WO2001023365A1 - Quinazolinones - Google Patents

Quinazolinones Download PDF

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Publication number
WO2001023365A1
WO2001023365A1 PCT/EP2000/008940 EP0008940W WO0123365A1 WO 2001023365 A1 WO2001023365 A1 WO 2001023365A1 EP 0008940 W EP0008940 W EP 0008940W WO 0123365 A1 WO0123365 A1 WO 0123365A1
Authority
WO
WIPO (PCT)
Prior art keywords
quinazolin
formula
phenyl
absent
formula lla
Prior art date
Application number
PCT/EP2000/008940
Other languages
English (en)
Inventor
Werner Mederski
Ralf Devant
Gerhard Barnickel
Sabine Bernotat-Danielowski
Guido Melzer
Daljit Dhanoa
Bao-Ping Zhao
James Rinker
Mark Player
Richard Soll
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Priority to KR1020027003907A priority Critical patent/KR20020047186A/ko
Priority to US10/089,166 priority patent/US6890930B1/en
Priority to AU76548/00A priority patent/AU7654800A/en
Priority to EP00965991A priority patent/EP1216235A1/fr
Priority to CA002385921A priority patent/CA2385921A1/fr
Priority to BR0014294-8A priority patent/BR0014294A/pt
Publication of WO2001023365A1 publication Critical patent/WO2001023365A1/fr
Priority to NO20021502A priority patent/NO20021502D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

L'invention concerne des quinazolinones correspondant à la formule (I) dans laquelle R, R?1, R2, R3, R4¿, Y, Z, n et m possèdent les notations données dans la revendication 1. Elle concerne également des sels ou solvates de ces quinazolinones. Ces composés sont utiles en tant qu'antagonistes de la glycoprotéine IbIX.
PCT/EP2000/008940 1999-09-28 2000-09-13 Quinazolinones WO2001023365A1 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
KR1020027003907A KR20020047186A (ko) 1999-09-28 2000-09-13 퀴나졸리논
US10/089,166 US6890930B1 (en) 1999-09-28 2000-09-13 Quinazolinones
AU76548/00A AU7654800A (en) 1999-09-28 2000-09-13 Quinazolinones
EP00965991A EP1216235A1 (fr) 1999-09-28 2000-09-13 Quinazolinones
CA002385921A CA2385921A1 (fr) 1999-09-28 2000-09-13 Quinazolinones
BR0014294-8A BR0014294A (pt) 1999-09-28 2000-09-13 Quinazolinonas
NO20021502A NO20021502D0 (no) 1999-09-28 2002-03-26 Kinazolinoner

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40795899A 1999-09-28 1999-09-28
US09/407,958 1999-09-28

Publications (1)

Publication Number Publication Date
WO2001023365A1 true WO2001023365A1 (fr) 2001-04-05

Family

ID=23614261

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/008940 WO2001023365A1 (fr) 1999-09-28 2000-09-13 Quinazolinones

Country Status (8)

Country Link
EP (1) EP1216235A1 (fr)
KR (1) KR20020047186A (fr)
AR (1) AR025797A1 (fr)
AU (1) AU7654800A (fr)
BR (1) BR0014294A (fr)
CA (1) CA2385921A1 (fr)
NO (1) NO20021502D0 (fr)
WO (1) WO2001023365A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6545004B1 (en) 1999-10-27 2003-04-08 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
WO2003106435A1 (fr) * 2002-06-18 2003-12-24 Sankyo Company, Limited Derives de la pyrimidin-4(3h)-one a cycles fusionnes, spn procede de preparation et ses utilisations
WO2004013111A1 (fr) * 2002-08-01 2004-02-12 Euro-Celtique S.A. Composes benzoheterocycliques bicycliques substitues en 2 et leur utilisation en tant que bloqueurs du canal sodique
EP1558260A2 (fr) * 2002-11-04 2005-08-03 Nps Pharmaceuticals, Inc. Composes de quinazolinone utilises comme calcilytiques
US7671200B2 (en) 1999-10-27 2010-03-02 Cytokinetics, Inc. Quinazolinone KSP inhibitors
US7763628B2 (en) 1999-10-27 2010-07-27 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3558610A (en) * 1966-12-30 1971-01-26 Squibb & Sons Inc Quinazolinone derivatives
EP0169537A2 (fr) * 1984-07-26 1986-01-29 Mitsubishi Kasei Corporation 2-Phénylalkyl-3-aminoalkyl-4(3H)-quinazolinones, procédés pour leur préparation, compositions pharmaceutiques et usage
EP0749974A1 (fr) * 1994-03-08 1996-12-27 Otsuka Pharmaceutical Factory, Inc. Derive de diester phosphonique
WO1998011438A1 (fr) * 1996-09-13 1998-03-19 Trega Biosciences, Inc. Synthese de banques de quinazolinone et de derives de celui-ci

