WO2001009619A1 - Plaque reactive biochimique - Google Patents

Plaque reactive biochimique Download PDF

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Publication number
WO2001009619A1
WO2001009619A1 PCT/CN2000/000218 CN0000218W WO0109619A1 WO 2001009619 A1 WO2001009619 A1 WO 2001009619A1 CN 0000218 W CN0000218 W CN 0000218W WO 0109619 A1 WO0109619 A1 WO 0109619A1
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WO
WIPO (PCT)
Prior art keywords
plate
hole
biochemical
reagent
biochemical reagent
Prior art date
Application number
PCT/CN2000/000218
Other languages
English (en)
French (fr)
Inventor
Gang Niu
Yang Zhang
Delu Gao
Original Assignee
Gang Niu
Yang Zhang
Delu Gao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gang Niu, Yang Zhang, Delu Gao filed Critical Gang Niu
Priority to AU62579/00A priority Critical patent/AU6257900A/en
Publication of WO2001009619A1 publication Critical patent/WO2001009619A1/zh

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0644—Valves, specific forms thereof with moving parts rotary valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/065—Valves, specific forms thereof with moving parts sliding valves

Definitions

  • the utility model relates to a disposable biochemical reagent board dedicated to an automatic biochemical analyzer, which is used for detecting a sample instead of a cuvette.
  • biochemical analyzers Since its introduction in the late 1950s, biochemical analyzers have developed extremely rapidly, and they can be applied to many fields such as medicine, food, environment, and medical clinics. In particular, it is widely used in clinical medicine. Because its role is mainly to analyze and determine various biochemical indicators in human blood, and to guide clinicians to make accurate diagnosis of patients, it has become an indispensable test in hospital work. instrument.
  • the development of biochemical analyzers has also undergone manual operations, with fewer indicators that can be detected. It has gradually developed to semi-automatic biochemical analyzers and the most widely used fully automatic biochemical analyzers.
  • the detection indicators have also been developed from the original ones to now, and more than 60 items can be tested. For example, detection of three or five items of blood lipids (cholesterol, triglyceride, lipoprotein, etc.), and biochemical indicators that reflect changes in the heart muscle.
  • the most widely used automatic biochemical analyzer is based on the principle of two reagents and two reactions, and the colorimetric method is used for detection and analysis.
  • the detection process is as follows: firstly, quantify the serum sample of the subject into the cuvette, quantitatively draw the reaction reagent and the diluent with a fully automatic syringe, and then add it to the same cuvette, mix and measure by colorimetry. Prior to the next sample test, all used motor syringes and cuvettes need to be cleaned; procedures such as air bubbles in the tubing must be drained. Due to its complete functions and fast speed, the advantages are prominent, and the parts to be solved and improved are more prominent.
  • the purpose of this utility model is to design a single-use biochemical T-type agent plate, improve the detection speed and accuracy of the biochemical analyzer, and simplify the detection process.
  • the biochemical reagent plate is characterized in that it is a plate-shaped body, and a through hole 3 is opened in the center of the plate-shaped body 2.
  • the biochemical reagent is injected into the through hole 3 in advance. Both ends of hole 3 are sealed with a transparent material.
  • the biochemical reagent injected into the through hole 3 in advance is a standard solution.
  • the biochemical reagent injected into the through-hole 3 in advance is an accurate amount of a reaction reagent or a reaction solution.
  • a ventilation tube 7 is drawn above the through-hole 3 to the upper end of the plate-shaped body 2, and a hole 5 is opened at the upper end of the plate-shaped body 2.
  • the hole is sealed with a parafilm.
  • the lower end of the hole is a lumen 6 in the plate-shaped body.
  • the diluent is injected into the lumen 6 in advance.
  • the lumen 6 communicates with the ventilation 7 through a groove.
  • a control device 8 capable of controlling the directional flow of the liquid is provided.
  • an inner cavity 9 is also provided in the plate-shaped body 3, and another accurate amount of a reaction reagent or a reaction solvent is injected into the inner cavity 9 in advance, and the inner cavity 9 is also communicated with the ventilation tube 7 through the control device 8.
  • the control device 8 is a spring switch, a mechanical tee, a rotary switch, a horizontal movement switch or an electromagnetic switch.
  • the plate-shaped body is made of plastic.
  • the biochemical reagent standard plate with stable quality can calibrate and calibrate the instrument at any time. Compared with the calibration and calibration process of traditional biochemical analyzer, it is more accurate and reliable, the operation is simpler, and the standard solution as a consumable is saved.
