WO2001014564A3 - Polynucleotides expressed in activated t-lymphocytes and proteins encoded thereby - Google Patents

Polynucleotides expressed in activated t-lymphocytes and proteins encoded thereby Download PDF

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Publication number
WO2001014564A3
WO2001014564A3 PCT/US2000/022699 US0022699W WO0114564A3 WO 2001014564 A3 WO2001014564 A3 WO 2001014564A3 US 0022699 W US0022699 W US 0022699W WO 0114564 A3 WO0114564 A3 WO 0114564A3
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WIPO (PCT)
Prior art keywords
lymphocytes
activated
proteins encoded
polypeptide
nucleic acid
Prior art date
Application number
PCT/US2000/022699
Other languages
French (fr)
Other versions
WO2001014564A2 (en
Inventor
John A Peyman
Cynthia D Green
Andro Hsu
Jeffrey A Browning
John Carulli
Original Assignee
Curagen Corp
Biogen Inc
John A Peyman
Cynthia D Green
Andro Hsu
Jeffrey A Browning
John Carulli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curagen Corp, Biogen Inc, John A Peyman, Cynthia D Green, Andro Hsu, Jeffrey A Browning, John Carulli filed Critical Curagen Corp
Priority to JP2001518877A priority Critical patent/JP2003507070A/en
Priority to AU67857/00A priority patent/AU6785700A/en
Priority to CA002382123A priority patent/CA2382123A1/en
Priority to EP00955700A priority patent/EP1204754A2/en
Publication of WO2001014564A2 publication Critical patent/WO2001014564A2/en
Publication of WO2001014564A3 publication Critical patent/WO2001014564A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
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  • Engineering & Computer Science (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Genetics & Genomics (AREA)
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  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
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  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)

Abstract

Disclosed are four novel human nucleic acid sequences expressed in activated T-lymphocytes. Also provided are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to a polypeptide of the invention, or any derivative, variant, mutant or fragment of the polypeptide, polynucleotide or antibody. The invention further provides therapeutic, diagnostic and research methods for treating and diagnosing disorders related to these novel human T-lymphocyte proteins.
PCT/US2000/022699 1999-08-20 2000-08-18 Polynucleotides expressed in activated t-lymphocytes and proteins encoded thereby WO2001014564A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2001518877A JP2003507070A (en) 1999-08-20 2000-08-18 Novel polynucleotides expressed in activated T lymphocytes and proteins encoded thereby
AU67857/00A AU6785700A (en) 1999-08-20 2000-08-18 Novel polynucleotides expressed in activated t-lymphocytes and proteins encoded thereby
CA002382123A CA2382123A1 (en) 1999-08-20 2000-08-18 Novel polynucleotides expressed in activated t-lymphocytes and proteins encoded thereby
EP00955700A EP1204754A2 (en) 1999-08-20 2000-08-18 Polynucleotides expressed in activated t-lymphocytes and proteins encoded thereby

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US15010599P 1999-08-20 1999-08-20
US60/150,105 1999-08-20
US56153300A 2000-04-28 2000-04-28
US56094800A 2000-04-28 2000-04-28
US56036500A 2000-04-28 2000-04-28
US56010100A 2000-04-28 2000-04-28
US09/560,948 2000-04-28
US09/560,365 2000-04-28
US09/561,533 2000-04-28
US09/560,101 2000-04-28

Publications (2)

Publication Number Publication Date
WO2001014564A2 WO2001014564A2 (en) 2001-03-01
WO2001014564A3 true WO2001014564A3 (en) 2001-11-22

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/022699 WO2001014564A2 (en) 1999-08-20 2000-08-18 Polynucleotides expressed in activated t-lymphocytes and proteins encoded thereby

Country Status (5)

Country Link
EP (1) EP1204754A2 (en)
JP (1) JP2003507070A (en)
AU (1) AU6785700A (en)
CA (1) CA2382123A1 (en)
WO (1) WO2001014564A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2265389T3 (en) 2000-12-22 2007-02-16 Bristol-Myers Squibb Company HUMAN PROTEIN CONTAINING REPETITIONS RICH IN LEUCINE EXPRESSED PREDOMINANTLY IN THE INTESTINE DELGADO, HLRRSI1.
CA2353371A1 (en) 2001-01-29 2002-07-29 Robert J. Mcleod Apparatus for stripping a coating from an optical fibre
US20050069549A1 (en) 2002-01-14 2005-03-31 William Herman Targeted ligands
US20040002593A1 (en) * 2002-04-04 2004-01-01 Reed John C. PAAD domain-containing polypeptides, encoding nucleic acids, and methods of use
US20040203132A1 (en) 2003-02-28 2004-10-14 Cognetix, Inc. Conus protein disulfide isomerase