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3558610A (en) * 1966-12-30 1971-01-26 Squibb & Sons Inc Quinazolinone derivatives
EP0169537A2 (fr) * 1984-07-26 1986-01-29 Mitsubishi Kasei Corporation 2-Phénylalkyl-3-aminoalkyl-4(3H)-quinazolinones, procédés pour leur préparation, compositions pharmaceutiques et usage
EP0749974A1 (fr) * 1994-03-08 1996-12-27 Otsuka Pharmaceutical Factory, Inc. Derive de diester phosphonique
WO1998011438A1 (fr) * 1996-09-13 1998-03-19 Trega Biosciences, Inc. Synthese de banques de quinazolinone et de derives de celui-ci

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DEAN W D ET AL: "SYNTHESIS OF 4(3H)-QHINAZOLINONES FROM DERIVATIVES OF METHYL 2-ISOTHIOCYANATOBENZOATE", JOURNAL OF HETEROCYCLIC CHEMISTRY,US,HETEROCORPORATION. PROVO, vol. 19, 1 September 1982 (1982-09-01), pages 1117 - 1123, XP002045780, ISSN: 0022-152X *
L. LEGRAND ET AL., BULL. SOC. CHIM. FR., no. 11-12, pt. 2, 1976, pages 1853 - 6, XP000971914 *
Y. KUROGI ET AL., J. MED. CHEM., vol. 39, no. 7, 1996, pages 1433 - 7, XP002158860 *

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7671200B2 (en) 1999-10-27 2010-03-02 Cytokinetics, Inc. Quinazolinone KSP inhibitors
US6562831B1 (en) 1999-10-27 2003-05-13 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
US6630479B1 (en) 1999-10-27 2003-10-07 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
US6545004B1 (en) 1999-10-27 2003-04-08 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
US8470838B2 (en) 1999-10-27 2013-06-25 Cytokinetics, Incorporated Methods and compositions utilizing quinazolinones
US6831085B1 (en) 1999-10-27 2004-12-14 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
US8008311B2 (en) 1999-10-27 2011-08-30 Cytokinetics, Inc. Methods and compostions utilizing quinazolinones
US7763628B2 (en) 1999-10-27 2010-07-27 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
WO2003106435A1 (fr) * 2002-06-18 2003-12-24 Sankyo Company, Limited Derives de la pyrimidin-4(3h)-one a cycles fusionnes, spn procede de preparation et ses utilisations
WO2004013111A1 (fr) * 2002-08-01 2004-02-12 Euro-Celtique S.A. Composes benzoheterocycliques bicycliques substitues en 2 et leur utilisation en tant que bloqueurs du canal sodique
EP1558260A4 (fr) * 2002-11-04 2006-10-25 Nps Pharma Inc Composes de quinazolinone utilises comme calcilytiques
JP2006512315A (ja) * 2002-11-04 2006-04-13 エヌピーエス ファーマスーティカルズ インコーポレイテッド カルシリティックとしてのキナゾリノン化合物
EP1558260A2 (fr) * 2002-11-04 2005-08-03 Nps Pharmaceuticals, Inc. Composes de quinazolinone utilises comme calcilytiques

Also Published As

Publication number Publication date
AR025797A1 (es) 2002-12-11
NO20021502L (no) 2002-03-26
BR0014294A (pt) 2002-05-21
AU7654800A (en) 2001-04-30
EP1216235A1 (fr) 2002-06-26
NO20021502D0 (no) 2002-03-26
KR20020047186A (ko) 2002-06-21
CA2385921A1 (fr) 2001-04-05

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