  • the plate type wet automatic biochemical analyzer does not require diluent, cleaning solution, deionized water and other consumables and its associated equipment, which not only saves costs, but also reduces the chance of contamination between the reagent room and the sample room, saving The time for cleaning improves the detection speed.
  • the biochemical reagent board after the test is easy to handle as solid waste.
  • Figure 1 is a schematic diagram of the structure of a standard biochemical reagent plate
  • Figure 2 is a schematic diagram of the structure of a single reagent biochemical reagent plate
  • Figure 3 is a schematic diagram of the structure of a dual reagent biochemical reagent plate
  • the standard biochemical reagent board can be produced and calibrated in the production workshop.
  • the standard biochemical reagent plate contains a sealed standard solution of known concentration. It is used many times within a relatively long validity period, with high accuracy, and no deviation should occur. However, the calibration and calibration of traditional biochemical analyzers require the consumption of standard solutions and the cleaning process. Self-calibration is performed. Large-scale quality control is prone to deviations.
  • the standard biochemical reagent board 1 is made of plate-shaped body 2 made of plastic. The dimensions of its length X width X thickness can be: 40mm X 25mm X 4mm.
  • a through hole 3 is opened in the center of the plate-shaped body 2.
  • the standard solution is pre-filled and reused.
  • the transparent material seals both ends of the through hole 3 containing the standard solution.
  • the three biochemical reagents designed by the present utility model have a common feature, that is, a plate-shaped body as a whole, and a through hole 3 is opened in the center of the plate-shaped body.
  • the biochemical reagent is injected in advance, and the biochemical reagent referred to herein may be a standard solution, or a reaction reagent or a reaction solvent, and then both ends of the through hole 3 are sealed with a transparent material so that the color of the biochemical reagent can be observed from the outside.
  • the biochemical reagent referred to herein may be a standard solution, or a reaction reagent or a reaction solvent, and then both ends of the through hole 3 are sealed with a transparent material so that the color of the biochemical reagent can be observed from the outside.
  • the specifications of the single-reagent biochemical reagent plate 4 are the same as those of the standard biochemical reagent plate 1 and are also made of plastic.
  • a through hole 3 is opened in the center of the plate-shaped body 2, and an accurate amount of reaction reagent or reaction solvent is injected in advance. Then, it is sealed with a transparent material to form a reaction tank.
  • a ventilation tube 7 is arranged above the reaction tank 3 to pass through the upper end of the plate-shaped body 2, and a hole 5 is opened on the upper end side of the plate-shaped body 2.
  • the hole 5 is sealed with a sealing film Below the hole 5 is an internal cavity 6, and the diluent is injected into the internal cavity 6 in advance, and the internal cavity 6 is connected to the ventilation tube 7 through the control device 8.
  • the sealing film is punctured and the test sample is added, such as a serum sample.
  • the test sample is injected into the inner cavity 6 and diluted.
  • the operation control device 8 causes the diluted sample to flow from the inner cavity 6 into the reaction tank 3 and react with the reaction. Reagents are mixed. When the reaction is completed, the color of the liquid in the reaction tank is compared with the standard biochemical reagent plate to obtain accurate data.
  • the dual-reagent biochemical reagent plate 10 shown in FIG. 3 is designed. Its shape and structure are basically the same as those in FIG. 2. The difference is that an inner plate is provided in the plate-shaped body 2. The cavity 9 is pre-injected with a second reaction reagent, and the inner cavity 9 is in communication with the control device 8.
  • control devices refer to all devices capable of controlling the directional flow of liquid, such as a spring switch, a mechanical tee, a rotary switch, a horizontal movement switch, an electromagnetic switch, and a gas switch.
  • the utility model produces a secondary reagent plate by injection molding, and in the production workshop, the reagents participating in the reaction are quantitatively filled into the reaction tank of the reagent plate in advance, and the control device on the reagent plate is controlled and adjusted to make it suitable for detection and reception.
  • the sample When testing a sample, the sample must be quantitatively added to the biochemical reagent plate, and the pre-sealed quantitative reaction reagents and diluent in the biochemical reagent plate are mixed with the reaction tank of the sample on the biochemical reagent plate.
  • the inner cavity 6 or 9 of the reagent plate is Under the control of the control device, it flows into the next reaction via the channel. -Step reaction. After the reaction is completed, colorimetric measurement is performed. The colorimetric measurement is based on a biochemical reaction tank.