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993005073A1 (en) * 1991-09-11 1993-03-18 The Trustees Of Boston University ANGIOTENSIN IIcAMP/VASOPRESSINV2 RECEPTORS AND RELATED MOLECULES AND METHODS
WO1997006260A1 (en) * 1995-08-03 1997-02-20 Bio Merieux Viral material and nucleotide fragments associated with multiple sclerosis useful for diagnostic, preventive and therapeutic purposes
WO1998023755A1 (en) * 1996-11-26 1998-06-04 Bio Merieux Viral material and nucleotide fragments associated with multiple sclerosis, for diagnostic, prophylactic and therapeutic purposes
FR2762601A1 (en) * 1997-04-29 1998-10-30 Bio Merieux POLYPEPTIDE CAPABLE OF RESPONDING TO ANTIBODIES OF PATIENTS WITH MULTIPLE SCLEROSIS AND USES

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993005073A1 (en) * 1991-09-11 1993-03-18 The Trustees Of Boston University ANGIOTENSIN IIcAMP/VASOPRESSINV2 RECEPTORS AND RELATED MOLECULES AND METHODS
WO1997006260A1 (en) * 1995-08-03 1997-02-20 Bio Merieux Viral material and nucleotide fragments associated with multiple sclerosis useful for diagnostic, preventive and therapeutic purposes
WO1998023755A1 (en) * 1996-11-26 1998-06-04 Bio Merieux Viral material and nucleotide fragments associated with multiple sclerosis, for diagnostic, prophylactic and therapeutic purposes
FR2762601A1 (en) * 1997-04-29 1998-10-30 Bio Merieux POLYPEPTIDE CAPABLE OF RESPONDING TO ANTIBODIES OF PATIENTS WITH MULTIPLE SCLEROSIS AND USES

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
ALLEN P B ET AL: "SPINOPHILIN, A NOVEL PROTEIN PHOSPHATASE 1 BINDING PROTEIN LOCALIZED TO DENDRITIC SPINES", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA,NATIONAL ACADEMY OF SCIENCE. WASHINGTON,US, vol. 94, no. 18, September 1997 (1997-09-01), pages 9956 - 9961, XP000971408, ISSN: 0027-8424 *
DATABASE EMBL 11 September 1997 (1997-09-11), B. BIRREN ET AL.: "Homo sapiens chromosome 17, clone RPC875H18", XP002156741 *
DATABASE EMBL 19 September 1997 (1997-09-19), R. PAVITT ET AL.: "Homo sapiens DNA sequence from PAC 262D12 on chromosome 1q23.3-24.3", XP002166772 *
DATABASE EMBL 26 August 1997 (1997-08-26), G.A. EVANS ET AL.: "Homo sapiens chromosome 11 from 11p15.5 region", XP002166767 *
DATABASE EMBL 29 June 2000 (2000-06-29), G.A. KOMATSOULIS ET AL.: "WO-A-200006698", XP002166770 *
DATABASE EMBL 7 December 1999 (1999-12-07), GENETECH INC.: "WO-A-9 946 281", XP002166768 *
DATABASE EMBL 8 May 2000 (2000-05-08), O. BANDMAN ET AL.: "WO-A-20005368", XP002166769 *
DATABASE EMBL M. BECKER ET AL.: "The sequence of H. sapiens PAC clone RP3-404F18.", XP002166771 *
J-M. WONG ET AL.: "Cloning of a cDNA encoding an Acanthamoeba castellanii PDI-like protein.", GENE, vol. 150, 1994, pages 175 - 179, XP002166765 *
M. HIROKAWA ET AL.: "Signal transduction by B7/BB1 expressed on activted T lymphocytes: cross-linking of B7/BB1 induces protein tyrosine phosphorylation and synergizes with signalling through T-cell receptor/CD3.", IMMUNOLOGY, vol. 86, 1995, pages 155 - 161, XP002156740 *
R. WILSON ET AL.: "2.2Mb of contiguous nucleotide sequence from chromosome III of C. elegans.", NATURE, vol. 368, 1994, pages 32 - 38, XP002166766 *
SATOH A ET AL: "NEURABIN-II/SPINOPHILIN AN ACTIN FILAMENT-BINDING PROTEIN WITH ONE PDZ DOMAIM LOCALIZED AT CADHERIN-BASED CELL-CELL ADHESION SITES", JOURNAL OF BIOLOGICAL CHEMISTRY,AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD,US, vol. 273, no. 6, 6 February 1998 (1998-02-06), XP000971409, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
WO2001014564A2 (en) 2001-03-01
JP2003507070A (en) 2003-02-25
EP1204754A2 (en) 2002-05-15
AU6785700A (en) 2001-03-19
CA2382123A1 (en) 2001-03-01

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