WO2001018232A3 - Isogenes cibles de medicaments: polymorphismes dans le gene de proteine bruleuse de graisses excedentaires (mitochondriale, porteuse de protons) - Google Patents

Isogenes cibles de medicaments: polymorphismes dans le gene de proteine bruleuse de graisses excedentaires (mitochondriale, porteuse de protons) Download PDF

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Publication number
WO2001018232A3
WO2001018232A3 PCT/US2000/024784 US0024784W WO0118232A3 WO 2001018232 A3 WO2001018232 A3 WO 2001018232A3 US 0024784 W US0024784 W US 0024784W WO 0118232 A3 WO0118232 A3 WO 0118232A3
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WO
WIPO (PCT)
Prior art keywords
gene
polymorphisms
mitochondrial
uncoupling protein
drug target
Prior art date
Application number
PCT/US2000/024784
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English (en)
Other versions
WO2001018232A2 (fr
Inventor
Anne Chew
Julie Y Choi
R Rex Denton
Krishnan Nandabalan
Original Assignee
Genaissance Pharmaceuticals
Stephens Joel Claiborne
Anne Chew
Julie Y Choi
R Rex Denton
Krishnan Nandabalan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaissance Pharmaceuticals, Stephens Joel Claiborne, Anne Chew, Julie Y Choi, R Rex Denton, Krishnan Nandabalan filed Critical Genaissance Pharmaceuticals
Priority to AU2000273645A priority Critical patent/AU2000273645A1/en
Publication of WO2001018232A2 publication Critical patent/WO2001018232A2/fr
Publication of WO2001018232A3 publication Critical patent/WO2001018232A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/40—Population genetics; Linkage disequilibrium
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Evolutionary Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Medical Informatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Physiology (AREA)
  • Wood Science & Technology (AREA)
  • Ecology (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne des polynucléotides comprenant un ou plusieurs des 19 nouveaux polymorphismes nucléotidiques individuels identifiés dans le gène de protéine UCP3 humaine brûleuse de graisses excédentaires (mitochondriale, porteuse de protons). L'invention concerne en outre des compositions et des procédés permettant de déceler un ou plusieurs de ces polymorphismes. L'invention concerne enfin divers génotypes et haplotypes correspondant au gène de protéine UCP3 qui existent dans la population.
PCT/US2000/024784 1999-09-08 2000-09-08 Isogenes cibles de medicaments: polymorphismes dans le gene de proteine bruleuse de graisses excedentaires (mitochondriale, porteuse de protons) WO2001018232A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2000273645A AU2000273645A1 (en) 1999-09-08 2000-09-08 Drug target isogenes: polymorphisms in the uncoupling protein 3 (mitochondrial, proton carrier) gene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15278999P 1999-09-08 1999-09-08
US60/152,789 1999-09-08

Publications (2)

Publication Number Publication Date
WO2001018232A2 WO2001018232A2 (fr) 2001-03-15
WO2001018232A3 true WO2001018232A3 (fr) 2001-09-27

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/024784 WO2001018232A2 (fr) 1999-09-08 2000-09-08 Isogenes cibles de medicaments: polymorphismes dans le gene de proteine bruleuse de graisses excedentaires (mitochondriale, porteuse de protons)

Country Status (2)

Country Link
AU (1) AU2000273645A1 (fr)
WO (1) WO2001018232A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104131096B (zh) * 2014-07-28 2016-08-17 福建农林大学 一种检测肉牛ucp3基因单核苷酸多态性的方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999048905A1 (fr) * 1998-03-23 1999-09-30 Musc Foundation For Research Development Methodes pour identifier les risques de developper un dysfonctionnement lie a un variant des genes ucp2 et ucp3, et compositions s'y rapportant
US5972614A (en) * 1995-12-06 1999-10-26 Genaissance Pharmaceuticals Genome anthologies for harvesting gene variants
US5974164A (en) * 1994-10-21 1999-10-26 Affymetrix, Inc. Computer-aided visualization and analysis system for sequence evaluation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5974164A (en) * 1994-10-21 1999-10-26 Affymetrix, Inc. Computer-aided visualization and analysis system for sequence evaluation
US5972614A (en) * 1995-12-06 1999-10-26 Genaissance Pharmaceuticals Genome anthologies for harvesting gene variants
WO1999048905A1 (fr) * 1998-03-23 1999-09-30 Musc Foundation For Research Development Methodes pour identifier les risques de developper un dysfonctionnement lie a un variant des genes ucp2 et ucp3, et compositions s'y rapportant

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CAMERON E.R.: "Recent advances in transgenic technology", MOLECULAR BIOTECHNOLOGY, vol. 7, 1997, pages 253 - 265, XP002938360 *
OTABE S. ET AL.: "Mutation screening and association studies of the human uncoupling protein 3 gene in normoglycemic and diabetic morbidly obese patients", DIABETES, vol. 48, January 1999 (1999-01-01), pages 206 - 208, XP002938361 *

Also Published As

Publication number Publication date
AU2000273645A1 (en) 2001-04-10
WO2001018232A2 (fr) 2001-03-15

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