Description

生化试剂板 技术领域
本实用新型涉及一种专用于 ^自动生化分折仪的一次性生化试剂板， 用 于取代比色杯对样品进行检测。
背景技术
生化分析仪自本世纪 50年代末面世以来， 发展极其迅速， 它可应用于药 品、 食品、 环境、 医学临床等诸多领域。 特别是在医学临床中应用相当广泛， 由于它的作用主要是对人体血液中的各种生化指标进行分析测定， 指导临床 医师对患者作出准确的诊断， 它已经是医院工作中绝不可缺少的检测仪器。 生化分析仪的发展同样是经过了原来的手工操作， 可进行检测的指标较少， 逐步发展到半自动生化分析仪以及目前应用最广泛的全自动生化分析仪。 检 测的指标也由原来的几个发展到现在的可以进行 60多个项目的检测。 例如血 脂三项、 五项 （胆固醇、 甘油三指、 脂蛋白等等） 、 反映心肌变化的生化指 标的检测。
目前， 应用最广泛的全自动生化分析仪是采用双试剂、 双反应原理， 用 比色法进行检测和分析。 检测工作过程是： 先将受试者的血清样品定量加入 比色杯， 用全自动注射器定量吸取反应试剂和稀释液后加入同一个的比色杯 中， 混合均匀用比色的方法测定。 进行下一个样品检测前， 需要清洗所有使 用过的电动注射器和比色杯； 还要排出管道中的气泡等程序。 由于它的功能 齐全， 速度快， 优点是突出了， ^要解决和改进的部分也就比较突出地显现 出来， 比如： 它有复杂的结构， 其价格昂贵； 多次取样误差出现的几率大； 清洗系统庞大， 增加检测的费用； 标准品的使用是相对进行自身的校对， 且 价格不菲等等。 即使这样， 由于它自身设计的严谨和多年的发展， 己经趋于 完善。
发明内容
针对上述现有生化分析仪中采用比色杯所存在的不足， 本实用新型的目 的是设计一种一次性使用的生化 t式剂板， 提高生化分析仪的检测速度和精 度， 简化检测工序。
实现上述目的的主要技术方： ¾是： 该生化试剂板， 其特征在于它呈板状 体， 在板状体 2的中央开有一通孔 3 ， 在通孔 3 内预先注入有生化试剂， 通 孔 3 的两端用透明材料密封。 还在通孔 3 内预先注入的生化试剂是标准液。 或者在通孔 3内预先注入的生化试剂是准确量的反应试剂或反应溶液，通孔 3 的上方引出一通气管 7至板状体 2的上端， 在板状体 2的上端开有一孔 5， 该孔用封口膜密封， 孔的下端在板状体内是一内腔 6， 内腔 6 内预先注入稀 释剂， 内腔 6通过一沟槽与通气 7相连通， 在通气孔与沟槽相连处设置有 能控制液体定向流动的控制装置 8。 或者在板状体 3 内还设置有内腔 9， 内 腔 9内预先注入另一种准确量的的反应试剂或反应溶剂， 内腔 9亦通过控制 装置 8与通气管 7相连通。 所述控制装置 8是弹簧幵关、 机械三通、 旋转开 关、 水平移动开关或电磁开关。 该板状体采用塑料制造。
本实用新型的优点是：
1、 由于参与反应的生化试剂和稀释液均在生产车间定量加入，避免了一 般生化分析仪可能出现的取样、 加样剂量不准确的问题， 检测结果重现性好， 易于进行大范围的质量控制， 不同仪器的检测结果可比性强。
2、 质量稳定的生化试剂标准板可以随时对仪器进行标定、 校正， 与传统 生化分析仪的标定、 校正过程相比更加准确可靠， 操作更简单， 节省了作为 消耗品的标准液。
3、在保证检测样品的灵敏度的同时，大大降低了仪器的制造、维护成本， 使医院和患者都减少了支出。
4、 板式湿式全自动生化分析仪不需要稀释液， 清洗液、 去离子水等消耗 品和与之配套的设备， 不仅节约了费用， 而且减少了试剂间和样品间发生污 染的机会， 节省了用于清洗的时间， 提高了检测速度。
5、 检测后的生化试剂板作为固体废物易于处理。
6、 可以安装多个反应器， 使之进行试剂板的连续检测， 检测速度加快。 以下结合附图对本实用新型作进一步详细描述：
附图概述
图 1为标准生化试剂板的结构示意图
图 2为单试剂生化试剂板的结构示意图
图 3为双试剂生化试剂板的结构示意图
最佳实施方式
标准生化试剂板请参阅图 】 ， 可以在生产车间制作完成标准的生化试剂 板对仪器的标定、 校正。 标准生化试剂板内有密封的已知浓度的标准液， 可 在相当长的有效期内多次使用， 准确性高， 不宜出现偏差。 而传统生化分析 仪的标定、 校正需要消耗标准液， 也需要清洗过程， 进行的是自身的校正， 大范围的质控极易发生偏差。 标准生化试剂板 1 用塑料制成板状体 2 ， 其长 X宽 X厚的尺寸可为： 40mm X 25mm X 4mm， 在板状体 2的中央开一通孔 3， 预先注入标准液， 再用透明材料将装有标准液的通孔 3的两端予以密封。
参阅图 1 、 图 2、 图 3， 本实用新型所设计的三种生化试剂均具有共同 的特征， 即整体为板状体， 在板状体的中央开有一通孔 3 ， 在通孔 3 内预先 注入有生化试剂， 这里所说的生化试剂可以是标准液， 也可以是反应试剂或 反应溶剂， 然后将通孔 3 的两端用透明材料密封， 以便从外部能观察到生化 试剂的颜色。 当其作为单试剂或双试剂生化试剂板时， 其内部结构需作如下 改变：
如图 2所示， 单试剂生化试剂板 4的规格同标准生化试剂板 1 ， 亦采用 塑料制成， 在板状体 2的中央开一通孔 3 ， 预先注入准确量的反应试剂或反 应溶剂， 再用透明材料密封， 形成一反应槽， 该反应槽 3 上方设置有一通气 管 7直通板状体 2的上端，在板状体 2的上端一侧开有孔 5， 该孔 5用封口膜 密封， 孔 5下方是内腔 6， 在内腔 6内预先注入稀释液， 内腔 6通过控制装 置 8与通气管 7相连。 使用时， 封口膜被刺穿后加入被测样品， 如血清样品， 被测样品注入内腔 6内被稀释， 操作控制装置 8使被稀释的样品由内腔 6内 流入反应槽 3 内与反应试剂混合， 当反应完毕， 再将反应槽内的液体颜色与 标准生化试剂板进行比较， 即可得到准确的数据。
有些样品的检测需要两种试剂才能完成， 为此设计了图 3 所示的双试剂 生化试剂板 10， 其形状和构造与图 2基本相同， 不同点在于在板状体 2内还 设置有一内腔 9， 预先注入第二种反应试剂， 内腔 9与控制装置 8相通。
上述的控制装置是指所有能控制液体的定向流动的装置， 例如弹簧幵 关、 机械三通、 旋转开关、 水平移动开关、 电磁开关、 气体幵关等。
工业应用性
本实用新型通过注塑生产出 次性试剂板， 并在生产车间中将参与反应 的试剂预先定量地装入试剂板的反应槽中， 通过控制和调节试剂板上的控制 装置， 使之在检测受检样品时， 需将样品定量加入生化试剂板中， 使生化 试剂板中预先密封的定量反应试剂和稀释液与样品在生化试剂板上的反应槽 混合， 试剂板上的内腔 6或 9在控制装置的控制下经通道定向流入下一个反 -步反应， 待反应完毕， 再进行比色测定， 比色测定是靠生化 应槽， 完成下
分析仪来完成的。

Claims

权 利 要 ^ ^
1、 一种生化试剂板， 其特征在于它呈板状体， 在板状体 （ 2 ) 的中央开 有一通孔 （ 3 ) ， 在通孔 （ 3 ) 内预先注入有生化试剂， 通孔 （ 3 ) 的两端 用透明材料密封。
2、 根据权利要求 1所述的生化试剂板， 其特征在于在通孔 （ 3 ) 内预先 注入的生化试剂是标准液。
3、 根据权利要求 1所述的生化试剂板， 其特征在于通孔 （ 3 ) 内预先注 入的生化试剂是准确量的反应试剂或反应溶液， 通孔 （ 3 ) 的上方引出一通 气管 （ 7 ) 至板状体 （ 2 ) 的上端， 在板状体 （ 2 ) 的上端幵有一孔 （ 5 ) ， 该孔用封口膜密封， 孔的下端在板状体内是一内腔 （ 6 ) ， 内腔 （ 6 ) 内预 先注入稀释剂， 内腔 （ 6 ) 通过一沟槽与通气管 （ 7 ) 相连通， 在通气孔与 沟槽相连处设置有能控制液体定向流动的控制装置 （ 8 ) 。
4、 根据权利要求 3所述的生化试剂板， 其特征在于在板状体 （ 3 ) 内还 设置有内腔 （ 9 ) ， 内腔 （ 9 ) 内预先注入另一种准确量的反应试剂或反应 溶剂， 内腔 （ 9 ) 亦通过控制装置 （ 8 ) 与通气管 （ 7 ) 相连通。
5、 根据权利要求 3或 4所述的生化试剂板， 其特征在于控制装置 （ 8 ) 是弹簧开关、 机械三通、 旋转幵关、 水平移动开关或电磁开关。
6、 根据权利要求 1或 2或 3或 4所述的生化试剂板， 其特征在于板状体 采用塑料制造。
PCT/CN2000/000218 1999-08-03 2000-08-01 Plaque reactive biochimique WO2001009619A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU62579/00A AU6257900A (en) 1999-08-03 2000-08-01 A biochemical reagent plate

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN99217522.4 1999-08-03
CN99217522U CN2382019Y (zh) 1999-08-03 1999-08-03 生化试剂板

Publications (1)

Publication Number Publication Date
WO2001009619A1 true WO2001009619A1 (fr) 2001-02-08

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AU (1) AU6257900A (zh)
WO (1) WO2001009619A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10088939B2 (en) 2012-04-10 2018-10-02 Idex Asa Biometric sensing

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN88200537U (zh) * 1988-01-12 1988-11-09 邹福强 非平面型的分析试剂卡
JPH0392762A (ja) * 1989-09-05 1991-04-17 Fuji Photo Film Co Ltd 生化学分析装置
CN2082864U (zh) * 1990-09-17 1991-08-14 姜光斗 高效多用免疫生化反应器
CN1154476A (zh) * 1995-09-05 1997-07-16 株式会社日立制作所 自动分析装置和显示方法
US5904899A (en) * 1997-05-15 1999-05-18 Tosoh Corporation Assaying apparatus and a vessel holder device in use with the assaying apparatus

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN88200537U (zh) * 1988-01-12 1988-11-09 邹福强 非平面型的分析试剂卡
JPH0392762A (ja) * 1989-09-05 1991-04-17 Fuji Photo Film Co Ltd 生化学分析装置
CN2082864U (zh) * 1990-09-17 1991-08-14 姜光斗 高效多用免疫生化反应器
CN1154476A (zh) * 1995-09-05 1997-07-16 株式会社日立制作所 自动分析装置和显示方法
US5904899A (en) * 1997-05-15 1999-05-18 Tosoh Corporation Assaying apparatus and a vessel holder device in use with the assaying apparatus

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10088939B2 (en) 2012-04-10 2018-10-02 Idex Asa Biometric sensing

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AU6257900A (en) 2001-02-19

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