WO2001017566A3 - L-selectin-kontrastmittel - Google Patents

L-selectin-kontrastmittel Download PDF

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Publication number
WO2001017566A3
WO2001017566A3 PCT/EP2000/008693 EP0008693W WO0117566A3 WO 2001017566 A3 WO2001017566 A3 WO 2001017566A3 EP 0008693 W EP0008693 W EP 0008693W WO 0117566 A3 WO0117566 A3 WO 0117566A3
Authority
WO
WIPO (PCT)
Prior art keywords
contrast agents
selectin
depicting
relates
changes
Prior art date
Application number
PCT/EP2000/008693
Other languages
English (en)
French (fr)
Other versions
WO2001017566A2 (de
Inventor
Nils-Peter Debus
Sabine Sydow
Birte Hofmann
Andreas Briel
Georg Roessling
Original Assignee
Diagnostikforschung Inst
Debus Nils Peter
Sabine Sydow
Birte Hofmann
Andreas Briel
Georg Roessling
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10013849A external-priority patent/DE10013849A1/de
Application filed by Diagnostikforschung Inst, Debus Nils Peter, Sabine Sydow, Birte Hofmann, Andreas Briel, Georg Roessling filed Critical Diagnostikforschung Inst
Priority to EP00964128A priority Critical patent/EP1210125A2/de
Priority to AU75158/00A priority patent/AU7515800A/en
Priority to JP2001521354A priority patent/JP2003508499A/ja
Publication of WO2001017566A2 publication Critical patent/WO2001017566A2/de
Publication of WO2001017566A3 publication Critical patent/WO2001017566A3/de
Priority to NO20021128A priority patent/NO20021128L/no

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6425—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0058—Antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/124—Macromolecular compounds dendrimers, dendrons, hyperbranched compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/221—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by the targeting agent or modifying agent linked to the acoustically-active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Abstract

Die Erfindung betrifft neue Kontrastmittel zur Darstellung von Lymphknotenveränderungen und entzündlichen Prozessen sowie von pathologischen Veränderungen, die mit der spezifischen Expression von endothelialen und/oder leukozytären Liganden verbunden sind, sowie Verfahren zu deren Herstellung.
PCT/EP2000/008693 1999-09-08 2000-09-06 L-selectin-kontrastmittel WO2001017566A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP00964128A EP1210125A2 (de) 1999-09-08 2000-09-06 L-selectin-kontrastmittel
AU75158/00A AU7515800A (en) 1999-09-08 2000-09-06 L-selectin contrast agents
JP2001521354A JP2003508499A (ja) 1999-09-08 2000-09-06 Ｌ−セレクチン造影剤
NO20021128A NO20021128L (no) 1999-09-08 2002-03-07 L-selektinkontrastmidler

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19943710.6 1999-09-08
DE19943710 1999-09-08
DE10013849A DE10013849A1 (de) 1999-09-08 2000-03-15 L-Selectin-Kontrastmittel
DE10013849.7 2000-03-15

Publications (2)

Publication Number Publication Date
WO2001017566A2 WO2001017566A2 (de) 2001-03-15
WO2001017566A3 true WO2001017566A3 (de) 2001-12-20

Family

ID=26004930

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/008693 WO2001017566A2 (de) 1999-09-08 2000-09-06 L-selectin-kontrastmittel

Country Status (5)

Country Link
EP (1) EP1210125A2 (de)
JP (1) JP2003508499A (de)
AU (1) AU7515800A (de)
NO (1) NO20021128L (de)
WO (1) WO2001017566A2 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7087212B2 (en) * 2001-08-17 2006-08-08 Mallinckrodt, Inc Multicomponent assemblies having enhanced binding properties for diagnosis and therapy

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994000477A1 (en) * 1992-06-29 1994-01-06 Glycomed Incorporated Substituted lactose derivatives as cell adhesion inhibitors
WO1998018498A2 (en) * 1996-10-28 1998-05-07 Marsden, John, Christopher Improvements in or relating to diagnostic/therapeutic agents
WO1998018501A2 (en) * 1996-10-28 1998-05-07 Marsden, John, Christopher Improvements in or relating to diagnostic/therapeutic agents
WO1999032154A1 (de) * 1997-12-18 1999-07-01 Schering Aktiengesellschaft Dendritische polymer-saccharid-konjugate, diese enthaltende pharmazeutische mittel, verfahren zu ihrer herstellung und ihre verwendung

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994000477A1 (en) * 1992-06-29 1994-01-06 Glycomed Incorporated Substituted lactose derivatives as cell adhesion inhibitors
WO1998018498A2 (en) * 1996-10-28 1998-05-07 Marsden, John, Christopher Improvements in or relating to diagnostic/therapeutic agents
WO1998018501A2 (en) * 1996-10-28 1998-05-07 Marsden, John, Christopher Improvements in or relating to diagnostic/therapeutic agents
WO1999032154A1 (de) * 1997-12-18 1999-07-01 Schering Aktiengesellschaft Dendritische polymer-saccharid-konjugate, diese enthaltende pharmazeutische mittel, verfahren zu ihrer herstellung und ihre verwendung

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KIKUTA, AKIO ET AL: "Localization of ligands for L- selectin in mouse peripheral lymph node high endothelial cells by colloidal gold conjugates", BLOOD (1994), 84(11), 3766-75, XP001015464 *
WATSON, SUSAN R. ET AL: "A homing receptor-IgG chimera as a probe for adhesive ligands of lymph node high endothelial venules", J. CELL BIOL. (1990), 110(6), 2221-9, XP001015456 *

Also Published As

Publication number Publication date
NO20021128D0 (no) 2002-03-07
NO20021128L (no) 2002-03-07
AU7515800A (en) 2001-04-10
WO2001017566A2 (de) 2001-03-15
JP2003508499A (ja) 2003-03-04
EP1210125A2 (de) 2002-06-05

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