ARMSTRONG ET AL.: "Suspension arrays for high throughput, multiplexed single nucleotide polymorphism genotyping", XP002938281, accession no. STN Database accession no. 2000:406810 *
YANG ET AL: "Daxx, a novel fas-binding protein that activates JNK and apoptosis", CELL, vol. 89, 27 June 1997 (1997-06-27), pages 1067 - 1076, XP002938280 *

Also Published As

Publication number Publication date
AU2000278606A1 (en) 2001-05-10
WO2001025245A2 (fr) 2001-04-12

Similar Documents

Publication Publication Date Title
WO2001023410A3 (fr) Isogenes cibles a usage medicamenteux: polymorphismes dans le gene d'interleukine
WO2001090122A3 (fr) Haplotypes du gene ctla4
WO2001079229A3 (fr) Haplotypes du gene cxcr4
WO2001027312A3 (fr) Isogenes cibles pour medicaments: polymorphismes dans le gene recepteur de l'acetylcholine muscarinique m1
WO2001025245A3 (fr) Isogenes de ciblage de medicament: polymorphismes du gene de la proteine 6 associe a l'apoptose
WO2001079234A3 (fr) Haplotypes du gene apoe
WO2001011010A3 (fr) Isogenes cibles de medicaments : polymorphismes dans le gene de la sous-unite alpha du recepteur i de l'immunoglobuline e
WO2001029176A3 (fr) Isogenes cibles de medicaments: polymorphismes dans le gene 3 muscarinique, de recepteur cholinergique
WO2001090123A3 (fr) Haplotypes du gene agtrl1
WO2001077124A3 (fr) Haplotypes du gene apoa4
WO2001079230A3 (fr) Haplotypes du gene ugt1a1
WO2001058914A3 (fr) Haplotypes du gene de l'interleukine 15
WO2001077363A3 (fr) Haplotypes du gene impdh2
WO2001027311A3 (fr) Isogenes cibles de medicaments: les polymorphismes du gene recepteur 1d de la 5-hydroxytryptamine (serotonine)
WO2001025194A3 (fr) Isogenes cibles de medicaments: polymorphismes dans le gene du recepteur 1b de 5-hydroxytryptamine (serotonine)
WO2001018232A3 (fr) Isogenes cibles de medicaments: polymorphismes dans le gene de proteine bruleuse de graisses excedentaires (mitochondriale, porteuse de protons)
WO2002026764A3 (fr) Haplotypes du gene ccr6
WO2001079240A3 (fr) Haplotypes du gene rangap1
WO2001077131A3 (fr) Haplotypes du gene bglap
WO2001027313A3 (fr) Isogenes cibles pour medicaments: polymorphisme dans le gene muscarinique 2 recepteur cholinergique
WO2001092278A3 (fr) Haplotypes du gene rlbp1
WO2001072966A3 (fr) Haplotypes du gene pltp
WO2001077129A3 (fr) Haplotypes du gene apoc1
WO2001075063A3 (fr) Haplotypes du gene chrnb3
WO2001074833A3 (fr) Haplotypes du gene chrnb2

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WPC Withdrawal of priority claims after completion of the technical preparations for international publication
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP